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Conserved domains on  [gi|212646530|ref|NP_506837|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 17778750)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 267-410 2.26e-24

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 98.03  E-value: 2.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646530  267 KTNVNFVEDVFKSVKDLHLEKINFKGINYEEIDTILRHLKTGVLKEIsfdyKITNSTIIPPIGDMVYLEQWKNAENLCIH 346
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEI----ELSSESDEDQFEEIVELEQWKNAKSLKIE 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212646530  347 SHISLGSLLDHISHFHTIDILCHTFSRLQILQLQKIIDTSKTMRKCVFRGPI-NLFGLAKVFDPK 410
Cdd:pfam01827  77 GSSLSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDlNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 149-194 2.67e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 2.67e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 212646530 149 LPDLPSELLQKITKQLDTRNRMTIRKVCRILRDAIDYQGSGVKSVK 194
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 267-410 2.26e-24

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 98.03  E-value: 2.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646530  267 KTNVNFVEDVFKSVKDLHLEKINFKGINYEEIDTILRHLKTGVLKEIsfdyKITNSTIIPPIGDMVYLEQWKNAENLCIH 346
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEI----ELSSESDEDQFEEIVELEQWKNAKSLKIE 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212646530  347 SHISLGSLLDHISHFHTIDILCHTFSRLQILQLQKIIDTSKTMRKCVFRGPI-NLFGLAKVFDPK 410
Cdd:pfam01827  77 GSSLSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDlNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 149-194 2.67e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 2.67e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 212646530 149 LPDLPSELLQKITKQLDTRNRMTIRKVCRILRDAIDYQGSGVKSVK 194
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
152-192 1.39e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 1.39e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 212646530   152 LPSELLQKITKQLDTRNRMTIRKVCRILRDAIDYQGSGVKS 192
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 149-184 7.79e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.83  E-value: 7.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 212646530  149 LPDLPSELLQKITKQLDTRNRMTIRKVCRILRDAID 184
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 267-410 2.26e-24

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 98.03  E-value: 2.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646530  267 KTNVNFVEDVFKSVKDLHLEKINFKGINYEEIDTILRHLKTGVLKEIsfdyKITNSTIIPPIGDMVYLEQWKNAENLCIH 346
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEI----ELSSESDEDQFEEIVELEQWKNAKSLKIE 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212646530  347 SHISLGSLLDHISHFHTIDILCHTFSRLQILQLQKIIDTSKTMRKCVFRGPI-NLFGLAKVFDPK 410
Cdd:pfam01827  77 GSSLSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDlNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 149-194 2.67e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 2.67e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 212646530 149 LPDLPSELLQKITKQLDTRNRMTIRKVCRILRDAIDYQGSGVKSVK 194
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
152-192 1.39e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 1.39e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 212646530   152 LPSELLQKITKQLDTRNRMTIRKVCRILRDAIDYQGSGVKS 192
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 149-184 7.79e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.83  E-value: 7.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 212646530  149 LPDLPSELLQKITKQLDTRNRMTIRKVCRILRDAID 184
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 149-184 1.85e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 35.92  E-value: 1.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 212646530  149 LPDLPSELLQKITKQLDTRNRMTIRKVCRILRDAID 184
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELAS 36
F-box_AtSKP2-like cd22161
F-box domain found in Arabidopsis thaliana SKP2-like proteins (AtSKP2A and AtSKP2B) and ...
 151-183 2.96e-03

F-box domain found in Arabidopsis thaliana SKP2-like proteins (AtSKP2A and AtSKP2B) and similar proteins; AtSKP2A, also called FBL5-like protein (AtFBL5), is an F-box protein that regulates cell division and is degraded via the ubiquitin pathway. It acts as an auxin receptor. AtSKP2B, also called F-box/LRR-repeat protein 5 (AtFB5), is an F-box protein that does not interact with auxin. Both AtSKP2A and AtSKP2B are components of SCF(SKP2A/SKP2B) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (including cell cycle repressors). AtSKP2A regulates the stability of the transcription factors E2FC and DPB, repressors of cell proliferation. It confers increased tolerance to osmotic stress by promoting cell division, especially in meristems and promotes the formation of lateral root primordia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438932  Cd Length: 48  Bit Score: 35.49  E-value: 2.96e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 212646530 151 DLPSELLQKITKQLDTRNRMTIRKVCRILRDAI 183
Cdd:cd22161    4 DLPMELLVRILSLVDDRTVIIASGVCTGWRDAV 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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