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Conserved domains on  [gi|24643350|ref|NP_523411|]
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zwischenferment, isoform A [Drosophila melanogaster]

Protein Classification

glucose-6-phosphate 1-dehydrogenase( domain architecture ID 1000188)

glucose-6-phosphate 1-dehydrogenase (G6PD) catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes

EC:  1.1.1.-
Gene Ontology:  GO:0006006|GO:0050661|GO:0016614

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 37-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 694.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   37 TFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLT--VDSIKEQCLPYMKVQPHEQKKYEEFWALNEYVSG 114
Cdd:PTZ00309  56 TIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHISYISG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  115 RYDGRTGFELLNQQLEIMENKNKA-----NRIFYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSD 189
Cdd:PTZ00309 136 SYDEDEDFKRLNKLIERMEEAFQGpekggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSEELSN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  190 HLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLL 269
Cdd:PTZ00309 216 QLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  270 QILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTnddaRTGYVEDPTVSNDSNTPTYALGVLKI 349
Cdd:PTZ00309 296 QILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGS----IPGYLEDEGVPKDSTTPTFAAAVLHI 371

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  350 NNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEG-NTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLT 428
Cdd:PTZ00309 372 NNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGdDTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTELDLT 451

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  429 YEHRYkDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKY 508
Cdd:PTZ00309 452 YKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNGFKS 530


                 ....*.
gi 24643350  509 SGSYKW 514
Cdd:PTZ00309 531 SKGYQW 536
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 37-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 694.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   37 TFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLT--VDSIKEQCLPYMKVQPHEQKKYEEFWALNEYVSG 114
Cdd:PTZ00309  56 TIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHISYISG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  115 RYDGRTGFELLNQQLEIMENKNKA-----NRIFYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSD 189
Cdd:PTZ00309 136 SYDEDEDFKRLNKLIERMEEAFQGpekggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSEELSN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  190 HLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLL 269
Cdd:PTZ00309 216 QLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  270 QILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTnddaRTGYVEDPTVSNDSNTPTYALGVLKI 349
Cdd:PTZ00309 296 QILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGS----IPGYLEDEGVPKDSTTPTFAAAVLHI 371

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  350 NNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEG-NTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLT 428
Cdd:PTZ00309 372 NNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGdDTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTELDLT 451

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  429 YEHRYkDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKY 508
Cdd:PTZ00309 452 YKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNGFKS 530


                 ....*.
gi 24643350  509 SGSYKW 514
Cdd:PTZ00309 531 SKGYQW 536
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 35-498 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 623.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350    35 PHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSI-KEQCLPYMKVQPHE-QKKYEEFWALNEYV 112
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFrKVVREAIIKFETDEiDEQWDEFAQRLSYV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   113 SGRYDGRTGFELLNQQLEIMENK--NKANRIFYLALPPSVFEEVTVNIKQICMSVCG-WNRVIIEKPFGRDDASSQALSD 189
Cdd:TIGR00871  82 SGDVDDDESYDSLAELLEQLDKTygTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   190 HLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLL 269
Cdd:TIGR00871 162 ALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   270 QILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDD--MVLGQYLGNPQGtnDDARTGYVEDPTVSNDSNTPTYALGVL 347
Cdd:TIGR00871 242 QLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIG--GVSVPGYLEEEGVDKDSNTETFAALKL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   348 KINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTK----RNELVIRVQPGEALYFKMMTKSPGITFDIEET 423
Cdd:TIGR00871 320 EIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdanpRNALVIRIQPDEGVYLKFNAKKPGLNFETRPV 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24643350   424 ELDLTYEHRYKDSyLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIR-PITYQYGSRGPKEAD 498
Cdd:TIGR00871 400 KLDFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPsPPNYPAGSWGPKEAD 474
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 35-499 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 525.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  35 PHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDS----IKEQCLPYMKvQPHEQKKYEEFWALNE 110
Cdd:COG0364   9 PCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEfreeVREALEEFSR-KPFDEEVWERFLERLH 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 111 YVSGRYDGRTGFELLNQQL-EIMENKNKANRIFYLALPPSVFEEVTVNIKQICM-SVCGWNRVIIEKPFGRDDASSQALS 188
Cdd:COG0364  88 YVSGDFTDPEGYERLKELLeELDEERTPGNRVFYLATPPSLFGPICENLGAAGLaTEGGWRRVVIEKPFGHDLASARELN 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 189 DHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHL 268
Cdd:COG0364 168 DELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHL 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 269 LQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDM----VLGQYLGnpqGT-NDDARTGYVEDPTVSNDSNTPTYA 343
Cdd:COG0364 248 LQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTA---GWiGGEPVPGYREEPGVAPDSTTETFV 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 344 LGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTKR---NELVIRVQPGEALYFKMMTKSPGITFDI 420
Cdd:COG0364 325 ALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMRL 404

