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Conserved domains on  [gi|17537217|ref|NP_496814|]
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Protein mac-1 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
191-804 5.36e-155

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 470.16  E-value: 5.36e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   191 AVSDTISPRESHVKFEHIGG---ADRQFLEVCRLAMhlKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPM 267
Cdd:TIGR01243 163 PVREEIERKVPKVTYEDIGGlkeAKEKIREMVELPM--KHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYF 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   268 LQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkd 347
Cdd:TIGR01243 241 ISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGL----------- 309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   348 qltfgddgsvaiigdsptaAGAG-VLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILeKICKVN--LAGDVT 424
Cdd:TIGR01243 310 -------------------KGRGrVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEIL-KVHTRNmpLAEDVD 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   425 LKQIAKLTPGYVGADLQALIREAAKVAIDRVFdtivvkNEGHKNLTVEQIKEELdrvlawlqgdddpsaLSElnggLQIS 504
Cdd:TIGR01243 370 LDKLAEVTHGFVGADLAALAKEAAMAALRRFI------REGKINFEAEEIPAEV---------------LKE----LKVT 424
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   505 FEDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLL 584
Cdd:TIGR01243 425 MKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIR-PPKGVLLFGPPGTGKTLL 503
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   585 AKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGA-RLVNQLLTEMD 663
Cdd:TIGR01243 504 AKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTdRIVNQLLTEMD 583
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   664 GVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTrpmLGEDIDFHEIAQLPElaGFTG 743
Cdd:TIGR01243 584 GIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP---LAEDVDLEELAEMTE--GYTG 658
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17537217   744 ADLAALIHESSLLALQARV---------LENDESVKG--VGMRHFREAASRIRPSVTEADRKKYEHMKKIYG 804
Cdd:TIGR01243 659 ADIEAVCREAAMAALRESIgspakekleVGEEEFLKDlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
Nucleolin_bd super family cl25070
Nucleolin binding domain; This domain adopts a three helix fold resembling part of a winged ...
5-65 1.55e-08

Nucleolin binding domain; This domain adopts a three helix fold resembling part of a winged helix motif. It binds nucleolin.


The actual alignment was detected with superfamily member pfam16725:

Pssm-ID: 465247  Cd Length: 70  Bit Score: 51.86  E-value: 1.55e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537217     5 MGFPSDPALLPRVQAHIRKFPGTKYFKPELVAYDLQQEHPEYQRKNHKVFMGMVREALERI 65
Cdd:pfam16725   4 SGYFSDPRLVPRVEQYLEDNSDSTYVDVDAMADELQRQYREYGRRKRNAFRIQVEKAYEII 64
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
191-804 5.36e-155

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 470.16  E-value: 5.36e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   191 AVSDTISPRESHVKFEHIGG---ADRQFLEVCRLAMhlKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPM 267
Cdd:TIGR01243 163 PVREEIERKVPKVTYEDIGGlkeAKEKIREMVELPM--KHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYF 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   268 LQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkd 347
Cdd:TIGR01243 241 ISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGL----------- 309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   348 qltfgddgsvaiigdsptaAGAG-VLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILeKICKVN--LAGDVT 424
Cdd:TIGR01243 310 -------------------KGRGrVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEIL-KVHTRNmpLAEDVD 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   425 LKQIAKLTPGYVGADLQALIREAAKVAIDRVFdtivvkNEGHKNLTVEQIKEELdrvlawlqgdddpsaLSElnggLQIS 504
Cdd:TIGR01243 370 LDKLAEVTHGFVGADLAALAKEAAMAALRRFI------REGKINFEAEEIPAEV---------------LKE----LKVT 424
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   505 FEDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLL 584
Cdd:TIGR01243 425 MKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIR-PPKGVLLFGPPGTGKTLL 503
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   585 AKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGA-RLVNQLLTEMD 663
Cdd:TIGR01243 504 AKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTdRIVNQLLTEMD 583
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   664 GVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTrpmLGEDIDFHEIAQLPElaGFTG 743
Cdd:TIGR01243 584 GIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP---LAEDVDLEELAEMTE--GYTG 658
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17537217   744 ADLAALIHESSLLALQARV---------LENDESVKG--VGMRHFREAASRIRPSVTEADRKKYEHMKKIYG 804
Cdd:TIGR01243 659 ADIEAVCREAAMAALRESIgspakekleVGEEEFLKDlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
538-699 9.86e-103

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 313.66  E-value: 9.86e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 538 LVEVRKQLEWSILYPIKRADDFAALGIDCrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVR 617
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYKALGIDL-PTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 618 TVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKIL 697
Cdd:cd19530  80 QVFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTL 159

                ..
gi 17537217 698 FV 699
Cdd:cd19530 160 YV 161
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
506-793 5.71e-100

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 312.71  E-value: 5.71e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 506 EDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLA 585
Cdd:COG1222  51 NDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIE-PPKGVLLYGPPGTGKTLLA 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 586 KAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSG-GARLVNQLLTEMDG 664
Cdd:COG1222 130 KAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGeVQRTVNQLLAELDG 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 665 VEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNgtRPmLGEDIDFHEIAQLPElaGFTGA 744
Cdd:COG1222 210 FESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRD--MP-LADDVDLDKLAKLTE--GFSGA 284
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17537217 745 DLAALIHESSLLALQARVLEndesvkgVGMRHFREAASRIRPSVTEADR 793
Cdd:COG1222 285 DLKAIVTEAGMFAIREGRDT-------VTMEDLEKAIEKVKKKTETATN 326
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
528-785 1.30e-71

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 240.12  E-value: 1.30e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  528 PDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNM 607
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIE-PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQK 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  608 YVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGA---RLVNQLLTEMDGVEGRQKVFLIGATNRPDIVD 684
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSGDRevqRTLMQLLAEMDGFDPRGNVKIIAATNRIDILD 284
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  685 AAILRPGRLDKILFVDFPSVEDRVDILRKSTKNgtrpM-LGEDIDFHEIAQLPElaGFTGADLAALIHESSLLALQarvl 763
Cdd:PRK03992 285 PAILRPGRFDRIIEVPLPDEEGRLEILKIHTRK----MnLADDVDLEELAELTE--GASGADLKAICTEAGMFAIR---- 354
                        250       260
                 ....*....|....*....|..
gi 17537217  764 eNDESVkgVGMRHFREAASRIR 785
Cdd:PRK03992 355 -DDRTE--VTMEDFLKAIEKVM 373
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
571-700 1.61e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 181.25  E-value: 1.61e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   571 ILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSG 650
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17537217   651 GARLVNQLLTEMDGVEGRQ-KVFLIGATNRPDIVDAAILrpGRLDKILFVD 700
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
cell_div_CdvC NF041006
cell division protein CdvC;
528-797 3.90e-52

