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Conserved domains on  [gi|18398079|ref|NP_566322|]
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F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F_box_assoc_1 super family cl44343
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 120-349 1.53e-21

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


The actual alignment was detected with superfamily member TIGR01640:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 92.42  E-value: 1.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398079   120 VGSCNGLLCLSdslYNDSLYLYNPFTTNSLELPECSNKYHDQE-LVFGFGFHEMTKEYKVLKIVYFRGSSSnnngiyrgr 198
Cdd:TIGR01640   1 VVPCDGLICFS---YGKRLVVWNPSTGQSRWLPTPKSRRSNKEsDTYFLGYDPIEKQYKVLCFSDRSGNRN--------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398079   199 griqykQSEVQILTLSSKttdqslSWRSLGKAPYKFVKRSSEALVNGRLHFVTRPRRHVPDRKFVSFDLEDEEFKEIPKP 278
Cdd:TIGR01640  69 ------QSEHQVYTLGSN------SWRTIECSPPHHPLKSRGVCINGVLYYLAYTLKTNPDYFIVSFDVSSERFKEFIPL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18398079   279 DCGGLNRTNHR-LVNLKGCLCAVVYGNYG-KLDIWVMKTYGvKESWGKEYSIGTYLPKGLKQNLDRPMWIWKN 349
Cdd:TIGR01640 137 PCGNSDSVDYLsLINYKGKLAVLKQKKDTnNFDLWVLNDAG-KQEWSKLFTVPIPPLPDLVDDNFLSGFTDKG 208
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 26-60 1.58e-09

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22157:

Pssm-ID: 459239  Cd Length: 39  Bit Score: 52.85  E-value: 1.58e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18398079  26 ESLPEDIIADIFSRLPISSIARLMFVCRSWRSVLT 60
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLIS 35
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 120-349 1.53e-21

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 92.42  E-value: 1.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398079   120 VGSCNGLLCLSdslYNDSLYLYNPFTTNSLELPECSNKYHDQE-LVFGFGFHEMTKEYKVLKIVYFRGSSSnnngiyrgr 198
Cdd:TIGR01640   1 VVPCDGLICFS---YGKRLVVWNPSTGQSRWLPTPKSRRSNKEsDTYFLGYDPIEKQYKVLCFSDRSGNRN--------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398079   199 griqykQSEVQILTLSSKttdqslSWRSLGKAPYKFVKRSSEALVNGRLHFVTRPRRHVPDRKFVSFDLEDEEFKEIPKP 278
Cdd:TIGR01640  69 ------QSEHQVYTLGSN------SWRTIECSPPHHPLKSRGVCINGVLYYLAYTLKTNPDYFIVSFDVSSERFKEFIPL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18398079   279 DCGGLNRTNHR-LVNLKGCLCAVVYGNYG-KLDIWVMKTYGvKESWGKEYSIGTYLPKGLKQNLDRPMWIWKN 349
Cdd:TIGR01640 137 PCGNSDSVDYLsLINYKGKLAVLKQKKDTnNFDLWVLNDAG-KQEWSKLFTVPIPPLPDLVDDNFLSGFTDKG 208
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 26-60 1.58e-09

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 52.85  E-value: 1.58e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18398079  26 ESLPEDIIADIFSRLPISSIARLMFVCRSWRSVLT 60
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLIS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 25-58 1.17e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.86  E-value: 1.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 18398079    25 LESLPEDIIADIFSRLPISSIARLMFVCRSWRSV 58
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWREL 34
FBOX smart00256
A Receptor for Ubiquitination Targets;
28-63 1.62e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 1.62e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18398079     28 LPEDIIADIFSRLPISSIARLMFVCRSWRSVLTQHG 63
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
FBA_3 pfam08268
F-box associated domain;
263-325 8.38e-04

F-box associated domain;


Pssm-ID: 285468  Cd Length: 125  Bit Score: 39.19  E-value: 8.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18398079   263 VSFDLEDEEFK--EIPKPDCGGLNRTnhrLVNLKGCLCAVVYGNYGKLDIWVMKTyGVKESWGKE 325
Cdd:pfam08268  23 VSFDVRSEKFDfiKLPVPLANDLSST---LINYKGKLAVVSHTSDGGIELWVLED-AEKHEWSKK 83
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 120-349 1.53e-21

