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Conserved domains on  [gi|17561346|ref|NP_507998|]
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SAM domain-containing protein [Caenorhabditis elegans]

Protein Classification

SAM domain-containing protein; ACK family non-receptor tyrosine-protein kinase( domain architecture ID 10175790)

SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation| ACK (activated Cdc42-associated kinase) family non-receptor tyrosine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates; such as TNK1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SAM_CS047 cd09531
SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a ...
1-65 7.16e-32

SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a putative protein-protein interaction domain. Proteins of this subfamily have a SAM domain at the N-terminus. SAM is a widespread domain in signaling and regulatory proteins. In many cases SAM mediates homodimerization/oligomerization. The exact function of proteins belonging to this group is unknown.


:

Pssm-ID: 188930 [Multi-domain]  Cd Length: 65  Bit Score: 114.32  E-value: 7.16e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17561346   1 MEAWTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKAAK 65
Cdd:cd09531   1 TSEWIKFFKDAGIPSGLAAKYAVIFVENRIQKEMLLDLNKEILKEMGITVMGDIIAILKHAKKVH 65
 
Name Accession Description Interval E-value
SAM_CS047 cd09531
SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a ...
1-65 7.16e-32

SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a putative protein-protein interaction domain. Proteins of this subfamily have a SAM domain at the N-terminus. SAM is a widespread domain in signaling and regulatory proteins. In many cases SAM mediates homodimerization/oligomerization. The exact function of proteins belonging to this group is unknown.


Pssm-ID: 188930 [Multi-domain]  Cd Length: 65  Bit Score: 114.32  E-value: 7.16e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17561346   1 MEAWTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKAAK 65
Cdd:cd09531   1 TSEWIKFFKDAGIPSGLAAKYAVIFVENRIQKEMLLDLNKEILKEMGITVMGDIIAILKHAKKVH 65
SAM_4 pfam18017
SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the ...
4-76 3.36e-14

SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the N-terminus of the human C19orf47 protein.


Pssm-ID: 407856 [Multi-domain]  Cd Length: 84  Bit Score: 67.40  E-value: 3.36e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17561346     4 WTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKAA-KSAIEREAEEAI 76
Cdd:pfam18017  11 WIQFFKDAGIPAGLAVNYAVMFVDNRIQKNMLLDLNKDIMMDLGITVIGDIIAILKHAKQVhRQDMCKAATEAI 84
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
1-65 2.12e-07

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 47.68  E-value: 2.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17561346      1 MEAWTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDK-STLSELGVSAIGDQLCILRRIKAAK 65
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLLTSeEDLKELGITKLGHRKKILKAIQKLK 66
 
Name Accession Description Interval E-value
SAM_CS047 cd09531
SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a ...
1-65 7.16e-32

SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a putative protein-protein interaction domain. Proteins of this subfamily have a SAM domain at the N-terminus. SAM is a widespread domain in signaling and regulatory proteins. In many cases SAM mediates homodimerization/oligomerization. The exact function of proteins belonging to this group is unknown.


Pssm-ID: 188930 [Multi-domain]  Cd Length: 65  Bit Score: 114.32  E-value: 7.16e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17561346   1 MEAWTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKAAK 65
Cdd:cd09531   1 TSEWIKFFKDAGIPSGLAAKYAVIFVENRIQKEMLLDLNKEILKEMGITVMGDIIAILKHAKKVH 65
SAM_4 pfam18017
SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the ...
4-76 3.36e-14

SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the N-terminus of the human C19orf47 protein.


Pssm-ID: 407856 [Multi-domain]  Cd Length: 84  Bit Score: 67.40  E-value: 3.36e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17561346     4 WTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKAA-KSAIEREAEEAI 76
Cdd:pfam18017  11 WIQFFKDAGIPAGLAVNYAVMFVDNRIQKNMLLDLNKDIMMDLGITVIGDIIAILKHAKQVhRQDMCKAATEAI 84
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
2-65 3.33e-12

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 61.13  E-value: 3.33e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17561346     2 EAWTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKAAK 65
Cdd:pfam00536   1 DGWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQRLK 64
SAM_Ste11_fungal cd09534
SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a ...
20-62 3.71e-08

SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a protein-protein interaction domain. Proteins of this subfamily have SAM domain at the N-terminus and protein kinase domain at the C-terminus. They participate in regulation of mating pheromone response, invasive growth and high osmolarity growth response. MAP triple kinase Ste11 from S.cerevisia is known to interact with Ste20 kinase and Ste50 regulator. These kinases are able to form homodimers interacting through their SAM domains as well as heterodimers or heterogenous complexes when either SAM domain of monomeric or homodimeric form of Ste11 interacts with Ste50 regulator.


