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Conserved domains on  [gi|17551022|ref|NP_510426|]
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Leucine-rich repeat-containing protein let-4 [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-408 7.66e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 7.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  84 RIKKLILSNNRiekihdhAFTGLENVmQELSLSENNLKEVPTSaLAGLRVLNILSLKCNKIENITtKAFVNMTSLIDVNL 163
Cdd:COG4886  97 NLTELDLSGNE-------ELSNLTNL-ESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 164 GCNQICSMAADtFANVKmSLQNLILDNNCMTEFPsKAVRNMNNLIALHIKYNKINAIrQNDFVNLTSLSMLSLNGNNISE 243
Cdd:COG4886 167 SNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 244 IKggALQNTPNLHYLYLNENNLQTLDNgvLEQFKQLQVLDLSFNNFTDITKEMFEGL--ESIQHLNLDSNRISAVAPGAF 321
Cdd:COG4886 243 LP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLlgLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 322 AGTPLLLLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSLQNKSLSGPENLAVR 401
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398


                ....*..
gi 17551022 402 LQENPVV 408
Cdd:COG4886 399 GVLLLTL 405
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-408 7.66e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 7.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  84 RIKKLILSNNRiekihdhAFTGLENVmQELSLSENNLKEVPTSaLAGLRVLNILSLKCNKIENITtKAFVNMTSLIDVNL 163
Cdd:COG4886  97 NLTELDLSGNE-------ELSNLTNL-ESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 164 GCNQICSMAADtFANVKmSLQNLILDNNCMTEFPsKAVRNMNNLIALHIKYNKINAIrQNDFVNLTSLSMLSLNGNNISE 243
Cdd:COG4886 167 SNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 244 IKggALQNTPNLHYLYLNENNLQTLDNgvLEQFKQLQVLDLSFNNFTDITKEMFEGL--ESIQHLNLDSNRISAVAPGAF 321
Cdd:COG4886 243 LP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLlgLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 322 AGTPLLLLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSLQNKSLSGPENLAVR 401
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398


                ....*..
gi 17551022 402 LQENPVV 408
Cdd:COG4886 399 GVLLLTL 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 228-407 1.81e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 228 LTSLSMLSLNGNNISEIkgGALQNTPNLHYLYLNENNLQTLDNgvLEQFKQLQVLDLSFNNftdITK-EMFEGLESIQHL 306
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQ---IEKiENLENLVNLKKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 307 NLDSNRISAV-------------------APGafagtpllllwlpnnCLTEVSQQTLKG-APFLRMVSLSNNNIREVHEL 366
Cdd:cd21340  74 YLGGNRISVVeglenltnleelhienqrlPPG---------------EKLTFDPRSLAAlSNSLRVLNISGNNIDSLEPL 138

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 17551022 367 SfdHLPNLHTLDLANNKIMSLQN--KSLSGPENLA-VRLQENPV 407
Cdd:cd21340 139 A--PLRNLEQLDASNNQISDLEEllDLLSSWPSLReLDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
253-313 9.44e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 9.44e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17551022   253 PNLHYLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRI 313
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-318 1.26e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   74 EVGPKAFKTLRIKKLILSNNRIE-KIHDHAFTgLENVMQELSLSENNLK-EVPTSALAGLRVLNilsLKCNKIENITTKA 151
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDIFT-TSSSLRYLNLSNNNFTgSIPRGSIPNLETLD---LSNNMLSGEIPND 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  152 FVNMTSLIDVNLGCNQICSMAADTFANVKmSLQNLILDNNCMTEFPSKAVRNMNNLIALHIKYNKINAIRQNDFVNLTSL 231
Cdd:PLN00113 160 IGSFSSLKVLDLGGNVLVGKIPNSLTNLT-SLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  232 SMLSLNGNNISEIKGGALQNTPNLHYLYLNEN-----------NLQTL------DNG-------VLEQFKQLQVLDLSFN 287
Cdd:PLN00113 239 NHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifSLQKLisldlsDNSlsgeipeLVIQLQNLEILHLFSN 318

