BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDHEKCsLPKDEYQLMRILRE 86
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLP-LPSDFVELEELLAE 79

                ....
gi 71991536  87 AVFF 90
Cdd:cd18316  80 AEFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDHEKCsLPKDEYQLMRILRE 86
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLP-LPSDFVELEELLAE 79

                ....
gi 71991536  87 AVFF 90
Cdd:cd18316  80 AEFY 83

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536      7 ISLDVEGVYFKTRIATLKSiEGTYFTKLFETNWREqLDRDGRLFIDRDSSVFPVILNFLRDHEkcsLPKDEYQLMRILRE 86
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAA-HSPYFKALFSSDFKE-SDKSEIYLDDVSPEDFRALLNFLYTGK---LDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|
gi 71991536     87 AVFFKIGPLRNMIEHKLRTF 106
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKL 96

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 71991536 180 DSISLPRNFTHIAHVGWNGasVLFDkKMTDDPTVRKICDAAA 221
Cdd:cd00132   1 MEISTPTDFKHISHVGWDG--VGFD-GANLPPDLQSLFQTAG 39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDHEKCsLPKDEYQLMRILRE 86
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLP-LPSDFVELEELLAE 79

                ....
gi 71991536  87 AVFF 90
Cdd:cd18316  80 AEFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDHEKCSLPKDEYQLMRILRE 86
Cdd:cd18376   1 VKLNVGGQKFTTTLDTLTKDPDSMLAAMFSGRHSLKKDEDGSYFIDRDGTHFRHILNYLRDGEVKIPTEDRSVLKELLEE 80

                ....*....
gi 71991536  87 AVFFKIGPL 95
Cdd:cd18376  81 AEYYQLRGL 89

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536     7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDHEKCSLPKDEyQLMRILRE 86
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEV-CLDEFLEE 79

                  ....*....
gi 71991536    87 AVFFKIGPL 95
Cdd:pfam02214  80 AEFYGLDEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   2 PPPPLISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRD--GRLFIDRDSSVFPVILNFLRDhEKCSLPKDEYQ 79
Cdd:cd18396   1 PFPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSRRAARELPRDnrGRFFIDRDGFLFRYVLDYLRD-KQLALPDHFPE 79

                        90       100
                ....*....|....*....|....
gi 71991536  80 LMRILREAVFFKIGPLRNMIEHKL 103
Cdd:cd18396  80 KERLLREAEYFQLGDLVKLLTPKV 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDhEKCSLPKDeYQLMRIL-R 85
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRYPDSMLGAMFSGKFPTKKDSQGNCFIDRDGKIFRYILNFLRT-SHLDLPED-FQEMGLLkR 80

                        90
                ....*....|....*..
gi 71991536  86 EAVFFKIGPLRNMIEHK 102
Cdd:cd18395  81 EADFYQIQPLIEALQEK 97

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536      7 ISLDVEGVYFKTRIATLKSiEGTYFTKLFETNWREqLDRDGRLFIDRDSSVFPVILNFLRDHEkcsLPKDEYQLMRILRE 86
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAA-HSPYFKALFSSDFKE-SDKSEIYLDDVSPEDFRALLNFLYTGK---LDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|
gi 71991536     87 AVFFKIGPLRNMIEHKLRTF 106
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   6 LISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDHEkCSLPKDEYQLMRILR 85
Cdd:cd18375   2 LVTLNVGGKKFTTRPSTLRRFPDSRLARMLDGKDQDFKVVNGQFFVDRDGSLFSYILDYLRTGQ-LTLPTEFSDYNRLAR 80

                        90
                ....*....|....*
gi 71991536  86 EAVFFKIGPLRNMIE 100
Cdd:cd18375  81 EAEFYGLYSLADLLS 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   5 PLISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDHEkcsLPKDEYQLMRIL 84
Cdd:cd18363   2 DIINLNVGGKRFSTSRQTLTWIPDSFFTSLLSGRISSLKDETGAIFIDRDPKLFSIILNYLRTKE---IDLRNVDISSLR 78

                ....*...
gi 71991536  85 REAVFFKI 92
Cdd:cd18363  79 HEAEFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   4 PPLISLDVEGVYFKTRIATLKSIEGTYFTKLF--ETNWREQLDRD--GRLFIDRDSSVFPVILNFLRDhEKCSLPKDEYQ 79
Cdd:cd18398   2 PEVVELNVGGQVYFTRHATLVSIPHSLLWKMFspKRDTANDLAKDskGRFFIDRDGFLFRYILDYLRD-RQVVLPDHFPE 80

