|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
35-495 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 588.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 35 QAIVLIVTFLAYASYHAARKTTSIVKSALDPQSpdtglnSLLLRFTSFGSSVKEEGGWAPFNGPDGTVLLGEIDVAFLAV 114
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNC------SALIPPPNIVLNNTTWCGWAPFDGKNGTELLGALDSAFLFA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 115 YAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWGNIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNKKKR 194
Cdd:cd17344 75 YAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 195 GLIMGIWNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPenvgaerdevldsssekignsvne 274
Cdd:cd17344 155 GLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 275 plllsssdsetddkkravgfieawriPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIegeyLSDETAGNLSTMFDVGG 354
Cdd:cd17344 211 --------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAI----LSAKKAGDLSTLFDVGG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 355 VVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGPYALITTAVSADLGTHSSLKG 434
Cdd:cd17344 261 IVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKG 340
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408421 435 NSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGsWTAVFTMLMGAAFVAGLLLTRLVMAE 495
Cdd:cd17344 341 NARALATVTAIIDGTGSIGAALGPLLAGLISSRG-WNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
37-478 |
4.02e-102 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 312.71 E-value: 4.02e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 37 IVLIVTFLAYASYHAARKTTSIVKSALDPQspdtglnslLLRFTSFGSSVKEEGGWAP----FNGPDGTVLLGEIDVAFL 112
Cdd:cd17342 3 VVFILTFFSYALLHATRKTFSNVKPSISAE---------WTPSNSNTSIELHEETWNAnplfPSQDDAALFLGVLDTIFL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 113 AVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFG-VGYWGNIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNK 191
Cdd:cd17342 74 FSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGvLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 192 KKRGLIMGIWNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPenvgaerdevldsssekigns 271
Cdd:cd17342 154 SSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP--------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 272 vneplllsssdsetddkkravgfieawriPGVAPFALCLFFAKLVAYTFLYWLPFYVShtaiEGEYLSDETAGNLSTMFD 351
Cdd:cd17342 213 -----------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLS----NNFHWKESEADQLSIWYD 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 352 VGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGhVSLLANASLMFLTGMLVNGPYALITTAVSADLGTHSS 431
Cdd:cd17342 260 VGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSP-SDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQ 338
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 18408421 432 LKGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLM 478
Cdd:cd17342 339 LRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFI 385
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
37-492 |
8.07e-68 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 222.53 E-value: 8.07e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 37 IVLIVTFLAYASYHAARKTTSIVKSALdpqspdtglnslllrftsfgssvKEEGGWAPfngpdgtVLLGEIDVAFLAVYA 116
Cdd:cd17312 3 RIFLGVFLGYAAYYVCRKNFSVAKPPI-----------------------VEEIGLSK-------DDLGIIGSAFLIAYA 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 117 FGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNKKKRGL 196
Cdd:cd17312 53 VGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGT 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 197 IMGIWNAHTSVGNITGSLIAAA-MLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPenvgaerdevldsssekignsvnep 275
Cdd:cd17312 128 VYGIWSTSHNFGGILAPILAASlASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 276 lllsssdsetddkkravgfieawriPGVAPFALCLFFAKLVAYTFLYWLPFYVShtaiEGEYLSDETAGNLSTMFDVGGV 355
Cdd:cd17312 183 -------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLY----EVKGYSLIDAGWFSSLYEVGGI 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 356 VGGIMAGYISDRI--GARAITAASFMYCSIPALFFYRSYGHVSLLaNASLMFLTGMLVNGPYALITTAVSADLGTHsslk 433
Cdd:cd17312 234 AGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLL-SIVLLFLIGFFVGGPINLIGGAAAQDIGRK---- 308
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 18408421 434 gnsRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLV 492
Cdd:cd17312 309 ---EAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-492 |
7.60e-38 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 142.70 E-value: 7.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 30 SYSAYQAIVLIVTFLAYASYHAARKTTSIVKSALdpqspdtglnslllrftsfgssvKEEGGWapfngpdGTVLLGEIDV 109
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPL-----------------------QADLGL-------SAAQLGLLAS 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGviivviglvnyaflpvspenvgaerdevldssseki 268
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILG------------------------------------ 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvneplllsssdsetddkkrAVGFIEAwrIPGVAPFALCLFFAKLVAYTFLYWLPFYVshtaIEGEYLSDETAGNLST 348
Cdd:COG2271 172 ----------------------LPGLLLA--LLRFWLLALAYFLVYFALYGFLTWLPTYL----VEVRGLSLAQAGLLLS 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 349 MFDVGGVVGGIMAGYISDRIGAR-AITAASFMYCSIPALFFYRSYGHVSLLanASLMFLTGMLVNGPYALITTAVSADLG 427
Cdd:COG2271 224 LPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSPALA--IALLFLAGFGLGGAFGLLWALAAELFP 301
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 428 THsslkgnsrALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLV 492
Cdd:COG2271 302 KK--------ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
104-474 |
1.75e-34 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 133.66 E-value: 1.75e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 104 LGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGvgyWGNihSFYYFLIMQMLAGLFQSSGWPSVVA 183
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 184 VVGNWFNKKKRGLIMGIWNAHTSVGN--ITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEvL 261
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGglLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAE-E 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 262 DSSSEKIGNSVNEPLLLSssdSETDDKKRAVGFIEAWRIpgvapfALCLFFAKLVAYTFLYWLPFYvshtAIEGEYLSDE 341
Cdd:TIGR00881 186 MPNEEPDGDAEKKEEELT---KKQIFLQYVLLNKVLWYI------SLGYVFVYVVRTGILDWSPLY----LTQEKGFSKE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 342 TAGNLSTMFDVGGVVGGIMAGYISDRI--GARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGPYALIt 419
Cdd:TIGR00881 253 KASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLI- 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 420 tavsadlGTHSSLKGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVF 474
Cdd:TIGR00881 332 -------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
38-488 |
4.79e-32 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 127.36 E-value: 4.79e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 38 VLIVTFLAYASYHAARKTTSIvksaldpQSPDtglnslllrftsfgssVKEEGGWApfngpdgTVLLGEIDVAFLAVYAF 117
Cdd:cd17345 4 VFLGIFIGYAGYYLVRNNFSL-------AQPY----------------LIEQYGLS-------KTEIGLIGSALSIAYGL 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 118 GMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWGnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNKKKRGLI 197
Cdd:cd17345 54 SKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA-TSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTW 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 198 MGIWN-AHTSVGNITGSLIAAAMLRYG---WGWSFVVPGVIIVVIGLVNYAFLPVSPENVGaerdevLDSSSEKIGNSVN 273
Cdd:cd17345 133 TSIWNiSHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEG------LPPIEEYKGDYPE 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 274 EPlllSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVShtaiEGEYLSDETAGNLSTMFDVG 353
Cdd:cd17345 207 EA---DGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLS----EVKGFSKAQAMWAFSLFEWA 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 354 GVVGGIMAGYISDRI--GARAITAASFMYCSIPALFFYrsYGHVSLLANASLMFLTGMLVNGPYALITTavsadlgthSS 431
Cdd:cd17345 280 AIPGTLLAGWLSDKLfkGRRAPTGIIFMILVIVALIVY--WLAPNVLVDLIALIALGFLIYGPVMLIGL---------QA 348
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 18408421 432 LKGNSRALATVTAIIDGTGS--VGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17345 349 LELVPKKAAGTAAGLTGLFGylGGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFL 407
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
110-491 |
4.77e-29 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 117.67 E-value: 4.77e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGS-LIAAAMLRYGWGWSFVVPgviivviglvnyAFLPVspenvgaerdevldssseki 268
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPpLSGWLLLLFGWRWAFIIE------------GLLGL-------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvneplllsssdsetddkkrAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIegeyLSDETAGNLST 348
Cdd:cd17319 169 ----------------------LLAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARG----FSLKQVGLLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 349 MFDVGGVVGGIMAGYISDRI--GARAITAASFMYCSIPALFFyrSYGHVSLLANASLMFLTGMLVNGPYALITTaVSADL 426
Cdd:cd17319 223 IPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLL--AYLTTSPVVAVILLSLAGFGIGAASPVFWS-LPADL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18408421 427 GthsslkgNSRALATVTAIIDGTGSVGAAVGPLLTGYISSR-GSWTAVFTMLMGAAFVAGLLLTRL 491
