|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
128-527 |
1.16e-176 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 504.45 E-value: 1.16e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 128 VAVAMVYFVQGVLGLARLAVSFYLKDDLHLDPAETAVITGLSSLPWLVKPLYGFISDSVPLFGYRRRSYLVLSGLLGAFS 207
Cdd:cd17484 1 SVIAVVYFSQGVAGLSWLAVSYYYKDDLHLGPASVQALTSIASLPWAIKPLYGLLSDSVPIFGYRRKPYLILAGALGALS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 208 WSLMAGFV-DSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSLCWGSSAFGGIVSSYFSGSLVESYGV 286
Cdd:cd17484 81 WLALALVSnSSLALALLLLLLASLGVAFSDVVIDALVVEASRGAPQSLAGDLQSLCWGSSAIGGIVGSYFSGYLLELLGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 287 RFVFGVTALLPLITSAVAVLVNEQRVVRPAsgqkenitllspgFLQTSKQNMIQLWGAIKQPNVFLPTLFIFLWQATPHS 366
Cdd:cd17484 161 RTVFAVTSFFPLLLLIVAFFVKEERVPPHR-------------TKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 367 DSAMFYFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMTQVILVSGFNRQLGISDE 446
Cdd:cd17484 228 GSAMFYFMTNELGFSPEFLGRLRVIGSIASLLGVLLYNRFLKHVPFRKIFFWTTVLLVLLGLTDLILVTRWNLKLGIPDH 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 447 WFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGITRDSFGNLSTLIILC 526
Cdd:cd17484 308 AFVLGDDAVVTVIGEILFMPILVLAARLCPPGIEGTVFALLMSISNLGSLTSSFLGALLTKALGVTSTNFDNLWLLILIC 387
|
.
gi 18402856 527 N 527
Cdd:cd17484 388 N 388
|
|
| fbt |
TIGR00788 |
folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The ... |
115-560 |
2.23e-175 |
|
folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The only functionally characterized members of the family are from protozoa and include FT1, the major folate transporter in Leishmania, and BT1, the Leishmania biopterin/folate transporter. A related protein in Trypanosoma brucei, ESAGIO, shows weak folate/biopterin transport activity. [Cell envelope, Other]
Pssm-ID: 273268 Cd Length: 468 Bit Score: 503.55 E-value: 2.23e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 115 RIKFYGVELSPDNVAVAMVYFVQGVLGLARLAVSFYLKDDLHLDPAETAVITGLSSLPWLVKPLYGFISDSVPLFGYRRR 194
Cdd:TIGR00788 16 YIPVFSFHPRVVLAIGLQVLFVKGIAGLMRLPLSPMLTDDLGLDGARYQRLVGLSSLGWALKPFAGVMSDTFPLFGYTKR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 195 SYLVLSGLLG-AFSWSLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARgESQSVSGSLQSLCWGSSAFGGIVS 273
Cdd:TIGR00788 96 WYLVLSGLLGsAILYGLLPGKVSSAKVAAAFIFLAALAKALYDVLVDSLYSERIR-ESPSAGPSLVSWMWGASATGGLIS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 274 SYFSGSLVESYGVRFVFGVTALLPLITSAVAVLVNEQRV-VRPASGQ--KENITLLSPGFLQTSKQNMIQLWGAIKQPNV 350
Cdd:TIGR00788 175 SLLGGPLLDKTLTRILFLITAALLLLQLFVSNLSKERRAfVRPRIGTylEMNMALLTLGVLANVKVQILGLRGAIQLLEI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 351 FLPTLFIFL-WQATPHSDSAMFYFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMT 429
Cdd:TIGR00788 255 AKPLIFIFLsYANLPGASGSVFCATTQCLPGGPSFSGMSKVVGNLGSLCGVGGYDRFLKTFPYRLLFGVTTLLYTLSSLF 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 430 QVILVSGFNRQLGISDEWFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAF 509
