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Conserved domains on  [gi|71988420|ref|NP_499971|]
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CUTiclin-Like [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APPLE smart00223
APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple ...
 30-103 1.33e-15

APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.


:

Pssm-ID: 128519  Cd Length: 79  Bit Score: 72.03  E-value: 1.33e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988420     30 LKSVNSTASLIIRKSVDSLSQCTRFCSSVPNCTHFTFSNAEPIEKKnggfnCHLH---SKSPVLTTSGSRTVG--TKTC 103
Cdd:smart00223   6 YKNVDFRGSDINTVYVPSAQVCQKRCTSHPRCLFFTFSTNEPPEEK-----CLLKdsvSGTPTRITKTGAVSGysLKSC 79
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 114-192 4.69e-11

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


:

Pssm-ID: 459635  Cd Length: 76  Bit Score: 59.10  E-value: 4.69e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988420   114 AFEKFPGRSLVNSSfIIKTFSISMEECLSQCQKESSCRAALHNNDTSLCQLSRVSLNSvyNPRLyFKASYSVDLYENNC 192
Cdd:pfam00024   2 DFERVPGSSLSGVD-VSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGS--LPRL-KRSDNKVDYYEKSC 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 202-292 3.98e-08

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


:

Pssm-ID: 459635  Cd Length: 76  Bit Score: 50.63  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988420   202 CTFMRVNGGGLKSVSDQLIqNVGSFDECEQMCVIRSRisdvCRSYTYDNSTNECNLMWASARMLGRsplesmkpnlFHGD 281
Cdd:pfam00024   1 CDFERVPGSSLSGVDVSTV-TVSSAEECAQRCTNEPR----CRSFTYNPKSKKCHLKSSSSGSLPR----------LKRS 65

                          90
                  ....*....|.
gi 71988420   282 LDDCVNFSLKC 292
Cdd:pfam00024  66 DNKVDYYEKSC 76
 
Name Accession Description Interval E-value
APPLE smart00223
APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple ...
 30-103 1.33e-15

APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.


Pssm-ID: 128519  Cd Length: 79  Bit Score: 72.03  E-value: 1.33e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988420     30 LKSVNSTASLIIRKSVDSLSQCTRFCSSVPNCTHFTFSNAEPIEKKnggfnCHLH---SKSPVLTTSGSRTVG--TKTC 103
Cdd:smart00223   6 YKNVDFRGSDINTVYVPSAQVCQKRCTSHPRCLFFTFSTNEPPEEK-----CLLKdsvSGTPTRITKTGAVSGysLKSC 79
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 114-192 4.69e-11

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 59.10  E-value: 4.69e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988420   114 AFEKFPGRSLVNSSfIIKTFSISMEECLSQCQKESSCRAALHNNDTSLCQLSRVSLNSvyNPRLyFKASYSVDLYENNC 192
Cdd:pfam00024   2 DFERVPGSSLSGVD-VSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGS--LPRL-KRSDNKVDYYEKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 110-191 8.00e-11

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 58.36  E-value: 8.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988420    110 KRSFAFEKFPGRSLVNSSFIIKTfSISMEECLSQCQKES-SCRAALHNNDTSLCQLSrvSLNSVYNPRLyfKASYSVDLY 188
Cdd:smart00473   1 KSDDCFVRLPNTKLPGFSRIVIS-VASLEECASKCLNSNcSCRSFTYNNGTKGCLLW--SESSLGDARL--FPSGGVDLY 75


                   ...
gi 71988420    189 ENN 191
Cdd:smart00473  76 EKI 78
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 110-191 2.01e-10

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 57.48  E-value: 2.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988420 110 KRSFAFEKFPGRSLVnSSFIIKTFSISMEECLSQCQKESS--CRAALHNNDTSLCQLSRVSLNSVYNPRLYFKasySVDL 187
Cdd:cd01099   1 LNDFKFVLVLNKILV-SEVKTEITVASLEECLRKCLEETEftCRSFNYNYKSKECILSDEDRMSSGVKLLYDS---NVDY 76


                ....
gi 71988420 188 YENN 191
Cdd:cd01099  77 YENK 80
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 202-292 3.98e-08

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 50.63  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988420   202 CTFMRVNGGGLKSVSDQLIqNVGSFDECEQMCVIRSRisdvCRSYTYDNSTNECNLMWASARMLGRsplesmkpnlFHGD 281
Cdd:pfam00024   1 CDFERVPGSSLSGVDVSTV-TVSSAEECAQRCTNEPR----CRSFTYNPKSKKCHLKSSSSGSLPR----------LKRS 65

                          90
                  ....*....|.
gi 71988420   282 LDDCVNFSLKC 292
Cdd:pfam00024  66 DNKVDYYEKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 199-261 6.19e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 47.57  E-value: 6.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71988420    199 SSACTFMRVNGGGLKSVSDQLIqNVGSFDECEQMCvirSRISDVCRSYTYDNSTNECNLMWAS 261
Cdd:smart00473   1 KSDDCFVRLPNTKLPGFSRIVI-SVASLEECASKC---LNSNCSCRSFTYNNGTKGCLLWSES 59
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 45-108 7.43e-05