Cdd:cd17319 300 L-------PGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
110-502 |
1.35e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 108.43 E-value: 1.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:COG2223 48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERdevldssseki 268
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA----------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvneplllsssdsetddKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYvshtAIEGEYLSDETAGNLST 348
Cdd:COG2223 192 -------------------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPY----LVDQFGLSAATAGLLAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 349 MFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFyrSYGHVSLLANASLMFLTGMLVNGPYALITTAVSADLGT 428
Cdd:COG2223 249 LFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPT 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 429 hsslkgnsRALATVTAIIDGTGSVGAAVGPLLTGYISSR-GSWTAVFtMLMGAAFVAGLLLTRLVMAEVAEKIAE 502
Cdd:COG2223 327 --------KNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYTAAF-LVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
104-495 |
5.95e-24 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 104.74 E-value: 5.95e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 104 LGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWGNIHSFYYFLIMQMLAGLFQSSGWPSVVA 183
Cdd:PRK09556 66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 184 VVGNWFNKKKRGLIMGIWNA-HtsvgNITGSLIAAAMLrygWGWS----------FVVPGVIIVVIGLVNYAFLPVSPEN 252
Cdd:PRK09556 146 TITRWTPRRKRGRFLGFWNIsH----NLGGAGAGGVAL---WGANyffdghvigmFIFPSIIALIIGFIGLRYGSDSPEE 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 253 VGAERDEVLdsssekignsVNEPLLLSSSDSETDDKKRAVGFIEaWRIPGVAPFALClffaklVAYTFLY--------WL 324
Cdd:PRK09556 219 LGWGKAEEI----------FGEPISEEDKETESTDMTKWQIFVE-YVLKNPVIWLLC------FANIFLYivrigidnWS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 325 PFYvshtAIEGEYLSDETAGNLSTMFDVGGVVGGIMAGYISDRI-GARAITAASFMYCSIPALFFYRsYGHVSLLANASL 403
Cdd:PRK09556 282 PVY----AFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLAnGRRALVACIALALIIFTLGVYQ-HATSEYMYLASL 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 404 MFLtGMLVNGPYALI------------TTAVSADLGTHSSLKGNSRALATVTAIIDGTGSVGAAVGPLLTGyissrgsWT 471
Cdd:PRK09556 357 FAL-GFLVFGPQLLIgvaavgfvpkkaIGVANGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFGYTLTG-------WA 428
|
410 420
....*....|....*....|....
gi 18408421 472 AVFTMLMGAAFVAGLLLTRLVMAE 495
Cdd:PRK09556 429 GTFAALDIAAIGCICLMAIVAVME 452
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
103-458 |
4.04e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 4.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 103 LLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVV 182
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 183 AVVGNWFNKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEVl 261
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEA- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 262 dsssekignsvneplllsssdsetddKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVshtaiEGEYLSDE 341
Cdd:pfam07690 187 --------------------------RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-----EVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 342 TAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGPYALITTA 421
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340 350
....*....|....*....|....*....|....*..
gi 18408421 422 VSADLGTHsslkgnsrALATVTAIIDGTGSVGAAVGP 458
Cdd:pfam07690 316 VSDLAPKE--------ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
110-492 |
4.53e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.95 E-value: 4.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGVIIVVIGLVNYAFLPVSPEnvgaerdevldssseki 268
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAALALLALVLALLLLPEPRP----------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvneplllSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAiegeYLSDETAGNLST 348
Cdd:cd17325 177 ----------PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG----GLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 349 MFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTgmlvngpYALITTAVSADLGT 428
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLG-------LGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18408421 429 HSSlkgnSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLV 492
Cdd:cd17325 316 IVP----PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
110-452 |
3.13e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 91.96 E-value: 3.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAMLRY-GWGWSFVVPGVIIVVIGLVNYAFLPVSPenvgaerdevldssseki 268
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLPESR------------------ 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvneplllsssdsETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAiegeYLSDETAGNLST 348
Cdd:COG2814 190 ---------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL----GLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 349 MFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVNGPYALITTAVSADLGT 428
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLL---ALFLLGFGFGLLFPLLQALVAELAPP 327
|
330 340
....*....|....*....|....
gi 18408421 429 HSSlkgnSRALATVTAIIDGTGSV 452
Cdd:COG2814 328 EAR----GRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
110-488 |
1.94e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.18 E-value: 1.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIA---AAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPvspenvgaerdevldssse 266
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGgilASSLGFGWRAVFLIAAALALLAAILLLLVVP------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 267 kignsvNEPLLLSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYvshtAIEGEYLSDETAGNL 346
Cdd:cd06174 175 ------DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF----LLDLGGLSVAVAGLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 347 STMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLanASLMFLTGMLVNGPYALITTAVSADL 426
Cdd:cd06174 245 LSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL--LLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18408421 427 gthsslkgNSRALATVTAIIDGTGSVGAAVGPLLTGYISSR-GSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd06174 323 --------PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
35-490 |
2.45e-19 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 90.09 E-value: 2.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 35 QAIVLIVTFLAYASYHAARKTTSIVKSALdpqspdtgLNSLLLRftsfgssvKEEggwapfngpdgtvlLGEIDVAFLAV 114
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSL--------MNELGLD--------KSD--------------LGLITSSQSLA 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 115 YAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGvgyWGNihSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNKKKR 194
Cdd:cd17343 51 YAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS---GSS--SVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQF 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 195 GLIMGIWNAHTSVGNITGSLIAAAM-LRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEVLDSSSEKIGNSVN 273
Cdd:cd17343 126 GTWWSVLSTSMNLAGSLGPILATLLaLSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRG 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 274 EPLLLsssdsetddkkravgfiEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVshtaIEGEYLSDETAGNLSTMFDVG 353
Cdd:cd17343 206 ESTLK-----------------ELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFL----IQDKGQSALTGSSFMSSLEVG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 354 GVVGGIMAGYISDRIGA----------RAITAASFMYCSIPALFFYRSY--GHVSLLANASLMFLTGMLVNGPYALIttA 421
Cdd:cd17343 265 GFVGSIAAGYLSDWAVAkhgsssrgnpRMPLALVFMAGLTVSLHLFRVHitSDSSELFILLLGFLIGFSLYGPIAIF--G 342
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408421 422 VSADLGTHSSLKGNSRALATVTAiidgtgSVGAAVGPLLTGYISSRGSWTAVFTML--MGAAFVAGLLLTR 490
Cdd:cd17343 343 VIANESAPSHLCGTSHAIVALAA------NVGGVLAGLPFSYIAKHYDWRTAFLLLeiLCAITVVILFLLR 407
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
104-502 |
6.16e-19 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 89.00 E-value: 6.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 104 LGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVA 183
Cdd:PRK11663 60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 184 VVGNWFNKKKRGLIMGIWN-AHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPE-----NVGAER 257
Cdd:PRK11663 135 LLTAWYSRTERGGWWAIWNtAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQamglpSVGEWR 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 258 DEVLDSSSEKIGNSVNEPLLLsssdsetddKKRAVGFIEAWRIpgvapfALCLFFAKLVAYTFLYWLPFYVShtaiEGEY 337
Cdd:PRK11663 215 HDALELAQQQEGAGLSRKEIL---------TKYVLLNPYIWLL------SFSYVLVYVVRAAINDWGNLYMS----ETLG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRI-----GARAITAASFMYCSIPALFFYRSyghVSLLANASLMFLTGMLVN 412
Cdd:PRK11663 276 VDLVTANSAVSMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPF---ASYVMQAACFFTIGFFVF 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 413 GPYALITTAvsADLGTHSSLKGNSralatvtaiidgTGSVG--AAVGPLLTGY----ISSRGSWTAVFTMLMGAAFVAGL 486
Cdd:PRK11663 353 GPQMLIGMA--AAECSHKEAAGAA------------TGFVGlfAYLGAALSGYplakVLEIWHWTGFFVVISIAAGISAL 418
|
410
....*....|....*.