Cdd:TIGR00788 335 DLILVKRWNLAFGISDEVFVLGDSIIAEVLAQLKFMPFLVLLARLCPSGCESSVFALLASILHLGSSVSGFLGVLLMETI 414
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 18402856 510 GITRDSFGNLSTLIILCNLSSLLPLPLLGL--LPRDSPDTLTKDDADVEMKSN 560
Cdd:TIGR00788 415 GITCDNSNNLWLLILGHSLAPLLPLPLLHLlpRLEDVIDTEGKRAISKAAPEN 467
|
|
| BT1 |
pfam03092 |
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ... |
137-527 |
1.50e-161 |
|
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
Pssm-ID: 308617 Cd Length: 432 Bit Score: 467.21 E-value: 1.50e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 137 QGV-LGLARLAVSFYLKDDLHLDPAETAVITGLSSLPWLVKPLYGFISDSVPLFGYRRRSYLVLSGLLGAFSWSLMAGFV 215
Cdd:pfam03092 1 QGVaLGLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLYGLLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 216 DSKYS---AAFCILLGSLSVAFSDVVVDSMVVERARGeSQSVSGSLQSLCWGSSAFGGIVSSYFSGSLVESYGVRFVFGV 292
Cdd:pfam03092 81 ASEASapvAAAFIFLSSLGVAIVDVLVDALVSERARQ-SPTPGPSLQSWIWGCSAVGGIIGSVLSGPLLDTFKPQISFFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 293 TALLPLITSAVAVLVNEQRVVRPASGQKENITLLSPGFLQTSKQNMIQLWGAIKQPNVFLPTLFIFLWQAT-PH--SDSA 369
Cdd:pfam03092 160 TAALQLLTCVVALLIKESSLGLPAKHEPKRPVPCLFGLFEMNREVISRNWKAFRYSEILTPTLFAMLSQAIlPLviAKAN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 370 MFYFTTNKLG--FTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMTQVILVSGFNRQLGISDEW 447
Cdd:pfam03092 240 VFFYTTNVLGpnFSYSFYGTVKVIGSIAGLIGVTLYNRFLKKHPYRLTFGVTTVLQVLSGLFDLILVKRWNRYIGISDHM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 448 FAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGITRDSFGNLSTLIILCN 527
Cdd:pfam03092 320 YILGDSIILEVLYMLKFMPVLVLLARLCPRGSESTVFALLASIANLGQSVSSSLGALLMEYLGVTRCDFSNLPLLLLIGS 399
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
105-522 |
6.79e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 6.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 105 PRKGRNLSSSRIKFYGVelspDNVAVAMVYFVQGVLglarlaVSFYLKDDLHLDPAETAVITGLSSLpW--LVKPLYGFI 182
Cdd:COG2211 1 TAAKKKLSLKEKLAYGL----GDLGLNLAFGLLSAY------LLYFYTDVLGLSAALVGLILLVARL-WdaITDPLIGAL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 183 SDSVPLFGYRRRSYLVLSGLLGAFSWSLMAGFVDSKYSAAF-----CILLGSLSVAFSDVVVDSMVVERARGESQSvsGS 257
Cdd:COG2211 70 SDRTRTRWGRRRPWILIGAIPLALSFVLLFTAPDLSPTGKLiyalvTYLLLGLAYTLVNIPYSALGAELTPDYEER--TR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 258 LQSLCWGSSAFGGIVSSYFSGSLVESY------GVRFVFGVTALLPLITSAVAVLVNEQRVVRPASgqkenitllspgfl 331
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE-------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 332 qtsKQNMIQLWGAIKQPNVFLPTLFIFL--WQATPHSDSAMFYFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKT 409
Cdd:COG2211 214 ---KVSLKESLKALLKNRPFLLLLLAYLlfFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 410 VPLRKIFLVTTIFGtglgmtqvILVSGFNRQLGISDEWFAIGdSLILTVLAQASFMPVL-VLAARLCPEG-------MEA 481
Cdd:COG2211 291 FGKKKAFIIGLLLA--------ALGLLLLFFLGPGNLWLLLV-LAALAGIGLGAILVLPwAMLADVVDYDewktgrrREG 361
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 18402856 482 TLFATLMSISNGGSVLGGLMGAGLTQAFGITRDSFGNLSTL 522
