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Conserved domains on  [gi|17555168|ref|NP_498632|]
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Anamorsin homolog [Caenorhabditis elegans]

Protein Classification

CIAPIN1 domain-containing protein( domain architecture ID 1004834)

CIAPIN1 (cytokine-induced apoptosis inhibitor 1) domain-containing protein similar to anamorsin that is a component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins

Gene Ontology:  GO:0051536|GO:0016226|GO:0009055|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIAPIN1 super family cl37720
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 163-232 4.49e-31

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


The actual alignment was detected with superfamily member pfam05093:

Pssm-ID: 398662  Cd Length: 99  Bit Score: 110.05  E-value: 4.49e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555168   163 CGPDdPNKKKRACKNCSCGLAEQEELEKMGQIAAEPK-----------------------SSCGNCSLGDAFRCSTCPYL 219
Cdd:pfam05093   8 CEPN-GKKRRKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgktGSCGSCALGDAFRCSGCPYL 86

                          90
                  ....*....|...
gi 17555168   220 GQPPFKPGETVKI 232
Cdd:pfam05093  87 GLPAFKPGEEVTI 99
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 163-232 4.49e-31

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 110.05  E-value: 4.49e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555168   163 CGPDdPNKKKRACKNCSCGLAEQEELEKMGQIAAEPK-----------------------SSCGNCSLGDAFRCSTCPYL 219
Cdd:pfam05093   8 CEPN-GKKRRKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgktGSCGSCALGDAFRCSGCPYL 86

                          90
                  ....*....|...
gi 17555168   220 GQPPFKPGETVKI 232
Cdd:pfam05093  87 GLPAFKPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
135-233 1.57e-29

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 111.78  E-value: 1.57e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555168 135 DEDLIDEDGLLQEEDFEKptgdQLKAGGCGPDdPNKKKRACKNCSCGLAEQEELEKM-------------------GQIA 195
Cdd:COG5636 160 DPRTIMEDELLDEDSEDK----AIQRSECPPS-KTKKKRACKDCTCGLKEEEENEIVrtrqdkvvkftedelteidFTID 234

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 17555168 196 AEPKSSCGNCSLGDAFRCSTCPYLGQPPFKPGETVKIS 233
Cdd:COG5636 235 GKKVSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFS 272
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 163-232 4.49e-31

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 110.05  E-value: 4.49e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555168   163 CGPDdPNKKKRACKNCSCGLAEQEELEKMGQIAAEPK-----------------------SSCGNCSLGDAFRCSTCPYL 219
Cdd:pfam05093   8 CEPN-GKKRRKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgktGSCGSCALGDAFRCSGCPYL 86

                          90
                  ....*....|...
gi 17555168   220 GQPPFKPGETVKI 232
Cdd:pfam05093  87 GLPAFKPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
135-233 1.57e-29

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 111.78  E-value: 1.57e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555168 135 DEDLIDEDGLLQEEDFEKptgdQLKAGGCGPDdPNKKKRACKNCSCGLAEQEELEKM-------------------GQIA 195
Cdd:COG5636 160 DPRTIMEDELLDEDSEDK----AIQRSECPPS-KTKKKRACKDCTCGLKEEEENEIVrtrqdkvvkftedelteidFTID 234

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 17555168 196 AEPKSSCGNCSLGDAFRCSTCPYLGQPPFKPGETVKIS 233
Cdd:COG5636 235 GKKVSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFS 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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