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Conserved domains on  [gi|24663169|ref|NP_524034|]
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neurexin IV, isoform A [Drosophila melanogaster]

Protein Classification

neurexin-3; LamG domain-containing protein( domain architecture ID 10811351)

neurexin-3 is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion, and may also mediate intracellular signaling| LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 57-184 1.18e-51

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 178.31  E-value: 1.18e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169   57 LTATSSLT-ERGPDKARLNGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRM--HTDEFVTEYIVQYSDDGEFWRSYV 133
Cdd:cd00057   14 ITASSSYSsGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKggGSSEWVTSYKVQYSLDGETWTTYK 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24663169  134 NPtSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYG 184
Cdd:cd00057   94 DK-GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 192-340 2.86e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.69  E-value: 2.86e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  192 LYFNGTGLVRYDlrREPITSTKESIRFRFKTAFANGVMMY-SRGTQGDYYALQLKDNKMVLNLDLGSRVmTSLSVGSLLD 270
Cdd:cd00110    2 VSFSGSSYVRLP--TLPAPRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGS-LVLSSKTPLN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24663169  271 DNVWHDVVISRNQRDIIFSVDR-VIVRGRIQGEFTRLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFN 340
Cdd:cd00110   79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDLKspGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
819-943 2.58e-28

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.89  E-value: 2.58e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     819 DIYLEFRTTQENSVIFHATGP--TDYIKLSLNGGnKLQFQYQAGSGPLGVnVGTSYHLNDNNWHTVSVERNRKEARLVVD 896
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDG-RLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 24663169     897 GSIKAEVREPPGPVRaLHLTSDLVIGATTE--------YRDGYVGCIRALLLNGK 943
Cdd:smart00282   79 GGNRVSGESPGGLTI-LNLDGPLYLGGLPEdlklpplpVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 376-514 6.36e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.25  E-value: 6.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  376 PVTFTtRSSFVRLKGYEN-SQRLNVSFYFRTYEETGVMLH-HDFYSGGYLKVFLEFGKVKIDLKVKDKARIIldNYDDQF 453
Cdd:cd00110    1 GVSFS-GSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGSLVL--SSKTPL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24663169  454 NDGKWHSFVISIEKNRLILNIDQ-RPMTTTKSM---QVATGAQYYIAG---------GKDKNGFVGCMRLISVD 514
Cdd:cd00110   78 NDGQWHSVSVERNGRSVTLSVDGeRVVESGSPGgsaLLNLDGPLYLGGlpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1156 5.62e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.79  E-value: 5.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169   1032 FTTTIPKGFLLgFSSNLTGEYLTIQISNsGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKngGSTVVLKVDNYEP 1111
Cdd:pfam02210    1 FRTRQPNGLLL-YAGGGGSDFLALELVN-GRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERN--GNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24663169   1112 VEYNfdiKASADAQFNNIQYMYIG--------KNESMTDGFVGCVSRVQFDDI 1156
Cdd:pfam02210   77 VSSL---PPGESLLLNLNGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-998 1.24e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.24e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 24663169  966 CES-NPCLNNGTCIERYDGYSCDCRwSAFKGPIC 998
Cdd:cd00054    5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 546-575 1.00e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.00e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 24663169    546 CNPNPCQHKGLCHQNSREFFCDCGHtGYAG 575
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPE-GYTG 29
4.1m smart00294
putative band 4.1 homologues' binding motif;
1239-1255 1.07e-03

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 37.51  E-value: 1.07e-03
                            10
                    ....*....|....*..
gi 24663169    1239 GRYLHRHKGDYLTHEDQ 1255
Cdd:smart00294    2 YRYKHRDEGSYHTHEPK 18
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 57-184 1.18e-51

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 178.31  E-value: 1.18e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169   57 LTATSSLT-ERGPDKARLNGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRM--HTDEFVTEYIVQYSDDGEFWRSYV 133
Cdd:cd00057   14 ITASSSYSsGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKggGSSEWVTSYKVQYSLDGETWTTYK 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24663169  134 NPtSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYG 184
Cdd:cd00057   94 DK-GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 46-185 1.69e-36

