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Conserved domains on  [gi|18397465|ref|NP_566270|]
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trichome birefringence-like protein (DUF828) [Arabidopsis thaliana]

Protein Classification

trichome birefringence-like family protein( domain architecture ID 10627628)

trichome birefringence-like (TBL) family protein belongs to the SGNH/GDSL hydrolase superfamily of hydrolytic enzymes

CATH:  3.40.50.1110
PubMed:  20657172|35871440|15522763
SCOP:  3001315

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
 155-340 5.70e-92

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


:

Pssm-ID: 463996  Cd Length: 281  Bit Score: 276.00  E-value: 5.70e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   155 LPRFDAKLMLEKLRDKRLVFVGDSIGRNQWESLLCLLSSAVKNESLIYeingsPITKHKGFLVFKFEEYNCTVEYYRSPF 234
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSVY-----KITKDRGFRRFRFPDYNFTVEFYWSPF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   235 LVpQSRPPIGSPGKVKTSLKLDTMDWT-SSKWRDADVLVLNTGHWWNEGKTT-RTGCYFQEGEEVKLKMNVDDAYKRALN 312
Cdd:pfam13839  76 LV-DSVEDPNGPGKGKRVLHLDSIDERwASQWKGADVLVFNTGHWWLRPKIYyEGGDYFGCGGKNYTDMDRLDAYRKALR 154

                         170       180
                  ....*....|....*....|....*...
gi 18397465   313 TVVKWIHTELDSNKTQVFFRTFAPVHFR 340
Cdd:pfam13839 155 TWARWVDSNLDPSKTRVFFRTFSPSHFE 182
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
 102-154 1.56e-23

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


:

Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 91.78  E-value: 1.56e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18397465   102 GCDVFDGDWVWDE-SYPLYQSKDCRFLDEGFRCSDFGRSDLFYTQWRWQPRHCN 154
Cdd:pfam14416   1 ECDLFDGRWVYDEdSYPLYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
 
Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
 155-340 5.70e-92

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


Pssm-ID: 463996  Cd Length: 281  Bit Score: 276.00  E-value: 5.70e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   155 LPRFDAKLMLEKLRDKRLVFVGDSIGRNQWESLLCLLSSAVKNESLIYeingsPITKHKGFLVFKFEEYNCTVEYYRSPF 234
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSVY-----KITKDRGFRRFRFPDYNFTVEFYWSPF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   235 LVpQSRPPIGSPGKVKTSLKLDTMDWT-SSKWRDADVLVLNTGHWWNEGKTT-RTGCYFQEGEEVKLKMNVDDAYKRALN 312
Cdd:pfam13839  76 LV-DSVEDPNGPGKGKRVLHLDSIDERwASQWKGADVLVFNTGHWWLRPKIYyEGGDYFGCGGKNYTDMDRLDAYRKALR 154

                         170       180
                  ....*....|....*....|....*...
gi 18397465   313 TVVKWIHTELDSNKTQVFFRTFAPVHFR 340
Cdd:pfam13839 155 TWARWVDSNLDPSKTRVFFRTFSPSHFE 182
PLN02629 PLN02629
powdery mildew resistance 5
 92-339 9.58e-66

powdery mildew resistance 5


Pssm-ID: 215338 [Multi-domain]  Cd Length: 387  Bit Score: 212.46  E-value: 9.58e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   92 RVGFLEESGSGCDVFDGDWVWDESYPLYQSKDC-RFLDEGFRCSDFGRSDLFYTQWRWQPRHCNLPRFDAKLMLEKLRDK 170
Cdd:PLN02629  42 RRPSLQANQSTCALFVGTWVRDDSYPLYQSSDCpGVIDPEFNCQMYGRPDSDYLKYRWQPLNCELPRFNGLEFLLKMKGK 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465  171 RLVFVGDSIGRNQWESLLCLLSSAVKNESliyeingSPITKHKGFLVFKFEEYNCTVEYYRSPFLVPQSRPpigspgKVK 250
Cdd:PLN02629 122 TVMFVGDSLGRNQWESLICLISSSVPSTR-------TQMSRGDPLSTFKFLDYGVSISFYKAPYLVDIDAV------QGK 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465  251 TSLKLDTMDWTSSKWRDADVLVLNTGHWWNEGKTTRTGCYFQEGEEVKLKMNVDDAYKRALNTVVKWIHTELDSNKTQVF 330
Cdd:PLN02629 189 RVLKLEEISGNANAWRDADVLIFNTGHWWSHQGSLQGWDYIESGGTYYQDMDRLVALEKALRTWAYWVDTNVDRSRTRVF 268