Pssm-ID: 188933  Cd Length: 62  Bit Score: 49.52  E-value: 3.71e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 17561346  20 KYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIK 62
Cdd:cd09534  17 QYLDIFEKNLITGDLLLELDKEALKELGITKVGDRIRLLRAIK 59
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
4-62 8.96e-08

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 48.39  E-value: 8.96e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17561346   4 WTQFFVRAGIPseiakKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIK 62
Cdd:cd09487   2 VAEWLESLGLE-----QYADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQ 55
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
1-65 2.12e-07

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 47.68  E-value: 2.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17561346      1 MEAWTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDK-STLSELGVSAIGDQLCILRRIKAAK 65
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLLTSeEDLKELGITKLGHRKKILKAIQKLK 66
SAM_SLA1_fungal cd09532
SAM domain of SLA1 subfamily; SAM (sterile alpha motif) domain of fungal SLA1 proteins is a ...
4-62 3.25e-07

SAM domain of SLA1 subfamily; SAM (sterile alpha motif) domain of fungal SLA1 proteins is a protein-protein interaction domain. Proteins of this group consist of a few N-terminal SH3 domains followed by SHD1 domain, SAM domain (also known as SHD2) and multiple C-terminal repeats. The yeast SLA1 protein is an endocytic clathrin adaptor. It is associated with a variety of endocytic accessory factors and required for endocytic vesicle formation and for clathrin and actin-dependent cargo recognition. SLA1 binds clathrin through a variant clathrin-binding motif (vCB). The SAM domain negatively regulates this binding by blocking the vCB site. The SAM domains of SLA1 proteins can form oligomers via their mid-loop (ML) and end-helix (EH) regions. Such self-associations apparently are important for SLA1 function. A proposed regulatory model suggests that SAM can be considered a mediator of two aspects of clathrin adaptor function. It plays a role in negative regulation of clathrin binding via an intramolecular interaction with the vCB, and a role in positive regulation of vesicle coat assembly via self-oligomerization.


Pssm-ID: 188931 [Multi-domain]  Cd Length: 62  Bit Score: 47.01  E-value: 3.25e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17561346   4 WTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAiGDqlcILRRIK 62
Cdd:cd09532   3 WFEFFLNCGVDVSLCQRYASNFERDQMDESVLPDINPSTLRTLGLRE-GD---IIRVMK 57
SAM_Ste50-like_fungal cd09533
SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or ...
20-61 5.33e-06

SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or Ubc2 for Ustilago bypass of cyclase) subfamily is a putative protein-protein interaction domain. This group includes only fungal proteins. Basidiomycetes have an N-terminal SAM domain, central UBQ domain, and C-terminal SH3 domain, while Ascomycetes lack the SH3 domain. Ubc2 of Ustilago maydis is a major virulence and maize pathogenicity factor. It is required for filamentous growth (the budding haploid form of Ustilago maydis is a saprophyte, while filamentous dikaryotic form is a pathogen). Also the Ubc2 protein is involved in the pheromone-responsive morphogenesis via the MAP kinase cascade. The SAM domain is necessary for ubc2 function; deletion of SAM eliminates this function. A Lys-to-Glu mutation in the SAM domain of ubc2 gene induces temperature sensitivity.


Pssm-ID: 188932  Cd Length: 58  Bit Score: 43.46  E-value: 5.33e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17561346  20 KYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRI 61
Cdd:cd09533  13 QYEDQFIENGITGDVLVALDHEDLKEMGITSVGHRLTILKAV 54
SAM_Shank1,2,3 cd09506
SAM domain of Shank1,2,3 family proteins; SAM (sterile alpha motif) domain of Shank1,2,3 ...
4-62 7.27e-06

SAM domain of Shank1,2,3 family proteins; SAM (sterile alpha motif) domain of Shank1,2,3 family proteins is a protein-protein interaction domain. Shank1,2,3 proteins are scaffold proteins that are known to interact with a variety of cytoplasmic and membrane proteins. SAM domains of the Shank1,2,3 family are prone to homooligomerization. They are highly enriched in the postsynaptic density, acting as scaffolds to organize assembly of postsynaptic proteins. SAM domains of Shank3 proteins can form large sheets of helical fibers. Shank genes show distinct patterns of expression, in rat Shank1 mRNA is found almost exclusively in brain, Shank2 in brain, kidney and liver, and Shank3 in heart, brain and spleen.