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 186.09  E-value: 3.90e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  528 PDVSWDDIGALVEVRKQLEWSILYPIKRADDFAaLGIdcrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNM 607
Cdd:NF041006  98 PKVTFSDIVGLEDVKEALKEAIVYPSKRPDLFP-LGW---PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSK 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  608 YVGESERAVRTVFQRAR-----DSQPCVIFFDEIDALVPKRShGESSGGARLVNQLLTEMDGVEGRQ---KVFLIGATNR 679
Cdd:NF041006 174 WLGEAEKNVAKIFKKARekskeEGKPAIIFIDEIDALLGVYS-SEVGGEVRVRNQFLKEMDGLQDKSenyHVYVIGATNK 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  680 PDIVDAAILRpgRLDKILFVDFPSVEDRVDILRKSTKngtRPMLGEDIDFHEIAQLPElaGFTGADLAALIHESSLLALQ 759
Cdd:NF041006 253 PWRLDEPFLR--RFQKRIYIPLPDREQRLELLKYYTS---KIKLENDVDLDELAEMTE--GYTASDIRDIVQAAHMRVVK 325
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 17537217  760 ARVLENDESVKGVGMRHFREAASRIRPSVTEADRKKYE 797
Cdd:NF041006 326 EMFEKGLGEPRPITMEDFKEVLKIRKPSVNQEMLKAYE 363
cell_div_CdvC NF041006
cell division protein CdvC;
226-480 2.11e-25

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 109.05  E-value: 2.11e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  226 KRPKTFAtLGVdpPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTA-----KQNSPC 300
Cdd:NF041006 124 KRPDLFP-LGW--PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKArekskEEGKPA 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  301 ILILDDIDAIAPRRETaQREMERRVVSQLCSSLDELVlpPREKPLKdqltfgddgsvaiigdsptaagagVLVIGTTSRP 380
Cdd:NF041006 201 IIFIDEIDALLGVYSS-EVGGEVRVRNQFLKEMDGLQ--DKSENYH------------------------VYVIGATNKP 253
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  381 DAVDGGLRRagRFENEISLGIPDETAREKILEKIC-KVNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAIDRVFDti 459
Cdd:NF041006 254 WRLDEPFLR--RFQKRIYIPLPDREQRLELLKYYTsKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFE-- 329
                        250       260
                 ....*....|....*....|..
gi 17537217  460 vvKNEGH-KNLTVEQIKEELDR 480
Cdd:NF041006 330 --KGLGEpRPITMEDFKEVLKI 349
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
567-700 6.50e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 83.96  E-value: 6.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217    567 RPQGILLCGPPGCGKTLLAKAVANE---TGMNFISVKGPELL--------------NMYVGESERAVRTVFQRARDSQPC 629
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARElgpPGGGVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537217    630 VIFFDEIDALVPKRSHGEssggaRLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPgRLDKILFVD 700
Cdd:smart00382  81 VLILDEITSLLDAEQEAL-----LLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
Nucleolin_bd pfam16725
Nucleolin binding domain; This domain adopts a three helix fold resembling part of a winged ...
5-65 1.55e-08

Nucleolin binding domain; This domain adopts a three helix fold resembling part of a winged helix motif. It binds nucleolin.


Pssm-ID: 465247  Cd Length: 70  Bit Score: 51.86  E-value: 1.55e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537217     5 MGFPSDPALLPRVQAHIRKFPGTKYFKPELVAYDLQQEHPEYQRKNHKVFMGMVREALERI 65
Cdd:pfam16725   4 SGYFSDPRLVPRVEQYLEDNSDSTYVDVDAMADELQRQYREYGRRKRNAFRIQVEKAYEII 64
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
191-804 5.36e-155

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 470.16  E-value: 5.36e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   191 AVSDTISPRESHVKFEHIGG---ADRQFLEVCRLAMhlKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPM 267
Cdd:TIGR01243 163 PVREEIERKVPKVTYEDIGGlkeAKEKIREMVELPM--KHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYF 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   268 LQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkd 347
Cdd:TIGR01243 241 ISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGL----------- 309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   348 qltfgddgsvaiigdsptaAGAG-VLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILeKICKVN--LAGDVT 424
Cdd:TIGR01243 310 -------------------KGRGrVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEIL-KVHTRNmpLAEDVD 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   425 LKQIAKLTPGYVGADLQALIREAAKVAIDRVFdtivvkNEGHKNLTVEQIKEELdrvlawlqgdddpsaLSElnggLQIS 504
Cdd:TIGR01243 370 LDKLAEVTHGFVGADLAALAKEAAMAALRRFI------REGKINFEAEEIPAEV---------------LKE----LKVT 424
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   505 FEDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLL 584
Cdd:TIGR01243 425 MKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIR-PPKGVLLFGPPGTGKTLL 503
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   585 AKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGA-RLVNQLLTEMD 663
Cdd:TIGR01243 504 AKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTdRIVNQLLTEMD 583
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   664 GVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTrpmLGEDIDFHEIAQLPElaGFTG 743
Cdd:TIGR01243 584 GIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP---LAEDVDLEELAEMTE--GYTG 658
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17537217   744 ADLAALIHESSLLALQARV---------LENDESVKG--VGMRHFREAASRIRPSVTEADRKKYEHMKKIYG 804
Cdd:TIGR01243 659 ADIEAVCREAAMAALRESIgspakekleVGEEEFLKDlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
538-699 9.86e-103

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 313.66  E-value: 9.86e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 538 LVEVRKQLEWSILYPIKRADDFAALGIDCrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVR 617
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYKALGIDL-PTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 618 TVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKIL 697
Cdd:cd19530  80 QVFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTL 159

                ..
gi 17537217 698 FV 699
Cdd:cd19530 160 YV 161
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
506-793 5.71e-100

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 312.71  E-value: 5.71e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 506 EDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLA 585
Cdd:COG1222  51 NDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIE-PPKGVLLYGPPGTGKTLLA 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 586 KAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSG-GARLVNQLLTEMDG 664
Cdd:COG1222 130 KAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGeVQRTVNQLLAELDG 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 665 VEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNgtRPmLGEDIDFHEIAQLPElaGFTGA 744
Cdd:COG1222 210 FESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRD--MP-LADDVDLDKLAKLTE--GFSGA 284
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17537217 745 DLAALIHESSLLALQARVLEndesvkgVGMRHFREAASRIRPSVTEADR 793
Cdd:COG1222 285 DLKAIVTEAGMFAIREGRDT-------VTMEDLEKAIEKVKKKTETATN 326
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
207-399 6.12e-94

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 291.23  E-value: 6.12e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 207 HIGGADRQFLEVCRLAMHLKRPKT-FATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEE 285
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEyFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 286 KIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELVLPPRekplkdqltfgddgsvaiigdspt 365
Cdd:cd19518  81 KIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKT------------------------ 136
                       170       180       190
                ....*....|....*....|....*....|....
gi 17537217 366 aAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISL 399
Cdd:cd19518 137 -AGGPVLVIGATNRPDSLDPALRRAGRFDREICL 169
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
541-699 2.83e-82

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 259.91  E-value: 2.83e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 541 VRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVF 620
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRLGIR-PPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 621 QRARDSQPCVIFFDEIDALVPKRShGESSGGA--RLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILF 698
Cdd:cd19511  80 QKARQAAPCIIFFDEIDSLAPRRG-QSDSSGVtdRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIY 158

                .
gi 17537217 699 V 699
Cdd:cd19511 159 V 159
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
442-785 9.79e-77