Cdd:COG2211 362 LYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSAL 402
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
128-527 |
1.16e-176 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 504.45 E-value: 1.16e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 128 VAVAMVYFVQGVLGLARLAVSFYLKDDLHLDPAETAVITGLSSLPWLVKPLYGFISDSVPLFGYRRRSYLVLSGLLGAFS 207
Cdd:cd17484 1 SVIAVVYFSQGVAGLSWLAVSYYYKDDLHLGPASVQALTSIASLPWAIKPLYGLLSDSVPIFGYRRKPYLILAGALGALS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 208 WSLMAGFV-DSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSLCWGSSAFGGIVSSYFSGSLVESYGV 286
Cdd:cd17484 81 WLALALVSnSSLALALLLLLLASLGVAFSDVVIDALVVEASRGAPQSLAGDLQSLCWGSSAIGGIVGSYFSGYLLELLGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 287 RFVFGVTALLPLITSAVAVLVNEQRVVRPAsgqkenitllspgFLQTSKQNMIQLWGAIKQPNVFLPTLFIFLWQATPHS 366
Cdd:cd17484 161 RTVFAVTSFFPLLLLIVAFFVKEERVPPHR-------------TKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 367 DSAMFYFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMTQVILVSGFNRQLGISDE 446
Cdd:cd17484 228 GSAMFYFMTNELGFSPEFLGRLRVIGSIASLLGVLLYNRFLKHVPFRKIFFWTTVLLVLLGLTDLILVTRWNLKLGIPDH 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 447 WFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGITRDSFGNLSTLIILC 526
Cdd:cd17484 308 AFVLGDDAVVTVIGEILFMPILVLAARLCPPGIEGTVFALLMSISNLGSLTSSFLGALLTKALGVTSTNFDNLWLLILIC 387
|
.
gi 18402856 527 N 527
Cdd:cd17484 388 N 388
|
|
| fbt |
TIGR00788 |
folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The ... |
115-560 |
2.23e-175 |
|
folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The only functionally characterized members of the family are from protozoa and include FT1, the major folate transporter in Leishmania, and BT1, the Leishmania biopterin/folate transporter. A related protein in Trypanosoma brucei, ESAGIO, shows weak folate/biopterin transport activity. [Cell envelope, Other]
Pssm-ID: 273268 Cd Length: 468 Bit Score: 503.55 E-value: 2.23e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 115 RIKFYGVELSPDNVAVAMVYFVQGVLGLARLAVSFYLKDDLHLDPAETAVITGLSSLPWLVKPLYGFISDSVPLFGYRRR 194
Cdd:TIGR00788 16 YIPVFSFHPRVVLAIGLQVLFVKGIAGLMRLPLSPMLTDDLGLDGARYQRLVGLSSLGWALKPFAGVMSDTFPLFGYTKR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 195 SYLVLSGLLG-AFSWSLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARgESQSVSGSLQSLCWGSSAFGGIVS 273
Cdd:TIGR00788 96 WYLVLSGLLGsAILYGLLPGKVSSAKVAAAFIFLAALAKALYDVLVDSLYSERIR-ESPSAGPSLVSWMWGASATGGLIS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 274 SYFSGSLVESYGVRFVFGVTALLPLITSAVAVLVNEQRV-VRPASGQ--KENITLLSPGFLQTSKQNMIQLWGAIKQPNV 350
Cdd:TIGR00788 175 SLLGGPLLDKTLTRILFLITAALLLLQLFVSNLSKERRAfVRPRIGTylEMNMALLTLGVLANVKVQILGLRGAIQLLEI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 351 FLPTLFIFL-WQATPHSDSAMFYFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMT 429
Cdd:TIGR00788 255 AKPLIFIFLsYANLPGASGSVFCATTQCLPGGPSFSGMSKVVGNLGSLCGVGGYDRFLKTFPYRLLFGVTTLLYTLSSLF 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 430 QVILVSGFNRQLGISDEWFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAF 509
