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Conserved domains on  [gi|18079321|ref|NP_542174|]
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V-set and transmembrane domain-containing protein 2-like protein precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 43-144 1.88e-07

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 47.25  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321    43 FTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWwyvrsHRDwtDKQawasnqLKASQQedagkeatkisvVKVVGSN 122
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTVTGTPDP----EVSW-----FKD--GQP------LRSSDR------------FKVTYEG 53

                          90       100
                  ....*....|....*....|..
gi 18079321   123 ISHKLRLSRVKPTDEGTYECRV 144
Cdd:pfam07679  54 GTYTLTISNVQPDDSGKYTCVA 75
 
Name Accession Description Interval E-value
I-set pfam07679
Immunoglobulin I-set domain;
43-144 1.88e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 47.25  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321    43 FTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWwyvrsHRDwtDKQawasnqLKASQQedagkeatkisvVKVVGSN 122
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTVTGTPDP----EVSW-----FKD--GQP------LRSSDR------------FKVTYEG 53

                          90       100
                  ....*....|....*....|..
gi 18079321   123 ISHKLRLSRVKPTDEGTYECRV 144
Cdd:pfam07679  54 GTYTLTISNVQPDDSGKYTCVA 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 47-144 1.10e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.19  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321     47 PHDMTARTGEDVEMACSFRGSGSPSYsleiqWWYvrshrdwTDKQAWASNQLKasqqedagkeatkisvVKVVGSNISHK 126
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-----TWY-------KQGGKLLAESGR----------------FSVSRSGSTST 52

                           90
                   ....*....|....*...
gi 18079321    127 LRLSRVKPTDEGTYECRV 144
Cdd:smart00410  53 LTISNVTPEDSGTYTCAA 70
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 41-164 5.43e-05

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 41.10  E-value: 5.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321  41 ALFTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWWYVRSHRDWTDKQAWasnqlkasqqedagkEATKISVVKVVG 120
Cdd:cd20940   1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQLW---------------DGARLDRVHINA 61

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18079321 121 SNISH---KLRLSRVKPTDEGTYECRVidfSDGKARHH-----KVKaYLRVQ 164
Cdd:cd20940  62 TYHQHatsTISIDNLTEEDTGTYECRA---SNDPDRNHltrapKVK-WIRSQ 109
 
Name Accession Description Interval E-value
I-set pfam07679
Immunoglobulin I-set domain;
43-144 1.88e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 47.25  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321    43 FTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWwyvrsHRDwtDKQawasnqLKASQQedagkeatkisvVKVVGSN 122
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTVTGTPDP----EVSW-----FKD--GQP------LRSSDR------------FKVTYEG 53

                          90       100
                  ....*....|....*....|..
gi 18079321   123 ISHKLRLSRVKPTDEGTYECRV 144
Cdd:pfam07679  54 GTYTLTISNVQPDDSGKYTCVA 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 47-144 1.10e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.19  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321     47 PHDMTARTGEDVEMACSFRGSGSPSYsleiqWWYvrshrdwTDKQAWASNQLKasqqedagkeatkisvVKVVGSNISHK 126
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-----TWY-------KQGGKLLAESGR----------------FSVSRSGSTST 52

                           90
                   ....*....|....*...
gi 18079321    127 LRLSRVKPTDEGTYECRV 144
Cdd:smart00410  53 LTISNVTPEDSGTYTCAA 70
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-150 5.59e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.60  E-value: 5.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321    45 ETPHDMTARTGEDVEMACSFrgsgSPSYSLEIQW--WYVRSHRDWTDKQ-AWASNQLKASQQEDAgkeatkisvVKVVGS 121
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTY----SSSMSEASTSvyWYRQPPGKGPTFLiAYYSNGSEEGVKKGR---------FSGRGD 67

