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Conserved domains on  [gi|17537547|ref|NP_496971|]
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Coiled-coil domain-containing protein 25 [Caenorhabditis elegans]

Protein Classification

CCDC25 family protein( domain architecture ID 10529311)

CCDC25 family protein such as vertebrate coiled-coil domain-containing protein 25 and yeast protein JLP2

PubMed:  32528174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 15-112 3.52e-40

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


:

Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 133.12  E-value: 3.52e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537547    15 MIYMGVDKVENEDLIKYGWPE-DVWFHVDKLSSAHVYLRLHSGMtidSIPEALLIDCCQLVKQNSIE-GCKLNNVAIVYT 92
Cdd:pfam05670  12 LVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEGE---DIPPETLEEAAQLAKANSIAwGNKQNNISVWYT 88

                          90       100
                  ....*....|....*....|...
gi 17537547    93 MWSNLKKTGD---MAVGQVGFHS 112
Cdd:pfam05670  89 PASQVSKTGPsgyLDTGSFMFKG 111
tolA super family cl35847
cell envelope integrity inner membrane protein TolA; Provisional
 131-183 1.94e-03

cell envelope integrity inner membrane protein TolA; Provisional


The actual alignment was detected with superfamily member PRK09510:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 38.25  E-value: 1.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537547  131 RLEKTRRKDDIDYKEERDARDAKERQKLKKLEQER-------KDREKKEMLAQNEKKRIE 183
Cdd:PRK09510  76 RAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERlaaqeqkKQAEEAAKQAALKQKQAE 135
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 15-112 3.52e-40

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 133.12  E-value: 3.52e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537547    15 MIYMGVDKVENEDLIKYGWPE-DVWFHVDKLSSAHVYLRLHSGMtidSIPEALLIDCCQLVKQNSIE-GCKLNNVAIVYT 92
Cdd:pfam05670  12 LVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEGE---DIPPETLEEAAQLAKANSIAwGNKQNNISVWYT 88

                          90       100
                  ....*....|....*....|...
gi 17537547    93 MWSNLKKTGD---MAVGQVGFHS 112
Cdd:pfam05670  89 PASQVSKTGPsgyLDTGSFMFKG 111
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 131-183 1.94e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 38.25  E-value: 1.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537547  131 RLEKTRRKDDIDYKEERDARDAKERQKLKKLEQER-------KDREKKEMLAQNEKKRIE 183
Cdd:PRK09510  76 RAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERlaaqeqkKQAEEAAKQAALKQKQAE 135
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 126-183 7.73e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 36.39  E-value: 7.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17537547   126 NEIVNRLEKTRRK-DDIDYKEERDARDAKERQKLKKLEQERKDREKKEMLAQNEKKRIE 183
Cdd:pfam07946 256 PEALKKAKKTREEeIEKIKKAAEEERAEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEE 314
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 15-112 3.52e-40

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 133.12  E-value: 3.52e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537547    15 MIYMGVDKVENEDLIKYGWPE-DVWFHVDKLSSAHVYLRLHSGMtidSIPEALLIDCCQLVKQNSIE-GCKLNNVAIVYT 92
Cdd:pfam05670  12 LVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEGE---DIPPETLEEAAQLAKANSIAwGNKQNNISVWYT 88

                          90       100
                  ....*....|....*....|...
gi 17537547    93 MWSNLKKTGD---MAVGQVGFHS 112
Cdd:pfam05670  89 PASQVSKTGPsgyLDTGSFMFKG 111
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 131-183 1.94e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 38.25  E-value: 1.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537547  131 RLEKTRRKDDIDYKEERDARDAKERQKLKKLEQER-------KDREKKEMLAQNEKKRIE 183
Cdd:PRK09510  76 RAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERlaaqeqkKQAEEAAKQAALKQKQAE 135
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 126-183 7.73e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 36.39  E-value: 7.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17537547   126 NEIVNRLEKTRRK-DDIDYKEERDARDAKERQKLKKLEQERKDREKKEMLAQNEKKRIE 183
Cdd:pfam07946 256 PEALKKAKKTREEeIEKIKKAAEEERAEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEE 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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