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 134.56  E-value: 1.69e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169      46 DCNQPLMERAVLTATSSLTERGPDKARLNG--NAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVqYS 123
Cdd:smart00231    1 PCNEPLGLESDSQITASSSYWAAKIARLNGgsDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYKLE-YS 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24663169     124 DDGEFWRSYVNPTSEpqMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGC 185
Cdd:smart00231   80 DDGVNWTTYKDGNSK--VFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 192-340 2.86e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.69  E-value: 2.86e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  192 LYFNGTGLVRYDlrREPITSTKESIRFRFKTAFANGVMMY-SRGTQGDYYALQLKDNKMVLNLDLGSRVmTSLSVGSLLD 270
Cdd:cd00110    2 VSFSGSSYVRLP--TLPAPRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGS-LVLSSKTPLN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24663169  271 DNVWHDVVISRNQRDIIFSVDR-VIVRGRIQGEFTRLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFN 340
Cdd:cd00110   79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDLKspGLPVSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 57-182 7.08e-31

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 118.32  E-value: 7.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     57 LTATSSLTERGPDKARLNGNA--AWTPVENTYNHFLTLDLGDPRMVRKIATMGRMH-TDEFVTEYIVQYSDDGEFWRSYV 133
Cdd:pfam00754    2 ITASSSYSGEGPAAAALDGDPntAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDgSNGYVTSYKIEYSLDGENWTTVK 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 24663169    134 NPtsepqMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHD--RISMRVEL 182
Cdd:pfam00754   82 DE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGgnGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 220-342 1.08e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 117.52  E-value: 1.08e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    220 FKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIV-RGR 298
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 24663169    299 IQGEFTRLNLNRELYLGGVPNV--QEGLIVQQNFSGCLENIYFNST 342
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLllLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
215-341 1.03e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 115.13  E-value: 1.03e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     215 SIRFRFKTAFANGVMMYSRG-TQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVD-R 292
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSkGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDgG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|.
gi 24663169     293 VIVRGRIQGEFTRLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFNS 341
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKlpPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
819-943 2.58e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.89  E-value: 2.58e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     819 DIYLEFRTTQENSVIFHATGP--TDYIKLSLNGGnKLQFQYQAGSGPLGVnVGTSYHLNDNNWHTVSVERNRKEARLVVD 896
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDG-RLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 24663169     897 GSIKAEVREPPGPVRaLHLTSDLVIGATTE--------YRDGYVGCIRALLLNGK 943
Cdd:smart00282   79 GGNRVSGESPGGLTI-LNLDGPLYLGGLPEdlklpplpVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 824-943 2.84e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 110.59  E-value: 2.84e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    824 FRTTQENSVIFHATG-PTDYIKLSLNGGnKLQFQYQAGSGPLGVNVgTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAE 902
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNG-RLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 24663169    903 VRePPGPVRALHLTSDLVIGA--------TTEYRDGYVGCIRALLLNGK 943
Cdd:pfam02210   79 SL-PPGESLLLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 810-941 1.18e-27