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 254.07  E-value: 9.79e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 442 ALIREAAKVAIDRVFDTIVVKNEGHKNLTVEQIKEELDRVLAWLQGDDDPSALSELNGGLQISFEDFERALSTIQPAAKR 521
Cdd:COG0464  66 AALLLLALLLLALLALLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLE 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 522 EGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKG 601
Cdd:COG0464 146 EELLELREAILDDLGGLEEVKEELRELVALPLKRPELREEYGLP-PPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDL 224
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 602 PELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGRqkVFLIGATNRPD 681
Cdd:COG0464 225 SDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEELRSD--VVVIAATNRPD 302
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 682 IVDAAILRpgRLDKILFVDFPSVEDRVDILRKSTKNgtRPmLGEDIDFHEIAQlpELAGFTGADLAALIHESSLLALQar 761
Cdd:COG0464 303 LLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRK--RP-LDEDVDLEELAE--ATEGLSGADIRNVVRRAALQALR-- 373
                       330       340
                ....*....|....*....|....
gi 17537217 762 vlendESVKGVGMRHFREAASRIR 785
Cdd:COG0464 374 -----LGREPVTTEDLLEALERED 392
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
528-785 1.30e-71

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 240.12  E-value: 1.30e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  528 PDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNM 607
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIE-PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQK 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  608 YVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGA---RLVNQLLTEMDGVEGRQKVFLIGATNRPDIVD 684
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSGDRevqRTLMQLLAEMDGFDPRGNVKIIAATNRIDILD 284
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  685 AAILRPGRLDKILFVDFPSVEDRVDILRKSTKNgtrpM-LGEDIDFHEIAQLPElaGFTGADLAALIHESSLLALQarvl 763
Cdd:PRK03992 285 PAILRPGRFDRIIEVPLPDEEGRLEILKIHTRK----MnLADDVDLEELAELTE--GASGADLKAICTEAGMFAIR---- 354
                        250       260
                 ....*....|....*....|..
gi 17537217  764 eNDESVkgVGMRHFREAASRIR 785
Cdd:PRK03992 355 -DDRTE--VTMEDFLKAIEKVM 373
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
541-699 3.89e-66

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 216.99  E-value: 3.89e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 541 VRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVF 620
Cdd:cd19528   1 VKRELQELVQYPVEHPDKFLKFGMT-PSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 621 QRARDSQPCVIFFDEIDALVPKR--SHGESSGGA-RLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKIL 697
Cdd:cd19528  80 DKARAAAPCVLFFDELDSIAKARggNIGDAGGAAdRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLI 159

                ..
gi 17537217 698 FV 699
Cdd:cd19528 160 YI 161
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
162-459 1.46e-64

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 218.72  E-value: 1.46e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 162 TPVSTPKNQATKKPPGASAAPPALPRGLGAVSDTISPRESHVKFEHIGGADRQFLEVC-RLAMHLKRPKTFATLGVDPPR 240
Cdd:COG1222  34 QPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIReAVELPLKNPELFRKYGIEPPK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 241 GFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRR-ETAQR 319
Cdd:COG1222 114 GVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRtDDGTS 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 320 EMERRVVSQLCSSLDElvlpprekplkdqltFGDDGSvaiigdsptaagagVLVIGTTSRPDAVDGGLRRAGRFENEISL 399
Cdd:COG1222 194 GEVQRTVNQLLAELDG---------------FESRGD--------------VLIIAATNRPDLLDPALLRPGRFDRVIEV 244
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537217 400 GIPDETAREKILEKICK-VNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAIDRVFDTI 459
Cdd:COG1222 245 PLPDEEAREEILKIHLRdMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIREGRDTV 305
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
540-699 2.59e-64

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 211.97  E-value: 2.59e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 540 EVRKQLEWSILYPikraDDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTV 619
Cdd:cd19529   4 ELKEAVEWPLLKP----EVFKRLGIR-PPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 620 FQRARDSQPCVIFFDEIDALVPKRSHGESSG-GARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILF 698
Cdd:cd19529  79 FRKARQVAPCVIFFDEIDSIAPRRGTTGDSGvTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIY 158

                .
gi 17537217 699 V 699
Cdd:cd19529 159 I 159
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
541-698 1.30e-62

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 207.28  E-value: 1.30e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 541 VRKQLEWSILYPIKRADDFAALGIDCRpQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVF 620
Cdd:cd19526   1 VKKALEETIEWPSKYPKIFASSPLRLR-SGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLF 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17537217 621 QRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILF 698
Cdd:cd19526  80 SRAQSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
534-695 9.72e-60

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 199.83  E-value: 9.72e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAALGIDCrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESE 613
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRALGLKP-PRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 614 RAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRL 693
Cdd:cd19503  80 KNLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGRF 159

                ..
gi 17537217 694 DK 695
Cdd:cd19503 160 DR 161
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
541-699 1.75e-59

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 198.89  E-value: 1.75e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 541 VRKQLEWSILYPIKRADDFAaLGIDCRpQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVF 620
Cdd:cd19527   1 VKKEILDTIQLPLEHPELFS-SGLRKR-SGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 621 QRARDSQPCVIFFDEIDALVPKRSHGESSGGA--RLVNQLLTEMDGVE-GRQKVFLIGATNRPDIVDAAILRPGRLDKIL 697
Cdd:cd19527  79 QKARDAKPCVIFFDELDSLAPSRGNSGDSGGVmdRVVSQLLAELDGMSsSGQDVFVIGATNRPDLLDPALLRPGRFDKLL 158

                ..
gi 17537217 698 FV 699
Cdd:cd19527 159 YL 160
ftsH CHL00176
cell division protein; Validated
480-784 1.49e-58

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 211.06  E-value: 1.49e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  480 RVLAWLQGDDdpsalSELNGGLQISFEDFERALSTIQPAAKRegfatvpDVSWDDIGALVEVRKQLEwSILYPIKRADDF 559
Cdd:CHL00176 142 GVLWFFFQRS-----SNFKGGPGQNLMNFGKSKARFQMEADT-------GITFRDIAGIEEAKEEFE-EVVSFLKKPERF 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  560 AALGIDCrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDAL 639
Cdd:CHL00176 209 TAVGAKI-PKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGVGAARVRDLFKKAKENSPCIVFIDEIDAV 287
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  640 VPKRshGESSGGA-----RLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKS 714
Cdd:CHL00176 288 GRQR--GAGIGGGndereQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALLRPGRFDRQITVSLPDREGRLDILKVH 365
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  715 TKNGTrpmLGEDIDFHEIAQlpELAGFTGADLAALIHESSLLALQARvlendesVKGVGMRHFREAASRI 784
Cdd:CHL00176 366 ARNKK---LSPDVSLELIAR--RTPGFSGADLANLLNEAAILTARRK-------KATITMKEIDTAIDRV 423
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
528-784 1.04e-57

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 205.21  E-value: 1.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   528 PDVSWDDIGALVEVRKQLEwSILYPIKRADDFAALG--IdcrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELL 605
Cdd:TIGR01241  50 PKVTFKDVAGIDEAKEELM-EIVDFLKNPSKFTKLGakI---PKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   606 NMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGG---ARLVNQLLTEMDGVEGRQKVFLIGATNRPDI 682
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNderEQTLNQLLVEMDGFGTNTGVIVIAATNRPDV 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   683 VDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTrpmLGEDIDFHEIAQLPelAGFTGADLAALIHESSLLAlqARv 762
Cdd:TIGR01241 206 LDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKK---LAPDVDLKAVARRT--PGFSGADLANLLNEAALLA--AR- 277
                         250       260
                  ....*....|....*....|..
gi 17537217   763 lENDESVKgvgMRHFREAASRI 784
Cdd:TIGR01241 278 -KNKTEIT---MNDIEEAIDRV 295
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
548-699 1.10e-56