                        250       260       270
                 ....*....|....*....|....*....|.
gi 17551022  288 NFTDITKEMFEGLESIQHLNLDSNRISAVAP 318
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLWSNKFSGEIP 349
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-408 7.66e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 7.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  84 RIKKLILSNNRiekihdhAFTGLENVmQELSLSENNLKEVPTSaLAGLRVLNILSLKCNKIENITtKAFVNMTSLIDVNL 163
Cdd:COG4886  97 NLTELDLSGNE-------ELSNLTNL-ESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 164 GCNQICSMAADtFANVKmSLQNLILDNNCMTEFPsKAVRNMNNLIALHIKYNKINAIrQNDFVNLTSLSMLSLNGNNISE 243
Cdd:COG4886 167 SNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 244 IKggALQNTPNLHYLYLNENNLQTLDNgvLEQFKQLQVLDLSFNNFTDITKEMFEGL--ESIQHLNLDSNRISAVAPGAF 321
Cdd:COG4886 243 LP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLlgLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 322 AGTPLLLLWLPNNCLTEVSQQTLKGAPFLRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSLQNKSLSGPENLAVR 401
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398


                ....*..
gi 17551022 402 LQENPVV 408
Cdd:COG4886 399 GVLLLTL 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 228-407 1.81e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 228 LTSLSMLSLNGNNISEIkgGALQNTPNLHYLYLNENNLQTLDNgvLEQFKQLQVLDLSFNNftdITK-EMFEGLESIQHL 306
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQ---IEKiENLENLVNLKKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 307 NLDSNRISAV-------------------APGafagtpllllwlpnnCLTEVSQQTLKG-APFLRMVSLSNNNIREVHEL 366
Cdd:cd21340  74 YLGGNRISVVeglenltnleelhienqrlPPG---------------EKLTFDPRSLAAlSNSLRVLNISGNNIDSLEPL 138

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 17551022 367 SfdHLPNLHTLDLANNKIMSLQN--KSLSGPENLA-VRLQENPV 407
Cdd:cd21340 139 A--PLRNLEQLDASNNQISDLEEllDLLSSWPSLReLDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
203-398 3.68e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 3.68e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 203 NMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNiseikggALQNTPNLHYLYLNENNLQTLDNGvLEQFKQLQVL 282
Cdd:COG4886  70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKEL 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 283 DLSFNNFTDITKEmFEGLESIQHLNLDSNRISAVAPGafagtpllllwlpnncltevsqqtLKGAPFLRMVSLSNNNIRE 362
Cdd:COG4886 142 DLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE------------------------LGNLTNLKELDLSNNQITD 196

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 17551022 363 VHElSFDHLPNLHTLDLANNKIMSLqNKSLSGPENL 398
Cdd:COG4886 197 LPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNL 230
LRR_8 pfam13855
Leucine rich repeat;
253-313 9.44e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 9.44e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17551022   253 PNLHYLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRI 313
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 147-384 4.04e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 65.58  E-value: 4.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 147 ITTKAFVNMTSLIDVNLGCNQICSMAADTFANVKMSLQN---LILDNNCMTEFPSKAvrnmnnlIALHIKYNKinAIRQN 223
Cdd:COG5238 171 ISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTvttLWLKRNPIGDEGAEI-------LAEALKGNK--SLTTL 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 224 DFVNL-----------------TSLSMLSLNGNNISEiKGG-----ALQNTPNLHYLYLNENNLQtlDNGV------LEQ 275
Cdd:COG5238 242 DLSNNqigdegvialaealknnTTVETLYLSGNQIGA-EGAialakALQGNTTLTSLDLSVNRIG--DEGAialaegLQG 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 276 FKQLQVLDLSFNNFTDI-TKEMFEGLE---SIQHLNLDSNRISAVAPGAFAgtpllllwlpnncltevsqQTLKGAPFLR 351
Cdd:COG5238 319 NKTLHTLNLAYNGIGAQgAIALAKALQentTLHSLDLSDNQIGDEGAIALA-------------------KYLEGNTTLR 379

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 17551022 352 MVSLSNNNI--REVHELSfDHL--PNLHTLDLANNKI 384
Cdd:COG5238 380 ELNLGKNNIgkQGAEALI-DALqtNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
229-289 9.70e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 9.70e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17551022   229 TSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNF 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 182-315 8.42e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 8.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 182 SLQNLILDNNCMTEFPSkaVRNMNNLIALHIKYNKINAIrqNDFVNLTSLSMLSLNGNNISEIKGgaLQNTPNLHYLYLN 261
Cdd:cd21340  25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 262 E--------------------NNLQTLD---NGV-----LEQFKQLQVLDLSFNNFTDIT--KEMFEGLESIQHLNLDSN 311
Cdd:cd21340  99 NqrlppgekltfdprslaalsNSLRVLNisgNNIdslepLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178