gi 18408421 487 LLTRLVMAEVAEKIAE 502
Cdd:PRK11663 419 LLLPFLNAQAPREASE 434
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
101-464 |
1.67e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 87.41 E-value: 1.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 101 TVLLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYwgnihSFYYFLIMQMLAGLFQSSGWPS 180
Cdd:TIGR00895 51 PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT-----NVTQLLILRFLAGLGLGGLMPN 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 181 VVAVVGNWFNKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDE 259
Cdd:TIGR00895 126 LNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 260 VLDSSSEKIGNSVNEPLL--LSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLY-WLPFYVSHTAiege 336
Cdd:TIGR00895 206 TVRRIVNAIAPQMQAEAQsaLPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTnWLPKLMVELG---- 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 337 yLSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARaITAASFMYCSIPALFFYRSYGHVSLLanASLMFLTGMLVNGPYA 416
Cdd:TIGR00895 282 -FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-VTALLLLLGAVFAVLVGSTLFSPTLL--LLLGAIAGFFVNGGQS 357
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 18408421 417 LittavsadLGTHSSLKGNSRALATVTAIIDGTGSVGAAVGPLLTGYI 464
Cdd:TIGR00895 358 G--------LYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
112-498 |
5.15e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 83.00 E-value: 5.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 112 LAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNK 191
Cdd:COG2807 63 LLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 192 KkRGLIMGIWNAHTSVGNITGSLIAAAMLR-YGWGWSFVVPGViivvigLVNYAFLPVSPenvgaerdevldsssekign 270
Cdd:COG2807 138 R-VGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWAL------LALLALLLWLP-------------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 271 svneplLLSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLP-FYVSHtaieGeyLSDETAGNLSTM 349
Cdd:COG2807 191 ------LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPpILRDA----G--LSAATAGLLLSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 350 FDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYrsyghvsLLANASLMFLTGMLVNGPYALITTAVSADLGTH 429
Cdd:COG2807 259 FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGL-------LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLR 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 430 SslkGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSR-GSWTAVFTMLMGAAFVAGLLLTRLVMAEVAE 498
Cdd:COG2807 332 A---RTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtGSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
110-489 |
2.16e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 80.67 E-value: 2.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:cd17324 42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAM-LRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEVLdssseki 268
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLS------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvNEPLLLSSsdsetddkkravgfieaWRIPGVAPFALCLFFAKLVAYTFlywLPFYVSHTAiegeYLSDETAGNLST 348
Cdd:cd17324 190 ----SLLLLLRN-----------------PRLRLAYLITFLLFGGFFALYTY---LAPFLTDVP----GFSSSAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 349 MFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVNGPYALITTAVSadlgt 428
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLV---GLVLWGLGFFAAHSALQTRVL----- 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408421 429 hsslKGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVfTMLMGAAFVAGLLLT 489
Cdd:cd17324 314 ----RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGV-GWVGAALLLLALLLA 369
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
121-488 |
6.44e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 79.14 E-value: 6.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 121 FAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNwFNKKKRGLIMGI 200
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEGARLASQ-AAGGRRGLAMSI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 201 WNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEVLDSSSEKIGNSVNEPLLLSS 280
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLII 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 281 SdsetddkkravgfieawripgvapFALCLFFAKLVAYtflywLPFYVSHtaiegEYLSDETAGNLSTMFDVGGVVGGIM 360
Cdd:cd17478 204 V------------------------FLRSWVLSSLTTF-----LPFYLVQ-----RGYSLVFAGLLLSLFLFAGAIGTLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 361 AGYISDRIGARAITAASFMYCSIPALFFYrsygHVSLLANASLMFLTGMLVNGPYALITTAVsadlgthSSLKGNSRALA 440
Cdd:cd17478 250 GGPLSDRFGRRRVIIASLLLAAPFLLLFL----LTPGIWSYILLVLAGFLLFASFPVTVVLA-------QELLPGNVGLA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 18408421 441 tvTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17478 319 --SGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
104-488 |
1.33e-15 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 78.22 E-value: 1.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 104 LGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVA 183
Cdd:cd17488 40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPPCAR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 184 VVGNWFNKKKRGLIMGIWN-AHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVviglvnyaflpvspenvgaerdevld 262
Cdd:cd17488 115 LLTHWYSRNERGFWWSIWNtSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAI-------------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 263 sssekignsvneplllsssdsetddkkrAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIEGEYLSDET 342
Cdd:cd17488 169 ----------------------------LMGIVLCWRLRDRPPYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 343 AGNLSTMFDVGGVVGGIMAGYISDRI--GARAITAASF---MYCSIPALFFYRSYGHVSLlanASLMFLTGMLVNGPYAL 417
Cdd:cd17488 221 ANSAVSLFEVGGLIGALVAGWGSDKLfkGNRGPMNLIFalgLLVSVGALWLVPVHSYWLL---ATCFFTIGFFVFGPQML 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408421 418 IttAVSADLGTHSSLKGnsralaTVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17488 298 I--GMAAAECSHKDAAG------SATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLL 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
111-488 |
9.93e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 72.72 E-value: 9.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 111 FLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFN 190
Cdd:cd17371 43 TLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA-----QNYWQLLILRALAGLGFGGEWAAGAALMAEYVP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 191 KKKRGLIMGIWNAHTSVGNITGSLIAAAMLRY-----GWGWSFVVPGVIIVVIGLVNYaFLPVSPE--NVGAERDEVLDS 263
Cdd:cd17371 118 ARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeiAWRVLFLLGALPALLVLFIRR-FVKEPPQwqAARAARRHFADR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 264 SSEK-IGNSVNEPLLLSSSdsetddkkravgfieawripgvapfaLCLFFAKLVAYTFLYWLPFYVSHTaiegEYLSDET 342
Cdd:cd17371 197 PSLReLFSPPLLRTTLLAS--------------------------LLATGALGGYYGITTWLPSYLTGE----RGLSFEG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 343 AGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYC--SIPALFFYrsygHVSLLANASLMFLTGMLVNGPYALITT 420