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 191.34  E-value: 1.10e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 548 SILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQ 627
Cdd:cd19481   7 EAVEAPRRGSRLRRYGLG-LPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLA 85
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17537217 628 PCVIFFDEIDALVPKRS-HGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFV 699
Cdd:cd19481  86 PCILFIDEIDAIGRKRDsSGESGELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
559-794 1.37e-56

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 204.12  E-value: 1.37e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 559 FAALG--IdcrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVG--ESeRaVRTVFQRARDSQPCVIFFD 634
Cdd:COG0465 167 FTRLGakI---PKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGvgAS-R-VRDLFEQAKKNAPCIIFID 241
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 635 EIDALvpKRSHGESSGGA---R---LvNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRV 708
Cdd:COG0465 242 EIDAV--GRQRGAGLGGGhdeReqtL-NQLLVEMDGFEGNEGVIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDVKGRE 318
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 709 DILRKSTKNgtRPmLGEDIDFHEIAQL-PelaGFTGADLAALIHESSLLAlqARvlENDESvkgVGMRHFREAASRI--- 784
Cdd:COG0465 319 AILKVHARK--KP-LAPDVDLEVIARRtP---GFSGADLANLVNEAALLA--AR--RNKKA---VTMEDFEEAIDRViag 385
                       250
                ....*....|....
gi 17537217 785 --RPS--VTEADRK 794
Cdd:COG0465 386 peRKSrvISEKEKK 399
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
531-697 6.78e-55

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 186.77  E-value: 6.78e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 531 SWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVG 610
Cdd:cd19502   1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIE-PPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 611 ESERAVRTVFQRARDSQPCVIFFDEIDALVPKRShGESSGGARLVN----QLLTEMDGVEGRQKVFLIGATNRPDIVDAA 686
Cdd:cd19502  80 EGARLVRELFEMAREKAPSIIFIDEIDAIGAKRF-DSGTGGDREVQrtmlELLNQLDGFDPRGNIKVIMATNRPDILDPA 158
                       170
                ....*....|.
gi 17537217 687 ILRPGRLDKIL 697
Cdd:cd19502 159 LLRPGRFDRKI 169
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
527-765 9.30e-54

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 194.54  E-value: 9.30e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   527 VPDVSWDDIGALVE----VRKQLEWSILYP-IKRADDFAAlgidcrPQGILLCGPPGCGKTLLAKAVAN-------ETGM 594
Cdd:TIGR03689 176 VPDVTYADIGGLGSqieqIRDAVELPFLHPeLYREYGLKP------PKGVLLYGPPGCGKTLIAKAVANslaarigAEGG 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   595 N---FISVKGPELLNMYVGESERAVRTVFQRAR----DSQPCVIFFDEIDALVPKRSHGESSG-GARLVNQLLTEMDGVE 666
Cdd:TIGR03689 250 GksyFLNIKGPELLNKYVGETERQIRLIFQRARekasEGRPVIVFFDEMDSLFRTRGSGVSSDvETTVVPQLLAEIDGVE 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   667 GRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKstkngtrpMLGEDIDFHEiaQLPELAGFTGADL 746
Cdd:TIGR03689 330 SLDNVIVIGASNREDMIDPAILRPGRLDVKIRIERPDAEAAADIFAK--------YLTDDLPLPE--DLAAHDGDREATA 399
                         250
                  ....*....|....*....
gi 17537217   747 AALIhESSLLALQARVLEN 765
Cdd:TIGR03689 400 AALI-QRVVDALYARSEAN 417
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
571-700 1.61e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 181.25  E-value: 1.61e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   571 ILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSG 650
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17537217   651 GARLVNQLLTEMDGVEGRQ-KVFLIGATNRPDIVDAAILrpGRLDKILFVD 700
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
cell_div_CdvC NF041006
cell division protein CdvC;
528-797 3.90e-52

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 186.09  E-value: 3.90e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  528 PDVSWDDIGALVEVRKQLEWSILYPIKRADDFAaLGIdcrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNM 607
Cdd:NF041006  98 PKVTFSDIVGLEDVKEALKEAIVYPSKRPDLFP-LGW---PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSK 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  608 YVGESERAVRTVFQRAR-----DSQPCVIFFDEIDALVPKRShGESSGGARLVNQLLTEMDGVEGRQ---KVFLIGATNR 679
Cdd:NF041006 174 WLGEAEKNVAKIFKKARekskeEGKPAIIFIDEIDALLGVYS-SEVGGEVRVRNQFLKEMDGLQDKSenyHVYVIGATNK 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  680 PDIVDAAILRpgRLDKILFVDFPSVEDRVDILRKSTKngtRPMLGEDIDFHEIAQLPElaGFTGADLAALIHESSLLALQ 759
Cdd:NF041006 253 PWRLDEPFLR--RFQKRIYIPLPDREQRLELLKYYTS---KIKLENDVDLDELAEMTE--GYTASDIRDIVQAAHMRVVK 325
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 17537217  760 ARVLENDESVKGVGMRHFREAASRIRPSVTEADRKKYE 797
Cdd:NF041006 326 EMFEKGLGEPRPITMEDFKEVLKIRKPSVNQEMLKAYE 363
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
58-481 2.05e-51

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 185.11  E-value: 2.05e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  58 VREALERIQLVAKEENDEKMEEKEAMDDVQEIPIVKALETRKRKAPAAGRKSTGQAAAAKEVVLSDDSEDERAARQLEKQ 137
Cdd:COG0464   9 VALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 138 IESLKTNRANKTVLNLYTKKSAPSTPVSTPKNQATKKPPGASAAPPALPRGLGAVSDTISPRESHVKFEHIGGAD--RQF 215
Cdd:COG0464  89 LELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLGGLEevKEE 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 216 LEVcRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAK 295
Cdd:COG0464 169 LRE-LVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKAR 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 296 QNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdsptaaGAGVLVIG 375
Cdd:COG0464 248 GLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEEL-------------------------------RSDVVVIA 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 376 TTSRPDAVDGGLRRagRFENEISLGIPDETAREKILEKIC-KVNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAIDr 454
Cdd:COG0464 297 ATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLrKRPLDEDVDLEELAEATEGLSGADIRNVVRRAALQALR- 373
                       410       420
                ....*....|....*....|....*..
gi 17537217 455 vfdtivvknEGHKNLTVEQIKEELDRV 481
Cdd:COG0464 374 ---------LGREPVTTEDLLEALERE 391
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
530-699 3.42e-51

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 176.65  E-value: 3.42e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 530 VSWDDIGALVEVRKQLEWSILYpIKRADDFAALGIDCrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYV 609
Cdd:cd19501   1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKI-PKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 610 GESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGG---ARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAA 686
Cdd:cd19501  79 GVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHderEQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPA 158
                       170
                ....*....|...
gi 17537217 687 ILRPGRLDKILFV 699
Cdd:cd19501 159 LLRPGRFDRQVYV 171
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
534-695 5.53e-51

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 175.70  E-value: 5.53e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESE 613
Cdd:cd19519   1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIK-PPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 614 RAVRTVFQRARDSQPCVIFFDEIDALVPKR--SHGESSggARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPG 691
Cdd:cd19519  80 SNLRKAFEEAEKNAPAIIFIDEIDAIAPKRekTHGEVE--RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFG 157

                ....
gi 17537217 692 RLDK 695
Cdd:cd19519 158 RFDR 161
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
208-397 1.71e-49

