Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410069  95 IESAVSAARPGDTIlIVAGGNYRvSNIQIKKPLCLVGGGEipdetTLVCARGSDSALELLST-CKLANLTVK-------A 166
Cdd:COG3420  24 LQAAIDAAPPGDTI-EVPPGTYE-GNIVIDKPLTLIGEGG-----AVIDGGGKGTVITITADnVTVRGLTITgsgdsltD 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18410069 167 ELGCCLLHRSGRLTIDGCvlqcetnpldhlscpivstagdeDIENILSHVEVKetvtgkiKANSVTVLQTRIEGGAKAVS 246
Cdd:COG3420  97 DDAGIYVRGADNAVIENN-----------------------RIENNLFGIYLE-------GSDNNVIRNNTISGNRDLRA 146

                       170
                ....*....|....*.
gi 18410069 247 TRGDLvlqrVRVMYSK 262
Cdd:COG3420 147 DRGNG----IHLWNSP 158

F-box-like; This is an F-box-like family.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18410069    43 LMHILSFLSPiPDRYNTALVCHRWRYLACHPRLWLRVD 80
Cdd:pfam12937   9 LLQIFSYLDP-KDLLRLALVCRRWRELASDDSLWRRLC 45

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18410069     38 LDDGCLMHILSFLSPIpDRYNTALVCHRWRYLACHPRLWLR 78
Cdd:smart00256   1 LPDEILEEILSKLDPK-DLLRLRKVSRKWRSLIDSHDFWFK 40

F-box-like; This is an F-box-like family.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18410069    43 LMHILSFLSPiPDRYNTALVCHRWRYLACHPRLWLRVD 80
Cdd:pfam12937   9 LLQIFSYLDP-KDLLRLALVCRRWRELASDDSLWRRLC 45

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18410069  42 CLMHILSFLSPIpDRYNTALVCHRWRYLACHPRLWLRVD 80
Cdd:cd22138   8 CQLKIFSFLSEV-DKCLAATVCRSWSELIRSPRLWRTVD 45

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 18410069  36 NNLDDGCLMHILSFLSPiPDRYNTALVCHRWRYLAC 71
Cdd:cd09917   1 SDLPDEILLKILSYLDP-RDLLRLSLVCKRWRELAS 35

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18410069  35 LNNLDDGCLMHILSFLsPIPDRYNTALVCHRWRYLACHPRLW 76
Cdd:cd22123   1 LDQLPENVLLEILSYL-PVRDLLRISRVCKRWRRLVYDKTLW 41

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|..
gi 18410069  35 LNNLDDGCLMHILSFLSPIPDRYNTALVCHRW 66
Cdd:cd22159   1 IDLLPDEILELIFSYLSDPWDRNSCSLVCKRW 32

F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called FBX39, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a cancer/testis antigen from colon cancer patients by serological analysis of recombinant cDNA expression libraries (SEREX). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 18410069  37 NLDDGCLMHILSFLsPIPDRYNTALVCHRWRYLACHPRLW 76
Cdd:cd22108   3 NLPDVCLRHVFRWL-GDRDRSRAALVCKRWNQAMYSPALW 41

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18410069  36 NNLDDGCLMHILSFLSPiPDRYNTALVCHRWRYLACHPRLWLR 78
Cdd:cd22122   2 HVLPREVWLPVFQYLSP-KDLCVCMRVCKTWNRWCCDPSLWKR 43

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|....
gi 18410069  46 ILSFLSPiPDRYNTALVCHRWRYLACHPRLWLRV 79
Cdd:cd22109  14 VFSYLDT-KSLLRCAEVCREWRDVSRHPALWQRV 46

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|....
gi 18410069  43 LMHILSFLSPIpDRYNTALVCHRWRYLACHPRLW 76
Cdd:cd22118   9 MLKIFSYLNPQ-DLCRCAQVCTKWSQLARDGSLW 41

F-box domain found in F-box/LRR-repeat protein 22 (FBXL22) and similar proteins; FBXL22, also called F-box and leucine-rich repeat protein 22, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). It acts as a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18410069  35 LNNLDDGCLMHILSFLSPiPDRYNTALVCHRWRYLACHPRLW 76
Cdd:cd22129   1 ITELNRECLLHLFSFLDK-DSRRSLSLTCHRLRDVFLDPALW 41