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Conserved domains on  [gi|72000302|ref|NP_505871|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
15-316 6.93e-91

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 273.65  E-value: 6.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    15 DTHDFLGLYSHLISIIAIPVNVLGIWLIFYKTPIRMKNMKGVMLNCHVWGLVGDFMLGTLTIPYVFFPVIAGTPLGILTr 94
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLS- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    95 FFDINAFFQTYLAVACIAEVGSSIVFMFENRQNQTVTSNWKISSATGRKSFVSINLVFPWVASTISLLRIPNQTWAKLEL 174
Cdd:pfam10318  80 YLGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302   175 LKTIPCPSAEFFQL-PIIIVTTEAKSIGLALLALVLFYAIQILVFIIHSSLYLCISTKSfSMSEKTKKLKRKYFIAVCVQ 253
Cdd:pfam10318 160 LKKLPCLPPEFFDNpPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKS-SLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72000302   254 VFIPFVIMAVPVNYYSFSIITDYYNQSANNFCFLIMSLHGFFSTIATIAIYENYRNYILHILR 316
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
15-316 6.93e-91

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 273.65  E-value: 6.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    15 DTHDFLGLYSHLISIIAIPVNVLGIWLIFYKTPIRMKNMKGVMLNCHVWGLVGDFMLGTLTIPYVFFPVIAGTPLGILTr 94
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLS- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    95 FFDINAFFQTYLAVACIAEVGSSIVFMFENRQNQTVTSNWKISSATGRKSFVSINLVFPWVASTISLLRIPNQTWAKLEL 174
Cdd:pfam10318  80 YLGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302   175 LKTIPCPSAEFFQL-PIIIVTTEAKSIGLALLALVLFYAIQILVFIIHSSLYLCISTKSfSMSEKTKKLKRKYFIAVCVQ 253
Cdd:pfam10318 160 LKKLPCLPPEFFDNpPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKS-SLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72000302   254 VFIPFVIMAVPVNYYSFSIITDYYNQSANNFCFLIMSLHGFFSTIATIAIYENYRNYILHILR 316
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
15-316 6.93e-91

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 273.65  E-value: 6.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    15 DTHDFLGLYSHLISIIAIPVNVLGIWLIFYKTPIRMKNMKGVMLNCHVWGLVGDFMLGTLTIPYVFFPVIAGTPLGILTr 94
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLS- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    95 FFDINAFFQTYLAVACIAEVGSSIVFMFENRQNQTVTSNWKISSATGRKSFVSINLVFPWVASTISLLRIPNQTWAKLEL 174
Cdd:pfam10318  80 YLGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302   175 LKTIPCPSAEFFQL-PIIIVTTEAKSIGLALLALVLFYAIQILVFIIHSSLYLCISTKSfSMSEKTKKLKRKYFIAVCVQ 253
Cdd:pfam10318 160 LKKLPCLPPEFFDNpPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKS-SLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72000302   254 VFIPFVIMAVPVNYYSFSIITDYYNQSANNFCFLIMSLHGFFSTIATIAIYENYRNYILHILR 316
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
14-311 2.53e-15

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 75.27  E-value: 2.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    14 FDTHDFLGLYSHLISIIAIPVNVLGIWLIFYKTPiRMKNMKGVMLNCHVWGLVGDFMLGTLTIPYVFFPVIAGTPLGILT 93
Cdd:pfam10327   5 FTVPFWLILYYHIIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302    94 RFFDINAFFQTYLAVACIAEVGSSIVFMFENRQN--QTVTSNWKIsSATGRKSFVSINLVFPWV-ASTISLLRIPNQTwa 170
Cdd:pfam10327  84 TVFGISSHYLMTIFVFLLSFQLESLLLCFVRKHQaiAKILSKHVI-PKWLYIFLYILCHIFPFLtAFLFYQSGLSREE-- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302   171 KLELLK-TIPCPSAEFFQLP---------IIIVTTEAKSIGLALLALVLFYAIqILVFIIHSSLYLCISTKSFSMsektk 240
Cdd:pfam10327 161 QLEYVKeNYPEYLSQFSSLPnfaiydynpWLIVFGILAIFGGSLSFLILVYLT-VDMFRMLKRLRKKISAQTYQK----- 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72000302   241 klKRKYFIAVCVQVFIPFVIMaVPVNYYSFSIITDYYN-QSANNFCFLIMSLHGFFSTIATIAIYENYRNYI 311
Cdd:pfam10327 235 --HRAALRSLIAQFATSPVCI-LPPFAFVVVVLFPIEYsQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
210-312 1.09e-03

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 40.13  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302   210 FYAIQILVFIIHSSL----------YLCISTKSFSMSEKTKKLKRKYFIAVCVQVFIPFVIMAVPVNYYSFSIITDYYNQ 279
Cdd:pfam10326 195 LIGLLIMTFIIGISFsiiiycgikmYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIG 274
                          90       100       110
                  ....*....|....*....|....*....|...
gi 72000302   280 SANNFCFLIMSLHGFFSTIATIAIYENYRNYIL 312
Cdd:pfam10326 275 FLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
194-311 7.00e-03

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 37.61  E-value: 7.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000302   194 TTEAKSIGLALLALVLFYAIQILVFI---IHSSLylciSTKSFSMSEKTKKLKRKYFIAVCVQVFIPFVIMAVP--VNYY 268
Cdd:pfam10319 193 TVFRSWLGILLLTVISVYSIILYIVLgykIMRKL----NKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPcvLAWY 268
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 72000302   269 SfSIITDYYNQSANNFCFLIMSLHGFFSTIATIAIYENYRNYI 311
Cdd:pfam10319 269 S-PIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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