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Conserved domains on  [gi|18401821|ref|NP_566604|]
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Reticulon family protein [Arabidopsis thaliana]

Protein Classification

reticulon family protein( domain architecture ID 10493657)

reticulon family protein associates with the endoplasmic reticulum (ER) through a C-terminal di-lysine ER retention motif; such as mammalian RTN4/Nogo, a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching

Gene Ontology:  GO:0005789|GO:0005783
PubMed:  12832288|18177508|22425683|33924890

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 39-195 4.10e-53

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


:

Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 168.05  E-value: 4.10e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401821    39 VADILLWREPKIAATLVIGVSILWFLMEVVEYNFITLICHASMTSMLFFFIWSTASDFLNWERPLIPEVVLDESSFKQLA 118
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRPPPPIPELELSEETVRELA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18401821   119 RSFHVRFNQILTKLLDVACGRDPPLFFLTTISLYIVSIIGTYFNFVNLLFIGFVSMQTLPVMYEMYEDDVDTAAGKL 195
Cdd:pfam02453  81 DSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDAYVEKA 157
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 39-195 4.10e-53

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 168.05  E-value: 4.10e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401821    39 VADILLWREPKIAATLVIGVSILWFLMEVVEYNFITLICHASMTSMLFFFIWSTASDFLNWERPLIPEVVLDESSFKQLA 118
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRPPPPIPELELSEETVRELA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18401821   119 RSFHVRFNQILTKLLDVACGRDPPLFFLTTISLYIVSIIGTYFNFVNLLFIGFVSMQTLPVMYEMYEDDVDTAAGKL 195
Cdd:pfam02453  81 DSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDAYVEKA 157
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 39-195 4.10e-53

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 168.05  E-value: 4.10e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401821    39 VADILLWREPKIAATLVIGVSILWFLMEVVEYNFITLICHASMTSMLFFFIWSTASDFLNWERPLIPEVVLDESSFKQLA 118
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRPPPPIPELELSEETVRELA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18401821   119 RSFHVRFNQILTKLLDVACGRDPPLFFLTTISLYIVSIIGTYFNFVNLLFIGFVSMQTLPVMYEMYEDDVDTAAGKL 195
Cdd:pfam02453  81 DSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDAYVEKA 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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