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Conserved domains on  [gi|17552230|ref|NP_497826|]
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Hemiasterlin resistant protein 1 [Caenorhabditis elegans]

Protein Classification

coiled-coil-helix-coiled-coil-helix domain-containing protein( domain architecture ID 20324817)

coiled-coil-helix-coiled-coil-helix (CHCH) domain-containing protein carries (CX9C) type motifs and is imported into the mitochondrion with the help of the disulfide relay-dependent MIA import pathway

CATH:  1.10.287.2900
PubMed:  19345215|26782138
SCOP:  4006184

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CHCH pfam06747
CHCH domain; we have identified a conserved motif in the LOC118487 protein that we have called ...
 119-152 7.03e-06

CHCH domain; we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.


:

Pssm-ID: 429096  Cd Length: 35  Bit Score: 40.68  E-value: 7.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17552230   119 CEFEWRQFVDCAQNQSD-VSLCNGFNDIFKQCKAR 152
Cdd:pfam06747   1 CGEEFKAFLKCLKDNEDeLSKCRKQFDAFRQCVKK 35
COG3416 super family cl47320
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
4-95 1.40e-04

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


The actual alignment was detected with superfamily member COG3416:

Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 40.39  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552230   4 RRTASPSPSAPVRSAPRPAAQSSfaappprPAAAAPAYHPPAAPTPMGAPMGAPSQGPGLMKQMAATAGGVAIGSAVGHA 83
Cdd:COG3416  94 QRPPPAPQPSQPGPQQQPAPPSG-------PWGQAAPQQPGYGQPQYGQPAAGPSGGGGFLGGALQTAAGVAGGVLLANA 166

                        90
                ....*....|..
gi 17552230  84 VGGMFTGGGSSH 95
Cdd:COG3416 167 LTGMFSGSHPGE 178
 
Name Accession Description Interval E-value
CHCH pfam06747
CHCH domain; we have identified a conserved motif in the LOC118487 protein that we have called ...
 119-152 7.03e-06

CHCH domain; we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.


Pssm-ID: 429096  Cd Length: 35  Bit Score: 40.68  E-value: 7.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17552230   119 CEFEWRQFVDCAQNQSD-VSLCNGFNDIFKQCKAR 152
Cdd:pfam06747   1 CGEEFKAFLKCLKDNEDeLSKCRKQFDAFRQCVKK 35
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
4-95 1.40e-04

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 40.39  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552230   4 RRTASPSPSAPVRSAPRPAAQSSfaappprPAAAAPAYHPPAAPTPMGAPMGAPSQGPGLMKQMAATAGGVAIGSAVGHA 83
Cdd:COG3416  94 QRPPPAPQPSQPGPQQQPAPPSG-------PWGQAAPQQPGYGQPQYGQPAAGPSGGGGFLGGALQTAAGVAGGVLLANA 166

                        90
                ....*....|..
gi 17552230  84 VGGMFTGGGSSH 95
Cdd:COG3416 167 LTGMFSGSHPGE 178
DUF2076 pfam09849
Uncharacterized protein conserved in bacteria (DUF2076); This domain, found in various ...
 4-95 8.51e-03

Uncharacterized protein conserved in bacteria (DUF2076); This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.


Pssm-ID: 430876  Cd Length: 263  Bit Score: 35.10  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552230     4 RRTASPSPSAPVRSAPRPAAQSSFAAPPPRPAAAAPAYHPPAAPTPMGAPMGAPSQGPGLMKQMAATAGGVAIGSAVGHA 83
Cdd:pfam09849  99 SQSRPPPPPQARPAWPAGQAPGQPQPYPGQPGYAQQGQPQYGQPAQPPRGPWGPGGGGGFLGGALQTAAGVAGGVLLAQG 178

                          90
                  ....*....|..
gi 17552230    84 VGGMFTGGGSSH 95
Cdd:pfam09849 179 IESLFSGGHGGF 190
 
Name Accession Description Interval E-value
CHCH pfam06747
CHCH domain; we have identified a conserved motif in the LOC118487 protein that we have called ...
 119-152 7.03e-06

CHCH domain; we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.


Pssm-ID: 429096  Cd Length: 35  Bit Score: 40.68  E-value: 7.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17552230   119 CEFEWRQFVDCAQNQSD-VSLCNGFNDIFKQCKAR 152
Cdd:pfam06747   1 CGEEFKAFLKCLKDNEDeLSKCRKQFDAFRQCVKK 35
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
4-95 1.40e-04

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 40.39  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552230   4 RRTASPSPSAPVRSAPRPAAQSSfaappprPAAAAPAYHPPAAPTPMGAPMGAPSQGPGLMKQMAATAGGVAIGSAVGHA 83
Cdd:COG3416  94 QRPPPAPQPSQPGPQQQPAPPSG-------PWGQAAPQQPGYGQPQYGQPAAGPSGGGGFLGGALQTAAGVAGGVLLANA 166

                        90
                ....*....|..
gi 17552230  84 VGGMFTGGGSSH 95
Cdd:COG3416 167 LTGMFSGSHPGE 178
DUF2076 pfam09849
Uncharacterized protein conserved in bacteria (DUF2076); This domain, found in various ...
 4-95 8.51e-03

Uncharacterized protein conserved in bacteria (DUF2076); This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.


Pssm-ID: 430876  Cd Length: 263  Bit Score: 35.10  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552230     4 RRTASPSPSAPVRSAPRPAAQSSFAAPPPRPAAAAPAYHPPAAPTPMGAPMGAPSQGPGLMKQMAATAGGVAIGSAVGHA 83
Cdd:pfam09849  99 SQSRPPPPPQARPAWPAGQAPGQPQPYPGQPGYAQQGQPQYGQPAQPPRGPWGPGGGGGFLGGALQTAAGVAGGVLLAQG 178

                          90
                  ....*....|..
gi 17552230    84 VGGMFTGGGSSH 95
Cdd:pfam09849 179 IESLFSGGHGGF 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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