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 109.82  E-value: 1.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  810 PPFDMGHSGDIYLEFRTTQENSVIFHATG--PTDYIKLSLNGGnKLQFQYQAGSGPLGVNVGTsyHLNDNNWHTVSVERN 887
Cdd:cd00110   14 TLPAPRTRLSISFSFRTTSPNGLLLYAGSqnGGDFLALELEDG-RLVLRYDLGSGSLVLSSKT--PLNDGQWHSVSVERN 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24663169  888 RKEARLVVDGSIKAEVREPPGPVRaLHLTSDLVIGATTE--------YRDGYVGCIRALLLN 941
Cdd:cd00110   91 GRSVTLSVDGERVVESGSPGGSAL-LNLDGPLYLGGLPEdlkspglpVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 376-514 6.36e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.25  E-value: 6.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  376 PVTFTtRSSFVRLKGYEN-SQRLNVSFYFRTYEETGVMLH-HDFYSGGYLKVFLEFGKVKIDLKVKDKARIIldNYDDQF 453
Cdd:cd00110    1 GVSFS-GSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGSLVL--SSKTPL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24663169  454 NDGKWHSFVISIEKNRLILNIDQ-RPMTTTKSM---QVATGAQYYIAG---------GKDKNGFVGCMRLISVD 514
Cdd:cd00110   78 NDGQWHSVSVERNGRSVTLSVDGeRVVESGSPGgsaLLNLDGPLYLGGlpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1156 5.62e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.79  E-value: 5.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169   1032 FTTTIPKGFLLgFSSNLTGEYLTIQISNsGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKngGSTVVLKVDNYEP 1111
Cdd:pfam02210    1 FRTRQPNGLLL-YAGGGGSDFLALELVN-GRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERN--GNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24663169   1112 VEYNfdiKASADAQFNNIQYMYIG--------KNESMTDGFVGCVSRVQFDDI 1156
Cdd:pfam02210   77 VSSL---PPGESLLLNLNGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
398-516 3.44e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.08  E-value: 3.44e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     398 NVSFYFRTYEETGVMLHHDFYSGG-YLKVFLEFGKVKIDLKV-KDKARIILDNYddQFNDGKWHSFVISIEKNRLILNID 475
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdYLALELRDGRLVLRYDLgSGPARLTSDPT--PLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 24663169     476 QRPMTTTKSMQVATG----AQYYIAG---------GKDKNGFVGCMRLISVDGN 516
Cdd:smart00282   79 GGNRVSGESPGGLTIlnldGPLYLGGlpedlklppLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1003-1154 6.72e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 84.78  E-value: 6.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169 1003 GVNLRSSSIIRYEFEGSFRSTiaENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNsGHLRCVFDFGFERQEIIfPKKH 1082
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTR--LSISFSFRTTSPNGLLLYAGSQNGGDFLALELED-GRLVLRYDLGSGSLVLS-SKTP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169 1083 FGLGQYHDMHFMRKngGSTVVLKVDNYEPVEYnfdIKASADAQFNNIQYMYIG--------KNESMTDGFVGCVSRVQFD 1154
Cdd:cd00110   77 LNDGQWHSVSVERN--GRSVTLSVDGERVVES---GSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1027-1154 9.31e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 78.15  E-value: 9.31e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    1027 NIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNsGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKngGSTVVLKV 1106
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRD-GRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERN--GRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663169    1107 DNYEPVEynfdIKASADAQFNNIQY-MYIG--------KNESMTDGFVGCVSRVQFD 1154
Cdd:smart00282   78 DGGNRVS----GESPGGLTILNLDGpLYLGglpedlklPPLPVTPGFRGCIRNLKVN 130
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 403-516 1.12e-14

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 71.68  E-value: 1.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    403 FRTYEETGVMLHHDFYSGGYLKVFLEFGKVKIDLKVkDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQRP---- 478
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTvvss 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 24663169    479 MTTTKSMQVATGAQYYIaGG----------KDKNGFVGCMRLISVDGN 516
Cdd:pfam02210   80 LPPGESLLLNLNGPLYL-GGlppllllpalPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-998 1.24e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.24e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 24663169  966 CES-NPCLNNGTCIERYDGYSCDCRwSAFKGPIC 998
Cdd:cd00054    5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 966-988 1.29e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.29e-05
                           10        20
                   ....*....|....*....|...
gi 24663169    966 CESNPCLNNGTCIERYDGYSCDC 988
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCIC 23
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 546-575 1.00e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.00e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 24663169    546 CNPNPCQHKGLCHQNSREFFCDCGHtGYAG 575
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPE-GYTG 29
4.1m smart00294
putative band 4.1 homologues' binding motif;
1239-1255 1.07e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 37.51  E-value: 1.07e-03
                            10
                    ....*....|....*..
gi 24663169    1239 GRYLHRHKGDYLTHEDQ 1255
Cdd:smart00294    2 YRYKHRDEGSYHTHEPK 18
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-989 2.54e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.54e-03
                            10        20
                    ....*....|....*....|....*
gi 24663169     966 CES-NPCLNNGTCIERYDGYSCDCR 989
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECP 29
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 57-184 1.18e-51