Cdd:TIGR00788 335 DLILVKRWNLAFGISDEVFVLGDSIIAEVLAQLKFMPFLVLLARLCPSGCESSVFALLASILHLGSSVSGFLGVLLMETI 414
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 18402856 510 GITRDSFGNLSTLIILCNLSSLLPLPLLGL--LPRDSPDTLTKDDADVEMKSN 560
Cdd:TIGR00788 415 GITCDNSNNLWLLILGHSLAPLLPLPLLHLlpRLEDVIDTEGKRAISKAAPEN 467
|
|
| BT1 |
pfam03092 |
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ... |
137-527 |
1.50e-161 |
|
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
Pssm-ID: 308617 Cd Length: 432 Bit Score: 467.21 E-value: 1.50e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 137 QGV-LGLARLAVSFYLKDDLHLDPAETAVITGLSSLPWLVKPLYGFISDSVPLFGYRRRSYLVLSGLLGAFSWSLMAGFV 215
Cdd:pfam03092 1 QGVaLGLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLYGLLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 216 DSKYS---AAFCILLGSLSVAFSDVVVDSMVVERARGeSQSVSGSLQSLCWGSSAFGGIVSSYFSGSLVESYGVRFVFGV 292
Cdd:pfam03092 81 ASEASapvAAAFIFLSSLGVAIVDVLVDALVSERARQ-SPTPGPSLQSWIWGCSAVGGIIGSVLSGPLLDTFKPQISFFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 293 TALLPLITSAVAVLVNEQRVVRPASGQKENITLLSPGFLQTSKQNMIQLWGAIKQPNVFLPTLFIFLWQAT-PH--SDSA 369
Cdd:pfam03092 160 TAALQLLTCVVALLIKESSLGLPAKHEPKRPVPCLFGLFEMNREVISRNWKAFRYSEILTPTLFAMLSQAIlPLviAKAN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 370 MFYFTTNKLG--FTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMTQVILVSGFNRQLGISDEW 447
Cdd:pfam03092 240 VFFYTTNVLGpnFSYSFYGTVKVIGSIAGLIGVTLYNRFLKKHPYRLTFGVTTVLQVLSGLFDLILVKRWNRYIGISDHM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 448 FAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGITRDSFGNLSTLIILCN 527
Cdd:pfam03092 320 YILGDSIILEVLYMLKFMPVLVLLARLCPRGSESTVFALLASIANLGQSVSSSLGALLMEYLGVTRCDFSNLPLLLLIGS 399
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
133-526 |
5.23e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.82 E-value: 5.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 133 VYFVQGVLGLARLAVSFYLKD---DLHLDPAETAVITGLSSLPWLV-KPLYGFISDSvplfgYRRRSYLVLSGLLGAFSW 208
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPAllqSFGLSASQLGLLFALFSLGYALlQPLAGLLADR-----FGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 209 SLMAgFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQsvsGSLQSLCWGSSAFGGIVSSYFSGSLVE--SYGV 286
Cdd:cd06174 76 LLFA-FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERER---GRALGLLQAFGSVGGILGPLLGGILASslGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 287 RFVFGVTALLPLITSAVAVLVNEQRVVRPASGQKEnitllspgflQTSKQNMIQLWGAIKQPNVFLPTLFIFLWQATPHS 366
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEE----------ASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 367 DSAMF-YFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMtqVILVSGFNRQLGISd 445
Cdd:cd06174 222 FSTLLpLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL--ALLLLAPSLLLLLL- 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 446 ewfaigdSLILTVLAQASFMPV-LVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGITRDSFGNLSTLII 524
Cdd:cd06174 299 -------LLLLLGFGLGGLLPLsFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
..
gi 18402856 525 LC 526
Cdd:cd06174 372 LA 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
105-522 |
6.79e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 6.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 105 PRKGRNLSSSRIKFYGVelspDNVAVAMVYFVQGVLglarlaVSFYLKDDLHLDPAETAVITGLSSLpW--LVKPLYGFI 182
Cdd:COG2211 1 TAAKKKLSLKEKLAYGL----GDLGLNLAFGLLSAY------LLYFYTDVLGLSAALVGLILLVARL-WdaITDPLIGAL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 183 SDSVPLFGYRRRSYLVLSGLLGAFSWSLMAGFVDSKYSAAF-----CILLGSLSVAFSDVVVDSMVVERARGESQSvsGS 257
Cdd:COG2211 70 SDRTRTRWGRRRPWILIGAIPLALSFVLLFTAPDLSPTGKLiyalvTYLLLGLAYTLVNIPYSALGAELTPDYEER--TR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 258 LQSLCWGSSAFGGIVSSYFSGSLVESY------GVRFVFGVTALLPLITSAVAVLVNEQRVVRPASgqkenitllspgfl 331
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE-------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 332 qtsKQNMIQLWGAIKQPNVFLPTLFIFL--WQATPHSDSAMFYFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKT 409
Cdd:COG2211 214 ---KVSLKESLKALLKNRPFLLLLLAYLlfFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 410 VPLRKIFLVTTIFGtglgmtqvILVSGFNRQLGISDEWFAIGdSLILTVLAQASFMPVL-VLAARLCPEG-------MEA 481
Cdd:COG2211 291 FGKKKAFIIGLLLA--------ALGLLLLFFLGPGNLWLLLV-LAALAGIGLGAILVLPwAMLADVVDYDewktgrrREG 361
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 18402856 482 TLFATLMSISNGGSVLGGLMGAGLTQAFGITRDSFGNLSTL 522
Cdd:COG2211 362 LYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSAL 402
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
128-512 |
6.92e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.20 E-value: 6.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 128 VAVAMVYFVQGVLGLARLavsfYLKDDLHLDPAETAVITGLSSLPW-LVKPLYGFISDSVPlfgyRRRSYLVLSGLLGAF 206
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAP----PLQADLGLSAAQLGLLASAFFLGYaLGQIPAGLLADRFG----RRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 207 SwsLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQsvsGSLQSLCWGSSAFGGIVSSYFSGSLVESYGV 286
Cdd:COG2271 89 T--LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKER---GRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 287 RFVFGVTALLPLITSAVAVLVneqrvvrpasgqkenitLLSPGFLQTSKQNMIQLWgaikqpnvfLPTLFiflwqatphs 366
Cdd:COG2271 164 RAAFLILGLPGLLLALLRFWL-----------------LALAYFLVYFALYGFLTW---------LPTYL---------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 367 dsamfyftTNKLGFTPEFLGRVKLVTSIASLLGvGLYNGFL--KTVPLRKIFLVTTIFGTGLGMTQVILVSGFnrqlgis 444
Cdd:COG2271 208 --------VEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLsdRLGRRRKLVLAIGLLLAALALLLLALLPSP------- 271
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18402856 445 deWFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGIT 512
Cdd:COG2271 272 --ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
128-498 |
2.23e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 65.52 E-value: 2.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 128 VAVAMVYFVQGVLGLArlaVSFYLKDDLHLDPAETAVITGLSSLP-WLVKPLYGFISDsvpLFGYRRrsyLVLSGLLGAF 206
Cdd:pfam07690 3 LAAFLAALGRSLLGPA---LPLLLAEDLGISPTEIGLLLTLFSLGyALAQPLAGRLSD---RFGRRR---VLLIGLLLFA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 207 SWSLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSLCWGssaFGGIVSSYFSGSLVESYGV 286
Cdd:pfam07690 74 LGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFG---LGAALGPLLGGLLASLFGW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 287 RFVFGVTALLPLITSAVAVLVNEQRVVRPASGQKENITLLspgflqtskqnmIQLWGAIKQPNVFLPTLFIFLWQATPHS 366
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL------------IVAWKALLRDPVLWLLLALLLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 367 DSAMFYFTTNKLGFTPEFLGRVKLVTSIASLLGvGLYNGFLKTVPLRKIFLVTTIFGTGLGMTQVILVSgfnrqlGISDE 446
Cdd:pfam07690 219 LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIG-RLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS------LTLSS 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 18402856 447 WFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLG 498
Cdd:pfam07690 292 LWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
129-497 |
4.25e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 64.61 E-value: 4.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 129 AVAMVYFVQGVLGLARLAVSF---YLKDDLHLDPAETAVITGLSSLPWLV-KPLYGFISDSVPlfgyRRRSYLVLSGLLG 204
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPalpLIAADLGASPAQAGLVVTAYLLGAALgAPLAGRLADRFG----RRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 205 AFSwsLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSLCWGssaFGGIVSSYFSGSLVESY 284
