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Conserved domains on  [gi|71992424|ref|NP_509443|]
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Apple domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 444-527 7.86e-15

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 70.58  E-value: 7.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424  444 KRDGCFEVIDDHLMVSVAGGLEHDMSIEECQCMCANSktsrrYEFQCRSATYYHAERDCILNLEDRNiksKLFEKQFTDV 523
Cdd:cd01099    1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEE-----TEFTCRSFNYNYKSKECILSDEDRM---SSGVKLLYDS 72


                 ....
gi 71992424  524 NVTY 527
Cdd:cd01099   73 NVDY 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 572-656 2.54e-12

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


:

Pssm-ID: 214680  Cd Length: 78  Bit Score: 63.37  E-value: 2.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     572 KSDDCYVELNDFVLEGTAIAVETAVTPEECKCKCAEGhklyGEECASFLYYYDSKTCLINKQNRFSNPEKFNfvpsiNQS 651
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNS----NCSCRSFTYNNGTKGCLLWSESSLGDARLFP-----SGG 71


                    ....*
gi 71992424     652 RSYFE 656
Cdd:smart00473   72 VDLYE 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 32-100 2.07e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


:

Pssm-ID: 214680  Cd Length: 78  Bit Score: 49.50  E-value: 2.07e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424      32 IRYDQAIEIDFYYTGINLASVKECAAFCAGREF-CRSAVYNSRTKTCGISYEYTVACASRTQRFKEYQVE 100
Cdd:smart00473    7 VRLPNTKLPGFSRIVISVASLEECASKCLNSNCsCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVDLYE 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 238-316 2.51e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


:

Pssm-ID: 214680  Cd Length: 78  Bit Score: 49.11  E-value: 2.51e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     238 KGPVCYRTIRHRYLLGADFEEHDVDSVNDCRCLCAatylpnNKKNKCMSFQFRNKT--CTLNKGNHLGQYDLIE-QRKTL 314
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCL------NSNCSCRSFTYNNGTkgCLLWSESSLGDARLFPsGGVDL 74


                    ..
gi 71992424     315 YQ 316
Cdd:smart00473   75 YE 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 1063-1139 1.64e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


:

Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.30  E-value: 1.64e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71992424   1063 CSYsALYQTSFLGRRLLKAVRVKTPADCFAAC-YALRCRSANLIAQGefNSCELYRDSLIDYrrPDMIGYDASTVYFD 1139
Cdd:pfam00024    1 CDF-ERVPGSSLSGVDVSTVTVSSAEECAQRCtNEPRCRSFTYNPKS--KKCHLKSSSSGSL--PRLKRSDNKVDYYE 73
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 444-527 7.86e-15

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 70.58  E-value: 7.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424  444 KRDGCFEVIDDHLMVSVAGGLEHDMSIEECQCMCANSktsrrYEFQCRSATYYHAERDCILNLEDRNiksKLFEKQFTDV 523
Cdd:cd01099    1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEE-----TEFTCRSFNYNYKSKECILSDEDRM---SSGVKLLYDS 72


                 ....
gi 71992424  524 NVTY 527
Cdd:cd01099   73 NVDY 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 572-656 2.54e-12

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 63.37  E-value: 2.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     572 KSDDCYVELNDFVLEGTAIAVETAVTPEECKCKCAEGhklyGEECASFLYYYDSKTCLINKQNRFSNPEKFNfvpsiNQS 651
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNS----NCSCRSFTYNNGTKGCLLWSESSLGDARLFP-----SGG 71


                    ....*
gi 71992424     652 RSYFE 656
Cdd:smart00473   72 VDLYE 76
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 572-658 1.00e-11

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 61.72  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424  572 KSDDCYVELNDFVLEGTAIAVETAVTPEECKCKCAEGhklYGEECASFLYYYDSKTCLINKQNRFSNPEKFnfvpSINQS 651
Cdd:cd01099    1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEE---TEFTCRSFNYNYKSKECILSDEDRMSSGVKL----LYDSN 73


                 ....*..
gi 71992424  652 RSYFEWT 658
Cdd:cd01099   74 VDYYENK 80
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 444-522 6.63e-11

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 59.51  E-value: 6.63e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71992424     444 KRDGCFEVIDDHLMVSVAGGLEHDMSIEECQCMCANSKtsrryeFQCRSATYYHAERDCILNLEDRNIKSKLFEKQFTD 522
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSN------CSCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVD 73
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 577-659 6.42e-08

