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Conserved domains on  [gi|115534098|ref|NP_497516|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 17778750)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 116-258 1.13e-43

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 146.18  E-value: 1.13e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534098  116 DNTTCFINLLKSEECIKAQEIEFTRIPFNAVVSILPIFDSQALDYMVLLFakSDPIEQFERITYLDQWKNAKNLRLYVSK 195
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSS--ESDEDQFEEIVELEQWKNAKSLKIEGSS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115534098  196 L-ETSMLNMFHFENFSIgKMSNFPVEMAVKIRDDLITKSTFHSCSIEFDtsNSNPIDIAKTFKP 258
Cdd:pfam01827  80 LsSFPIEHLFHFEEFDI-KLDSFSVEDAIKIRDILLKSSTFQSCTIRSP--DLNPIEIAKVFDP 140
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 2-47 2.04e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 2.04e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 115534098   2 LLNLPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVDKFGVSFWKIS 47
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 116-258 1.13e-43

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 146.18  E-value: 1.13e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534098  116 DNTTCFINLLKSEECIKAQEIEFTRIPFNAVVSILPIFDSQALDYMVLLFakSDPIEQFERITYLDQWKNAKNLRLYVSK 195
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSS--ESDEDQFEEIVELEQWKNAKSLKIEGSS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115534098  196 L-ETSMLNMFHFENFSIgKMSNFPVEMAVKIRDDLITKSTFHSCSIEFDtsNSNPIDIAKTFKP 258
Cdd:pfam01827  80 LsSFPIEHLFHFEEFDI-KLDSFSVEDAIKIRDILLKSSTFQSCTIRSP--DLNPIEIAKVFDP 140
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 2-47 2.04e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 2.04e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 115534098   2 LLNLPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVDKFGVSFWKIS 47
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
5-41 2.03e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 49.36  E-value: 2.03e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 115534098     5 LPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVDKFGV 41
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 2-45 1.40e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.15  E-value: 1.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 115534098    2 LLNLPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVDKfgVSFWK 45
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDS--LKLWK 42
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 116-258 1.13e-43

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 146.18  E-value: 1.13e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534098  116 DNTTCFINLLKSEECIKAQEIEFTRIPFNAVVSILPIFDSQALDYMVLLFakSDPIEQFERITYLDQWKNAKNLRLYVSK 195
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSS--ESDEDQFEEIVELEQWKNAKSLKIEGSS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115534098  196 L-ETSMLNMFHFENFSIgKMSNFPVEMAVKIRDDLITKSTFHSCSIEFDtsNSNPIDIAKTFKP 258
Cdd:pfam01827  80 LsSFPIEHLFHFEEFDI-KLDSFSVEDAIKIRDILLKSSTFQSCTIRSP--DLNPIEIAKVFDP 140
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 2-47 2.04e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 2.04e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 115534098   2 LLNLPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVDKFGVSFWKIS 47
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
5-41 2.03e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 49.36  E-value: 2.03e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 115534098     5 LPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVDKFGV 41
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 2-45 1.40e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.15  E-value: 1.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 115534098    2 LLNLPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVDKfgVSFWK 45
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDS--LKLWK 42
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 3-37 4.35e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 34.34  E-value: 4.35e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 115534098   3 LNLPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVD 37
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
 2-48 4.51e-03

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 34.70  E-value: 4.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 115534098   2 LLNLPLDVVNLVLEKMEPKDLL-RSRKVCRTLRTTVDkfGVSFWKISC 48
Cdd:cd22169    1 LSLLPEELLLLVLSHVPARTLVtRCRLVCRDWRDLVD--GPTLWKLKC 46
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 5-37 9.31e-03

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 33.94  E-value: 9.31e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 115534098   5 LPLDVVNLVLEKMEPKDLLRSRKVCRTLRTTVD 37
Cdd:cd22133   21 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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