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Conserved domains on  [gi|18403505|ref|NP_566715|]
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homocysteine S-methyltransferase 3 [Arabidopsis thaliana]

Protein Classification

betaine--homocysteine S-methyltransferase( domain architecture ID 10010811)

betaine--homocysteine S-methyltransferase (BHMT) is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02489 PLN02489
homocysteine S-methyltransferase
2-337 0e+00

homocysteine S-methyltransferase


:

Pssm-ID: 215269  Cd Length: 335  Bit Score: 643.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505    2 GSFVKEETSSLMTDFLEKCGGYAVVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQAT 81
Cdd:PLN02489   1 GGYVLPQMSSLLEDLLRQAGGCAVIDGGFATELERHGADLNDPLWSAKCLITSPHLIRKVHLDYLEAGADIIITASYQAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   82 IQGFVAKGLSVGEAENLLRRSVEITYEAREIFYNRCTKGSWdFAYAGKASRRPILVAASVGSYGAYLADGSEYSGIYGDS 161
Cdd:PLN02489  81 IQGFESRGLSREESETLLRKSVEIACEARDIFWDKCQKGST-SRPGRELSYRPILVAASIGSYGAYLADGSEYSGDYGPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  162 VSKETLKDFHRRRVQILAKSGADLIAFETIPNKLEAEAYADLLEEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSC 241
Cdd:PLN02489 160 VTLEKLKDFHRRRLQVLAEAGPDLIAFETIPNKLEAQAYVELLEEENIKIPAWISFNSKDGVNVVSGDSLLECASIADSC 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  242 KNVVAIGINCTAPRYIHALIISLRQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRDAGASLFGGCCRT 321
Cdd:PLN02489 240 KKVVAVGINCTPPRFIHGLILSIRKVTSKPIVVYPNSGETYDGEAKEWVESTGVSDEDFVSYVNKWRDAGASLIGGCCRT 319
                        330
                 ....*....|....*.
gi 18403505  322 TPNTIRAIAKVLSDEP 337
Cdd:PLN02489 320 TPNTIRAISKALSERL 335
 
Name Accession Description Interval E-value
PLN02489 PLN02489
homocysteine S-methyltransferase
2-337 0e+00

homocysteine S-methyltransferase


Pssm-ID: 215269  Cd Length: 335  Bit Score: 643.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505    2 GSFVKEETSSLMTDFLEKCGGYAVVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQAT 81
Cdd:PLN02489   1 GGYVLPQMSSLLEDLLRQAGGCAVIDGGFATELERHGADLNDPLWSAKCLITSPHLIRKVHLDYLEAGADIIITASYQAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   82 IQGFVAKGLSVGEAENLLRRSVEITYEAREIFYNRCTKGSWdFAYAGKASRRPILVAASVGSYGAYLADGSEYSGIYGDS 161
Cdd:PLN02489  81 IQGFESRGLSREESETLLRKSVEIACEARDIFWDKCQKGST-SRPGRELSYRPILVAASIGSYGAYLADGSEYSGDYGPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  162 VSKETLKDFHRRRVQILAKSGADLIAFETIPNKLEAEAYADLLEEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSC 241
Cdd:PLN02489 160 VTLEKLKDFHRRRLQVLAEAGPDLIAFETIPNKLEAQAYVELLEEENIKIPAWISFNSKDGVNVVSGDSLLECASIADSC 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  242 KNVVAIGINCTAPRYIHALIISLRQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRDAGASLFGGCCRT 321
Cdd:PLN02489 240 KKVVAVGINCTPPRFIHGLILSIRKVTSKPIVVYPNSGETYDGEAKEWVESTGVSDEDFVSYVNKWRDAGASLIGGCCRT 319
                        330
                 ....*....|....*.
gi 18403505  322 TPNTIRAIAKVLSDEP 337
Cdd:PLN02489 320 TPNTIRAISKALSERL 335
MHT1 COG2040
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and ...
21-337 1.38e-113

Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism];


