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Conserved domains on  [gi|17532717|ref|NP_496941|]
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Ski protein homolog [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
c-SKI_SMAD_bind super family cl07406
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 229-288 1.45e-04

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4


The actual alignment was detected with superfamily member pfam08782:

Pssm-ID: 471667  Cd Length: 94  Bit Score: 41.10  E-value: 1.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17532717   229 RCIECQHCEGKFTPTDFIMHHHYPIKpSGFVHTGCNSFQW---IRLIEVFDKSNEN--LEAWNKF 288
Cdd:pfam08782  27 ACIQCLECRLMFSPQKFVFHSHRSPE-NRTCHWGFDSANWrayLHLARYLDTPDREklEQLLEDL 90
 
Name Accession Description Interval E-value
c-SKI_SMAD_bind pfam08782
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 229-288 1.45e-04

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4


Pssm-ID: 462602  Cd Length: 94  Bit Score: 41.10  E-value: 1.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17532717   229 RCIECQHCEGKFTPTDFIMHHHYPIKpSGFVHTGCNSFQW---IRLIEVFDKSNEN--LEAWNKF 288
Cdd:pfam08782  27 ACIQCLECRLMFSPQKFVFHSHRSPE-NRTCHWGFDSANWrayLHLARYLDTPDREklEQLLEDL 90
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 230-281 1.01e-03

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


Pssm-ID: 198114  Cd Length: 95  Bit Score: 38.89  E-value: 1.01e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 17532717    230 CIECQHCEGKFTPTDFIMHHHYPIKpSGFVHTGCNSFQW---IRLIEVFDKSNEN 281
Cdd:smart01046  28 CIQCLECRGMFSPQKFVMHSHRSPE-KRTCHWGFDSANWrsyLHVAKDYGTEERE 81
 
Name Accession Description Interval E-value
c-SKI_SMAD_bind pfam08782
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 229-288 1.45e-04

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4


Pssm-ID: 462602  Cd Length: 94  Bit Score: 41.10  E-value: 1.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17532717   229 RCIECQHCEGKFTPTDFIMHHHYPIKpSGFVHTGCNSFQW---IRLIEVFDKSNEN--LEAWNKF 288
Cdd:pfam08782  27 ACIQCLECRLMFSPQKFVFHSHRSPE-NRTCHWGFDSANWrayLHLARYLDTPDREklEQLLEDL 90
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 230-281 1.01e-03

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


Pssm-ID: 198114  Cd Length: 95  Bit Score: 38.89  E-value: 1.01e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 17532717    230 CIECQHCEGKFTPTDFIMHHHYPIKpSGFVHTGCNSFQW---IRLIEVFDKSNEN 281
Cdd:smart01046  28 CIQCLECRGMFSPQKFVMHSHRSPE-KRTCHWGFDSANWrsyLHVAKDYGTEERE 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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