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Conserved domains on  [gi|17552810|ref|NP_498778|]
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Large ribosomal subunit protein uL18m [Caenorhabditis elegans]

Protein Classification

50S ribosomal protein L18( domain architecture ID 10087302)

50S ribosomal protein L18 is part of the 5S rRNA/L5/L18/L25 subcomplex; it contacts 5S and 23S rRNAs

Gene Ontology:  GO:0005840|GO:0003735
PubMed:  24362565|11470155

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
50-134 3.33e-14

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


:

Pssm-ID: 238246  Cd Length: 103  Bit Score: 64.87  E-value: 3.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552810  50 KSHREGRLVHYQ-DGVVISASTKEPSIASQLYSKTDTSAALNIGRVLALRCLQSGI---HFAMPGATKEAieksqHQTHF 125
Cdd:cd00432  20 NKHIYAQIIDDSgDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIkkvVFDRGGYRYHG-----RVKAL 94

                ....*....
gi 17552810 126 FKALEEEGL 134
Cdd:cd00432  95 AKGAREGGL 103
 
Name Accession Description Interval E-value
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
50-134 3.33e-14

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 64.87  E-value: 3.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552810  50 KSHREGRLVHYQ-DGVVISASTKEPSIASQLYSKTDTSAALNIGRVLALRCLQSGI---HFAMPGATKEAieksqHQTHF 125
Cdd:cd00432  20 NKHIYAQIIDDSgDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIkkvVFDRGGYRYHG-----RVKAL 94

                ....*....
gi 17552810 126 FKALEEEGL 134
Cdd:cd00432  95 AKGAREGGL 103
 
Name Accession Description Interval E-value
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
50-134 3.33e-14

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 64.87  E-value: 3.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552810  50 KSHREGRLVHYQ-DGVVISASTKEPSIASQLYSKTDTSAALNIGRVLALRCLQSGI---HFAMPGATKEAieksqHQTHF 125
Cdd:cd00432  20 NKHIYAQIIDDSgDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIkkvVFDRGGYRYHG-----RVKAL 94

                ....*....
gi 17552810 126 FKALEEEGL 134
Cdd:cd00432  95 AKGAREGGL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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