                ....
gi 17551022 312 RISA 315
Cdd:cd21340 179 PVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-318 1.26e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   74 EVGPKAFKTLRIKKLILSNNRIE-KIHDHAFTgLENVMQELSLSENNLK-EVPTSALAGLRVLNilsLKCNKIENITTKA 151
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDIFT-TSSSLRYLNLSNNNFTgSIPRGSIPNLETLD---LSNNMLSGEIPND 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  152 FVNMTSLIDVNLGCNQICSMAADTFANVKmSLQNLILDNNCMTEFPSKAVRNMNNLIALHIKYNKINAIRQNDFVNLTSL 231
Cdd:PLN00113 160 IGSFSSLKVLDLGGNVLVGKIPNSLTNLT-SLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  232 SMLSLNGNNISEIKGGALQNTPNLHYLYLNEN-----------NLQTL------DNG-------VLEQFKQLQVLDLSFN 287
Cdd:PLN00113 239 NHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifSLQKLisldlsDNSlsgeipeLVIQLQNLEILHLFSN 318

                        250       260       270
                 ....*....|....*....|....*....|.
gi 17551022  288 NFTDITKEMFEGLESIQHLNLDSNRISAVAP 318
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLWSNKFSGEIP 349
LRR_8 pfam13855
Leucine rich repeat;
182-241 4.53e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 4.53e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   182 SLQNLILDNNCMTEFPSKAVRNMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNI 241
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-291 1.41e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  63 RELALENADIIEVgPKAFKTL-RIKKLILSNNRIEKIhDHAFTGLENvMQELSLSENNLKEVPtsALAGLRVLNILSLKC 141
Cdd:COG4886 185 KELDLSNNQITDL-PEPLGNLtNLEELDLSGNQLTDL-PEPLANLTN-LETLDLSNNQLTDLP--ELGNLTNLEELDLSN 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 142 NKIENITTKAfvNMTSLIDVNLGCNQICSMAADTFANVKMSLQNLILDNNCMTEFPSKAVRNMNNLIALHIKYNKINAIR 221
Cdd:COG4886 260 NQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 222 QNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTD 291
Cdd:COG4886 338 TTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
LRR_8 pfam13855
Leucine rich repeat;
278-323 2.26e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.26e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17551022   278 QLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRISAVAPGAFAG 323
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
LRR_8 pfam13855
Leucine rich repeat;
302-384 3.21e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   302 SIQHLNLDSNRISAVAPGAFAGtpllllwlpnncltevsqqtLKGapfLRMVSLSNNNIREVHELSFDHLPNLHTLDLAN 381
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG--------------------LSN---LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58


                  ...
gi 17551022   382 NKI 384
Cdd:pfam13855  59 NRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-398 3.68e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 3.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  113 LSLSENNLKEVPTSALAGLRVLNILSLKCNKIENITTKAFVNMTSLIDVNLGCNQICSMAADTFANvKMSLQNLILDNNC 192
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCS-SGNLFKLILFSNS 391

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  193 MTEFPSKAVRNMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLqtldNGV 272
Cdd:PLN00113 392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----FGG 467

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  273 LEQF---KQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRISAVAPgafagtpllllwlpnncltevsqQTLKGAPF 349
Cdd:PLN00113 468 LPDSfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP-----------------------DELSSCKK 524