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 178.31  E-value: 1.18e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169   57 LTATSSLT-ERGPDKARLNGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRM--HTDEFVTEYIVQYSDDGEFWRSYV 133
Cdd:cd00057   14 ITASSSYSsGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKggGSSEWVTSYKVQYSLDGETWTTYK 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24663169  134 NPtSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYG 184
Cdd:cd00057   94 DK-GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 46-185 1.69e-36

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 134.56  E-value: 1.69e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169      46 DCNQPLMERAVLTATSSLTERGPDKARLNG--NAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVqYS 123
Cdd:smart00231    1 PCNEPLGLESDSQITASSSYWAAKIARLNGgsDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYKLE-YS 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24663169     124 DDGEFWRSYVNPTSEpqMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGC 185
Cdd:smart00231   80 DDGVNWTTYKDGNSK--VFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 192-340 2.86e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.69  E-value: 2.86e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  192 LYFNGTGLVRYDlrREPITSTKESIRFRFKTAFANGVMMY-SRGTQGDYYALQLKDNKMVLNLDLGSRVmTSLSVGSLLD 270
Cdd:cd00110    2 VSFSGSSYVRLP--TLPAPRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGS-LVLSSKTPLN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24663169  271 DNVWHDVVISRNQRDIIFSVDR-VIVRGRIQGEFTRLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFN 340
Cdd:cd00110   79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDLKspGLPVSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 57-182 7.08e-31

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 118.32  E-value: 7.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     57 LTATSSLTERGPDKARLNGNA--AWTPVENTYNHFLTLDLGDPRMVRKIATMGRMH-TDEFVTEYIVQYSDDGEFWRSYV 133
Cdd:pfam00754    2 ITASSSYSGEGPAAAALDGDPntAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDgSNGYVTSYKIEYSLDGENWTTVK 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 24663169    134 NPtsepqMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHD--RISMRVEL 182
Cdd:pfam00754   82 DE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGgnGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 220-342 1.08e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 117.52  E-value: 1.08e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    220 FKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIV-RGR 298
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 24663169    299 IQGEFTRLNLNRELYLGGVPNV--QEGLIVQQNFSGCLENIYFNST 342
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLllLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
215-341 1.03e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 115.13  E-value: 1.03e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     215 SIRFRFKTAFANGVMMYSRG-TQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVD-R 292
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSkGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDgG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|.
gi 24663169     293 VIVRGRIQGEFTRLNLNRELYLGGVPNVQE--GLIVQQNFSGCLENIYFNS 341
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKlpPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
819-943 2.58e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.89  E-value: 2.58e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     819 DIYLEFRTTQENSVIFHATGP--TDYIKLSLNGGnKLQFQYQAGSGPLGVnVGTSYHLNDNNWHTVSVERNRKEARLVVD 896
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDG-RLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 24663169     897 GSIKAEVREPPGPVRaLHLTSDLVIGATTE--------YRDGYVGCIRALLLNGK 943
Cdd:smart00282   79 GGNRVSGESPGGLTI-LNLDGPLYLGGLPEdlklpplpVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 824-943 2.84e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 110.59  E-value: 2.84e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    824 FRTTQENSVIFHATG-PTDYIKLSLNGGnKLQFQYQAGSGPLGVNVgTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAE 902
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNG-RLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 24663169    903 VRePPGPVRALHLTSDLVIGA--------TTEYRDGYVGCIRALLLNGK 943
Cdd:pfam02210   79 SL-PPGESLLLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 810-941 1.18e-27