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 171.71  E-value: 1.71e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 208 IGGADRQFLEVCRL-AMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEK 286
Cdd:cd19503   2 IGGLDEQIASLKELiELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 287 IRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdsptA 366
Cdd:cd19503  82 LREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGM-----------------------------S 132
                       170       180       190
                ....*....|....*....|....*....|.
gi 17537217 367 AGAGVLVIGTTSRPDAVDGGLRRAGRFENEI 397
Cdd:cd19503 133 SRGKVVVIAATNRPDAIDPALRRPGRFDREV 163
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
535-699 2.47e-48

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 168.30  E-value: 2.47e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 535 IGALVEVRKQLEWSILYPIKRADDFAalGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESER 614
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLFP--GLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 615 AVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGR--QKVFLIGATNRPDIVDAAILRpgR 692
Cdd:cd19509  79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNKpeDRVLVLGATNRPWELDEAFLR--R 156

                ....*..
gi 17537217 693 LDKILFV 699
Cdd:cd19509 157 FEKRIYI 163
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
568-795 1.36e-47

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 169.29  E-value: 1.36e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 568 PQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARdSQPCVIFFDEIDALVPKRSHGE 647
Cdd:COG1223  35 PRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFAR-RAPCVIFFDEFDAIAKDRGDQN 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 648 SSG-GARLVNQLLTEMDGVegRQKVFLIGATNRPDIVDAAILRpgRLDKILFVDFPSVEDRVDILRKSTKNGTRPMlgeD 726
Cdd:COG1223 114 DVGeVKRVVNALLQELDGL--PSGSVVIAATNHPELLDSALWR--RFDEVIEFPLPDKEERKEILELNLKKFPLPF---E 186
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17537217 727 IDFHEIAQLpeLAGFTGADLAALIHEssllALQARVLENDESVKGvgmRHFREAASRIRPSVTEADRKK 795
Cdd:COG1223 187 LDLKKLAKK--LEGLSGADIEKVLKT----ALKKAILEDREKVTK---EDLEEALKQRKERKKEPKKEG 246
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
534-695 6.14e-46

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 161.80  E-value: 6.14e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESE 613
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVE-PPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 614 RAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGV----EGRQKVFLIGATNRPDIVDAAILR 689
Cdd:cd19518  80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPALRR 159

                ....*.
gi 17537217 690 PGRLDK 695
Cdd:cd19518 160 AGRFDR 165
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
513-759 7.44e-46

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 169.17  E-value: 7.44e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  513 STIQPAAKREGfatvPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANET 592
Cdd:PTZ00454 129 SSIQLLQMSEK----PDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGID-PPRGVLLYGPPGTGKTMLAKAVAHHT 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  593 GMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESsgGA-----RLVNQLLTEMDGVEG 667
Cdd:PTZ00454 204 TATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQT--GAdrevqRILLELLNQMDGFDQ 281
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  668 RQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTkngTRPMLGEDIDFHEIAQLPElaGFTGADLA 747
Cdd:PTZ00454 282 TTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFQTIT---SKMNLSEEVDLEDFVSRPE--KISAADIA 356
                        250
                 ....*....|..
gi 17537217  748 ALIHESSLLALQ 759
Cdd:PTZ00454 357 AICQEAGMQAVR 368
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
531-784 1.40e-45

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 173.68  E-value: 1.40e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  531 SWDDIGALVEVRKQLEWSILYpIKRADDFAALGIDCrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVG 610
Cdd:PRK10733 150 TFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKI-PKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVG 227
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  611 ESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGG---ARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAI 687
Cdd:PRK10733 228 VGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHderEQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPAL 307
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  688 LRPGRLDKILFVDFPSVEDRVDILRKSTKngtRPMLGEDIDFHEIAQlpELAGFTGADLAALIHESSLLALQArvlende 767
Cdd:PRK10733 308 LRPGRFDRQVVVGLPDVRGREQILKVHMR---RVPLAPDIDAAIIAR--GTPGFSGADLANLVNEAALFAARG------- 375
                        250
                 ....*....|....*..
gi 17537217  768 SVKGVGMRHFREAASRI 784
Cdd:PRK10733 376 NKRVVSMVEFEKAKDKI 392
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
203-452 4.89e-45

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 166.55  E-value: 4.89e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  203 VKFEHIGGADRQFLEVcRLA--MHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVS 280
Cdd:PRK03992 128 VTYEDIGGLEEQIREV-REAveLPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  281 GETEEKIRRLFDTAKQNSPCILILDDIDAIAPRR----ETAQREMERRVVsQLCSSLDelvlpprekplkdqlTFGDDGS 356
Cdd:PRK03992 207 GEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVQRTLM-QLLAEMD---------------GFDPRGN 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  357 VAIIgdsptAAgagvlvigtTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILeKIC--KVNLAGDVTLKQIAKLTPG 434
Cdd:PRK03992 271 VKII-----AA---------TNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEIL-KIHtrKMNLADDVDLEELAELTEG 335
                        250
                 ....*....|....*...
gi 17537217  435 YVGADLQALIREAAKVAI 452
Cdd:PRK03992 336 ASGADLKAICTEAGMFAI 353
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
203-486 2.20e-44

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 167.46  E-value: 2.20e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   203 VKFEHIGGADRQFLEVCRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGE 282
Cdd:TIGR01241  52 VTFKDVAGIDEAKEELMEIVDFLKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGV 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   283 TEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAqremerrvvsqLCSSLDElvlppREKPLkDQLTFGDDGsvaiigd 362
Cdd:TIGR01241 132 GASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAG-----------LGGGNDE-----REQTL-NQLLVEMDG------- 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   363 spTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILE-KICKVNLAGDVTLKQIAKLTPGYVGADLQ 441
Cdd:TIGR01241 188 --FGTNTGVIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDIKGREEILKvHAKNKKLAPDVDLKAVARRTPGFSGADLA 265
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 17537217   442 ALIREAAKVAIDRvfdtivvkneGHKNLTVEQIKEELDRVLAWLQ 486
Cdd:TIGR01241 266 NLLNEAALLAARK----------NKTEITMNDIEEAIDRVIAGPE 300
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
203-459 2.59e-43

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 161.12  E-value: 2.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   203 VKFEHIGGADRQFLEVCR-LAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSG 281
Cdd:TIGR01242 119 VSYEDIGGLEEQIREIREaVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVRKYIG 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   282 ETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkdqltfgdDGSVAiIG 361
Cdd:TIGR01242 199 EGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDREVQRTLMQLLAEL-----------------DGFDP-RG 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   362 DsptaagagVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILeKI--CKVNLAGDVTLKQIAKLTPGYVGAD 439
Cdd:TIGR01242 261 N--------VKVIAATNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEIL-KIhtRKMKLAEDVDLEAIAKMTEGASGAD 331
                         250       260
                  ....*....|....*....|
gi 17537217   440 LQALIREAAKVAIDRVFDTI 459
Cdd:TIGR01242 332 LKAICTEAGMFAIREERDYV 351
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
208-400 3.31e-43

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 154.13  E-value: 3.31e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 208 IGGADRQFLEVCRLA-MHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEK 286
Cdd:cd19519   2 IGGCRKQLAQIREMVeLPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 287 IRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdsptA 366
Cdd:cd19519  82 LRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGL-----------------------------K 132
                       170       180       190
                ....*....|....*....|....*....|....
gi 17537217 367 AGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLG 400
Cdd:cd19519 133 QRAHVIVMAATNRPNSIDPALRRFGRFDREIDIG 166
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
528-761 2.75e-42