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643350 421 EETELDLTYEHRYKDSYlPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADR 499
Cdd:COG0364 405 RPVSLDFSYSDAFGERS-PEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
216-515 3.36e-163

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 464.60  E-value: 3.36e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   216 MTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVKV 295
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   296 LKSIEALTLDDM----VLGQYLGNPQGtnDDARTGYVEDPTVSNDSNTPTYALGVLKINNERWQGVPFILRCGKALNERK 371
Cdd:pfam02781  81 LRSLRPITPEDVednvVRGQYGAGWIG--GEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   372 AEVRIQYQDVPGDIFEGNT--KRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKDsYLPDAYERLILDV 449
Cdd:pfam02781 159 TEIRIQFKDVPHNLFRDPGtlPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGE-RIPEAYERLLLDV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24643350   450 FCGSQMHFVRSDELREAWRIFTPILHQIEKEhiRPITYQYGSRGPKEADRKCEENNfkysgsYKWH 515
Cdd:pfam02781 238 MRGDQTLFVRSDEVEAAWRIVDPILEAWDEE--KPPPYPAGSWGPKAADELLARDG------RKWR 295
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 37-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 694.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   37 TFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLT--VDSIKEQCLPYMKVQPHEQKKYEEFWALNEYVSG 114
Cdd:PTZ00309  56 TIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHISYISG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  115 RYDGRTGFELLNQQLEIMENKNKA-----NRIFYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSD 189
Cdd:PTZ00309 136 SYDEDEDFKRLNKLIERMEEAFQGpekggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSEELSN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  190 HLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLL 269
Cdd:PTZ00309 216 QLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  270 QILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTnddaRTGYVEDPTVSNDSNTPTYALGVLKI 349
Cdd:PTZ00309 296 QILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGS----IPGYLEDEGVPKDSTTPTFAAAVLHI 371

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  350 NNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEG-NTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLT 428
Cdd:PTZ00309 372 NNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGdDTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTELDLT 451

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  429 YEHRYkDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKY 508
Cdd:PTZ00309 452 YKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNGFKS 530


                 ....*.
gi 24643350  509 SGSYKW 514
Cdd:PTZ00309 531 SKGYQW 536
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 35-498 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 623.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350    35 PHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSI-KEQCLPYMKVQPHE-QKKYEEFWALNEYV 112
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFrKVVREAIIKFETDEiDEQWDEFAQRLSYV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   113 SGRYDGRTGFELLNQQLEIMENK--NKANRIFYLALPPSVFEEVTVNIKQICMSVCG-WNRVIIEKPFGRDDASSQALSD 189
Cdd:TIGR00871  82 SGDVDDDESYDSLAELLEQLDKTygTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   190 HLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLL 269
Cdd:TIGR00871 162 ALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   270 QILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDD--MVLGQYLGNPQGtnDDARTGYVEDPTVSNDSNTPTYALGVL 347
Cdd:TIGR00871 242 QLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIG--GVSVPGYLEEEGVDKDSNTETFAALKL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   348 KINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTK----RNELVIRVQPGEALYFKMMTKSPGITFDIEET 423
Cdd:TIGR00871 320 EIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdanpRNALVIRIQPDEGVYLKFNAKKPGLNFETRPV 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24643350   424 ELDLTYEHRYKDSyLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIR-PITYQYGSRGPKEAD 498
Cdd:TIGR00871 400 KLDFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPsPPNYPAGSWGPKEAD 474
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 37-498 0e+00

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 619.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   37 TFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPT-KFCGYARSMLTVDSIKEQCLPYMKVQPHE-QKKYEEFWALNEYVSG 114
Cdd:PLN02539  19 SIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEvHIFGYARSKITDEELRDRIRGYLKDEKNApAEAVSKFLQLIKYVSG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  115 RYDGRTGFELLNQQLEIMENKNKAN-----RIFYLALPPSVFEEVTVNIKQICMSVCG-WNRVIIEKPFGRDDASSQALS 188
Cdd:PLN02539  99 AYDSEEGFRRLDKEISEHEISKNSAegssrRLFYLALPPSVYPPVCKMIKKCCMNKSGlWTRIVVEKPFGKDLESAEELS 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  189 DHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHL 268
Cdd:PLN02539 179 SQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHL 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  269 LQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYlgnpqgtnddarTGYVEDPTVSNDSNTPTYALGVLK 348
Cdd:PLN02539 259 LQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEVVLGQY------------EGYRDDPTVPDDSNTPTFASVVLR 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  349 INNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIF-EGNTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDL 427
Cdd:PLN02539 327 INNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFkCQKQGRNEFVIRLQPSEAMYMKLTVKQPGLEMSTVQSELDL 406

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24643350  428 TYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEAD 498
Cdd:PLN02539 407 SYGQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGPAEAD 477
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 35-499 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 532.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   35 PHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDS----IKEQCLPYMKvQPHEQKKYEEFWALNE 110
Cdd:PRK05722   9 PCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDfrevVREALKEFAR-TPFDEEVWERFLSRLY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  111 YVSGRYDGRTGFELLNQQLEIMENKN--KANRIFYLALPPSVFEEVTVNIKQICMSVC-GWNRVIIEKPFGRDDASSQAL 187
Cdd:PRK05722  88 YVSGDVTDPESYERLKELLEELDEERgtGGNRVFYLATPPSLFGTICENLAAAGLNEGgGWRRVVIEKPFGHDLASAREL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  188 SDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNH 267
Cdd:PRK05722 168 NDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNH 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  268 LLQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDM----VLGQYLGNPQgtNDDARTGYVEDPTVSNDSNTPTYA 343
Cdd:PRK05722 248 LLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVkentVRGQYTAGWI--GGKPVPGYREEEGVNPDSTTETFV 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  344 LGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTKR---NELVIRVQPGEALYFKMMTKSPGITFDI 420
Cdd:PRK05722 326 ALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEElgpNKLVIRIQPDEGISLRFNAKVPGEGMEL 405

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643350  421 EETELDLTYEHRYKDSyLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADR 499
Cdd:PRK05722 406 RPVKLDFSYSEAFGEA-SPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADA 483
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 35-499 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 525.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  35 PHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDS----IKEQCLPYMKvQPHEQKKYEEFWALNE 110
Cdd:COG0364   9 PCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEfreeVREALEEFSR-KPFDEEVWERFLERLH 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 111 YVSGRYDGRTGFELLNQQL-EIMENKNKANRIFYLALPPSVFEEVTVNIKQICM-SVCGWNRVIIEKPFGRDDASSQALS 188
Cdd:COG0364  88 YVSGDFTDPEGYERLKELLeELDEERTPGNRVFYLATPPSLFGPICENLGAAGLaTEGGWRRVVIEKPFGHDLASARELN 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 189 DHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHL 268
Cdd:COG0364 168 DELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHL 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 269 LQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDM----VLGQYLGnpqGT-NDDARTGYVEDPTVSNDSNTPTYA 343
Cdd:COG0364 248 LQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTA---GWiGGEPVPGYREEPGVAPDSTTETFV 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350 344 LGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTKR---NELVIRVQPGEALYFKMMTKSPGITFDI 420
Cdd:COG0364 325 ALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMRL 404