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 92.42  E-value: 1.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398079   120 VGSCNGLLCLSdslYNDSLYLYNPFTTNSLELPECSNKYHDQE-LVFGFGFHEMTKEYKVLKIVYFRGSSSnnngiyrgr 198
Cdd:TIGR01640   1 VVPCDGLICFS---YGKRLVVWNPSTGQSRWLPTPKSRRSNKEsDTYFLGYDPIEKQYKVLCFSDRSGNRN--------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18398079   199 griqykQSEVQILTLSSKttdqslSWRSLGKAPYKFVKRSSEALVNGRLHFVTRPRRHVPDRKFVSFDLEDEEFKEIPKP 278
Cdd:TIGR01640  69 ------QSEHQVYTLGSN------SWRTIECSPPHHPLKSRGVCINGVLYYLAYTLKTNPDYFIVSFDVSSERFKEFIPL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18398079   279 DCGGLNRTNHR-LVNLKGCLCAVVYGNYG-KLDIWVMKTYGvKESWGKEYSIGTYLPKGLKQNLDRPMWIWKN 349
Cdd:TIGR01640 137 PCGNSDSVDYLsLINYKGKLAVLKQKKDTnNFDLWVLNDAG-KQEWSKLFTVPIPPLPDLVDDNFLSGFTDKG 208
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 26-60 1.58e-09

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 52.85  E-value: 1.58e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18398079  26 ESLPEDIIADIFSRLPISSIARLMFVCRSWRSVLT 60
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLIS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 25-58 1.17e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.86  E-value: 1.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 18398079    25 LESLPEDIIADIFSRLPISSIARLMFVCRSWRSV 58
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWREL 34
FBOX smart00256
A Receptor for Ubiquitination Targets;
28-63 1.62e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 1.62e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18398079     28 LPEDIIADIFSRLPISSIARLMFVCRSWRSVLTQHG 63
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 26-60 3.22e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 46.28  E-value: 3.22e-07
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18398079  26 ESLPEDIIADIFSRLPISSIARLMFVCRSWRSVLT 60
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 25-60 4.11e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 46.38  E-value: 4.11e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 18398079    25 LESLPEDIIADIFSRLPISSIARLMFVCRSWRSVLT 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 25-60 3.19e-05

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 41.02  E-value: 3.19e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 18398079  25 LESLPEDIIADIFSRLPISSIARLMFVCRSWRSVLT 60
Cdd:cd22152   2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLS 37
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 27-56 3.73e-04

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 38.07  E-value: 3.73e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 18398079  27 SLPEDIIADIFSRLPISSIARLMFVCRSWR 56
Cdd:cd22151   2 KLPDDLLQEIFKRLDPKSLARAACVCRRWR 31
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 25-56 7.53e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 36.94  E-value: 7.53e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 18398079  25 LESLPEDIIADIFSRLPISSIARLMFVCRSWR 56
Cdd:cd22123   1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWR 32
FBA_3 pfam08268
F-box associated domain;
263-325 8.38e-04

F-box associated domain;


Pssm-ID: 285468  Cd Length: 125  Bit Score: 39.19  E-value: 8.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18398079   263 VSFDLEDEEFK--EIPKPDCGGLNRTnhrLVNLKGCLCAVVYGNYGKLDIWVMKTyGVKESWGKE 325
Cdd:pfam08268  23 VSFDVRSEKFDfiKLPVPLANDLSST---LINYKGKLAVVSHTSDGGIELWVLED-AEKHEWSKK 83
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 28-58 2.00e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 36.04  E-value: 2.00e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 18398079  28 LPEDIIADIFSRLpiSSIARLM---FVCRSWRSV 58
Cdd:cd22164   5 LPDDLTASILSRL--GAIDILTnaqKVCKLWRRI 36
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 25-61 4.54e-03

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 34.94  E-value: 4.54e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 18398079  25 LESLPEDIIADIFSRLPISSIAR-LMFVCRSWRSVLTQ 61
Cdd:cd22095   2 IQQLPEELLRNIFAFLPAEDLYQnISLVCRHWRDIVSD 39
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
 25-58 6.91e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438933  Cd Length: 46  Bit Score: 34.48  E-value: 6.91e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 18398079  25 LESLPEDIIADIFSRLPISSIARLMFVCRSWRSV 58
Cdd:cd22162   1 LEDLPEDCIALILSFTSPRDVCRLSAVSKTFRSA 34
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
 27-65 6.99e-03

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 34.23  E-value: 6.99e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18398079  27 SLPEDIIADIFSRLPISSIARLMFVCRSWRsVLTQHGRL 65
Cdd:cd22124   3 LLPRKAALKIFSYLDLRDLARCAQVCRSWK-VITQSSSL 40
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 26-59 7.09e-03

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 34.54  E-value: 7.09e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 18398079  26 ESLPEDIIADIFSRLPISSIARLMFVCRSWRSVL 59
Cdd:cd22104   2 ANLPSVVLVHIFSYLPPRDRLRASSTCRRWREAL 35
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 25-58 7.93e-03

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 34.21  E-value: 7.93e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 18398079  25 LESLPEDIIADIFSRLPISSIARLMFVCRSWRSV 58
Cdd:cd22147   2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNL 35
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 26-58 8.81e-03

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 33.89  E-value: 8.81e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 18398079  26 ESLPEDIIADIFSRLPISSIARLMFVCRSWRSV 58
Cdd:cd22149   2 ERLSDEIILSIFKWLPKKTLARCARVCRRWKRL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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