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 41.38  E-value: 7.43e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71988420    45 VDSLSQCTRFCSSVPNCTHFTFSNAEpiekknggFNCHLHSKSPVLTTSGSRTVGTKTCLENKC 108
Cdd:pfam00024  21 VSSAEECAQRCTNEPRCRSFTYNPKS--------KKCHLKSSSSGSLPRLKRSDNKVDYYEKSC 76
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 45-97 3.60e-04

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238533  Cd Length: 73  Bit Score: 39.34  E-value: 3.60e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 71988420  45 VDSLSQCTRFCSSVPNCTHFTFSNAEPIekknggfnCHLHSKSPVLT-----TSGSRT 97
Cdd:cd01100  24 ASSAEQCQAACTADPGCLAFTYNTKSKK--------CFLKSSEGTLTkstgaVSGPRL 73
 
Name Accession Description Interval E-value
APPLE smart00223
APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple ...
 30-103 1.33e-15

APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.


Pssm-ID: 128519  Cd Length: 79  Bit Score: 72.03  E-value: 1.33e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988420     30 LKSVNSTASLIIRKSVDSLSQCTRFCSSVPNCTHFTFSNAEPIEKKnggfnCHLH---SKSPVLTTSGSRTVG--TKTC 103
Cdd:smart00223   6 YKNVDFRGSDINTVYVPSAQVCQKRCTSHPRCLFFTFSTNEPPEEK-----CLLKdsvSGTPTRITKTGAVSGysLKSC 79
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 114-192 4.69e-11

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 59.10  E-value: 4.69e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71988420   114 AFEKFPGRSLVNSSfIIKTFSISMEECLSQCQKESSCRAALHNNDTSLCQLSRVSLNSvyNPRLyFKASYSVDLYENNC 192
Cdd:pfam00024   2 DFERVPGSSLSGVD-VSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGS--LPRL-KRSDNKVDYYEKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 110-191 8.00e-11

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 58.36  E-value: 8.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988420    110 KRSFAFEKFPGRSLVNSSFIIKTfSISMEECLSQCQKES-SCRAALHNNDTSLCQLSrvSLNSVYNPRLyfKASYSVDLY 188
Cdd:smart00473   1 KSDDCFVRLPNTKLPGFSRIVIS-VASLEECASKCLNSNcSCRSFTYNNGTKGCLLW--SESSLGDARL--FPSGGVDLY 75


                   ...
gi 71988420    189 ENN 191
Cdd:smart00473  76 EKI 78
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 110-191 2.01e-10

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 57.48  E-value: 2.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988420 110 KRSFAFEKFPGRSLVnSSFIIKTFSISMEECLSQCQKESS--CRAALHNNDTSLCQLSRVSLNSVYNPRLYFKasySVDL 187
Cdd:cd01099   1 LNDFKFVLVLNKILV-SEVKTEITVASLEECLRKCLEETEftCRSFNYNYKSKECILSDEDRMSSGVKLLYDS---NVDY 76


                ....
gi 71988420 188 YENN 191
Cdd:cd01099  77 YENK 80
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 202-292 3.98e-08

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 50.63  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988420   202 CTFMRVNGGGLKSVSDQLIqNVGSFDECEQMCVIRSRisdvCRSYTYDNSTNECNLMWASARMLGRsplesmkpnlFHGD 281
Cdd:pfam00024   1 CDFERVPGSSLSGVDVSTV-TVSSAEECAQRCTNEPR----CRSFTYNPKSKKCHLKSSSSGSLPR----------LKRS 65

                          90
                  ....*....|.
gi 71988420   282 LDDCVNFSLKC 292
Cdd:pfam00024  66 DNKVDYYEKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 199-261 6.19e-07

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 47.57  E-value: 6.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71988420    199 SSACTFMRVNGGGLKSVSDQLIqNVGSFDECEQMCvirSRISDVCRSYTYDNSTNECNLMWAS 261
Cdd:smart00473   1 KSDDCFVRLPNTKLPGFSRIVI-SVASLEECASKC---LNSNCSCRSFTYNNGTKGCLLWSES 59
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 45-108 7.43e-05

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 41.38  E-value: 7.43e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71988420    45 VDSLSQCTRFCSSVPNCTHFTFSNAEpiekknggFNCHLHSKSPVLTTSGSRTVGTKTCLENKC 108
Cdd:pfam00024  21 VSSAEECAQRCTNEPRCRSFTYNPKS--------KKCHLKSSSSGSLPRLKRSDNKVDYYEKSC 76
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 45-97 3.60e-04

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238533  Cd Length: 73  Bit Score: 39.34  E-value: 3.60e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 71988420  45 VDSLSQCTRFCSSVPNCTHFTFSNAEPIekknggfnCHLHSKSPVLT-----TSGSRT 97
Cdd:cd01100  24 ASSAEQCQAACTADPGCLAFTYNTKSKK--------CFLKSSEGTLTkstgaVSGPRL 73
PAN_4 pfam14295
PAN domain;
44-83 3.31e-03

PAN domain;


Pssm-ID: 433846  Cd Length: 51  Bit Score: 36.23  E-value: 3.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 71988420    44 SVDSLSQCTRFCSSVPNCTHFTFSNAEPIEKKNggfNCHL 83
Cdd:pfam14295  14 LVDSPEACCAACDADPRCNAWTFVKPGYQGSYA---RCWL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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