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643350 421 EETELDLTYEHRYKDSYlPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADR 499
Cdd:COG0364 405 RPVSLDFSYSDAFGERS-PEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 37-508 3.28e-166

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 482.98  E-value: 3.28e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   37 TFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSIKEQCLPYMKVQPHEQK----KYEEFWALNEYV 112
Cdd:PLN02640  90 SITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLTCRIDQREncgdKMDQFLKRCFYH 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  113 SGRYDGRTGFELLNQQLEIMENKNKANRIFYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSDHLA 192
Cdd:PLN02640 170 SGQYDSEEDFAELNKKLKEKEAGKLSNRLFYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELTRCLK 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  193 GLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQIL 272
Cdd:PLN02640 250 QYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQIL 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  273 SLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTNddARTGYVEDPTVSNDSNTPTYALGVLKINNE 352
Cdd:PLN02640 330 ALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGK--SYPAYTDDPTVPKHSLTPTFAAAALFINNA 407

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  353 RWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGN------TKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELD 426
Cdd:PLN02640 408 RWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYKRNfgtdldKATNELVLRVQPDEAIYLKINNKVPGLGMRLDRSDLN 487

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  427 LTYEHRYKDSyLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNF 506
Cdd:PLN02640 488 LLYRARYPRE-IPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSRGPVGAHYLAAKYNV 566


                 ..
gi 24643350  507 KY 508
Cdd:PLN02640 567 RW 568
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 12-494 4.80e-166

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 483.71  E-value: 4.80e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   12 DLIIKSLKSPTMVCEGTHFDGKIPHTFV---IFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSIKEQC 88
Cdd:PLN02333  91 DGLLSSIPSSEEDKVVAEFDGNKDESTVsitVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMV 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   89 LPYM--KVQPHEQ--KKYEEFWALNEYVSGRYDGRTGFELLNQQLEIMENKNKANRIFYLALPPSVFEEVTVNIKQICMS 164
Cdd:PLN02333 171 SKTLtcRIDKRENcgEKMEEFLKRCFYHSGQYDSQEHFAELDKKLKEHEGGRVSNRLFYLSIPPNIFVDAVKCASSSASS 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  165 VCGWNRVIIEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEP 244
Cdd:PLN02333 251 VNGWTRVIVEKPFGRDSESSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSED 330

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  245 FGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGtnDDAR 324
Cdd:PLN02333 331 FGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSHTKG--GVTY 408

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  325 TGYVEDPTVSNDSNTPTYALGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNT------KRNELVIR 398
Cdd:PLN02333 409 PAYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYNRNFgtdldqATNELVIR 488

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  399 VQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKDSyLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIE 478
Cdd:PLN02333 489 VQPDEAIYLKINNKVPGLGMRLDRSNLNLLYAARYSKE-IPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELE 567

                        490
                 ....*....|....*.
gi 24643350  479 KEHIRPITYQYGSRGP 494
Cdd:PLN02333 568 EKKIIPEYYPYGSRGP 583
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
216-515 3.36e-163

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 464.60  E-value: 3.36e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   216 MTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVKV 295
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   296 LKSIEALTLDDM----VLGQYLGNPQGtnDDARTGYVEDPTVSNDSNTPTYALGVLKINNERWQGVPFILRCGKALNERK 371
Cdd:pfam02781  81 LRSLRPITPEDVednvVRGQYGAGWIG--GEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   372 AEVRIQYQDVPGDIFEGNT--KRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKDsYLPDAYERLILDV 449
Cdd:pfam02781 159 TEIRIQFKDVPHNLFRDPGtlPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGE-RIPEAYERLLLDV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24643350   450 FCGSQMHFVRSDELREAWRIFTPILHQIEKEhiRPITYQYGSRGPKEADRKCEENNfkysgsYKWH 515
Cdd:pfam02781 238 MRGDQTLFVRSDEVEAAWRIVDPILEAWDEE--KPPPYPAGSWGPKAADELLARDG------RKWR 295
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
35-499 3.53e-162