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 109.82  E-value: 1.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  810 PPFDMGHSGDIYLEFRTTQENSVIFHATG--PTDYIKLSLNGGnKLQFQYQAGSGPLGVNVGTsyHLNDNNWHTVSVERN 887
Cdd:cd00110   14 TLPAPRTRLSISFSFRTTSPNGLLLYAGSqnGGDFLALELEDG-RLVLRYDLGSGSLVLSSKT--PLNDGQWHSVSVERN 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24663169  888 RKEARLVVDGSIKAEVREPPGPVRaLHLTSDLVIGATTE--------YRDGYVGCIRALLLN 941
Cdd:cd00110   91 GRSVTLSVDGERVVESGSPGGSAL-LNLDGPLYLGGLPEdlkspglpVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 376-514 6.36e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.25  E-value: 6.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169  376 PVTFTtRSSFVRLKGYEN-SQRLNVSFYFRTYEETGVMLH-HDFYSGGYLKVFLEFGKVKIDLKVKDKARIIldNYDDQF 453
Cdd:cd00110    1 GVSFS-GSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGSGSLVL--SSKTPL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24663169  454 NDGKWHSFVISIEKNRLILNIDQ-RPMTTTKSM---QVATGAQYYIAG---------GKDKNGFVGCMRLISVD 514
Cdd:cd00110   78 NDGQWHSVSVERNGRSVTLSVDGeRVVESGSPGgsaLLNLDGPLYLGGlpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1156 5.62e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.79  E-value: 5.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169   1032 FTTTIPKGFLLgFSSNLTGEYLTIQISNsGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKngGSTVVLKVDNYEP 1111
Cdd:pfam02210    1 FRTRQPNGLLL-YAGGGGSDFLALELVN-GRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERN--GNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24663169   1112 VEYNfdiKASADAQFNNIQYMYIG--------KNESMTDGFVGCVSRVQFDDI 1156
Cdd:pfam02210   77 VSSL---PPGESLLLNLNGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
398-516 3.44e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.08  E-value: 3.44e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169     398 NVSFYFRTYEETGVMLHHDFYSGG-YLKVFLEFGKVKIDLKV-KDKARIILDNYddQFNDGKWHSFVISIEKNRLILNID 475
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdYLALELRDGRLVLRYDLgSGPARLTSDPT--PLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 24663169     476 QRPMTTTKSMQVATG----AQYYIAG---------GKDKNGFVGCMRLISVDGN 516
Cdd:smart00282   79 GGNRVSGESPGGLTIlnldGPLYLGGlpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
220-343 3.56e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 84.68  E-value: 3.56e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    220 FKTAFANGVMMYS-RGTQGDYYALQLKDNKMVLNLDLGSRvMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGR 298
Cdd:pfam00054    1 FRTTEPSGLLLYNgTQTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 24663169    299 IQ--GEFTRLNLNRELYLGGVPN---VQEGLIVQQNFSGCLENIYFNSTN 343
Cdd:pfam00054   80 ESplGATTDLDVDGPLYVGGLPSlgvKKRRLAISPSFDGCIRDVIVNGKP 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1003-1154 6.72e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 84.78  E-value: 6.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169 1003 GVNLRSSSIIRYEFEGSFRSTiaENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNsGHLRCVFDFGFERQEIIfPKKH 1082
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTR--LSISFSFRTTSPNGLLLYAGSQNGGDFLALELED-GRLVLRYDLGSGSLVLS-SKTP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169 1083 FGLGQYHDMHFMRKngGSTVVLKVDNYEPVEYnfdIKASADAQFNNIQYMYIG--------KNESMTDGFVGCVSRVQFD 1154
Cdd:cd00110   77 LNDGQWHSVSVERN--GRSVTLSVDGERVVES---GSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_1 pfam00054
Laminin G domain;
824-946 6.82e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 83.91  E-value: 6.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    824 FRTTQENSVIFHATGPT--DYIKLSLNGGnKLQFQYQAGSGPLGVNVGTSyhLNDNNWHTVSVERNRKEARLVVDGSIKA 901
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDG-RLEVSYDLGSGAAVVRSGDK--LNDGKWHSVELERNGRSGTLSVDGEARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24663169    902 EVREPPGPVRALHLTSDLVIGATTE---------YRDGYVGCIRALLLNGKMVD 946
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGLPSlgvkkrrlaISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
1027-1154 9.31e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 78.15  E-value: 9.31e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    1027 NIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNsGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKngGSTVVLKV 1106
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRD-GRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERN--GRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663169    1107 DNYEPVEynfdIKASADAQFNNIQY-MYIG--------KNESMTDGFVGCVSRVQFD 1154
Cdd:smart00282   78 DGGNRVS----GESPGGLTILNLDGpLYLGglpedlklPPLPVTPGFRGCIRNLKVN 130
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 403-516 1.12e-14