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 17551022  350 LRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSLQNKSLSGPENL 398
Cdd:PLN00113 525 LVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
206-265 4.18e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   206 NLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNL 265
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
111-168 4.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17551022   111 QELSLSENNLKEVPTSALAGLRVLNILSLKCNKIENITTKAFVNMTSLIDVNLGCNQI 168
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 81-384 5.10e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 5.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  81 KTLRIKKLILSNNR----IEKIHDhaftglenvMQELSLSENNLKEVPTSALAGL----RVLNILSLKCNKIENITT--- 149
Cdd:cd00116   1 LQLSLKGELLKTERatelLPKLLC---------LQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRglq 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 150 ---KAFVNMTSLIDVNLGCNQICSMAADTFANV--KMSLQNLILDNNCM----TEFPSKAVR-NMNNLIALHIKYNkina 219
Cdd:cd00116  72 sllQGLTKGCGLQELDLSDNALGPDGCGVLESLlrSSSLQELKLNNNGLgdrgLRLLAKGLKdLPPALEKLVLGRN---- 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 220 irqndfvNLTSLSMLSLngnniseikGGALQNTPNLHYLYLNENNLQtlDNGV------LEQFKQLQVLDLSFNNFTD-- 291
Cdd:cd00116 148 -------RLEGASCEAL---------AKALRANRDLKELNLANNGIG--DAGIralaegLKANCNLEVLDLNNNGLTDeg 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 292 --ITKEMFEGLESIQHLNLDSNRISAVapGAfagtpllllwlpnnclTEVSQQTLKGAPFLRMVSLSNNNIREVHELSF- 368
Cdd:cd00116 210 asALAETLASLKSLEVLNLGDNNLTDA--GA----------------AALASALLSPNISLLTLSLSCNDITDDGAKDLa 271

                       330
                ....*....|....*....
gi 17551022 369 ---DHLPNLHTLDLANNKI 384
Cdd:cd00116 272 evlAEKESLLELDLRGNKF 290
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 74-208 6.84e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 46.00  E-value: 6.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022    74 EVGPKAFKTLRIKKLILSNNrIEKIHDHAFTGLENvMQELSLSeNNLKEVPTSALAGLrvlNILSLKC-NKIENITTKAF 152
Cdd:pfam13306   2 SIGSYAFYNCSLTSITIPSS-LTSIGEYAFSNCTS-LKSITLP-SSLTSIGSYAFYNC---SLTSITIpSSLTSIGEYAF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17551022   153 VNMTSLIDVNL--GCNQICSMAadtFANvkMSLQNLILDNNCmTEFPSKAVRNMNNLI 208
Cdd:pfam13306  76 SNCSNLKSITLpsNLTSIGSYA---FSN--CSLKSITIPSSV-TTIGSYAFSNCSNLK 127
LRR_8 pfam13855
Leucine rich repeat;
134-191 8.33e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17551022   134 LNILSLKCNKIENITTKAFVNMTSLIDVNLGCNQICSMAADTFANVKmSLQNLILDNN 191
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
350-398 1.11e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.11e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17551022   350 LRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKIMSLQNKSLSGPENL 398
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSL 51
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 230-394 3.78e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 3.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 230 SLSMLSLNGNNISEIK------GGALQNTPNLHYLYLNENNLQTLDNGVLEQFKQ---LQVLDLSfNNFTDITKEMF--E 298
Cdd:cd00116  52 SLKELCLSLNETGRIPrglqslLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLN-NNGLGDRGLRLlaK 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022 299 GLESIQH----LNLDSNRISAVAPGAFAGTpllllwlpnncltevsqqtLKGAPFLRMVSLSNNNIRE--VHEL--SFDH 370
Cdd:cd00116 131 GLKDLPPalekLVLGRNRLEGASCEALAKA-------------------LRANRDLKELNLANNGIGDagIRALaeGLKA 191

                       170       180
                ....*....|....*....|....
gi 17551022 371 LPNLHTLDLANNKIMSLQNKSLSG 394
Cdd:cd00116 192 NCNLEVLDLNNNGLTDEGASALAE 215
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-198 5.30e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   77 PKAFKTLRIKKLILSNNRIEKIHDHAFTGLENVMQeLSLSENNLKEVPTSALAGLRVLNILSLKCNKIENITTKAFVNMT 156
Cdd:PLN00113 469 PDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ-LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMP 547

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 17551022  157 SLIDVNLGCNQICSMAADTFANVKMSLQNLILDNNCMTEFPS 198
Cdd:PLN00113 548 VLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPS 589
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-209 2.37e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  86 KKLILSNNRIEKIhdhafTGLENV--MQELSLSENNLKEVPT--------SALAG-LRVLNILSlkcNKIENIttKAFVN 154
Cdd:cd21340  71 KKLYLGGNRISVV-----EGLENLtnLEELHIENQRLPPGEKltfdprslAALSNsLRVLNISG---NNIDSL--EPLAP 140