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 51.01  E-value: 6.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424    577 YVELNDFVLEGTAIAVETAVTPEECKCKCAEGhklygEECASFLYYYDSKTCLINKQNRFSNPekfNFVPSiNQSRSYFE 656
Cdd:pfam00024    3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTNE-----PRCRSFTYNPKSKKCHLKSSSSGSLP---RLKRS-DNKVDYYE 73


                   ...
gi 71992424    657 WTC 659
Cdd:pfam00024   74 KSC 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 449-532 1.66e-07

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 49.47  E-value: 1.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424    449 FEVIDDHLMVSVAGGLEHDMSIEECQCMCANSKTsrryefqCRSATYYHAERDCILNLEDRNIKSKLFEKqftDVNVTYI 528
Cdd:pfam00024    3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPR-------CRSFTYNPKSKKCHLKSSSSGSLPRLKRS---DNKVDYY 72


                   ....
gi 71992424    529 GLAC 532
Cdd:pfam00024   73 EKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 32-100 2.07e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 49.50  E-value: 2.07e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424      32 IRYDQAIEIDFYYTGINLASVKECAAFCAGREF-CRSAVYNSRTKTCGISYEYTVACASRTQRFKEYQVE 100
Cdd:smart00473    7 VRLPNTKLPGFSRIVISVASLEECASKCLNSNCsCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVDLYE 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 238-316 2.51e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 49.11  E-value: 2.51e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     238 KGPVCYRTIRHRYLLGADFEEHDVDSVNDCRCLCAatylpnNKKNKCMSFQFRNKT--CTLNKGNHLGQYDLIE-QRKTL 314
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCL------NSNCSCRSFTYNNGTkgCLLWSESSLGDARLFPsGGVDL 74


                    ..
gi 71992424     315 YQ 316
Cdd:smart00473   75 YE 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 32-112 1.60e-05

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 44.08  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     32 IRYDQAIEIDFYYTGINLASVKECAAFCAGREFCRSAVYNSRTKTCGISYEYTVacasRTQRFKEYQVedgqGTDLVQIA 111
Cdd:pfam00024    4 ERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSG----SLPRLKRSDN----KVDYYEKS 75


                   .
gi 71992424    112 C 112
Cdd:pfam00024   76 C 76
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 32-82 1.76e-04

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 41.30  E-value: 1.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 71992424   32 IRYDQAIEIDFYYTGINLASVKECAAFCAG--REFCRSAVYNSRTKTCGISYE 82
Cdd:cd01099    7 VLVLNKILVSEVKTEITVASLEECLRKCLEetEFTCRSFNYNYKSKECILSDE 59
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 243-301 8.77e-04

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 39.07  E-value: 8.77e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71992424    243 YRTIRHRYLLGADFEEHDVDSVNDCRCLCAatylpnnKKNKCMSFQFRNKT--CTLNKGNH 301
Cdd:pfam00024    3 FERVPGSSLSGVDVSTVTVSSAEECAQRCT-------NEPRCRSFTYNPKSkkCHLKSSSS 56
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 1063-1139 1.64e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.30  E-value: 1.64e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71992424   1063 CSYsALYQTSFLGRRLLKAVRVKTPADCFAAC-YALRCRSANLIAQGefNSCELYRDSLIDYrrPDMIGYDASTVYFD 1139
Cdd:pfam00024    1 CDF-ERVPGSSLSGVDVSTVTVSSAEECAQRCtNEPRCRSFTYNPKS--KKCHLKSSSSGSL--PRLKRSDNKVDYYE 73
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 444-527 7.86e-15

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 70.58  E-value: 7.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424  444 KRDGCFEVIDDHLMVSVAGGLEHDMSIEECQCMCANSktsrrYEFQCRSATYYHAERDCILNLEDRNiksKLFEKQFTDV 523
Cdd:cd01099    1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEE-----TEFTCRSFNYNYKSKECILSDEDRM---SSGVKLLYDS 72


                 ....
gi 71992424  524 NVTY 527
Cdd:cd01099   73 NVDY 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 572-656 2.54e-12

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 63.37  E-value: 2.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     572 KSDDCYVELNDFVLEGTAIAVETAVTPEECKCKCAEGhklyGEECASFLYYYDSKTCLINKQNRFSNPEKFNfvpsiNQS 651
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNS----NCSCRSFTYNNGTKGCLLWSESSLGDARLFP-----SGG 71