Pssm-ID: 441643 [Multi-domain]  Cd Length: 301  Bit Score: 331.77  E-value: 1.38e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  21 GGYAVVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQATIQGFVAKGLSVGEAENLLR 100
Cdd:COG2040  11 GRILLLDGGMGTELERRGGDLLDPLWSAFALLEAPELVRAVHRDYFAAGADVITTNSYQASPDGLAELGYSAEEAERLNR 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505 101 RSVEITYEAREIFynrctkgswdfayagkASRRPILVAASVGSYGayladgSEYSGIYGdsVSKETLKDFHRRRVQILAK 180
Cdd:COG2040  91 RAVALAREARDEY----------------TPGPPVLVAGSVGPYG------DEYRPDYG--LSAEEAEAYHRPRIEALAE 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505 181 SGADLIAFETIPNKLEAEAYADLLEEedIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGINCTAPRYIHAL 260
Cdd:COG2040 147 AGVDLLAAETIPSLAEAIAIARAAAE--AGKPVWISFTVEDDGRLRSGEPLAEAIAAVDTDPGPAAVGVNCSHPEHFEAA 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18403505 261 IISLRQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRDAGASLFGGCCRTTPNTIRAIAKVLSDEP 337
Cdd:COG2040 225 LEALAAWTGRPIGVYANAGEMSDAELKTWGGLDDGDPEELAEQAAEWVAAGARIIGGCCGTGPRHIAAIARALRAAG 301
S-methyl_trans pfam02574
Homocysteine S-methyltransferase; This is a family of related homocysteine ...
25-333 4.10e-106

Homocysteine S-methyltransferase; This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.


Pssm-ID: 460598 [Multi-domain]  Cd Length: 268  Bit Score: 311.40  E-value: 4.10e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505    25 VVDGGFATELQRHGADINDPLWSAKCLiTSPHLVTKVHLDYLESGANIIITASYQATIQGFvAKGLSVGEA-ENLLRRSV 103
Cdd:pfam02574   2 ILDGGMGTELQRRGLDLTEPLWSNELL-TRPEIIREIHRDYLEAGADIIETNTYQASPIKL-AEGLEEEEAvYELNRAAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   104 EITYEAREIFYnrctkgswdfayagkasrrpilVAASVGSYGAYLADGSeysgiygdSVSKETLKDFHRRRVQILAKSGA 183
Cdd:pfam02574  80 RLAREAADEYF----------------------VAGSIGPYGATLSDGY--------GLSFDELVDFHREQLEALLDGGV 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   184 DLIAFETIPNKLEAEAYADLLEEEdIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGINCTAPRYIHALIIS 263
Cdd:pfam02574 130 DLLLFETIPDLLEAKAALELLAEE-PDLPVWISFTIEDGTRLRSGTTLEAAVAALLHATGPLAVGVNCALPEEMLPLLKE 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18403505   264 LRQMTRKPIVVYPNS-GEVYDglnkkwiksegESEEDFVSYVSKWRDAGASLFGGCCRTTPNTIRAIAKVL 333
Cdd:pfam02574 209 LAKDAPTPVSVYPNStGEVYD-----------LTPEEWAEYAEGWLEAGANIIGGCCGTTPEHIRAIAEAL 268
 
Name Accession Description Interval E-value
PLN02489 PLN02489
homocysteine S-methyltransferase
2-337 0e+00