Cdd:cd17371 247 SAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSaiSILLYFFL----PLSPTLILILGFPLGFFASGPFSGMGA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18408421 421 AVSADLGThsslkgnsRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17371 323 YLTELFPT--------AVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
116-488 |
1.25e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 72.23 E-value: 1.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 116 AFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTslFGVGYWGNIHSFyyfLIMQMLAGLFQSSGWPSVVAVVGNWFNKKKRG 195
Cdd:cd17365 48 AIGALLAGPLADRFGRKRVLLVSVALFGLFT--LLTAFAQSVLQL---ALLRFLTGLGLGAAMPNAITLVSEYAPARRRS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 196 LIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPgviivviglvnyAFLPVspenvgaerdevldsssekignsVNE 274
Cdd:cd17365 123 LAVTLMFCGYPLGAALGGFLAAALIpAFGWRSVFLLG------------GVPPL-----------------------ILL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 275 PLLLSSsdsetddkkravgfieawripgvAPFALCLFFAKLVAYTFLYWLPfyvshTAIEGEYLSDETAGNLSTMFDVGG 354
Cdd:cd17365 168 PLLRGT-----------------------LLLWVTFFMGLLLVYLLNSWLP-----KLMVEAGYSLSQALTITLLLNIGG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 355 VVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLanASLMFLTGMLVNGPYALITTAVSADLGTHsslkg 434
Cdd:cd17365 220 VIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLL--YVLVFLAGACVNGAQVGLYALAARFYPTE----- 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 435 nSRALATVTAIidGTGSVGAAVGPLLTGYISSRG-SWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17365 293 -VRATGVGWAL--GVGRLGAILGPLLGGLLLAAGlGPESVFLALAIPAALGALAV 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
104-487 |
1.40e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.19 E-value: 1.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 104 LGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVA 183
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-----PSYPLLLLALFLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 184 VVGNWFNKKKRGLI--MGIWNahtSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPenvgaerdevl 261
Cdd:COG0738 120 YVAALGPETAASRLnlLHAFF---SLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK----------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 262 dsssekignsvneplLLSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYvshtAIEGEYLSDE 341
Cdd:COG0738 186 ---------------LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY----LKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 342 TAGNLSTMFDVGGVVGGIMAGYISDRIGAR------AITAASFMYCSIPAlffyrSYGHVSLLAnaslMFLTGMLVNGPY 415
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVrllrlsALLAAVGLLLALLA-----PGPWLALIG----LALVGLGLSLMF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18408421 416 ALITTAVSADLGTHSslkgnsralATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLL 487
Cdd:COG0738 318 PTIFSLALDGLGKRT---------AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
104-484 |
1.82e-13 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 71.97 E-value: 1.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 104 LGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVA 183
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT-----PSIYLFVVLMFLAGLGAGILDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 184 VVGNWFNKKkRGLIMGIWNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVgaerdevlds 263
Cdd:cd17333 108 FVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELP---------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 264 ssekignsvneplllSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYvshtAIEGEYLSDETA 343
Cdd:cd17333 177 ---------------SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSY----LVEKKHVSDGLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 344 GNLSTMFDVGGVVGGIMAGYISDRIGARAITaasFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGPYALITTAVS 423
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRRIKPHTLL---VLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGI 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408421 424 ADLGTHSSlkgnsralaTVTAIIDGTGSVGAAVGPLLTGYISSRGSwtAVFTMLMGAAFVA 484
Cdd:cd17333 315 SNLPYAKG---------KGTSVLLAAGSIGGAIIPFIMGFIAEAVG--IQTAMLLITILYA 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
114-488 |
4.03e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 70.73 E-value: 4.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 114 VYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLftSLFGVGYwgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNKKK 193
Cdd:cd17475 43 GVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMAL---VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 194 RGLIMGIWNAHTSVGNITGSLIAAAM-LRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERdevldsssekignsv 272
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATE--------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 273 neplllsSSDSETDDKKRAVGFIEAWRIpGVAPFALCLFFAKLVAYTFLYwlpfyvshtAIEGEYLSDETAGNLSTMFDV 352
Cdd:cd17475 183 -------SASTLLRSLKEVLRNRDVWLI-AIAGALLVAPQFALLTFLLLF---------LHDHLGLSVVAAGALLAVAQL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 353 GGVVGGIMAGYISDRIGA---RAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGPYALITTAVSADLGTH 429
Cdd:cd17475 246 GGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPE 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 430 SSlkgnsralATVTAIIDGTGSVGAAVGPLLTGYIS-SRGSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17475 326 QA--------GTALGLANTINFIGIAIGPPLFGLLVdATHSYAPAWLALALLLVLAALLL 377
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
105-508 |
7.00e-13 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 70.51 E-value: 7.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 105 GEIDVAFLAV---YAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWGNiHSFYYFLIMQMLAGLFQSSGWPSV 181
Cdd:PRK11273 63 GDLGFALSGIsiaYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWAT-SSIAVMFVLLFLCGWFQGMGWPPC 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 182 VAVVGNWFNKKKRGLIMGIWN-AHTSVGNITGSLIAAAMLRYG-WGWSFVVPGVIIVVIGLVNYAFLPVSPENVG----- 254
Cdd:PRK11273 142 GRTMVHWWSQKERGGIVSVWNcAHNVGGGLPPLLFLLGMAWFNdWHAALYMPAFAAILVALFAFAMMRDTPQSCGlppie 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 255 AERDEVLDSSSEKignsvneplllssSDSETDDKKRAVGFIEA----WRIpgvapfALCLFFAKLVAYTFLYWLPFYVSh 330
Cdd:PRK11273 222 EYKNDYPDDYNEK-------------HEQELTAKQIFMQYVLPnkllWYI------AIANVFVYLLRYGILDWSPTYLK- 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 331 taiEGEYLSDETAGNLSTMFDVGGVVGGIMAGYISDRI--GARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTG 408
Cdd:PRK11273 282 ---EVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrGNRGATGVFFMTLVTIATIVYWLNPAGNPTVDMACMIVIG 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 409 MLVNGPYALIttavsadlGTHSSLKGNSRALATVTAIIDGTGSVGAAVGP-LLTGYISSRGSWTAVFTMLMGAAFVAGLL 487
Cdd:PRK11273 359 FLIYGPVMLI--------GLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIGGSILAVIL 430
|
410 420
....*....|....*....|.