                    ....*
gi 71992424     652 RSYFE 656
Cdd:smart00473   72 VDLYE 76
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 572-658 1.00e-11

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 61.72  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424  572 KSDDCYVELNDFVLEGTAIAVETAVTPEECKCKCAEGhklYGEECASFLYYYDSKTCLINKQNRFSNPEKFnfvpSINQS 651
Cdd:cd01099    1 LNDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEE---TEFTCRSFNYNYKSKECILSDEDRMSSGVKL----LYDSN 73


                 ....*..
gi 71992424  652 RSYFEWT 658
Cdd:cd01099   74 VDYYENK 80
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 444-522 6.63e-11

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 59.51  E-value: 6.63e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71992424     444 KRDGCFEVIDDHLMVSVAGGLEHDMSIEECQCMCANSKtsrryeFQCRSATYYHAERDCILNLEDRNIKSKLFEKQFTD 522
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSN------CSCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVD 73
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 577-659 6.42e-08

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 51.01  E-value: 6.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424    577 YVELNDFVLEGTAIAVETAVTPEECKCKCAEGhklygEECASFLYYYDSKTCLINKQNRFSNPekfNFVPSiNQSRSYFE 656
Cdd:pfam00024    3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTNE-----PRCRSFTYNPKSKKCHLKSSSSGSLP---RLKRS-DNKVDYYE 73


                   ...
gi 71992424    657 WTC 659
Cdd:pfam00024   74 KSC 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 449-532 1.66e-07

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 49.47  E-value: 1.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424    449 FEVIDDHLMVSVAGGLEHDMSIEECQCMCANSKTsrryefqCRSATYYHAERDCILNLEDRNIKSKLFEKqftDVNVTYI 528
Cdd:pfam00024    3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPR-------CRSFTYNPKSKKCHLKSSSSGSLPRLKRS---DNKVDYY 72


                   ....
gi 71992424    529 GLAC 532
Cdd:pfam00024   73 EKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 32-100 2.07e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 49.50  E-value: 2.07e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424      32 IRYDQAIEIDFYYTGINLASVKECAAFCAGREF-CRSAVYNSRTKTCGISYEYTVACASRTQRFKEYQVE 100
Cdd:smart00473    7 VRLPNTKLPGFSRIVISVASLEECASKCLNSNCsCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVDLYE 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 238-316 2.51e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 49.11  E-value: 2.51e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     238 KGPVCYRTIRHRYLLGADFEEHDVDSVNDCRCLCAatylpnNKKNKCMSFQFRNKT--CTLNKGNHLGQYDLIE-QRKTL 314
Cdd:smart00473    1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCL------NSNCSCRSFTYNNGTkgCLLWSESSLGDARLFPsGGVDL 74


                    ..
gi 71992424     315 YQ 316
Cdd:smart00473   75 YE 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 32-112 1.60e-05

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 44.08  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71992424     32 IRYDQAIEIDFYYTGINLASVKECAAFCAGREFCRSAVYNSRTKTCGISYEYTVacasRTQRFKEYQVedgqGTDLVQIA 111
Cdd:pfam00024    4 ERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSG----SLPRLKRSDN----KVDYYEKS 75


                   .
gi 71992424    112 C 112
Cdd:pfam00024   76 C 76
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 32-82 1.76e-04

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 41.30  E-value: 1.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 71992424   32 IRYDQAIEIDFYYTGINLASVKECAAFCAG--REFCRSAVYNSRTKTCGISYE 82
Cdd:cd01099    7 VLVLNKILVSEVKTEITVASLEECLRKCLEetEFTCRSFNYNYKSKECILSDE 59
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 243-301 8.77e-04

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 39.07  E-value: 8.77e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71992424    243 YRTIRHRYLLGADFEEHDVDSVNDCRCLCAatylpnnKKNKCMSFQFRNKT--CTLNKGNH 301
Cdd:pfam00024    3 FERVPGSSLSGVDVSTVTVSSAEECAQRCT-------NEPRCRSFTYNPKSkkCHLKSSSS 56
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 1063-1139 1.64e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.30  E-value: 1.64e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71992424   1063 CSYsALYQTSFLGRRLLKAVRVKTPADCFAAC-YALRCRSANLIAQGefNSCELYRDSLIDYrrPDMIGYDASTVYFD 1139
Cdd:pfam00024    1 CDF-ERVPGSSLSGVDVSTVTVSSAEECAQRCtNEPRCRSFTYNPKS--KKCHLKSSSSGSL--PRLKRSDNKVDYYE 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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