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 71.68  E-value: 1.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    403 FRTYEETGVMLHHDFYSGGYLKVFLEFGKVKIDLKVkDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQRP---- 478
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTvvss 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 24663169    479 MTTTKSMQVATGAQYYIaGG----------KDKNGFVGCMRLISVDGN 516
Cdd:pfam02210   80 LPPGESLLLNLNGPLYL-GGlppllllpalPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
403-515 4.31e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.87  E-value: 4.31e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    403 FRTYEETGVML------HHDFYS----GGYLKVFLEFGKVKIDLKVKDKariildnyddqFNDGKWHSFVISIEKNRLIL 472
Cdd:pfam00054    1 FRTTEPSGLLLyngtqtERDFLAlelrDGRLEVSYDLGSGAAVVRSGDK-----------LNDGKWHSVELERNGRSGTL 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 24663169    473 NID--QRPMTTTKS---MQVATGAQYYIAG---GKDKN-------GFVGCMRLISVDG 515
Cdd:pfam00054   70 SVDgeARPTGESPLgatTDLDVDGPLYVGGlpsLGVKKrrlaispSFDGCIRDVIVNG 127
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 804-938 1.13e-05

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 46.61  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663169    804 DASINLPPFDMGhSGDIYLEF----RTTQENSVIFHATGPTDYIKLSLNGGNKLQFqYQAGSGPLGVNVGTSYHLNDNNW 879
Cdd:pfam13385    4 SDYVTLPDALLP-TSDFTVSAwvkpDSLPGWARAIISSSGGGGYSLGLDGDGRLRF-AVNGGNGGWDTVTSGASVPLGQW 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24663169    880 HTVSVERNRKEARLVVDGsikAEVREPPGPVRALHLTSD-LVIGATTEYRDGYVGCI-------RAL 938
Cdd:pfam13385   82 THVAVTYDGGTLRLYVNG---VLVGSSTLTGGPPPGTGGpLYIGRSPGGDDYFNGLIdevriydRAL 145
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-998 1.24e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.24e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 24663169  966 CES-NPCLNNGTCIERYDGYSCDCRwSAFKGPIC 998
Cdd:cd00054    5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 966-988 1.29e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.29e-05
                           10        20
                   ....*....|....*....|...
gi 24663169    966 CESNPCLNNGTCIERYDGYSCDC 988
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCIC 23
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 546-575 1.00e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.00e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 24663169    546 CNPNPCQHKGLCHQNSREFFCDCGHtGYAG 575
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPE-GYTG 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 967-989 5.07e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 5.07e-04
                         10        20
                 ....*....|....*....|...
gi 24663169  967 ESNPCLNNGTCIERYDGYSCDCR 989
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCP 26
4.1m smart00294
putative band 4.1 homologues' binding motif;
1239-1255 1.07e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 37.51  E-value: 1.07e-03
                            10
                    ....*....|....*..
gi 24663169    1239 GRYLHRHKGDYLTHEDQ 1255
Cdd:smart00294    2 YRYKHRDEGSYHTHEPK 18
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-989 2.54e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.54e-03
                            10        20
                    ....*....|....*....|....*
gi 24663169     966 CES-NPCLNNGTCIERYDGYSCDCR 989
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECP 29
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 971-988 6.35e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.39  E-value: 6.35e-03
                           10
                   ....*....|....*...
gi 24663169    971 CLNNGTCIERYDGYSCDC 988
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQC 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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