Pssm-ID: 188905  Cd Length: 66  Bit Score: 43.08  E-value: 7.27e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17561346   4 WTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIK 62
Cdd:cd09506   5 WTVDDVGDWLESLNLGEHRERFMDNEIDGSHLPNLDKEDLTELGVTRVGHRMNIERALK 63
SAM_TAL cd09523
SAM domain of TAL subfamily; SAM (sterile alpha motif) domain of TAL (Tsg101-associated ligase) ...
18-63 4.19e-04

SAM domain of TAL subfamily; SAM (sterile alpha motif) domain of TAL (Tsg101-associated ligase) proteins, also known as LRSAM1 (Leucine-rich repeat and sterile alpha motif-containing) proteins, is a putative protein-protein interaction domain. Proteins of this subfamily participate in the regulation of retrovirus budding and receptor endocytosis. They show E3 ubiquitin ligase activity. Human TAL protein interacts with Tsg101 and TAL's C-terminal ring finger domain is essential for the multiple monoubiquitylation of Tsg101.


Pssm-ID: 188922  Cd Length: 65  Bit Score: 38.04  E-value: 4.19e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17561346  18 AKKYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKA 63
Cdd:cd09523  17 AEHYLPVFARHRITMETLSTMTDEDLKKIGIHEIGLRKEILRAAQE 62
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
19-65 4.39e-04

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 38.02  E-value: 4.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 17561346    19 KKYAKSFATNRITK-EMLPELDKSTLSELGVSAIGDQLCILRRIKAAK 65
Cdd:pfam07647  19 EQYTDNFRDQGITGaELLLRLTLEDLKRLGITSVGHRRKILKKIQELK 66
SAM_WDSUB1 cd09505
SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins ...
2-65 3.05e-03

SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins is a putative protein-protein interaction domain. Proteins of this group contain multiple domains: SAM, one or more WD40 repeats and U-box (derived version of the RING-finger domain). Apparently the WDSUB1 subfamily proteins participate in protein degradation through ubiquitination, since U-box domain are known as a member of E3 ubiquitin ligase family, while SAM and WD40 domains most probably are responsible for an E2 ubiquitin-conjugating enzyme binding and a target protein binding.


Pssm-ID: 188904  Cd Length: 72  Bit Score: 36.14  E-value: 3.05e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17561346   2 EAWTQFFVRAGIPSEIAKKYAKSFATNRITKEMLPELDKSTLS-ELGVSAIGDQLCILRRIKAAK 65
Cdd:cd09505   3 QDWSEEDVCTWLRSIGLEQYVEVFRANNIDGKELLNLTKESLSkDLKIESLGHRNKILRKIEELK 67
SAM_Neurabin-like cd09512
SAM domain of SAM_Neurabin-like subfamily; SAM (sterile alpha motif) domain of Neurabin-like ...
20-67 8.79e-03

SAM domain of SAM_Neurabin-like subfamily; SAM (sterile alpha motif) domain of Neurabin-like (Neural actin-binding) subfamily is a putative protein-protein interaction domain. This group currently includes the SAM domains of neurobin-I, SAMD14 and neurobin-I/SAMD14-like proteins. Most are multidomain proteins and in addition to SAM domain they contain other protein-binding domains such as PDZ and actin-binding domains. Members of this subfamily participate in signal transduction. Neurabin-I is involved in the regulation of Ca signaling intensity in alpha-adrenergic receptors; it forms a functional pair of opposing regulators with neurabin-II. Neurabins are expressed almost exclusively in neuronal cells. They are known to interact with protein phosphatase 1 and inhibit its activity; they also can bind actin filaments; however, the exact role of the SAM domain is unclear, since SAM doesn't participate in these interactions.


Pssm-ID: 188911 [Multi-domain]  Cd Length: 70  Bit Score: 34.55  E-value: 8.79e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 17561346  20 KYAKSFATNRITKEMLPELDKSTLSELGVSAIGDQLCILRRIKAAKSA 67
Cdd:cd09512  23 QYIPEFTANNIDGQQLLQLDSSKLKALGITSSSDRSLLKKKLKELKAQ 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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