gi 18408421 488 LTRLVMAEVAEKIAESRPSEE 508
Cdd:PRK11273 431 LIVVMIGEKRHHEELLQKRNG 451
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
110-488 |
3.89e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.07 E-value: 3.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLftSLFGVGYWGNIHSFYyfLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA--GLVLLALATSLWQLY--LLWGLLGGGGAGTLAAVAFATVAAWW 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEVLDSSSEki 268
Cdd:cd17355 122 FERRRGLALGILTAGGGLGSLVFLPLGAALIeAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASP-- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvneplllsssdsetddkkrAVGFIEAWRIPG----VAPFALCLF-FAKLVAYTFLYWLPFYVSHTAiegeylsdetA 343
Cdd:cd17355 200 ----------------------GSTLKEALRSASfwllALAFFLCGFaVVGLIVHLVPYLADRGISPAA----------A 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 344 GNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIP-ALFFYRSYGHVSLLANASLMFLTGMLVNGPYALITtav 422
Cdd:cd17355 248 AVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGlALLLLLPFPPLALLLFAALFGLGWGATVPLTAALA--- 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18408421 423 sadlgthsSLKGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSR-GSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17355 325 --------ARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRtGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
110-491 |
1.73e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 65.67 E-value: 1.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPEnvgaerdevldsssekig 269
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKE------------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 270 nsvneplllsssDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAiegeYLSDETAGNLSTM 349
Cdd:cd17474 179 ------------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLY----GISPIIIGLLFAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 350 FDVGGVVGGIMAGYISD-RIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNgpyALITTAVSADLGT 428
Cdd:cd17474 243 WSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNL---PLLTTLVTELAPE 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18408421 429 HSslkgnsraLATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRL 491
Cdd:cd17474 320 EE--------RGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
109-458 |
4.51e-11 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 64.58 E-value: 4.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 109 VAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNW 188
Cdd:cd17327 48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 189 FNKKKRGLIMGIWNAHTSVGNITGSLIAAAMLR-------YGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEVL 261
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 262 DSSSEKIGNSvneplllSSSDSETDDKKRAVgfIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPfyvshTAIEGEYLSDE 341
Cdd:cd17327 203 ELAVERLRAN-------QTGKGDQKFKWKQI--KEAFKDPRTWLLFLFFFCSQITNNGISNFLP-----LILKSLGFYSL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 342 TAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFmycSIPALFFYRSYGHVSLLANASL-MFLTGMLVNGPYALITT 420
Cdd:cd17327 269 QTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFA---CVLALVGSIILLAAPNPPGAYFaAYILGGGSYAGFPILLS 345
|
330 340 350
....*....|....*....|....*....|....*...
gi 18408421 421 AVSADLGTHSSlkgnsraLATVTAIIDGTGSVGAAVGP 458
Cdd:cd17327 346 WISSNCAGYTK-------RATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
100-494 |
8.44e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.79 E-value: 8.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 100 GTVLLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGvgywgNIHSFYYFLIMQMLAGLFQSSGWP 179
Cdd:cd17328 32 DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS-----FAPNFWQLLLFRALVGIGEASYSP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 180 SVVAVVGNWFNKKKRGLIMGIWNAHTSVGN----ITGSLIAAAMlrYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGA 255
Cdd:cd17328 107 IAPTIIADLFPKEKRTRALGVFYFAIPLGSglgyVVGGLVAQAT--GGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 256 ERDEVLDSSSEKIGNSVNepLLlsssdsetddKKRAVGFIeawripgVAPFALCLFfaklVAYTFLYWLPFYVSHTAIEG 335
Cdd:cd17328 185 GGVMAKSTATSFLADLKA--LA----------KNPSFILS-------TLGFTAVSF----VTGALAFWAPTFFLRAFGVG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 336 EYLSDETAGNLSTMFDVGGVVGGIMAGYISDRIG-----ARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGML 410
Cdd:cd17328 242 DLSSADVGLIFGAITCIAGVLGVLLGGILADRLRrktprADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 411 VNGPYALITTAVSADlgthssLKGNSRALAtvTAI-IDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLT 489
Cdd:cd17328 322 LSLNWAPVFAILLYV------VIPTRRSTA--SAIqILLSHLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYALLLC 393
|
....*
gi 18408421 490 RLVMA 494
Cdd:cd17328 394 SFVLV 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
95-489 |
7.36e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 60.69 E-value: 7.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 95 FNGPDGTVLLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQ 174
Cdd:cd17316 29 FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL-----LPTPILLLVLRFLQGIGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 175 SSGWPSVVAVVGNWFNKKKRGLIMGIWNAHTSVGNITGSLIAAAMLR-----YGWGWSFvvpgviivviglvnyaFLPVS 249
Cdd:cd17316 104 GGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgdWGWRILF----------------LIGAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 250 PenvgaerdevldsssekignsvneplllsssdsetddkkravGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVS 329
Cdd:cd17316 168 P------------------------------------------ALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 330 HTAIegeyLSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPA-LFFYRSYGHVSLLANASLMF-LT 407
Cdd:cd17316 206 TVLG----LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAlPLFYLLSGSPTLLLLLLFILsFF 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 408 GMLVNGPYALITTAVSAdlgthsslkgnSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLL 487
Cdd:cd17316 282 VGGVWGALYAYLAELFP-----------TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
..
gi 18408421 488 LT 489
Cdd:cd17316 351 VA 352
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
100-491 |
1.96e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 100 GTVLLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWGNIHSFYYFLIMQMLAGLFQSSGWP 179
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 180 SVVAVVGNWFNKKKRGLIMGIWNAHTSVGNITGSLIAAAMLR-YGWGWSFVVPGVIIVVIGLVnYAFLPVSPENVGAERD 258
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALL-LLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 259 EVLDSSSEKignsvneplllsssdsetddkkravGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAiegeYL 338
Cdd:cd06173 191 SLLLRDLRE-------------------------GLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL----GG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 339 SDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGP-YAL 417
Cdd:cd06173 242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPlNTL 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18408421 418 ITTAVSADLgthsslkgnsraLATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRL 491
Cdd:cd06173 322 LQLRVPDEL------------RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
310-504 |
2.80e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 2.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 310 LFFAKLVAYTFLYWLPFYVSHTAIEGEYLSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFY 389
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 390 RSYGHVSLLAnasLMFLTGMLVNGPYALITTAVSAdlgthsSLKGNSRALATvtAIIDGTGSVGAAVGPLLTGYISSRGS 469
Cdd:pfam07690 81 FASSLWLLLV---LRVLQGLGAGALFPAALALIAD------WFPPEERGRAL--GLVSAGFGLGAALGPLLGGLLASLFG 149
|
170 180 190
....*....|....*....|....*....|....*
gi 18408421 470 WTAVFTMLMGAAFVAGLLLTRLVMAEVAEKIAESR 504
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
110-228 |
3.66e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.90 E-value: 3.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELF 131
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAMLRY-GWGWSF 228
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIF 171
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
121-488 |
6.70e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 6.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 121 FAGHLGDRMNLRIFLTVGMIGTGLFTSLfgvGYWgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNKKKRGLIMGI 200
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGLLLYGIGGVA---GLF--LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 201 WNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVnYAFLPvspenvgaeRDEVLDSSSEKIGNSVNEPLLLSS 280
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILV-LLFLP---------EPARKSKSAASPGAATAAALPWKR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 281 sdsetddkkravgfieawripgVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIegeyLSDETAGNLSTMFDVGGVVGGIM 360
Cdd:cd17473 199 ----------------------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGG----GSAALIGLALAIASLAGAIGALL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 361 AGYISDRIGARAITAASFMYCSIpalffyrSYGHVSLLANASLMFLTGMLVNGPYALITTAVSADLGTHSSLKGNSRALA 440
