NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17563624|ref|NP_503981|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-318 4.09e-110

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.87  E-value: 4.09e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    10 LKLIQDVSAVFSIVINTFLIALILTKSPKHLGAYKWLMIYISVFEIFYSILDVFLVPQHYSHGPTFLVIVGLKDKLFGPP 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    90 GLLILNSCYWGCFGASMAMFAVHFVYRWLVVTKHPLIETFYGWKICIWFSVPMWYGLTWICTGYILSAPNEHTSRFIKDN 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624   170 IKEIFELKIDAYVYLGPFLYERADNGTVNVHIVPFIGLAIISGTIISSVTIVLVFGILCYQKISCLVaiTVGSGKLIKLQ 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLK--SLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563624   250 RQLFFALVIQTLVPFLLMHIPAAIMFAFVFLDIDLGVYSAVVSMTIAIYPAVDPIPTLVIVKNYRKAII 318
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-318 4.09e-110

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.87  E-value: 4.09e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    10 LKLIQDVSAVFSIVINTFLIALILTKSPKHLGAYKWLMIYISVFEIFYSILDVFLVPQHYSHGPTFLVIVGLKDKLFGPP 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    90 GLLILNSCYWGCFGASMAMFAVHFVYRWLVVTKHPLIETFYGWKICIWFSVPMWYGLTWICTGYILSAPNEHTSRFIKDN 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624   170 IKEIFELKIDAYVYLGPFLYERADNGTVNVHIVPFIGLAIISGTIISSVTIVLVFGILCYQKISCLVaiTVGSGKLIKLQ 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLK--SLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563624   250 RQLFFALVIQTLVPFLLMHIPAAIMFAFVFLDIDLGVYSAVVSMTIAIYPAVDPIPTLVIVKNYRKAII 318
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-318 4.09e-110

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.87  E-value: 4.09e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    10 LKLIQDVSAVFSIVINTFLIALILTKSPKHLGAYKWLMIYISVFEIFYSILDVFLVPQHYSHGPTFLVIVGLKDKLFGPP 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    90 GLLILNSCYWGCFGASMAMFAVHFVYRWLVVTKHPLIETFYGWKICIWFSVPMWYGLTWICTGYILSAPNEHTSRFIKDN 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624   170 IKEIFELKIDAYVYLGPFLYERADNGTVNVHIVPFIGLAIISGTIISSVTIVLVFGILCYQKISCLVaiTVGSGKLIKLQ 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLK--SLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563624   250 RQLFFALVIQTLVPFLLMHIPAAIMFAFVFLDIDLGVYSAVVSMTIAIYPAVDPIPTLVIVKNYRKAII 318
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 16-317 2.15e-32

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 122.74  E-value: 2.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    16 VSAVFSIVINTFLIALILTKSPKHLGAYKWLMIYISVFEIFYSILDVFLVPQHYSHGPTFLVIV--GLKDKLFGPPGLLI 93
Cdd:pfam10319  13 IFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVsdGPFFEYSELGQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    94 LNSCywGCFGASMAMFAVHFVYRWLVVTKHPLIET-FYGWKICIWFSVPMWYGLTWICTGYILSAPNEHTSRFIKDNIKE 172
Cdd:pfam10319  93 SARC--SFISASYAVLLIHFIYRYLVLFNPQLTRHyFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624   173 IFELKIDAYVYLGPfLYERADNGTVNVHIvpfigLAIISGTIISSVTIVLVFgILCYQKISCLVAITVG-SGKLIKLQRQ 251
Cdd:pfam10319 171 TYGVDSMDINMLGA-LYWEASDETVFRSW-----LGILLLTVISVYSIILYI-VLGYKIMRKLNKMSVTmSKKTKRLQKQ 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563624   252 LFFALVIQTLVPFLLMHIPAAIMFAFVFLDIDLGVYSAVVSMT-IAIYPAVDPIPTLVIVKNYRKAI 317
Cdd:pfam10319 244 LLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 16-318 4.02e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 53.71  E-value: 4.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    16 VSAVFSIVINTFLIALILTKSPKHLGAYKWLMIYISVFEIFYSILDVFLVPQHYSHGPTFLVIVglkdklFGPPGLLILN 95
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALIS------YGPCKYFGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    96 SCYWG------CFGASMAMFAVHFVYRWLVVTK-HPLIETFYgwKICIWFSVPMWYGLTWICTgyILSAPNEhtsrfIKD 168
Cdd:pfam10317  81 FCYSGysllqhFLLHSGWSLLLTFYYRYYILKHvDPKRKKLI--LLIIIHYIPSLSQLIVIFL--SPTDFLP-----VEA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624   169 NIKEIF-ELKIDAYVYlgpflyeradNGTVNVHIVPfiglAIISGTIISSVTIVLVFGILCYQK--ISCLVAITVGSGKL 245
Cdd:pfam10317 152 LTKELHpNYNLTDYTV----------TGFSDLQSFP----ALINTLIMTIPVFPIPIIILILRRkiLKLLNSNSVNMSPT 217

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563624   246 IKLQ-RQLFFALVIQTLVPfLLMHIPAAIMFAF-VFLDIDLGVYSAVVSMTIAIYPAVDPIPTLVIVKNYRKAII 318
Cdd:pfam10317 218 TKAQhRQLIKGLTIQALLP-LFSYIPGVTLYLLsQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 18-321 3.89e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 51.00  E-value: 3.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    18 AVFSIVINTFLIALILTKSPKHLGAYKWLMIyisVFEIFYSILDVFLvpqhyshgpTFLVI------------VGLKDKL 85
Cdd:pfam10318  14 TVISIPIHIFGFYCILFKTPKKMKSVKWSLL---NLHFWSALLDLSL---------SFLTIpyiflpalagypLGLLSYL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624    86 FGPPGLL--ILNSCYwGCFGASMAMFavhFVYRWLVVTKHPlietfygWKICIWFSVPMWYGL--TWICTGYILsapneh 161
Cdd:pfam10318  82 GVPTPIQfyIGVTSL-ALVGVSIILL---FENRYSILFTNK-------KRITWKKTRVLYLIFnyIIALLFLIP------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624   162 tsrfIKDNIKEIFELKIDAYVYLGPFLYERADNGTVNVHIVPFIGLAIISGTIISSVTI-VLVFGILCYQKISCLVAITV 240
Cdd:pfam10318 145 ----IYLNIPDQEAAKLKVLKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIqILFFVFLTIYYLFKSVKSSL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563624   241 gSGKLIKLQRQLFFALVIQTLVPFLLMHIPAAIMFAFVFLDIDLGVYSAVVSMTIAIYPAVDPIPTLVIVKNYRKAIISY 320
Cdd:pfam10318 221 -SKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSL 299


                  .
gi 17563624   321 L 321
Cdd:pfam10318 300 F 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH