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Conserved domains on  [gi|72001188|ref|NP_503773|]
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Serpentine Receptor, class J [Caenorhabditis elegans]

Protein Classification

class J serpentine receptor( domain architecture ID 10563403)

class J serpentine receptor (Srj) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
1-309 1.75e-162

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 370974  Cd Length: 310  Bit Score: 455.55  E-value: 1.75e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188     1 MLDQWFFLYIPLIFCGLSFLVNPVFIYLIFTEKSTNFGNYRYLLLYFALFNLIYSVVYVAVPLDIHSYRYCFFLTVRNGW 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    81 FSEASEINFGIIALRCTMVAASYAVLLIHFIYRYLVIQNSSLTRHNF-HWYLTISAVVFVVYFATWYAICYFPGRANVEI 159
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFrPWGILISILFFLFHGSVWTAICYFLLRANDEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   160 KEYIRKDFFEIYGTDSMDYNMLGALFHDGSNETVYLSWVATMTWTAISTASIIAFTVMTRMIVRKLRKISTNASKKTSKF 239
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   240 QFELLRALIVQTVIPILISFSPCLLCWYSPMFGIPLAREINYLEICAFGVFPFADPVAIILCLPVFRKRI 309
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
1-309 1.75e-162

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 455.55  E-value: 1.75e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188     1 MLDQWFFLYIPLIFCGLSFLVNPVFIYLIFTEKSTNFGNYRYLLLYFALFNLIYSVVYVAVPLDIHSYRYCFFLTVRNGW 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    81 FSEASEINFGIIALRCTMVAASYAVLLIHFIYRYLVIQNSSLTRHNF-HWYLTISAVVFVVYFATWYAICYFPGRANVEI 159
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFrPWGILISILFFLFHGSVWTAICYFLLRANDEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   160 KEYIRKDFFEIYGTDSMDYNMLGALFHDGSNETVYLSWVATMTWTAISTASIIAFTVMTRMIVRKLRKISTNASKKTSKF 239
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   240 QFELLRALIVQTVIPILISFSPCLLCWYSPMFGIPLAREINYLEICAFGVFPFADPVAIILCLPVFRKRI 309
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
1-309 1.75e-162

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 455.55  E-value: 1.75e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188     1 MLDQWFFLYIPLIFCGLSFLVNPVFIYLIFTEKSTNFGNYRYLLLYFALFNLIYSVVYVAVPLDIHSYRYCFFLTVRNGW 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    81 FSEASEINFGIIALRCTMVAASYAVLLIHFIYRYLVIQNSSLTRHNF-HWYLTISAVVFVVYFATWYAICYFPGRANVEI 159
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFrPWGILISILFFLFHGSVWTAICYFLLRANDEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   160 KEYIRKDFFEIYGTDSMDYNMLGALFHDGSNETVYLSWVATMTWTAISTASIIAFTVMTRMIVRKLRKISTNASKKTSKF 239
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   240 QFELLRALIVQTVIPILISFSPCLLCWYSPMFGIPLAREINYLEICAFGVFPFADPVAIILCLPVFRKRI 309
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
9-310 8.48e-48

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 163.01  E-value: 8.48e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188     9 YIPLIFCGLSFLVNPVFIYLIFTEKSTNFGNYRYLLLYFALFNLIYSVVYVAVPLDIHSYRYCFFLTVRNGWFSEASEIN 88
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    89 FGIIALRCTMVAASYAVLLIHFIYRYLVIQNSSLTRHNFHWYLTISAVVFVVYFATWYAICYFPGRANVEIKEYIRKDFF 168
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   169 EIYGTDSMDYNMLGALF----HDGSNETVYLSWVATMTWTAISTASIIAFTVMTRMIVRKLRKISTNASKKTSKFQFELL 244
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYyptdENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72001188   245 RALIVQTVIPILISFSPCLLCWYSPMFGIPLAREINYLeICAFGVFPFADPVAIILCLPVFRKRIF 310
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGII-TATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
13-309 1.71e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 57.95  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    13 IFCGLSFLVNPVFIYLIFTEKSTNFGNYRYLLLYFALFNLIYSV---------VYVAVPLDIHSYRYCFFLTvrngwfse 83
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCIlafftqqriIPNGVSMALISYGPCKYFG-------- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    84 aSEINFGIIALRCTMVAASYAVLLIHFIYRYLVIQNSSLTRHNfhWYLTISAVVFVVYFatwYAICYFPGRANVEIKEYI 163
Cdd:pfam10317  79 -PWFCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKK--LILLIIIHYIPSLS---QLIVIFLSPTDFLPVEAL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   164 RKDFFEIYGTDsmDYNMLGAlfhdgSNETVYLSWVATMTWTAISTASIIAFTVMTRMIVRKLRKISTNASKKTSKFQFEL 243
Cdd:pfam10317 153 TKELHPNYNLT--DYTVTGF-----SDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQL 225
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72001188   244 LRALIVQTVIPILISFSPCLLCWYSPMFGIplarEINYLE--ICAFGVFP-FADPVAIILCLPVFRKRI 309
Cdd:pfam10317 226 IKGLTIQALLPLFSYIPGVTLYLLSQLTGT----EFLILEyfIFVLPALPpLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
204-272 3.22e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 41.76  E-value: 3.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72001188   204 TAISTASIIAFTVMTRMIVRKLRKISTnaSKKTSKFQFELLRALIVQTVIPILISFSPCLLCWYSPMFG 272
Cdd:pfam10318 194 ILILIIQILFFVFLTIYYLFKSVKSSL--SKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFG 260
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
18-309 1.12e-03

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 40.22  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    18 SFLVNPVFIYLIFTeKSTNFGNYRYLLLYFALFNLIY----SVVYVAVPL-DIHSYRYCFFLTVrngWFSEASEINFGII 92
Cdd:pfam10327  22 SLILNLLGIYLIIF-KSGKIDNFRYYLLYFQISCTLTdihlTFLMQPIPLfPIIAGYCNGFLAT---VFGISSHYLMTIF 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188    93 ALrctMVAASYAVLLIHFIYRYLVIQNsSLTRHNFHWYLTISAVVFVVYFATWYAICYFPGRANVEIK-EYIRKDF---- 167
Cdd:pfam10327  98 VF---LLSFQLESLLLCFVRKHQAIAK-ILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQlEYVKENYpeyl 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001188   168 --------FEIYgtdsmDYnmlgalfhdgsNETVYLSWVATMTWTAISTASIIAFTV-MTRMIVRKLRKISTNASKKtsk 238
Cdd:pfam10327 174 sqfsslpnFAIY-----DY-----------NPWLIVFGILAIFGGSLSFLILVYLTVdMFRMLKRLRKKISAQTYQK--- 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72001188   239 fQFELLRALIVQTVIPILISFSPClLCWYSPMFGIPLAREINYLEICAFGVFPFADPVAIILCLPVFRKRI 309
Cdd:pfam10327 235 -HRAALRSLIAQFATSPVCILPPF-AFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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