                          90       100       110
                  ....*....|....*....|....*....|.
gi 18079321   122 NISHK--LRLSRVKPTDEGTYECRVIDFSDG 150
Cdd:pfam07686  68 PSNGDgsLTIQNLTLSDSGTYTCAVIPSGEG 98
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 43-144 1.09e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.17  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321    43 FTETPHDMTARTGEDVEMACSFRGSGSPSYsleiqWWYvrshRDwtdkqawasnqlkasqqedaGKEATKISVVKVVGSN 122
Cdd:pfam13927   4 ITVSPSSVTVREGETVTLTCEATGSPPPTI-----TWY----KN--------------------GEPISSGSTRSRSLSG 54

                          90       100
                  ....*....|....*....|..
gi 18079321   123 ISHKLRLSRVKPTDEGTYECRV 144
Cdd:pfam13927  55 SNSTLTISNVTRSDAGTYTCVA 76
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 41-164 5.43e-05

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 41.10  E-value: 5.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321  41 ALFTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWWYVRSHRDWTDKQAWasnqlkasqqedagkEATKISVVKVVG 120
Cdd:cd20940   1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQLW---------------DGARLDRVHINA 61

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18079321 121 SNISH---KLRLSRVKPTDEGTYECRVidfSDGKARHH-----KVKaYLRVQ 164
Cdd:cd20940  62 TYHQHatsTISIDNLTEEDTGTYECRA---SNDPDRNHltrapKVK-WIRSQ 109
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 55-153 1.29e-04

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 39.89  E-value: 1.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321  55 GEDVEMACSFRGSGSPSySLEIQWWYVrSHRDWTDKQAWASNQLkaSQQEDAGKEATKISVVKVVGSNIShkLRLSRVKP 134
Cdd:cd20984  12 GEDGILSCTFTPDIKLS-DIVIQWLKE-GDSGLVHEFKEGKDEL--SRQSPMFRGRTSLFADQVHVGNAS--LRLKNVQL 85

                        90
                ....*....|....*....
gi 18079321 135 TDEGTYECRVIDfSDGKAR 153
Cdd:cd20984  86 TDAGTYLCIISN-SKGTGN 103
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 58-154 1.19e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.15  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321  58 VEMACSFRGSGSPsyslEIQWWYVrshrdwtdkqawasnqlkasqqedaGKEATKISVVKVVGSNISHKLRLSRVKPTDE 137
Cdd:cd00096   1 VTLTCSASGNPPP----TITWYKN-------------------------GKPLPPSSRDSRRSELGNGTLTISNVTLEDS 51

                        90
                ....*....|....*..
gi 18079321 138 GTYECRVIDFSDGKARH 154
Cdd:cd00096  52 GTYTCVASNSAGGSASA 68
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 55-148 1.76e-03

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 36.81  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321  55 GEDVEMACSFrgSGSPSYSL-EIQWWYVRSHRDWTDKQAWASNQLKASQQEDAGKEATKISVVKVVGsNIShkLRLSRVK 133
Cdd:cd20934  12 GTDATLRCSF--SPEPGFSLaQLSVFWQLTDTKQLVHSFTESQDQGRDQGSAYANRTALFPDLLAQG-NAS--LRLQRVR 86

                        90
                ....*....|....*..
gi 18079321 134 PTDEGTYEC--RVIDFS 148
Cdd:cd20934  87 VADEGSYTCfvSVQDFG 103
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 45-145 2.92e-03

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 36.27  E-value: 2.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079321  45 ETPHDMTARTGEDVEMACSFRGSgsPSYSLeIQWwyVRSHRDWTDKQ------AWASNQlKASQQEDAGKEATKISVVKv 118
Cdd:cd07700   3 QTPGSLLVQTNQTVKMSCEAKTS--PKNTR-IYW--LRQRQAPSKDShfeflaSWDPSK-GIVYGEGVDQEKLIILSDS- 75

                        90       100
                ....*....|....*....|....*..
gi 18079321 119 vgSNISHKLRLSRVKPTDEGTYECRVI 145
Cdd:cd07700  76 --DSSRYILSLMSVKPEDSGTYFCMTV 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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