homocysteine S-methyltransferase


Pssm-ID: 215269  Cd Length: 335  Bit Score: 643.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505    2 GSFVKEETSSLMTDFLEKCGGYAVVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQAT 81
Cdd:PLN02489   1 GGYVLPQMSSLLEDLLRQAGGCAVIDGGFATELERHGADLNDPLWSAKCLITSPHLIRKVHLDYLEAGADIIITASYQAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   82 IQGFVAKGLSVGEAENLLRRSVEITYEAREIFYNRCTKGSWdFAYAGKASRRPILVAASVGSYGAYLADGSEYSGIYGDS 161
Cdd:PLN02489  81 IQGFESRGLSREESETLLRKSVEIACEARDIFWDKCQKGST-SRPGRELSYRPILVAASIGSYGAYLADGSEYSGDYGPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  162 VSKETLKDFHRRRVQILAKSGADLIAFETIPNKLEAEAYADLLEEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSC 241
Cdd:PLN02489 160 VTLEKLKDFHRRRLQVLAEAGPDLIAFETIPNKLEAQAYVELLEEENIKIPAWISFNSKDGVNVVSGDSLLECASIADSC 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  242 KNVVAIGINCTAPRYIHALIISLRQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRDAGASLFGGCCRT 321
Cdd:PLN02489 240 KKVVAVGINCTPPRFIHGLILSIRKVTSKPIVVYPNSGETYDGEAKEWVESTGVSDEDFVSYVNKWRDAGASLIGGCCRT 319
                        330
                 ....*....|....*.
gi 18403505  322 TPNTIRAIAKVLSDEP 337
Cdd:PLN02489 320 TPNTIRAISKALSERL 335
mmuM PRK09485
homocysteine methyltransferase; Provisional
13-335 4.77e-151

homocysteine methyltransferase; Provisional


Pssm-ID: 181899 [Multi-domain]  Cd Length: 304  Bit Score: 426.97  E-value: 4.77e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   13 MTDFLEKC--GGYAVVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQATIQGFVAKGL 90
Cdd:PRK09485   1 MNPFKELLaqGPVLILDGALATELEARGCDLNDSLWSAKVLLENPELIYQVHLDYFRAGADCAITASYQATFQGFAARGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   91 SVGEAENLLRRSVEITYEAREifynrctkgswdfayagKASRRPILVAASVGSYGAYLADGSEYSGIYGdsVSKETLKDF 170
Cdd:PRK09485  81 SEAEAEELIRRSVELAKEARD-----------------EFWAEKPLVAGSVGPYGAYLADGSEYRGDYG--LSEEELQDF 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  171 HRRRVQILAKSGADLIAFETIPNKLEAEAYADLLEEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGIN 250
Cdd:PRK09485 142 HRPRIEALAEAGADLLACETIPNLDEAEALVELLKEEFPGVPAWLSFTLRDGTHISDGTPLAEAAALLAASPQVVAVGVN 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  251 CTAPRYIHALIISLRQMTRKPIVVYPNSGEVYDGLNKKWikSEGESEEDFVSYVSKWRDAGASLFGGCCRTTPNTIRAIA 330
Cdd:PRK09485 222 CTAPELVTAAIAALRAVTDKPLVVYPNSGEVYDAVTKTW--HGPADDASLGELAPEWYAAGARLIGGCCRTTPEDIAALA 299

                 ....*
gi 18403505  331 KVLSD 335
Cdd:PRK09485 300 AALKT 304
MHT1 COG2040
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and ...
21-337 1.38e-113

Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism];


Pssm-ID: 441643 [Multi-domain]  Cd Length: 301  Bit Score: 331.77  E-value: 1.38e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  21 GGYAVVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQATIQGFVAKGLSVGEAENLLR 100
Cdd:COG2040  11 GRILLLDGGMGTELERRGGDLLDPLWSAFALLEAPELVRAVHRDYFAAGADVITTNSYQASPDGLAELGYSAEEAERLNR 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505 101 RSVEITYEAREIFynrctkgswdfayagkASRRPILVAASVGSYGayladgSEYSGIYGdsVSKETLKDFHRRRVQILAK 180
Cdd:COG2040  91 RAVALAREARDEY----------------TPGPPVLVAGSVGPYG------DEYRPDYG--LSAEEAEAYHRPRIEALAE 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505 181 SGADLIAFETIPNKLEAEAYADLLEEedIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGINCTAPRYIHAL 260
Cdd:COG2040 147 AGVDLLAAETIPSLAEAIAIARAAAE--AGKPVWISFTVEDDGRLRSGEPLAEAIAAVDTDPGPAAVGVNCSHPEHFEAA 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18403505 261 IISLRQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRDAGASLFGGCCRTTPNTIRAIAKVLSDEP 337
Cdd:COG2040 225 LEALAAWTGRPIGVYANAGEMSDAELKTWGGLDDGDPEELAEQAAEWVAAGARIIGGCCGTGPRHIAAIARALRAAG 301
S-methyl_trans pfam02574
Homocysteine S-methyltransferase; This is a family of related homocysteine ...
25-333 4.10e-106

Homocysteine S-methyltransferase; This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.