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 469.38  E-value: 3.53e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   35 PHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVD----SIKEQCLPYMKvQPHEQKKYEEFWALNE 110
Cdd:PRK12853   8 PCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEqwraRVRESLRAFGA-DGFDDAVWDRLAARLS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  111 YVSGRYDGRTGFELLNQQLEimenkNKANRIFYLALPPSVFEEVTVNIKQICMSVcGWNRVIIEKPFGRDDASSQALSDH 190
Cdd:PRK12853  87 YVQGDVTDPADYARLAEALG-----PGGNPVFYLAVPPSLFAPVVENLGAAGLLP-EGRRVVLEKPFGHDLASARALNAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  191 LAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQ 270
Cdd:PRK12853 161 LAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLLQ 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  271 ILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDD--MVLGQYLGNPQGtnDDARTGYVEDPTVSNDSNTPTYALGVLK 348
Cdd:PRK12853 241 LLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDvhTVRGQYTAGTVG--GEPVPGYREEPGVDPDSRTETFVALKLE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  349 INNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGN--TKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELD 426
Cdd:PRK12853 319 IDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTgvEPPNRLVIRLQPDEGISLELNVKRPGPGMRLRPVELD 398

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24643350  427 LTYEHRYKDsylPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADR 499
Cdd:PRK12853 399 ADYADDERP---LEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADA 468
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 35-515 3.41e-116

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 351.64  E-value: 3.41e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   35 PHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDS----IKEQCLPYMKVqPHEQKKYEEFWALNE 110
Cdd:PRK12854  11 PTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAfrehARDALDEFGAR-KLDDGEWARFAKRLR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  111 YVSGRY---DGRTGFELLNQQLEimENKNKANRIFYLALPPSVFEEVTVNIKQICMSvcGWNRVIIEKPFGRDDASSQAL 187
Cdd:PRK12854  90 YVPGGFlsaGPGALAAAVAAARA--ELGGDARLVHYLAVPPSAFLDVTRALGEAGLA--EGSRVVMEKPFGTDLASAEAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  188 SDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNH 267
Cdd:PRK12854 166 NAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTH 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  268 LLQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYlgnpqgtnddarTGYVEDPTVSNDSNTPTYALGVL 347
Cdd:PRK12854 246 LFQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQY------------SGYRDEPGVAPDSTTETFVALKV 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  348 KINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFE----GNTKRNELVIRVQPGEALYFKMMTKSPGITFDIEET 423
Cdd:PRK12854 314 WIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFPagsvGAQGPDHLTFDLADNSKVSLSFYGKRPGPGMRLDKL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350  424 ELDLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILhqiekEHIRPI-TYQYGSRGPKEADRKCE 502
Cdd:PRK12854 394 SLQFSLKDTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLL-----EDPPPVkPYAPGSWGPNAIHQLAA 468

                        490
                 ....*....|...
gi 24643350  503 ENNFKYSGSYKWH 515
Cdd:PRK12854 469 PDAWRLPFEREWR 481
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
39-214 2.46e-88

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 268.91  E-value: 2.46e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350    39 VIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSIKEQCLPYMKVQP-HEQKKYEEFWALNEYVSGRYD 117
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFKeLDEEKWDRFLERLHYVSGDFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643350   118 GRTGFELLNQQLEIMENKNKANRIFYLALPPSVFEEVTVNIKQICMSV-CGWNRVIIEKPFGRDDASSQALSDHLAGLFQ 196
Cdd:pfam00479  81 DPESYEKLKERLEEHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEeGGWRRVVIEKPFGHDLESARELNDQLAKVFK 160

                         170
                  ....*....|....*...
gi 24643350   197 EDQLYRIDHYLGKEMVQN 214
Cdd:pfam00479 161 EEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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