Cdd:cd17473 253 FGRLKRRLGKRRLLAIGFALMAL-------GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 18408421 441 TVTAIIdgtgSVGAAVGPLLTGYISSR-GSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17473 326 IVTSAF----FLGQFLSPLVLGPLVNLtGGLSGAFLILGVLALVLAIVL 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
297-506 |
4.18e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.27 E-value: 4.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 297 AWRIPGVAPFALCLFFAKLVAYTFLYwlpfyvshTAIEGEY-LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITA 375
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLA--------PPLAEEFgLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 376 ASFMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVNGPYALITTAVSAdlgthsSLKGNSRALAtvTAIIDGTGSVGAA 455
Cdd:COG2223 75 IGLLLLGIGLLLLALAVSYWLLLL---LGLLLGIGGGGSFAVGIALVSK------WFPPDRRGLA--LGLAAGGGNLGAA 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 18408421 456 VGPLLTGYISSRGSWTAVFtMLMGAAFVAGLLLTRLVMAEVAEKIAESRPS 506
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAF-LILGILLLVVAVLAWLFLRDPPAGAAAAAKA 193
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
121-504 |
9.17e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 9.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 121 FAGHLGDRMNLRI-----FLTVGMIGTGLFTSL-FGVGYWGNIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF-NKKK 193
Cdd:COG2211 65 LIGALSDRTRTRWgrrrpWILIGAIPLALSFVLlFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTpDYEE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 194 RGLIMGIWNAHTSVGNITGSLIAAAMLRY-------GWGWSFVVPGVIIVVIGLVNYAFLPvspenvgaERDEVldssse 266
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGTK--------ERPVP------ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 267 kignsvneplllsssdsetddKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLY----WLPFYVSHTAiegeYLSDET 342
Cdd:COG2211 211 ---------------------EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALAlvaaLLLYYFKYVL----GLSAAL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 343 AGNLSTMFDVGGVVGGIMAGYISDRIGAR-AITAASFMYCSIPALFFYRSYGHVSLLAnaSLMFLTGmLVNGPYALITTA 421
Cdd:COG2211 266 VGLLLALYFLAALLGAPLWPRLAKRFGKKkAFIIGLLLAALGLLLLFFLGPGNLWLLL--VLAALAG-IGLGAILVLPWA 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 422 VSADLGTHSSLKGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSRG--------------------SWTAVFTMLMGAA 481
Cdd:COG2211 343 MLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqspsaltgirllfFLLPAVLLLLAAL 422
|
410 420
....*....|....*....|...
gi 18408421 482 FVAGLLLTRLVMAEVAEKIAESR 504
Cdd:COG2211 423 LLLFYPLTRERHAEIRAELAARR 445
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
110-483 |
9.52e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 54.10 E-value: 9.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWF 189
Cdd:cd17380 42 SFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 190 NKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGVIIVVIGLVNYAFLPvspenvgaerdevldssseki 268
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLeYYGWPSVFYFFGLLGLLWALVWLIYLP--------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 269 gnsvneplllsssdsetddkkravgfiEAWRIpgvapfALCLFFAKLVAYTFLYWLPFYVShtaiegEYLSDETAGNLST 348
Cdd:cd17380 178 ---------------------------PVWAI------IVAHFCMNWGFYILLSWLPTYFH------EVLVPLAKGWVFN 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 349 MFD-VGGVVGGIMAGYISDRIGARAITAAS---FMYCsipalffyrsyghVSLLANASLMFLTGMLVNGPYALI--TTAV 422
Cdd:cd17380 219 VVPwLVMFPSSNVAGWLADHLISRGWTVTSvrkLMQS-------------IGFLGPALFLLLLSHTDSFSLALLcmSVAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18408421 423 SADLGTHSSLKGNSRALA-----TVTAIIDGTGSVGAAVGPLLTGYI-SSRGSWTAVFTMlmgAAFV 483
Cdd:cd17380 286 GLSAFSSSGVLVNHQDIApnyagIVFGISNTAGTIPGIVGVYLTGYIlEATGSWSLVFVL---AAVV 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
298-492 |
1.69e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 298 WRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIegeylSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAAS 377
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGA-----SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 378 FMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVngpyALITTAVSADLGTHSSLKGNSRALATVTAIIdgtgSVGAAVG 457
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLA---ARFLQGLGA----GALFPAALALIADLVPPERRGRALGLLGAGL----GLGPALG 150
|
170 180 190
....*....|....*....|....*....|....*
gi 18408421 458 PLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLV 492
Cdd:COG2814 151 PLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
338-494 |
2.29e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.95 E-value: 2.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVNGPYAL 417
Cdd:COG2271 42 LSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLL---LRFLLGLGEAGFFPA 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18408421 418 ITTAVSadlgthSSLKGNSRALATvtAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLVMA 494
Cdd:COG2271 119 ALKLIA------EWFPPKERGRAL--GIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLLAL 187
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
338-508 |
2.39e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.93 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFyrsyghvsLLANASLMFLTGMLVNG-PYA 416
Cdd:COG0738 40 LSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF--------ALAPSYPLLLLALFLLGlGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 417 LITTAVSADLGTHSSLKGNSRalatvTAIIDGTGSVGAAVGPLLTGYISSRG---SWTAVFTMLMGAAFVAGLLLTRLVM 493
Cdd:COG0738 112 LLDVAANPYVAALGPETAASR-----LNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLALLFLRSKL 186
|
170
....*....|....*
gi 18408421 494 AEVAEKIAESRPSEE 508
Cdd:COG0738 187 PEIEEEEEEAAGSAA 201
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
109-497 |
2.48e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.95 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 109 VAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLfTSLFGvgywGNIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNW 188
Cdd:cd17321 38 NAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGL-ASLLC----ALAPSLAFLIAARALQGIGAAAIMPASLALIAAT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 189 FNKKKRGLIMGIWNAHTSVGNITGSLIAAAMLRY-GWGWSFvvpgviivvigLVNyafLPVSpenvgaerdevldsssek 267
Cdd:cd17321 113 FPGERRGRALGLWGAVVGIGAALGPLLGGLLLELfGWRWIF-----------LIN---VPIG------------------ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 268 ignsvneplllsssdsetddkkrAVGFIEAwriPGVAPFALCLFFAKLVAYTFLYWLPFYVshtaIEGEYLSDETAGNLS 347
Cdd:cd17321 161 -----------------------LVALLLA---RTFSGAVLAAFLLGAALGGLLFLLPLYL----QGVLGYSPLQAGLAL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 348 TMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGPYALITTAVSADLG 427
Cdd:cd17321 211 LPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVP 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18408421 428 THSSlkgnsralATVTAIIDGTGSVGAAVGP-----LLTGYISSRGSWTAVFTMLM--GAAFVAGLLLTRLVMAEVA 497
Cdd:cd17321 291 KEKA--------GAASGILNTARQLGGALGVallgaLLTAGLSANLGDSGVAALLSaaAAAFAAGFHLAFLVAAALA 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
111-487 |
9.65e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.07 E-value: 9.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 111 FLAVYAFGMYFAGHLGDRMNLRIFLTVGMI--GTGLFTSLFGVGYWgnihsfYYFLIMQMLAGLFQSSGWPSVVAVVGNW 188
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGGIlfGLGFILSAFAISLP------LLFLGYGVLGGIGAGIGYITPVSTAVKW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 189 FnKKKRGLIMGIWNAHTSVGN-ITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAErdevldsssek 267
Cdd:cd17353 121 F-PDKRGLATGIVIAGFGLGSlIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPP----------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 268 iGNSVNEPlllsssdsETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVA-YTFLYWLPFyvshtAIEGEYLSDETAGNL 346
Cdd:cd17353 189 -GVDPLAN--------NAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGlMLIGQAKPI-----GQEFAGLDAGIAALA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 347 STMFDVGGVVGGIMAGYISDRIG-ARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGmlvNGPYALITTAVSAD 425
Cdd:cd17353 255 VSILSIFNGGGRPFWGWLSDKIGrKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCY---GGGFALFPALTADF 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18408421 426 LGThsslkgnsRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLL 487
Cdd:cd17353 332 FGT--------KNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
338-512 |
4.94e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.73 E-value: 4.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGAR-AITAASFMYCSIPALFFY-RSYGHVsllanASLMFLTGMLVngpy 415
Cdd:cd17325 28 ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKrLLLLGLLLLAVSTLLFAFaTSYWQL-----LLARFLQGLAS---- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 416 ALITTAVSADLGTHSSLKGNSRALATVTAIIdgtgSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLVMAE 495
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAI----GLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP 174
|
170
....*....|....*..