Pssm-ID: 460598 [Multi-domain]  Cd Length: 268  Bit Score: 311.40  E-value: 4.10e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505    25 VVDGGFATELQRHGADINDPLWSAKCLiTSPHLVTKVHLDYLESGANIIITASYQATIQGFvAKGLSVGEA-ENLLRRSV 103
Cdd:pfam02574   2 ILDGGMGTELQRRGLDLTEPLWSNELL-TRPEIIREIHRDYLEAGADIIETNTYQASPIKL-AEGLEEEEAvYELNRAAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   104 EITYEAREIFYnrctkgswdfayagkasrrpilVAASVGSYGAYLADGSeysgiygdSVSKETLKDFHRRRVQILAKSGA 183
Cdd:pfam02574  80 RLAREAADEYF----------------------VAGSIGPYGATLSDGY--------GLSFDELVDFHREQLEALLDGGV 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   184 DLIAFETIPNKLEAEAYADLLEEEdIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGINCTAPRYIHALIIS 263
Cdd:pfam02574 130 DLLLFETIPDLLEAKAALELLAEE-PDLPVWISFTIEDGTRLRSGTTLEAAVAALLHATGPLAVGVNCALPEEMLPLLKE 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18403505   264 LRQMTRKPIVVYPNS-GEVYDglnkkwiksegESEEDFVSYVSKWRDAGASLFGGCCRTTPNTIRAIAKVL 333
Cdd:pfam02574 209 LAKDAPTPVSVYPNStGEVYD-----------LTPEEWAEYAEGWLEAGANIIGGCCGTTPEHIRAIAEAL 268
MetH1 COG0646
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport ...
25-344 1.93e-41

Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Methionine synthase I (cobalamin-dependent), methyltransferase domain is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440411 [Multi-domain]  Cd Length: 809  Bit Score: 154.24  E-value: 1.93e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  25 VVDGGFATELQRHGADINDPLWSAKCL----ITSPHLVTKVHLDYLESGANIIITASYQATIQGFVAKGLSvGEAENLLR 100
Cdd:COG0646  16 ILDGAMGTMLQAYGLTEGDFRGEKGCNellnLTRPDVIREIHRAYLEAGADIIETNTFGANRIKLADYGLE-DRVYEINR 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505 101 RSVEItyeAREIfynrctkgswdfayAGKASRRPILVAASVGSYGAYLADgseysgiYGDsVSKETLKDFHRRRVQILAK 180
Cdd:COG0646  95 AAARL---AREA--------------ADEFSDRPRFVAGSIGPTGKLLSP-------LGN-ITFDELVEAYREQAEGLIE 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505 181 SGADLIAFETIPNKLEAEA--YA--DLLEEEDIDIPAWFSFT-SKDGvsvpR---GDSVVECAKVADSCkNVVAIGINC- 251
Cdd:COG0646 150 GGVDLLLIETIFDTLEAKAaiFAarEAFEELGRDLPVMVSGTfDASG----RtlsGQTPEAFATSLEHL-GPDAIGLNCa 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505 252 TAPRYIHALIISLRQMTRKPIVVYPNSG--------EVYDglnkkwiksegESEEDFVSYVSKWRDAG-ASLFGGCCRTT 322
Cdd:COG0646 225 LGPDEMRPHVEELSEVADTPVSAYPNAGlpnlvggrTVYD-----------ETPEEMAEYAEEFAEAGgVNIVGGCCGTT 293
                       330       340
                ....*....|....*....|...
gi 18403505 323 PNTIRAIAKVLSD-EPSAASKPK 344
Cdd:COG0646 294 PEHIRAIAEAVKGlPPRKRPPPP 316
PRK08645 PRK08645
bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; ...
13-342 1.28e-34

bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed


Pssm-ID: 236321 [Multi-domain]  Cd Length: 612  Bit Score: 133.43  E-value: 1.28e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   13 MTDFLEKCGGYAVV-DGGFATELQRHGADINdplwsaKCL----ITSPHLVTKVHLDYLESGANIIITASYQATIQGFVA 87
Cdd:PRK08645   1 MMKLLERLKERVLIaDGAMGTLLYSRGVPLD------RCFeelnLSHPELILRIHREYIEAGADVIQTNTFGANRIKLKR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   88 KGLSvGEAENLLRRSVEItyeAREifynrctkgswdfayagkASRRPILVAASVGSYGAYLADGSeysgiygdsVSKETL 167
Cdd:PRK08645  75 YGLE-DKVKEINRAAVRL---ARE------------------AAGDDVYVAGTIGPIGGRGPLGD---------ISLEEI 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  168 KDFHRRRVQILAKSGADLIAFETIPNKLEAEAYADLLEEEDiDIP--AWFSFTsKDGVSVpRGDSVVECAKVADSCKnVV 245
Cdd:PRK08645 124 RREFREQIDALLEEGVDGLLLETFYDLEELLLALEAAREKT-DLPiiAQVAFH-EDGVTQ-NGTSLEEALKELVAAG-AD 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  246 AIGINCTA-PRYIHALIISLRQMTRKPIVVYPNSG--EVYDGlnkKWIKSEgeSEEDFVSYVSKWRDAGASLFGGCCRTT 322
Cdd:PRK08645 200 VVGLNCGLgPYHMLEALERIPIPENAPLSAYPNAGlpEYVDG---RYVYSA--NPEYFAEYALEFVEQGVRLIGGCCGTT 274
                        330       340
                 ....*....|....*....|
gi 18403505  323 PNTIRAIAKVLSDEPSAASK 342
Cdd:PRK08645 275 PEHIRAMARALKGLKPVTEK 294
PRK07534 PRK07534
betaine--homocysteine S-methyltransferase;
22-337 1.39e-17

betaine--homocysteine S-methyltransferase;


Pssm-ID: 236045 [Multi-domain]  Cd Length: 336  Bit Score: 82.49  E-value: 1.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   22 GYAVVDGGFATELQRHGADINDP--LWSakclITSPHLVTKVHLDYLESGANIIITASYQATiqgfvAKGLSVGEAE--- 96
Cdd:PRK07534  13 GVLLADGATGTNLFNMGLESGEApeLWN----EDHPDNITALHQGFVDAGSDIILTNSFGGT-----AARLKLHDAQdrv 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   97 -NLLRRSVEItyeAREIfynrctkgswdfayAGKASRrPILVAASVGSYGAYLADGSEYSgiYGDSVSKetlkdFHRRrV 175
Cdd:PRK07534  84 hELNRAAAEI---AREV--------------ADKAGR-KVIVAGSVGPTGEIMEPMGALT--HALAVEA-----FHEQ-A 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  176 QILAKSGADLIAFETIPNKLEAEAYADLLEEEDIDIPAWFSF----------TSKDGVSVprgdsvvecakVADSCKNVV 245
Cdd:PRK07534 138 EGLKAGGADVLWVETISAPEEIRAAAEAAKLAGMPWCGTMSFdtagrtmmglTPADLADL-----------VEKLGEPPL 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  246 AIGINCT--APRYIHALIISLRQMTRKPIVVYPNSG--EVYDGlnkkWIKSEGeSEEDFVSYVSKWRDAGASLFGGCCRT 321
Cdd:PRK07534 207 AFGANCGvgASDLLRTVLGFTAQGPERPIIAKGNAGipKYVDG----HIHYDG-TPELMAEYAVLARDAGARIIGGCCGT 281
                        330
                 ....*....|....*.
gi 18403505  322 TPNTIRAIAKVLSDEP 337
Cdd:PRK07534 282 MPEHLAAMRAALDARP 297
MetH2 COG1410
Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; ...
27-337 6.87e-14

Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Methionine synthase I, cobalamin-binding domain is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 441020 [Multi-domain]  Cd Length: 1141  Bit Score: 72.68  E-value: 6.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   27 DGGFATELQRHGADINDPLwsakcLITSPHLVTKVHLDYLESGANIIITASYQATIQGFVAKGLSVGEAENLLRRSVEIT 106
Cdd:COG1410   16 DGAMFTDLQLDLKGNNDLL-----GLTGPNEILEIHRPELEAGADIIETNTGADAAITAADGAAEALLAEYNGAAAALAL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  107 YEAReifynrctkgswdfAYAGKASRRPILVAASVGSYGAYLADGSEYSGIYGDSVSKETLKDFHRRRVQILAKSGADLI 186
Cdd:COG1410   91 EAAA--------------AAAAAAAAAARAVAGAPGPTGGTASPGPDVPGLGFRNFDFDELVEAYAEAGLGLGGGGADLL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  187 AFETIP--NKLEAEAYADLLEEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGINCTAPRYIHALIISL 264
Cdd:COG1410  157 LTETIFdtLNAAAAAAAAAAAAEEEGVPIPVMVTGTITDGSGRTLSGQTAEAFLESLGHAAPGSNGLNCALGAEELRPYL 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505  265 RQMTRKPIVV--------YPNSGEVYDglnkkwiksegESEEDFVSYVSKW-RDAGASLFGGCCRTTPNTIRAIAKVLSD 335
Cdd:COG1410  237 EELSRIPPSAvsnapnagLPNGFGEYD-----------ETPEEMAAALAEFaEEGGVNIVGGCCGTTPEHIRAIAEAVAG 305

                 ..
gi 18403505  336 EP 337
Cdd:COG1410  306 LK 307
metH PRK09490
B12-dependent methionine synthase; Provisional
25-337 2.04e-13

B12-dependent methionine synthase; Provisional


Pssm-ID: 236539 [Multi-domain]  Cd Length: 1229  Bit Score: 71.36  E-value: 2.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505    25 VVDGGFATELQRHG-----------ADI-------NDPLwsakcLITSPHLVTKVHLDYLESGANIIITASYQATiqgfv 86
Cdd:PRK09490   21 VLDGAMGTMIQRYKleeadyrgerfADWpcdlkgnNDLL-----VLTQPDVIEAIHRAYLEAGADIIETNTFNAT----- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505    87 akglSVGEA----ENLLRrsvEITYEAReifynRCTKGSWDfAYAGKASRRPILVAASVGSYG------------AYLAd 150
Cdd:PRK09490   91 ----TIAQAdygmESLVY---ELNFAAA-----RLAREAAD-EWTAKTPDKPRFVAGVLGPTNrtasispdvndpGFRN- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   151 gseysgiygdsVSKETLKDFHRRRVQILAKSGADLIAFETIPNKLEAEA--YA--DLLEEEDIDIPAWFSFTSKDG---- 222
Cdd:PRK09490  157 -----------VTFDELVAAYREQTRGLIEGGADLILIETIFDTLNAKAaiFAveEVFEELGVRLPVMISGTITDAsgrt 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403505   223 VSvprGDSV------VECAKvadscknVVAIGINCT-APRYIHALIISLRQMTRKPIVVYPNSG------EvYDglnkkw 289
Cdd:PRK09490  226 LS---GQTTeafwnsLRHAK-------PLSIGLNCAlGADELRPYVEELSRIADTYVSAHPNAGlpnafgE-YD------ 288
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 18403505   290 iksegESEEDFVSYVSKWRDAG-ASLFGGCCRTTPNTIRAIAKVLSDEP 337
Cdd:PRK09490  289 -----ETPEEMAAQIGEFAESGfLNIVGGCCGTTPEHIAAIAEAVAGLP 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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