F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 18412947  18 NWTELPPELTSAILHRLGAIEILENAQKVCRSWRRVCKDPSMWRKID 64
Cdd:cd22164   1 NWLDLPDDLTASILSRLGAIDILTNAQKVCKLWRRICKDPSMWRVID 47

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 18412947  18 NWTELPPELTSAILHRLGAIEILENAQKVCRSWRRVCKDPSMWRKID 64
Cdd:cd22164   1 NWLDLPDDLTASILSRLGAIDILTNAQKVCKLWRRICKDPSMWRVID 47

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412947 126 SQITDDGFVEAVVKLP--LEELELSYCSFSVESLRVVgQCCLNMKTLKLNKhpQKENDDDAL-AIAETMPKLRHLQL--C 200
Cdd:cd09293  12 GQITQSNISQLLRILHsgLEWLELYMCPISDPPLDQL-SNCNKLKKLILPG--SKLIDDEGLiALAQSCPNLQVLDLraC 88

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18412947 201 GNgLSDTGLNAILDNCSNLEHLDLRRCFNVNLVGDL 236
Cdd:cd09293  89 EN-ITDSGIVALATNCPKLQTINLGRHRNGHLITDV 123

Leucine-rich repeat (LRR) protein [Transcription];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412947 115 SNLRSLRLIRCS--QITDdgFVEAVVKLP-LEELELSYCSfsVESLRVVGQCCLNMKTLKLNKhpqkeNDDDAL--AIAE 189
Cdd:COG4886 133 ANLTNLKELDLSnnQLTD--LPEPLGNLTnLKSLDLSNNQ--LTDLPEELGNLTNLKELDLSN-----NQITDLpePLGN 203

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18412947 190 tMPKLRHLQLCGNGLSDtgLNAILDNCSNLEHLDLRRC 227
Cdd:COG4886 204 -LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNN 238

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 18412947  18 NWTELPPELTSAILHRLGAIEILENAQKVCRSWRRVCKDPSMWRKID 64
Cdd:cd22164   1 NWLDLPDDLTASILSRLGAIDILTNAQKVCKLWRRICKDPSMWRVID 47

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412947 126 SQITDDGFVEAVVKLP--LEELELSYCSFSVESLRVVgQCCLNMKTLKLNKhpQKENDDDAL-AIAETMPKLRHLQL--C 200
Cdd:cd09293  12 GQITQSNISQLLRILHsgLEWLELYMCPISDPPLDQL-SNCNKLKKLILPG--SKLIDDEGLiALAQSCPNLQVLDLraC 88

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18412947 201 GNgLSDTGLNAILDNCSNLEHLDLRRCFNVNLVGDL 236
Cdd:cd09293  89 EN-ITDSGIVALATNCPKLQTINLGRHRNGHLITDV 123

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 18412947    19 WTELPPELTSAILHRLGAIEILeNAQKVCRSWRRVCKDPSMWRK 62
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLL-RLSLVSKRWRSLVDSLKLWKK 43

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18412947  19 WTELPPELTSAILHRLGAIEILENAQK-------VCRSWRRVCKD 56
Cdd:cd22153   1 WANLPPELLRDIIQRVEESESAWPSRKnvvacasVCKSWREITKE 45

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18412947  20 TELPPELTSAILHRLGaIEILENAQKVCRSWRRVCKD-PSMWRK 62
Cdd:cd22113   2 ELLPPEMSLRIFSQLD-VQSLCRASQTCKTWNDLIENsDYLWRP 44

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18412947  19 WTELPPELTSAILHRLGAIEILeNAQKVCRSWRRVCKDPSMWRKI 63
Cdd:cd22132   1 WPLLPDSLLLHIFSYLSPKDLL-AAGQVCKQWYRVSRDEFLWKEL 44

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18412947  22 LPPELTSAILHRLGAIEILENAQkVCRSWRRVCKDPSMWRKI 63
Cdd:cd22147   5 LPVELSLKILSYLDAKSLCRAAQ-VSKKWRNLADDDELWKRM 45

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412947 103 TVDL-LNYIAH-----------RSSNLRSLRLiRCSQITDDGfVEAVVKL-----PLEELELSYCSFSVESLRVVGQCCL 165
Cdd:COG5238 268 TLYLsGNQIGAegaialakalqGNTTLTSLDL-SVNRIGDEG-AIALAEGlqgnkTLHTLNLAYNGIGAQGAIALAKALQ 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412947 166 NMKTLK-LNKHPQKENDDDALAIA---ETMPKLRHLQLCGNGLSDTGLNAILD--NCSNLEHLDLRrcfnVNLVGDLQKR 239
Cdd:COG5238 346 ENTTLHsLDLSDNQIGDEGAIALAkylEGNTTLRELNLGKNNIGKQGAEALIDalQTNRLHTLILD----GNLIGAEAQQ 421

F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and similar proteins; ScDIA2 is a replication origin-binding protein that plays a role in regulating DNA replication. It is a component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 18412947  19 WTELPPELTSAILHRLGAIEILENAQkVCRSWRRVCKD-PSMWRKIDM 65
Cdd:cd22142   2 WENLPLDILPLIFQKFSTKELITLSH-VCSSWRAKILDfPHLWKTVEL 48

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 18412947  22 LPPELTSAILHRLGAIEILENAQkVCRSWRRVCKDPSMWR 61
Cdd:cd22133  21 LPKELALYVLSFLEPKDLLQAAQ-TCRYWRILAEDNLLWR 59

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18412947  20 TELPPELTSAILHRLGAIEiLENAQKVCRSWRRVCKDPSMWRK 62
Cdd:cd22102   2 LDLPPELLVEIFSSLPGTD-LPSLAQVCKKFREILNTDTIWQR 43

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 18412947  20 TELPPELTSAILHRLGAIEILeNAQKVCRSWRRVCK 55
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLL-RLSLVCKRWRELAS 35

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18412947  20 TELPPELTSAILHRLgAIEILENAQKVCRSWRRVCKDPSMWRK 62
Cdd:cd22166   2 TKLPPELFRHILKFL-SPEDLTSCATVCRFLRGAASDESLWRR 43