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Conserved domains on  [gi|212646538|ref|NP_507162|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-317 1.31e-103

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 306.30  E-value: 1.31e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   11 VSQFGFFVTTSSQLTVIFLTVFCVRRDLGAYKHLVVLFSTVGVLFALLEFLLYPAsgLHSHSAAYIVYINNRPFDASKEF 90
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPF--IHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   91 LTVLLAVYCSLYCAAISLLAVQFIYRYIAVFCPIHLKYFNKCYLLIWIFYAVLIGVEWGIGIYKFDEVDEYSEEYMRETM 170
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538  171 MDYYQLDVTKIPCLVTVIYQTIPNsTETFIRWKNAFATINMTIFATLQYSIMIYCSYKLYNDMEEKLSLLSEDARKLHRQ 250
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDEN-GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212646538  251 IFKTLLLQLITPTIAMYTPVFTVIYLPFLNLEYTLPTGIFMGIFALYPALDAVILMYVITDYRRALI 317
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-317 1.31e-103

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 306.30  E-value: 1.31e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   11 VSQFGFFVTTSSQLTVIFLTVFCVRRDLGAYKHLVVLFSTVGVLFALLEFLLYPAsgLHSHSAAYIVYINNRPFDASKEF 90
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPF--IHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   91 LTVLLAVYCSLYCAAISLLAVQFIYRYIAVFCPIHLKYFNKCYLLIWIFYAVLIGVEWGIGIYKFDEVDEYSEEYMRETM 170
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538  171 MDYYQLDVTKIPCLVTVIYQTIPNsTETFIRWKNAFATINMTIFATLQYSIMIYCSYKLYNDMEEKLSLLSEDARKLHRQ 250
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDEN-GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212646538  251 IFKTLLLQLITPTIAMYTPVFTVIYLPFLNLEYTLPTGIFMGIFALYPALDAVILMYVITDYRRALI 317
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-317 1.31e-103

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 306.30  E-value: 1.31e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   11 VSQFGFFVTTSSQLTVIFLTVFCVRRDLGAYKHLVVLFSTVGVLFALLEFLLYPAsgLHSHSAAYIVYINNRPFDASKEF 90
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPF--IHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   91 LTVLLAVYCSLYCAAISLLAVQFIYRYIAVFCPIHLKYFNKCYLLIWIFYAVLIGVEWGIGIYKFDEVDEYSEEYMRETM 170
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538  171 MDYYQLDVTKIPCLVTVIYQTIPNsTETFIRWKNAFATINMTIFATLQYSIMIYCSYKLYNDMEEKLSLLSEDARKLHRQ 250
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDEN-GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212646538  251 IFKTLLLQLITPTIAMYTPVFTVIYLPFLNLEYTLPTGIFMGIFALYPALDAVILMYVITDYRRALI 317
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 27-316 1.56e-29

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 115.03  E-value: 1.56e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   27 IFLTVFCVRRDLGAYKHLVVLFSTVGVLFALLEFLLypASGLHSHSAAYIVYINNRPFDASKEFLTVLLAVYCSLYCAAI 106
Cdd:pfam10319  26 IYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLV--PLDIHSYRYCFVVFVSDGPFFEYSELGQHALSARCSFISASY 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538  107 SLLAVQFIYRYIAVFCP-IHLKYFNKCYLLIWIFYAVLIGVEWGIGIYKFDEVDEYSEEYMRETMMDYYQLDVTKIPCLV 185
Cdd:pfam10319 104 AVLLIHFIYRYLVLFNPqLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVDSMDINMLG 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538  186 TVIYQTIPNstetfIRWKNAFATINMTIFATLQYSIMIYCSYKLYNDMEEKLSLLSEDARKLHRQIFKTLLLQLITPTIA 265
Cdd:pfam10319 184 ALYWEASDE-----TVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICI 258

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 212646538  266 MYTPVFTVIYLPFLNLEYTLPTGIFMGI-FALYPALDAVILMYVITDYRRAL 316
Cdd:pfam10319 259 SFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 16-317 2.94e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 54.09  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   16 FFVTTSSQLTVIFLTVFCVRRDLGAYKHLVVLFSTVGVLFALLEFLLYPASGLHSHSAAYIVYINNRPFDASkeFLTVLL 95
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPW--FCYSGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   96 AVYCSLYCAAISLLAVQFIYRYIAVFCPiHLKyFNKCYLLIWIFYAVLIGVewgIGIYKFDEVDEYSEEYMRETMMDYYQ 175
Cdd:pfam10317  87 SLLQHFLLHSGWSLLLTFYYRYYILKHV-DPK-RKKLILLIIIHYIPSLSQ---LIVIFLSPTDFLPVEALTKELHPNYN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538  176 LDvtkipclvtvIYQTIPNSTetFIRWKNAFATINMTIFATLQYSIMIYCSYKLYNDMEEKLSLLSEDARKLHRQIFKTL 255
Cdd:pfam10317 162 LT----------DYTVTGFSD--LQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGL 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212646538  256 LLQLITPTIAMYTPVFTVIYLPFLNLEYTLPTGIFMGIFALYPALDAVILMYVITDYRRALI 317
Cdd:pfam10317 230 TIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 97-322 7.84e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 43.69  E-value: 7.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538   97 VYCSLYCAAISLLAVqFIYRYIAVFcPIHLKYFNKCYLLIWIFYAVLIGVEWGIGIYKFDEVDEYSEEYMRETMMDYYQL 176
Cdd:pfam10318  92 GVTSLALVGVSIILL-FENRYSILF-TNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLKKLPCLPPE 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646538  177 DVTKIPCLVTVIYQTIPNSTETFIrwkNAFATINMTIFATLqysimiyCSYKLYNDMEeklSLLSEDARKLHRQIFKTLL 256
Cdd:pfam10318 170 FFDNPPVFVLAIDSTYFLICIVLL---ILILIIQILFFVFL-------TIYYLFKSVK---SSLSKKTRKLQKKFFIALI 236

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212646538  257 LQLITPTIAMYTPVFTVIYLPFLNLEYTLPTGIFMGIFALYPALDAVILMYVITDYRRALIDVLKF 322
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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