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 159.94  E-value: 2.75e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  528 PDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNM 607
Cdd:PTZ00361 178 PLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIK-PPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQK 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  608 YVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRsHGESSGGARLVN----QLLTEMDGVEGRQKVFLIGATNRPDIV 683
Cdd:PTZ00361 257 YLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKR-YDATSGGEKEIQrtmlELLNQLDGFDSRGDVKVIMATNRIESL 335
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17537217  684 DAAILRPGRLDKILFVDFPSVEDRVDILRKSTkngTRPMLGEDIDFHE-IAQLPELagfTGADLAALIHESSLLALQAR 761
Cdd:PTZ00361 336 DPALIRPGRIDRKIEFPNPDEKTKRRIFEIHT---SKMTLAEDVDLEEfIMAKDEL---SGADIKAICTEAGLLALRER 408
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
217-480 2.88e-42

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 154.27  E-value: 2.88e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 217 EVCRLAMH-LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAK 295
Cdd:COG1223  12 KKLKLIIKeLRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFAR 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 296 QNsPCILILDDIDAIAPRRETAQREME-RRVVSQLCSSLDELVlpprekplkdqltfgddgsvaiigdsptaagAGVLVI 374
Cdd:COG1223  92 RA-PCVIFFDEFDAIAKDRGDQNDVGEvKRVVNALLQELDGLP-------------------------------SGSVVI 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 375 GTTSRPDAVDGGLRRagRFENEISLGIPDETAREKILEK-ICKVNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAId 453
Cdd:COG1223 140 AATNHPELLDSALWR--RFDEVIEFPLPDKEERKEILELnLKKFPLPFELDLKKLAKKLEGLSGADIEKVLKTALKKAI- 216
                       250       260
                ....*....|....*....|....*..
gi 17537217 454 rvfdtivvkNEGHKNLTVEQIKEELDR 480
Cdd:COG1223 217 ---------LEDREKVTKEDLEEALKQ 234
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
534-689 5.27e-42

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 150.65  E-value: 5.27e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAALGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESE 613
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17537217 614 RAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGV--EGRQKVFLIGATNRPDIVDAAILR 689
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLstDGNCRVIVMGATNRPQDLDEAILR 158
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
534-695 2.30e-41

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 149.20  E-value: 2.30e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAALGIDcRPQGILLCGPPGCGKTLLAKAVANETG-----MNFISVKGPELLNMY 608
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKIT-PPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 609 VGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAIL 688
Cdd:cd19517  80 VGEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPALR 159

                ....*..
gi 17537217 689 RPGRLDK 695
Cdd:cd19517 160 RPGRFDR 166
ftsH CHL00176
cell division protein; Validated
203-487 1.30e-39

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 155.98  E-value: 1.30e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  203 VKFEHIGGADRQFLEVCRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGE 282
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEEVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGV 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  283 TEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAqremerrvvsqLCSSLDElvlppREKPLKDQLTFGDdgsvaiiGD 362
Cdd:CHL00176 260 GAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAG-----------IGGGNDE-----REQTLNQLLTEMD-------GF 316
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  363 SPTaagAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILekicKV-----NLAGDVTLKQIAKLTPGYVG 437
Cdd:CHL00176 317 KGN---KGVIVIAATNRVDILDAALLRPGRFDRQITVSLPDREGRLDIL----KVharnkKLSPDVSLELIARRTPGFSG 389
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 17537217  438 ADLQALIREAAKVAIDRVFDTIvvkneghknlTVEQIKEELDRVLAWLQG 487
Cdd:CHL00176 390 ADLANLLNEAAILTARRKKATI----------TMKEIDTAIDRVIAGLEG 429
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
528-699 9.07e-39

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 141.54  E-value: 9.07e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 528 PDVSWDDIGALVEVRKQLEWSILYPIKRADDFAAlgiDCRP-QGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLN 606
Cdd:cd19521   2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTG---NRKPwSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 607 MYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGV-EGRQKVFLIGATNRPDIVDA 685
Cdd:cd19521  79 KWMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVgNDSQGVLVLGATNIPWQLDS 158
                       170
                ....*....|....
gi 17537217 686 AILRpgRLDKILFV 699
Cdd:cd19521 159 AIRR--RFEKRIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
528-699 3.41e-38

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 140.51  E-value: 3.41e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 528 PDVSWDDIGALVEVRKQLEWSILYPIKRADDFAalGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNM 607
Cdd:cd19525  17 PPINWADIAGLEFAKKTIKEIVVWPMLRPDIFT--GLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSK 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 608 YVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGV--EGRQKVFLIGATNRPDIVDA 685
Cdd:cd19525  95 WVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGAttSSEDRILVVGATNRPQEIDE 174
                       170
                ....*....|....
gi 17537217 686 AILRpgRLDKILFV 699
Cdd:cd19525 175 AARR--RLVKRLYI 186
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
225-399 6.44e-38

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 138.96  E-value: 6.44e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILIL 304
Cdd:cd19481  12 PRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLAPCILFI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 305 DDIDAIAPRRET-AQREMERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdsptAAGAGVLVIGTTSRPDAV 383
Cdd:cd19481  92 DEIDAIGRKRDSsGESGELRRVLNQLLTELDGV-----------------------------NSRSKVLVIAATNRPDLL 142
                       170
                ....*....|....*.
gi 17537217 384 DGGLRRAGRFENEISL 399
Cdd:cd19481 143 DPALLRPGRFDEVIEF 158
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
200-451 1.07e-37

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 150.18  E-value: 1.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  200 ESHVK--FEHIGGADRQFLEVCRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVS 277
Cdd:PRK10733 144 EDQIKttFADVAGCDEAKEEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVE 223
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  278 GVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAqremerrvvsqLCSSLDElvlppREKPLkDQLTFGDDGsv 357
Cdd:PRK10733 224 MFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAG-----------LGGGHDE-----REQTL-NQMLVEMDG-- 284
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  358 aiigdspTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILE-KICKVNLAGDVTLKQIAKLTPGYV 436
Cdd:PRK10733 285 -------FEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKvHMRRVPLAPDIDAAIIARGTPGFS 357
                        250
                 ....*....|....*
gi 17537217  437 GADLQALIREAAKVA 451
Cdd:PRK10733 358 GADLANLVNEAALFA 372
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
225-397 1.32e-37

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 137.80  E-value: 1.32e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILIL 304
Cdd:cd19511  13 LKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKARQAAPCIIFF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 305 DDIDAIAPRR-ETAQREMERRVVSQLCSSLDELVlpprekplkdqltfgddgsvaiigdsptaAGAGVLVIGTTSRPDAV 383
Cdd:cd19511  93 DEIDSLAPRRgQSDSSGVTDRVVSQLLTELDGIE-----------------------------SLKGVVVIAATNRPDMI 143
                       170
                ....*....|....
gi 17537217 384 DGGLRRAGRFENEI 397
Cdd:cd19511 144 DPALLRPGRLDKLI 157
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
534-699 3.22e-36

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 134.21  E-value: 3.22e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAalGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESE 613
Cdd:cd19524   1 DIAGQDLAKQALQEMVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 614 RAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVE--GRQKVFLIGATNRPDIVDAAILRpg 691
Cdd:cd19524  79 KLVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQsnGDDRVLVMGATNRPQELDDAVLR-- 156

