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Conserved domains on  [gi|17558648|ref|NP_503582|]
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Serpentine Receptor, class BC (Class B-like) [Caenorhabditis elegans]

Protein Classification

Srbc family chemoreceptor( domain architecture ID 10563385)

Srbc family chemoreceptor belongs to the G-protein coupled receptor (GPCR) superfamily and plays a role in chemoreception

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srbc pfam10316
Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis ...
 7-274 6.29e-84

Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402093  Cd Length: 273  Bit Score: 253.61  E-value: 6.29e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648     7 LKTSAVVITCFGVFFSIFNCVGNVAIIKKMG-----RRKNDMVLFYFRFLLDVIFGATSTIYLLSIIIFNLNYLKLsdLR 81
Cdd:pfam10316   1 MLLIAVIVTLIGIIFSIFTCFLNIYLLKKIFyskkiKKKPDMVLFYYRFALDVFYGFSVSIYLLYIILYSISPEFF--VK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648    82 VFIFFLGFLISNVRATRALLTMAISIDRVVAVYTPIWFLNYRSLVANSAVLGLTAAFGLSEYPVLYIFCEFEVDIPPKCV 161
Cdd:pfam10316  79 NLIFYLGLPSSNIGAIRSILALLISIERVIAVYFPIFYHNYRPKIPNFIILILIIAYGLFEQYILFGFCDNVIDIPLNCD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648   162 SINCALNDCFLQYWTTYKMIIFACTFIFTILLSLKLI---SKIFKDDNKDLNRANRLTLIDSTIIFATDFLPTMLCLMgH 238
Cdd:pfam10316 159 NFGCAVNQCFFQYWTTHEQIVFSLIVVFSILLSFKLFiwnKFKKTQSNKELSKANRLALLDSAIVFLFDFLPSFISNY-F 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 17558648   239 EDLFNTQNMGPFGAVLKQVGCAFEALLVLQTITRRN 274
Cdd:pfam10316 238 FPSFSFKNVGPYTAVLKNLGCAIEALIVFRILRRKK 273
 
Name Accession Description Interval E-value
7TM_GPCR_Srbc pfam10316
Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis ...
 7-274 6.29e-84

Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402093  Cd Length: 273  Bit Score: 253.61  E-value: 6.29e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648     7 LKTSAVVITCFGVFFSIFNCVGNVAIIKKMG-----RRKNDMVLFYFRFLLDVIFGATSTIYLLSIIIFNLNYLKLsdLR 81
Cdd:pfam10316   1 MLLIAVIVTLIGIIFSIFTCFLNIYLLKKIFyskkiKKKPDMVLFYYRFALDVFYGFSVSIYLLYIILYSISPEFF--VK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648    82 VFIFFLGFLISNVRATRALLTMAISIDRVVAVYTPIWFLNYRSLVANSAVLGLTAAFGLSEYPVLYIFCEFEVDIPPKCV 161
Cdd:pfam10316  79 NLIFYLGLPSSNIGAIRSILALLISIERVIAVYFPIFYHNYRPKIPNFIILILIIAYGLFEQYILFGFCDNVIDIPLNCD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648   162 SINCALNDCFLQYWTTYKMIIFACTFIFTILLSLKLI---SKIFKDDNKDLNRANRLTLIDSTIIFATDFLPTMLCLMgH 238
Cdd:pfam10316 159 NFGCAVNQCFFQYWTTHEQIVFSLIVVFSILLSFKLFiwnKFKKTQSNKELSKANRLALLDSAIVFLFDFLPSFISNY-F 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 17558648   239 EDLFNTQNMGPFGAVLKQVGCAFEALLVLQTITRRN 274
Cdd:pfam10316 238 FPSFSFKNVGPYTAVLKNLGCAIEALIVFRILRRKK 273
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
 63-199 8.80e-04

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 40.08  E-value: 8.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648  63 YLLSIIIFNLNY---LKLSDLRVFIFFLGFLISNV--RATRALLTMAISIDRVVAVYTPIWFLNYRSLVANSAVLGLTAA 137
Cdd:cd15110  48 FLLCIFILSIMYigpFNFSHSRDYVAMLIFIILFLfgYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWA 127

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17558648 138 FGLSEYPVLYIFCEFEVdippKCVSINCALndcflqywttykMIIFACTFIFTILLSLKLIS 199
Cdd:cd15110 128 LSVLMTSLEYLMCIDEG----FHVRNECRA------------VLIFIGILTFLVFTPLMLIS 173
 
Name Accession Description Interval E-value
7TM_GPCR_Srbc pfam10316
Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis ...
 7-274 6.29e-84

Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402093  Cd Length: 273  Bit Score: 253.61  E-value: 6.29e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648     7 LKTSAVVITCFGVFFSIFNCVGNVAIIKKMG-----RRKNDMVLFYFRFLLDVIFGATSTIYLLSIIIFNLNYLKLsdLR 81
Cdd:pfam10316   1 MLLIAVIVTLIGIIFSIFTCFLNIYLLKKIFyskkiKKKPDMVLFYYRFALDVFYGFSVSIYLLYIILYSISPEFF--VK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648    82 VFIFFLGFLISNVRATRALLTMAISIDRVVAVYTPIWFLNYRSLVANSAVLGLTAAFGLSEYPVLYIFCEFEVDIPPKCV 161
Cdd:pfam10316  79 NLIFYLGLPSSNIGAIRSILALLISIERVIAVYFPIFYHNYRPKIPNFIILILIIAYGLFEQYILFGFCDNVIDIPLNCD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648   162 SINCALNDCFLQYWTTYKMIIFACTFIFTILLSLKLI---SKIFKDDNKDLNRANRLTLIDSTIIFATDFLPTMLCLMgH 238
Cdd:pfam10316 159 NFGCAVNQCFFQYWTTHEQIVFSLIVVFSILLSFKLFiwnKFKKTQSNKELSKANRLALLDSAIVFLFDFLPSFISNY-F 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 17558648   239 EDLFNTQNMGPFGAVLKQVGCAFEALLVLQTITRRN 274
Cdd:pfam10316 238 FPSFSFKNVGPYTAVLKNLGCAIEALIVFRILRRKK 273
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
 63-199 8.80e-04

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 40.08  E-value: 8.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648  63 YLLSIIIFNLNY---LKLSDLRVFIFFLGFLISNV--RATRALLTMAISIDRVVAVYTPIWFLNYRSLVANSAVLGLTAA 137
Cdd:cd15110  48 FLLCIFILSIMYigpFNFSHSRDYVAMLIFIILFLfgYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWA 127

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17558648 138 FGLSEYPVLYIFCEFEVdippKCVSINCALndcflqywttykMIIFACTFIFTILLSLKLIS 199
Cdd:cd15110 128 LSVLMTSLEYLMCIDEG----FHVRNECRA------------VLIFIGILTFLVFTPLMLIS 173
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
 99-192 1.35e-03

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 39.66  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558648  99 ALLTMAISIDRVVAVYTPIWFLNYRSlvANSAVLGltAAFGLS---EYPVLYIFceFEVDIPPKCVSINCALNDCFLQYW 175
Cdd:cd15383  89 AFVTVVISLDRHAAILNPLAIGSARR--RNRIMLC--AAWGLSallALPQLFLF--HTVTATPPVNFTQCATHGSFPAHW 162

                        90
                ....*....|....*....
gi 17558648 176 --TTYKMIIFACTFIFTIL 192
Cdd:cd15383 163 qeTLYNMFTFFCLFLLPLL 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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