                        90
                ....*....|....*.
gi 71991536  80 LMRILREAVFFKIGPL 95
Cdd:cd18398  81 KGRLKREAEYFQLPDL 96

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 71991536    182 ISLPRNFTHIAHVGWNGASVLFDKKMTDDPTVRKIC 217
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNwREQLDRD--GRLFIDRDSSVFPVILNFLRdHEKCSLPKDEYQlMRIL 84
Cdd:cd18391   3 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGE-ELQSDRDetGAYLIDRDPTYFGPILNFLR-HGKLVLDKDMAE-EGVL 79

                        90
                ....*....|....*....
gi 71991536  85 REAVFFKIGPLRNMIEHKL 103
Cdd:cd18391  80 EEAEFYNIGPLIRIIKDRM 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSiEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDhEKCSLPKDEYQLMRILRE 86
Cdd:cd18369   1 VKLNVGGSLHYTTIGTLTK-QDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRD-GSVPLPESRRELAELLAE 78

                        90
                ....*....|..
gi 71991536  87 AVFFKIGPLRNM 98
Cdd:cd18369  79 AKYYLVQGLVEQ 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRD--GRLFIDRDSSVFPVILNFLRdHEKCSLPKDeYQLMRIL 84
Cdd:cd18362   2 VKLNVGGTYFLTTRTTLCRDPKSFLCRLCQEDPDLPSDKDetGAYLIDRDPTYFGPILNYLR-HGKLIIDKD-LAEEGVL 79

                ....*.
gi 71991536  85 REAVFF 90
Cdd:cd18362  80 EEAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSiEGTYFTKLFETNWREQLDRDGRLFIDRDSSVFPVILNFLRDhEKCSLPKDEYQLMRILRE 86
Cdd:cd18401   5 VRLNVGGSLYYTTVQVLTR-HDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRD-DTVALPKSRQEIKELMAE 82

                        90
                ....*....|....*...
gi 71991536  87 AVFFKIGPLRNMIEHKLR 104
Cdd:cd18401  83 AKYYLIQGLVDMCQAALQ 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDR-DGRLFIDRDSSVFPVILNFLRDhEKCSLPKDEYQLMRILR 85
Cdd:cd18388   4 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRT-SKLLLPEDFKDFNLLYE 82

                        90
                ....*....|....*
gi 71991536  86 EAVFFKIGPLRNMIE 100
Cdd:cd18388  83 EAKYYQLQPMVKELE 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWR----EQLDRDGRLFIDRDSSVFPVILNFLRDHeKCSLPKDEYQLMR 82
Cdd:cd18370   1 VTLNVGGTLYSTTLETLTRFPDSMLGAMFRAGTPippnLNMQGGGHYFIDRDGKAFRHILNFLRLG-RLDLPRGYGETAL 79

                ....*....
gi 71991536  83 ILREAVFFK 91
Cdd:cd18370  80 LRAEADFYQ 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDR-DGRLFIDRDSSVFPVILNFLRDhEKCSLPKDEYQLMRILR 85
Cdd:cd18387   5 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRT-SKLLIPDDFKDYSLLYE 83

                        90
                ....*....|....*
gi 71991536  86 EAVFFKIGPLRNMIE 100
Cdd:cd18387  84 EAKYFQLQPMLLELE 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWREQLDRD---GRLFIDRDSSVFPVILNFLR 66
Cdd:cd18414   5 IVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNFDYDpraDEFFFDRHPGVFAHILNYYR 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71991536   7 ISLDVEGVYFKTRIATLKSIEGTYFTKLFETNWReQLDRD---GRLFIDRDSSVFPVILNFLR 66
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEAS-AFDYDpvtGEFFFDRHPGVFAQILNYYR 62

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).

                          10        20
                  ....*....|....*....|..
gi 71991536   182 ISLPRNFTHIAHVGWNGASVLF 203
Cdd:pfam00786   2 ISAPTNFKHTVHVGFDPDTGFF 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991536   1 MPPPPL-----------ISLDVEGVYFKTRIATLKSiegtYFTKLFETNWREQL-DRDGR-LFIDRDSSVFPVILNFLRD 67
Cdd:cd18420  21 LPPPPVdqerrrtddekLIINVSGRRFETWRNTLEK----YPDTLLGSNEREFFyDEETKeYFFDRDPDIFRHILNYYRT 96

                        90       100
                ....*....|....*....|....*..
gi 71991536  68 HeKCSLPKDEYqLMRILREAVFFKIGP 94
Cdd:cd18420  97 G-KLHYPKHEC-LTAYDEELAFFGIMP 121