                ....*...
gi 17537217 692 RLDKILFV 699
Cdd:cd19524 157 RFTKRVYV 164
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
534-699 2.98e-34

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 128.95  E-value: 2.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAalGIDcRP-QGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGES 612
Cdd:cd19522   1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIR-RPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGES 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 613 ERAVRTVFQRARDSQPCVIFFDEIDALVPKR-SHGESSGGARLVNQLLTEMDGVEG-------RQKVFLIGATNRPDIVD 684
Cdd:cd19522  78 EKLVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVGGasenddpSKMVMVLAATNFPWDID 157
                       170
                ....*....|....*
gi 17537217 685 AAILRpgRLDKILFV 699
Cdd:cd19522 158 EALRR--RLEKRIYI 170
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
243-397 4.54e-34

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 126.94  E-value: 4.54e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   243 IVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREME 322
Cdd:pfam00004   2 LLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSES 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17537217   323 RRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdspTAAGAGVLVIGTTSRPDAVDGGLRraGRFENEI 397
Cdd:pfam00004  82 RRVVNQLLTELDGF----------------------------TSSNSKVIVIAATNRPDKLDPALL--GRFDRII 126
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
569-694 1.09e-33

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 127.61  E-value: 1.09e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 569 QGILLCGPPGCGKTLLAKAVANE-TGMNFISVKGPELLNMYVGESERAVRTVF------QRAR--DSQPCVIFFDEIDAL 639
Cdd:cd19504  36 KGILLYGPPGTGKTLMARQIGKMlNAREPKIVNGPEILNKYVGESEANIRKLFadaeeeQRRLgaNSGLHIIIFDEIDAI 115
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17537217 640 VPKR-SHGESSG-GARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLD 694
Cdd:cd19504 116 CKQRgSMAGSTGvHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLE 172
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
225-397 1.75e-33

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 126.07  E-value: 1.75e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILIL 304
Cdd:cd19529  13 LLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQVAPCVIFF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 305 DDIDAIAPRR-ETAQREMERRVVSQLCSSLDELVlpprekPLKDqltfgddgsvaiigdsptaagagVLVIGTTSRPDAV 383
Cdd:cd19529  93 DEIDSIAPRRgTTGDSGVTERVVNQLLTELDGLE------EMNG-----------------------VVVIAATNRPDII 143
                       170
                ....*....|....
gi 17537217 384 DGGLRRAGRFENEI 397
Cdd:cd19529 144 DPALLRAGRFDRLI 157
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
203-397 4.04e-33

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 125.42  E-value: 4.04e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 203 VKFEHIGGADRQFLEVCRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGE 282
Cdd:cd19501   1 VTFKDVAGCEEAKEELKEVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 283 TEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAqremerrvvsqLCSSLDElvlppREKPLkDQLTFGDDGsvaiigd 362
Cdd:cd19501  81 GASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAG-----------LGGGHDE-----REQTL-NQLLVEMDG------- 136
                       170       180       190
                ....*....|....*....|....*....|....*
gi 17537217 363 spTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEI 397
Cdd:cd19501 137 --FESNTGVIVIAATNRPDVLDPALLRPGRFDRQV 169
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
225-483 5.15e-33

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 135.16  E-value: 5.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVS-----GVSgeteeKIRRLFDTAKQNSP 299
Cdd:COG0465 161 LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEmfvgvGAS-----RVRDLFEQAKKNAP 235
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 300 CILILDDIDAIAPRRETAqremerrvvsqLCSSLDElvlppREKPLKDQLT----FGDDgsvaiigdsptaagAGVLVIG 375
Cdd:COG0465 236 CIIFIDEIDAVGRQRGAG-----------LGGGHDE-----REQTLNQLLVemdgFEGN--------------EGVIVIA 285
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 376 TTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILeKIC--KVNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAID 453
Cdd:COG0465 286 ATNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAIL-KVHarKKPLAPDVDLEVIARRTPGFSGADLANLVNEAALLAAR 364
                       250       260       270
                ....*....|....*....|....*....|
gi 17537217 454 RvfdtivvkneGHKNLTVEQIKEELDRVLA 483
Cdd:COG0465 365 R----------NKKAVTMEDFEEAIDRVIA 384
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
225-395 3.26e-31

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 119.90  E-value: 3.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILIL 304
Cdd:cd19530  16 IKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQRARASAPCVIFF 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 305 DDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdsptAAGAGVLVIGTTSRPDAVD 384
Cdd:cd19530  96 DEVDALVPKRGDGGSWASERVVNQLLTEMDGL-----------------------------EERSNVFVIAATNRPDIID 146
                       170
                ....*....|.
gi 17537217 385 GGLRRAGRFEN 395
Cdd:cd19530 147 PAMLRPGRLDK 157
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
203-452 4.84e-31

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 126.03  E-value: 4.84e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  203 VKFEHIGGADRQFLEVcRLAMHL--KRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVS 280
Cdd:PTZ00454 142 VTYSDIGGLDIQKQEI-REAVELplTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYL 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  281 GETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMER---RVVSQLCSSLDELvlpprekplkDQLTfgddgsv 357
Cdd:PTZ00454 221 GEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGADRevqRILLELLNQMDGF----------DQTT------- 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  358 aiigdsptaagaGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILEKIC-KVNLAGDVTLKQIAKLTPGYV 436
Cdd:PTZ00454 284 ------------NVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFQTITsKMNLSEEVDLEDFVSRPEKIS 351
                        250
                 ....*....|....*.
gi 17537217  437 GADLQALIREAAKVAI 452
Cdd:PTZ00454 352 AADIAAICQEAGMQAV 367
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
205-397 7.77e-30

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 116.28  E-value: 7.77e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 205 FEHIGGADRQFLEVCR-LAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGET 283
Cdd:cd19502   2 YEDIGGLDEQIREIREvVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 284 EEKIRRLFDTAKQNSPCILILDDIDAIAPRRE----TAQREMERRVVsQLCSSLDELvlppreKPLKDqltfgddgsvai 359
Cdd:cd19502  82 ARLVRELFEMAREKAPSIIFIDEIDAIGAKRFdsgtGGDREVQRTML-ELLNQLDGF------DPRGN------------ 142
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 17537217 360 igdsptaagagVLVIGTTSRPDAVDGGLRRAGRFENEI 397
Cdd:cd19502 143 -----------IKVIMATNRPDILDPALLRPGRFDRKI 169
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
189-452 4.52e-28

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 117.95  E-value: 4.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  189 LGAVSDTISPRESHVKFEH--------IGGADRQFLEVCR-LAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAV 259
Cdd:PTZ00361 158 VGILLDEVDPLVSVMKVDKaplesyadIGGLEQQIQEIKEaVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAV 237
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  260 AGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELvlp 339
Cdd:PTZ00361 238 ANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKEIQRTMLELLNQL--- 314
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  340 prekplkdqltfgdDGSvaiigDSPtaagAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILE-KICKVN 418
Cdd:PTZ00361 315 --------------DGF-----DSR----GDVKVIMATNRIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEiHTSKMT 371
                        250       260       270
                 ....*....|....*....|....*....|....
gi 17537217  419 LAGDVTLKQIAKLTPGYVGADLQALIREAAKVAI 452
Cdd:PTZ00361 372 LAEDVDLEEFIMAKDELSGADIKAICTEAGLLAL 405
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
228-397 2.63e-27