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17551022 155 MTSLIDVNLGCNQICSMA--ADTFANVKmSLQNLILDNNCMTefpsKAVRNMNNLIA 209
Cdd:cd21340 141 LRNLEQLDASNNQISDLEelLDLLSSWP-SLRELDLTGNPVC----KKPKYRDKIIL 192
PLN03150 PLN03150
hypothetical protein; Provisional
 224-323 3.11e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  224 DFVNLTSLSMLSLNGNNISEIKggALQNtpnlhyLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESI 303
Cdd:PLN03150 421 DGLGLDNQGLRGFIPNDISKLR--HLQS------INLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSL 492

                         90       100
                 ....*....|....*....|
gi 17551022  304 QHLNLDSNRISAVAPGAFAG 323
Cdd:PLN03150 493 RILNLNGNSLSGRVPAALGG 512
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 84-321 6.56e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 6.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   84 RIKKLILSNNRIEKIHDHAFtGLENVMQELSLSENNLKEVPTSALAGLRVLNILSLKCNKIE-NITTKAFvNMTSLIDVN 162
Cdd:PLN00113 381 NLFKLILFSNSLEGEIPKSL-GACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLS 458

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  163 LGCNQICSMAADTFANvkmslqnlildnncmtefpskavrnmNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNIS 242
Cdd:PLN00113 459 LARNKFFGGLPDSFGS--------------------------KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022  243 EIKGGALQNTPNLHYLYLNENNLQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSNRISAVAP--GA 320
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPstGA 592


                 .
gi 17551022  321 F 321
Cdd:PLN00113 593 F 593
LRR_9 pfam14580
Leucine-rich repeat;
218-290 1.01e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.52  E-value: 1.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17551022   218 NAIRQND-FVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLQTL-DNGVLEQFKQLQVLDLSFNNFT 290
Cdd:pfam14580  52 NEIRKLDgFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgDLDPLASLKKLTFLSLLRNPVT 126
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 253-293 1.21e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 17551022   253 PNLHYLYLNENNLQTLDNgvLEQFKQLQVLDLSFNNF-TDIT 293
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKiTDLS 40
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 43-256 1.62e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.78  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022    43 SGHDGLRMVEKLSTTttmeVRELALENADIIEVgPKAFKTLRIKKLILSNNRIEKIHDHA------FTGLENVMQELSLS 116
Cdd:PLN03210  712 SGCSRLKSFPDISTN----ISWLDLDETAIEEF-PSNLRLENLDELILCEMKSEKLWERVqpltplMTMLSPSLTRLFLS 786

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551022   117 EN-NLKEVPTSaLAGLRVLNILSL-KCNKIENITTKafVNMTSLIDVNL-GCNQIcsmaaDTFANVKMSLQNLILDNNCM 193
Cdd:PLN03210  787 DIpSLVELPSS-IQNLHKLEHLEIeNCINLETLPTG--INLESLESLDLsGCSRL-----RTFPDISTNISDLNLSRTGI 858

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17551022   194 TEFP------SKAVR----NMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKggalqNTPNLH 256
Cdd:PLN03210  859 EEVPwwiekfSNLSFldmnGCNNLQRVSLNISKLKHLETVDFSDCGALTEASWNGSPSEVAM-----ATDNIH 926
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 229-267 5.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17551022   229 TSLSMLSLNGNNISEIkgGALQNTPNLHYLYLNENNLQT 267
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 350-389 5.56e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 17551022   350 LRMVSLSNNNIREVHELSfdHLPNLHTLDLA-NNKIMSLQN 389
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLA--KLPNLETLDLSgNNKITDLSD 41
LRR_9 pfam14580
Leucine-rich repeat;
84-146 6.04e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.21  E-value: 6.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17551022    84 RIKKLILSNNRIEKIHDhaftGLENV---MQELSLSENNLKEVPT-SALAGLRVLNILSLKCNKIEN 146
Cdd:pfam14580  65 RLKTLLLNNNRICRIGE----GLGEAlpnLTELILTNNNLQELGDlDPLASLKKLTFLSLLRNPVTN 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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