Cdd:COG2814 87 LGS--LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLG---LGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 285 GVRFVFGVTALLPLITSAVAVLVNEQRVVRPASGQKENITLLspgflqtskqnmiqlwgaIKQPNVFLPTLFIFLWQATP 364
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLREL------------------LRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 365 HSDSAMF-YFTTNKLGFTPEFLGRVKLVTSIASLLGVGLYNGFLKTVPLRKIfLVTTIFGTGLGMTQVILVSGFnrqlgi 443
Cdd:COG2814 224 FALFTYLpLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLALAGSL------ 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 18402856 444 sdeWFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVL 497
Cdd:COG2814 297 ---WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
154-526 |
4.73e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.52 E-value: 4.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 154 DLHLDPAETAVITGLSSLPWLV-KPLYGFISDsvpLFGYRRrsyLVLSGLLGAFSWSLMAGFVDSKYSAAFCILLGSLSV 232
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLfSPPAGRLSD---RFGRKR---LLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 233 AFSDVVVDSMVVERARGESqsvSGSLQSLCWGSSAFGGIVSSYFSGSLVESYGVRFVFGVTALLPLITSAVAVLVNEQRV 312
Cdd:cd17325 99 AAVWPAAMALIADIAPPEE---RGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 313 VRPASGQKENITLLSPgflqtskqnmiqLWGAIKQPNVFLPTLFIFLWqatpHSDSAMFY-----FTTNKLGFTPEFLGR 387
Cdd:cd17325 176 PPPNKRAVSAARLRSG------------LRLLLRDRRLLALFLAIFVL----AFAFGALEpflplYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 388 VKLVTSIASLLgVGLYNGFLKTVPLRKIFLVTTIFGTGLGMTQVILVSGFnrqlgisdeWFAIGDSLILTVLAQASFMPV 467
Cdd:cd17325 240 LFGAQGLASAL-SQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF---------WLLLLLLALLGLGLGLVFPAT 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 18402856 468 LVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGItRDSFGNLSTLIILC 526
Cdd:cd17325 310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF-ATPFLAAAALLLLA 367
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
128-307 |
1.10e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.27 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 128 VAVAMVYFVQGVLGLARLAVSF----YLKDDLHLDPAETAVITGLSSLPWLV-KPLYGFISDsvpLFGYRRRSYLVLSGL 202
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTwlptYLVEVRGLSLAQAGLLLSLPFLAGIVgSLLGGWLSD---RLGRRRKLVLAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 203 LGAFSWsLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSLCwgsSAFGGIVSSYFSGSLVE 282
Cdd:COG2271 257 LAALAL-LLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTF---GFLGGALGPLLVGYLLD 332
|
170 180
....*....|....*....|....*
gi 18402856 283 SYGVRFVFGVTALLPLITSAVAVLV 307
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
129-510 |
6.15e-07 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 51.84 E-value: 6.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 129 AVAMVYFVQGV-LGLARLAVSFYLKD---DLhldpaeTAV-ITGLSSLPWLVKPLYGFISD--SVPLFGyRRRSYLVLS- 200
Cdd:cd17485 1 LLFGLYLAQGLpYGFQSQALPVLLRSagvSL------TAIgLLKLLYLPWVLKFLWAPLVDryGLPRLG-RRRSWLLPTq 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 201 -GLLGAFSWSLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSlcwGSSAFGGIVSSYFSGS 279
Cdd:cd17485 74 lGLALLLLALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQV---VGYKLGSLLGGGGLLW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 280 LVESYGVRFVFGVTALLPLITSAVAVLVNEQRVVrpasgQKENITLLSPGFLQTskqnmiqLWGAIKQPNVFLPTLFIFL 359
Cdd:cd17485 151 LYDLIGWQSLLLSLAALYLLLLLPVLFLRELELP-----QQPPASERGAALKAS-------LRAFLRRPGTRWLLLFLLL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 360 WQATPHSDSAMFYFTTNKLGFTPEFLGRVK-LVTSIASLLGVGLYNGFLKTVPLRKIFLVTTIFGTGLGMTQVILVSGfn 438
Cdd:cd17485 219 YKLGEQGALAMLPPFLVDRGFSLSQIGLLSgVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALG-- 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18402856 439 rqLGISDEWFAIGDSLILTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFG 510
Cdd:cd17485 297 --GSGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLG 366
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
150-307 |
3.70e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.02 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 150 YLKDDLHLDPAETAVITglsSLPWLV----KPLYGFISDSvpLFGYRRRSYLVLSGLLGAFSWsLMAGFVDSKYSAAFCI 225
Cdd:cd17319 205 YLKQARGFSLKQVGLLA---AIPFLAgaigMILGGRLSDR--LLRGARRLVIIIGLLLAAVGL-LLAYLTTSPVVAVILL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 226 LLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSLCwgsSAFGGIVSSYFSGSLVE-SYGVRFVFGVTALLPLITSAVA 304
Cdd:cd17319 279 SLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSG---GNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAALLV 355
|
...