gi 18408421 496 VAEKIAESRPSEECRSP 512
Cdd:cd17325 175 RPPPNKRAVSAARLRSG 191
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
308-490 |
3.18e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.49 E-value: 3.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 308 LCLFFAKLVAYTFLYWLPfyvSHTAIEGeyLSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITaaSFMYCSIPA-- 385
Cdd:PRK11551 227 ISYFFTLIVLYFLLNWLP---SLLVGQG--LSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVV--LLIYAGILAsl 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 386 LFFYRSYGHVSLLANAslmFLTGMLVNGP----YALITTAVSADL-GThsslkGNSRALAtvtaiidgTGSVGAAVGPLL 460
Cdd:PRK11551 300 AALAAAPSFAGMLLAG---FAAGLFVVGGqsvlYALAPLFYPTQVrGT-----GVGAAVA--------VGRLGSMAGPLL 363
|
170 180 190
....*....|....*....|....*....|....*..
gi 18408421 461 TGYISSRGSWTAVftmLMGA-------AFVAGLLLTR 490
Cdd:PRK11551 364 AGQLLALGRSTVG---VIGAsipvilvAALAALLLVS 397
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
111-248 |
3.88e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 46.03 E-value: 3.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 111 FLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFN 190
Cdd:cd17323 43 FVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALA-----PNIAMLIILRFLQGFFGSSPLAIGAGTIADLFT 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 18408421 191 KKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVPGVIIVVIGLVNYAFLPV 248
Cdd:cd17323 118 PEERGKAMGVYSLGPLLGPALGPIIGGFITqSLGWRWIFWFLAIISGFCLILIFLFLPI 176
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
109-220 |
5.29e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 5.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 109 VAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFgvgYWGNIHSFYYFLIMQMLAGLFQSSGWPSVVAVV--- 185
Cdd:COG2211 271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadv 347
|
90 100 110
....*....|....*....|....*....|....*....
gi 18408421 186 ---GNWFNKKKR-GLIMGIWNAHTSVGNITGSLIAAAML 220
Cdd:COG2211 348 vdyDEWKTGRRReGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
338-492 |
6.05e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 6.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFyrsyghvSLLANASLMFLTGMLVNGPYAL 417
Cdd:cd06174 28 LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-------AFAPSFWLLLLGRFLLGLGSGL 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18408421 418 ITTAVSADLGTHSslkgNSRALATVTAIIDGTGSVGAAVGPLLTGYISSR--GSWTAVFTMLMGAAFVAGLLLTRLV 492
Cdd:cd06174 101 IDPAVLALIADLF----PERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVV 173
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
311-507 |
8.64e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 311 FFAKLVAYTFLYWLPFYVSHTAIegeylSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFyr 390
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGG-----SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 391 syghvsLLANASLMFLTGMLVNG-PYALITTAvsadLGTHSSLKGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGS 469
Cdd:cd17489 79 ------LLATSVALLLVLRLIHGiGWGAFTTA----AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG 148
|
170 180 190
....*....|....*....|....*....|....*...
gi 18408421 470 WTAVFTMLMGAAFVAgLLLTRLVMAEVAEKIAESRPSE 507
Cdd:cd17489 149 FAVLFIVAAVLALLA-LLLVFLVKDPPPVAAEEAEAGT 185
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
338-506 |
1.02e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.86 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGA-RAITAASFMYCsipALFFYRSY-GHVSLLANASLMFLTGMLVNgpY 415
Cdd:COG2807 50 LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLeRTLLLALLLLA---AGLLLRSLaPSVALLLAGTALIGAGIAVG--N 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 416 ALITTAVSADLGTHSSLkgnsralatVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLVMAE 495
Cdd:COG2807 125 VLLPGLIKRWFPDRVGL---------MTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170
....*....|.
gi 18408421 496 VAEKIAESRPS 506
Cdd:COG2807 196 PAAAAAAPAAA 206
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
122-488 |
1.57e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.15 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 122 AGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWGNihsfYYFLI-MQMLAGLFQSSGWPSVVAVVGNWFNKKKRGLIMGI 200
Cdd:cd17318 76 GGYLAEKYGAKRVLGYSILITALLTLLTPLAARGG----YGALIvLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSI 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 201 WNAHTSVGNITGSLIAAAMLRYgWGWSFvvpgviivviglVNYAFlpvspenvGAerdevldsssekIGnsvneplllss 280
Cdd:cd17318 152 AYSGSQFGTVIAMPLSGFLCES-LGWPS------------IFYIF--------GG------------LG----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 281 sdsetddkkraVGFIEAWRIPGVAPFALCL--FFAKLVAYTFLYWLPFYVSHTAiegeYLSDETAGNLSTMFDVGGVVGG 358
Cdd:cd17318 188 -----------LLWCLLWFFLVLPVWAIVVahFGHNWGFYTLLTELPTYMSDVL----HFNIKSNGFLSSLPYLAMWICS 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 359 IMAGYISDRIGARAItaasfmycsIPALFFYRSYGHVSLLANASLMFLTGMLVNGPY---ALITTAVSADLGTHSSLKGN 435
Cdd:cd17318 253 IVGGYLADWLRSRGI---------LSTTTVRKLFTSIGFLGPGVFLIALGYLGSNATlavVFLTLSVGLSGACYSGFLVN 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18408421 436 SRALA-----TVTAIIDGTGSVGAAVGPLLTGYI----SSRGSWTAVFtMLMGAAFVAGLLL 488
Cdd:cd17318 324 HLDLApnyagTLMGITNTAATIAGIISPLIVGAIvkndQTIGQWRIVF-FISAAIYILGAIF 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
109-209 |
1.67e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 109 VAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNW 188
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-----AGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
90 100
....*....|....*....|.