                 ....*....
gi 18397465  331 FRTFAPVHF 339
Cdd:PLN02629 269 FQSISPTHY 277
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
 102-154 1.56e-23

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 91.78  E-value: 1.56e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18397465   102 GCDVFDGDWVWDE-SYPLYQSKDCRFLDEGFRCSDFGRSDLFYTQWRWQPRHCN 154
Cdd:pfam14416   1 ECDLFDGRWVYDEdSYPLYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
 
Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
 155-340 5.70e-92

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


Pssm-ID: 463996  Cd Length: 281  Bit Score: 276.00  E-value: 5.70e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   155 LPRFDAKLMLEKLRDKRLVFVGDSIGRNQWESLLCLLSSAVKNESLIYeingsPITKHKGFLVFKFEEYNCTVEYYRSPF 234
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSVY-----KITKDRGFRRFRFPDYNFTVEFYWSPF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   235 LVpQSRPPIGSPGKVKTSLKLDTMDWT-SSKWRDADVLVLNTGHWWNEGKTT-RTGCYFQEGEEVKLKMNVDDAYKRALN 312
Cdd:pfam13839  76 LV-DSVEDPNGPGKGKRVLHLDSIDERwASQWKGADVLVFNTGHWWLRPKIYyEGGDYFGCGGKNYTDMDRLDAYRKALR 154

                         170       180
                  ....*....|....*....|....*...
gi 18397465   313 TVVKWIHTELDSNKTQVFFRTFAPVHFR 340
Cdd:pfam13839 155 TWARWVDSNLDPSKTRVFFRTFSPSHFE 182
PLN02629 PLN02629
powdery mildew resistance 5
 92-339 9.58e-66

powdery mildew resistance 5


Pssm-ID: 215338 [Multi-domain]  Cd Length: 387  Bit Score: 212.46  E-value: 9.58e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465   92 RVGFLEESGSGCDVFDGDWVWDESYPLYQSKDC-RFLDEGFRCSDFGRSDLFYTQWRWQPRHCNLPRFDAKLMLEKLRDK 170
Cdd:PLN02629  42 RRPSLQANQSTCALFVGTWVRDDSYPLYQSSDCpGVIDPEFNCQMYGRPDSDYLKYRWQPLNCELPRFNGLEFLLKMKGK 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465  171 RLVFVGDSIGRNQWESLLCLLSSAVKNESliyeingSPITKHKGFLVFKFEEYNCTVEYYRSPFLVPQSRPpigspgKVK 250
Cdd:PLN02629 122 TVMFVGDSLGRNQWESLICLISSSVPSTR-------TQMSRGDPLSTFKFLDYGVSISFYKAPYLVDIDAV------QGK 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18397465  251 TSLKLDTMDWTSSKWRDADVLVLNTGHWWNEGKTTRTGCYFQEGEEVKLKMNVDDAYKRALNTVVKWIHTELDSNKTQVF 330
Cdd:PLN02629 189 RVLKLEEISGNANAWRDADVLIFNTGHWWSHQGSLQGWDYIESGGTYYQDMDRLVALEKALRTWAYWVDTNVDRSRTRVF 268


                 ....*....
gi 18397465  331 FRTFAPVHF 339
Cdd:PLN02629 269 FQSISPTHY 277
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
 102-154 1.56e-23

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 91.78  E-value: 1.56e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 18397465   102 GCDVFDGDWVWDE-SYPLYQSKDCRFLDEGFRCSDFGRSDLFYTQWRWQPRHCN 154
Cdd:pfam14416   1 ECDLFDGRWVYDEdSYPLYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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