gi 18402856 305 VLV 307
Cdd:cd17319 356 LLL 358
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
134-510 |
5.00e-05 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 45.67 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 134 YFVQGVLGLARLAVSFYLKDDLHLDPAeTAVITGLSSLPWLVKPLYGFISD--SVPLFGyRRRSYLVLSGLLGAFSWSLM 211
Cdd:cd17486 5 GFASGLPYLLTGTTLQAWLKEAGVDLD-TIGLFSLVGLPYSLKFLWAPLVDrySTPFLG-RRRGWILLTQILLMAALIAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 212 AGFVDSK---YSAAFCILLGSLSvAFSDVVVDSMVVERARGESQSVSGSLQSLCWgssAFGGIVSSYFSGSLVESYGVRF 288
Cdd:cd17486 83 AFLDPFTnlvLSALLFLLVAFFS-ATQDIAIDAYRIEALEDKEQGAGAGVRVNGY---RIGMLVAGAGALYLADSLSWSA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 289 VFGVTALLPLITSAVAVLVNEQRVVRPASGQKENITLLspgFLQTSKQnmiqlwgAIKQPNVFLPTLFIFLWQAtphSDS 368
Cdd:cd17486 159 VYLIMAALMGPGILATLFAPEPPRTDPPANSLSETVVA---FFAPFKD-------FFGQPGALLILAFILLYKL---GDA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 369 AMFYFTTN---KLGFTPEFLGRV-KLVTSIASLLGvGLYNGFLktvpLRKIFLVTTIFGTGLGMTQVIL------VSGFN 438
Cdd:cd17486 226 MLGAMATPfllDLGFTKTEIGAVyKTVGLIATIVG-GLLGGFL----MSRLGLKRSLWLFGILQALSNLgfiylaHAGPN 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18402856 439 RQL---GISDEWFAIGdsliltvLAQASFMPVLvlaARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFG 510
Cdd:cd17486 301 LTLlvaAVAVENFGGG-------LGTTAFVAYL---MSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALG 365
|
|
| PUCC |
pfam03209 |
PUCC protein; This protein is required for high-level transcription of the PUC operon. |
164-359 |
4.12e-04 |
|
PUCC protein; This protein is required for high-level transcription of the PUC operon.