gi 18408421 189 FNKKKRGLIMGIWNAHTSVGN 209
Cdd:COG2814 325 APPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
100-213 |
5.69e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 5.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 100 GTVLLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIgtGLFTSLFGVGYWGNIHSFYYFLIMQMLAGLFQSSGWP 179
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL--LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310
|
90 100 110
....*....|....*....|....*....|....
gi 18408421 180 SVVAVVGNWFNKKKRGLIMGIWNAHTSVGNITGS 213
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
110-488 |
7.40e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 7.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 110 AFLAVYAFGMYFAGHLGDRMNLRIFLTVG--MIGTGLFTSLFGVGYWgnihsfYYFLIMQMLAGLFQSSGWPSVVAVVGN 187
Cdd:cd17352 46 LLLGVSLFSGPLSSALVNRFGCRPVAIAGglLAALGLLLSSFATSLW------QLYLTYGVLGGLGLGLIYSPAIVIVGQ 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 188 WFnKKKRGLIMGIWNAHTSVGNITGSLIAAAML-RYGWGWSFVVpgviivviglvnYAFLPVSpenvgaerdevldssse 266
Cdd:cd17352 120 YF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLdNYGWRGALLI------------LGGLCLN----------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 267 kignsvnepLLLSSSdsetddkkravgFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIegeylSDETAGNL 346
Cdd:cd17352 170 ---------LCVCGL------------LLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGI-----DESDAAFL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 347 STMFDVGGVVGGIMAGYISDR--IGARAITAASFMYCSIPALFFYRSYGHVSLLANASlmfLTGMLVNGPYALITTAVSA 424
Cdd:cd17352 224 LSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSV---LFGFCSGSYSSLTPVILAD 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 425 DLGTHSSlkgnSRALATVTAIidgtGSVGAAVGPLLTGYI-SSRGSWTAVFtMLMGAAFVAGLLL 488
Cdd:cd17352 301 LVGLEKL----SNAYGLVLLF----QGLAALVGPPIAGLLrDYTGDYDAAF-YFCGACLLLSGVL 356
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
338-492 |
1.13e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.40 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVNGPYAL 417
Cdd:cd17319 35 LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV---LRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 418 ITTAVSadlgthSSLKGNSRALATvtAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLV 492
Cdd:cd17319 112 AIKALA------EWFPARERGRAT--GLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL 178
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
111-247 |
1.21e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.06 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 111 FLAVYAFGM----YFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVgywgnIHSFYYFLIMQMLAGLFQSSGWPSVVAVVG 186
Cdd:cd17329 40 VLALSAVAGivasLIGGRLADRFGRKPVMLAGLLLRALGFALLGF-----AHSPWLFAIALVLTGFGGGLFEPASEAMIA 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18408421 187 NWFNKKKRGLIMGIWNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLP 247
Cdd:cd17329 115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
338-511 |
1.38e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVNGPYAL 417
Cdd:cd17475 28 LSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLV---LLFLVGAGYGSVQPG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 418 ITTAVSAdlgthsSLKGNSRALAT---VTAIidgtgSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLVMA 494
Cdd:cd17475 105 GGRAIMR------WFPPRERGLAMgirQTGV-----PLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE 173
|
170
....*....|....*..
gi 18408421 495 EVAEKIAESRPSEECRS 511
Cdd:cd17475 174 PPAASAATESASTLLRS 190
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
337-489 |
2.10e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.31 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 337 YLSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALF--FYRSYGHVSLLANASLMFLTGMLVNGP 414
Cdd:cd17341 237 GLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALlsLSLPTSGTNLVLFLALFVALGLGAGAG 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 415 YALITTAVSADLGthsslkgnsRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLT 489
Cdd:cd17341 317 NGSVFRMVPFIFR---------RELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
275-488 |
3.02e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 275 PLLLSSSDSETDDKKRAVGFIEAWRIPGVApFALCLFFAKLVAyTFLYWLPFYVSHTAiegeyLSDETAGNLSTMFDVGG 354
Cdd:cd17477 164 PLLLTRRAAPEIEEAESISLRRLLRIAPLA-LLGAFVAGFLEG-AFYSLLPLYGLRLG-----LSVAQAALLLAAFVLGG 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 355 VVGGIMAGYISDRIG-ARAITAASFMYCSIPALFFYRSYGHVSLLAnasLMFLTGMLVNGPYALITTAVSADLGthsslk 433
Cdd:cd17477 237 LLLQWPLGWLADRFDrRRVLLGCALLGALAALLLPLVPGLPLALLV---LLFLWGGAAGPLYTLALALAGDRLP------ 307
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 434 gnSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLL 488
Cdd:cd17477 308 --GDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
111-228 |
8.29e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 38.90 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 111 FLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFN 190
Cdd:TIGR00711 46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA-----PNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYP 120
|
90 100 110
....*....|....*....|....*....|....*....
gi 18408421 191 KKKRGLIMGIWNAHTSVGNITGSLIAAAMLR-YGWGWSF 228
Cdd:TIGR00711 121 PEKRGRAMAIWGLTVLVAPALGPTLGGWIIEnYHWRWIF 159
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
103-222 |
8.41e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 103 LLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGywgniHSFYYFLIMQMLAGLFqSSGWPSVV 182
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS-----RNLWLLFLARFLDGLT-GGNVSVAQ 108
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 18408421 183 AVVGNWFNKKKRGLIMGIWNAHTSVGNITGSLIAAAMLRY 222
Cdd:cd17330 109 AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP 148
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
338-491 |
8.90e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 8.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLM-FLTGMLVNGPYA 416
Cdd:COG0477 46 ASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQgIGAGGLMPGALA 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18408421 417 LITTAVSAdlgthsslkgnsRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRL 491
Cdd:COG0477 126 LIAELFPA------------RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
299-492 |
9.20e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 9.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 299 RIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIEGEYLSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASF 378
Cdd:cd17504 175 RRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 379 MYCSIPALFfyRSYGHVSLLANASLMFLTGMLVNGPYA----LITTAVSAD-LGTHSSLKGNSRALATVTAIIDGTGSVG 453
Cdd:cd17504 255 VISAVGLLL--LALLHSSLWALVVALLLIGIGLGLAFAslpnIVVESVPPDrTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
170 180 190
....*....|....*....|....*....|....*....
gi 18408421 454 AAVGPLLTGYISSRGSWTAVFtMLMGAAFVAGLLLTRLV 492
Cdd:cd17504 333 TYTVSITSGGVPTEGAYVLAF-LIGAALALAALLLSLLI 370
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
338-489 |
9.95e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 9.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18408421 338 LSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARA-ITAASFMYCSIPALFFYRSyghvSLLANASLMFLTGmLVNGpya 416
Cdd:cd17333 28 LNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRtLILGLLLISLALALIFATP----SIYLFVVLMFLAG-LGAG--- 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18408421 417 LITTAVSADLGTHSSLKGNSRalatvTAIIDGTGSVGAAVGPLLTGY-ISSRGSWTAVFtMLMGAAFVAGLLLT 489
Cdd:cd17333 100 ILDTGANTFVGALFEESSATR-----LNVLHGFFGLGALIGPLIATSlLTSELSWSWAY-LIIGLIYLLLAILI 167
|
|
| |