Pssm-ID: 367394 Cd Length: 401 Bit Score: 42.73 E-value: 4.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 164 VITGLSSLPWLV---KPLYGFISDSVPLFGYRRRSYLVLSGL---------------LGAFSWSLMAGFVDSKYSAAFCI 225
Cdd:pfam03209 16 LVGAMIALPQLVapfRALIGFRSDTHRALGWKRTPYIWLGSLaqagglaimpfalivLSGSGDANGAPTWAGLILAAVAF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 226 LLGSLSVAFSDVVVDSMVVERARGESQSvsgSLQSLCWGSSAFGGIVSSYFSGSLVESYG----VRFVFGVTALLPLITS 301
Cdd:pfam03209 96 LLYGLGVHMSQTPGLALAADLADEERRP---KVVGIMWVMLLIGIIVSAITVGWLLDDYTparlIRVIQGVALITFVLNI 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 18402856 302 AVAVLVNEQRVVRPASGQKENITLLSPGFLQTSKQNMIQLWGAIkqpnvFLPTLFIFL 359
Cdd:pfam03209 173 IALWKIEVGRPSRPAERPEQDPSFLEAWLLLVAEPQALIFLFFL-----FLGTLAFFM 225
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
141-511 |
5.47e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 141 GLARLAVSFYLKDDLHlDPAETAVITGLSSLPWLV-KPLYGFISDSVPlfgyRRR----SYLVLSGLLGAFSWSLMAGFV 215
Cdd:cd06173 16 WIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLfSPFAGVLADRFD----RRRllilADLLRALLAAVLALLALLGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 216 DSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSLCWGSSAFGGIVSsyfsGSLVESYGVRFVFGVTAL 295
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALG----GLLVALLGPGGAFAINAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 296 LPLITSAVAVLVNEQRVVRPASGQKENITLLSPGFLQTSKQNMIQLwgaikqpnVFLPTLFIFLWQATPHSdsAMFYFTT 375
Cdd:cd06173 167 SFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRL--------LLLALALFALLGGALTV--LLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 376 NKLGFTPEFLGRVKLVTSIASLLGvGLYNGFLKTVPLRKIFLVTTIFGTGLGMtqviLVSGFNRQLgisdeWFAIGDSLI 455
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSKRRRRGRLLLIGALLLGLAL----LVLGLSPSL-----WLLLAALFL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 18402856 456 LTVLAQASFMPVLVLAARLCPEGMEATLFATLMSISNGGSVLGGLMGAGLTQAFGI 511
Cdd:cd06173 307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
128-521 |
7.31e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.18 E-value: 7.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 128 VAVAMVYFVQGVLGLARLavsfYLKDDLHLDPAETAVITGLSSLPW-LVKPLYGFISDsvpLFGyRRRSYLVLSGLLGAF 206
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAP----PLAEEFGLSAAQLGLLFAIPVLVGaLLRIPLGFLVD---RFG-PRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 207 SwsLMAGFVDSKYSAAFCILLGSLSVAFSDVVVDSMVVERARGESQSVSGSLQSlcwGSSAFGGIVSSYFSGSLVESYGV 286
Cdd:COG2223 84 L--LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAA---GGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 287 RFVFGVTALLPLITSAVAVLVneqrvvrpasgqkenITLLSPGFLQTSKQNMIQLWGAIKQPNVFLPTLFIFLWQATPHS 366
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLF---------------LRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 367 -DSAMFYFTTNKLGFTPEFLGrvkLVTSIASLLGVGL--YNGFLktvpLRKIFLVTTIFGTGLGMTQVILVSGFnrqlGI 443
Cdd:COG2223 224 fSSWLPPYLVDQFGLSAATAG---LLAALFALLGALGrpLGGWL----SDRIGGRRVLLIVFALMALGLLLLAL----AL 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18402856 444 SDEWFAIGDSLILTVLAQASFMPVlvlaARLCPEGMEATLFATLMSISNGGSVLGGLMGAgltQAFGITRDSFGNLST 521
Cdd:COG2223 293 GSLWLFLVLFLLLGLALGGGNGAV----FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP---LLFGALLDATGSYTA 363
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
163-359 |
3.56e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 39.79 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 163 AVITGLSSLPWLV---KPLYGFISDSVPLFGYRRRSYLVLSGLLGAFSWSLMA---------GFVDSKYSAAFCILLGSL 230
Cdd:cd06176 36 TLVGLLIALHYLVaplRVWIGHRSDTHPLRGYRRTPYIWLGMLLLALGLALAPfaalllagaAFWLGLALAVLAFLLYGI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18402856 231 SVAFSDVVVDSMVVERARGESQSvsgSLQSLCWGSSAFGGIVSSYFSGSLVESY---GVRFVFGVTALLPLITSAVAVLV 307
Cdd:cd06176 116 GVGAAGTAFLALLADLTPEERRP---RAVTVVWTMLILGIIVTAIVFGRLLDPYspeRLIQVFQIVALVALLLALLALWG 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 18402856 308 NEQRVVRPASGQKENitlLSPGFLQTSKqnmiQLWGaikQPNVFLPTLFIFL 359
Cdd:cd06176 193 VERRRSRAALAAEEA---PPETFREALR----LLWA---SPQARRFFIFLFL 234
|
|
| |