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 108.75  E-value: 2.63e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 228 PKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDI 307
Cdd:cd19528  16 PDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARAAAPCVLFFDEL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 308 DAIAPRRETAQRE---MERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdsptAAGAGVLVIGTTSRPDAVD 384
Cdd:cd19528  96 DSIAKARGGNIGDaggAADRVINQILTEMDGM-----------------------------NTKKNVFIIGATNRPDIID 146
                       170
                ....*....|...
gi 17537217 385 GGLRRAGRFENEI 397
Cdd:cd19528 147 PAILRPGRLDQLI 159
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
208-396 7.47e-27

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 107.60  E-value: 7.47e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 208 IGGADRQFLEVCRLAMH-LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVA-----GELAIPMLQLAATELVSGVSG 281
Cdd:cd19517   2 IGGLSHYINQLKEMVFFpLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAaecskGGQKVSFFMRKGADCLSKWVG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 282 ETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDelvlpprekplkdqltfGDDGSvaiig 361
Cdd:cd19517  82 EAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMD-----------------GLDNR----- 139
                       170       180       190
                ....*....|....*....|....*....|....*
gi 17537217 362 dsptaagAGVLVIGTTSRPDAVDGGLRRAGRFENE 396
Cdd:cd19517 140 -------GQVVVIGATNRPDALDPALRRPGRFDRE 167
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
226-394 8.24e-27

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 107.13  E-value: 8.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 226 KRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILD 305
Cdd:cd19526  14 KYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAQSAKPCILFFD 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 306 DIDAIAPRRETAQREMERRVVSQLCSSLDelvlpprekplkdqltfGDDGsvaiigdsptaaGAGVLVIGTTSRPDAVDG 385
Cdd:cd19526  94 EFDSIAPKRGHDSTGVTDRVVNQLLTQLD-----------------GVEG------------LDGVYVLAATSRPDLIDP 144

                ....*....
gi 17537217 386 GLRRAGRFE 394
Cdd:cd19526 145 ALLRPGRLD 153
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
567-700 8.49e-27

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 106.85  E-value: 8.49e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 567 RPQGILLCGPPGCGKTLLAKAVANET---GMNFISVKGPELLNMYVGESER---AVRTVFQRARDSQPCVIFFDEIDALV 640
Cdd:cd00009  18 PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDSLS 97
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 641 PKRShgessggARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVD 700
Cdd:cd00009  98 RGAQ-------NALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
225-397 4.10e-26

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 105.13  E-value: 4.10e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFaTLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILIL 304
Cdd:cd19509  19 SLRPDLF-PGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIVRALFALARELQPSIIFI 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 305 DDIDAIAPRRETAQREMERRVVSQLCSSLDELVlpprekplkdqltfgddgsvaiigdspTAAGAGVLVIGTTSRPDAVD 384
Cdd:cd19509  98 DEIDSLLSERGSGEHEASRRVKTEFLVQMDGVL---------------------------NKPEDRVLVLGATNRPWELD 150
                       170
                ....*....|...
gi 17537217 385 GGLRRagRFENEI 397
Cdd:cd19509 151 EAFLR--RFEKRI 161
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
534-689 5.12e-26

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 104.97  E-value: 5.12e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEWSILYPIKRADDFAalGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESE 613
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFS--GLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGE 78
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17537217 614 RAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGaRLVNQLLTEMDGV--EGRQKVFLIGATNRPDIVDAAILR 689
Cdd:cd19523  79 KILQASFLAARCRQPSVLFISDLDALLSSQDDEASPVG-RLQVELLAQLDGVlgSGEDGVLVVCTTSKPEEIDESLRR 155
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
223-394 7.82e-26

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 104.52  E-value: 7.82e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 223 MHLKRPKTFAtLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCIL 302
Cdd:cd19527  11 LPLEHPELFS-SGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKARDAKPCVI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 303 ILDDIDAIAPRRETAQRE--MERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdspTAAGAGVLVIGTTSRP 380
Cdd:cd19527  90 FFDELDSLAPSRGNSGDSggVMDRVVSQLLAELDGM----------------------------SSSGQDVFVIGATNRP 141
                       170
                ....*....|....
gi 17537217 381 DAVDGGLRRAGRFE 394
Cdd:cd19527 142 DLLDPALLRPGRFD 155
cell_div_CdvC NF041006
cell division protein CdvC;
226-480 2.11e-25

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 109.05  E-value: 2.11e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  226 KRPKTFAtLGVdpPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTA-----KQNSPC 300
Cdd:NF041006 124 KRPDLFP-LGW--PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKArekskEEGKPA 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  301 ILILDDIDAIAPRRETaQREMERRVVSQLCSSLDELVlpPREKPLKdqltfgddgsvaiigdsptaagagVLVIGTTSRP 380
Cdd:NF041006 201 IIFIDEIDALLGVYSS-EVGGEVRVRNQFLKEMDGLQ--DKSENYH------------------------VYVIGATNKP 253
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  381 DAVDGGLRRagRFENEISLGIPDETAREKILEKIC-KVNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAIDRVFDti 459
Cdd:NF041006 254 WRLDEPFLR--RFQKRIYIPLPDREQRLELLKYYTsKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFE-- 329
                        250       260
                 ....*....|....*....|..
gi 17537217  460 vvKNEGH-KNLTVEQIKEELDR 480
Cdd:NF041006 330 --KGLGEpRPITMEDFKEVLKI 349
ycf46 CHL00195
Ycf46; Provisional
470-753 2.64e-25

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 110.49  E-value: 2.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  470 TVEQIKEELDRVLAWLQGDDDPSALSELNGGLQ-ISFEDFERALSTIQPAAKREGFATVP-------------------- 528
Cdd:CHL00195 143 TESEIKKELTRLIKSLNIKIDSELLENLTRACQgLSLERIRRVLSKIIATYKTIDENSIPlileekkqiisqteilefys 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  529 -DVSWDDIGALVEVRKQLEwsilypiKRADDFAALGID---CRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPEL 604
Cdd:CHL00195 223 vNEKISDIGGLDNLKDWLK-------KRSTSFSKQASNyglPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKL 295
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  605 LNMYVGESERAVRTVFQRARDSQPCVIFFDEID-ALVPKRSHGESSGGARLVNQLLTEMDgvEGRQKVFLIGATNRPDIV 683
Cdd:CHL00195 296 FGGIVGESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESKGDSGTTNRVLATFITWLS--EKKSPVFVVATANNIDLL 373
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17537217  684 DAAILRPGRLDKILFVDFPSVEDRVDI----LRKStkngtRPMLGEDIDFHEIAQLPElaGFTGADLAALIHES 753
Cdd:CHL00195 374 PLEILRKGRFDEIFFLDLPSLEEREKIfkihLQKF-----RPKSWKKYDIKKLSKLSN--KFSGAEIEQSIIEA 440
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
534-699 8.22e-25

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 101.29  E-value: 8.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 534 DIGALVEVRKQLEwsilypiKRADDFA----ALGIDCrPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYV 609
Cdd:cd19507   1 DVGGLDNLKDWLK-------KRKAAFSkqasAYGLPT-PKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 610 GESERAVRTVFQRARDSQPCVIFFDEID-ALVPKRSHGESSGGARLVNQLLTEMDgvEGRQKVFLIGATNRPDIVDAAIL 688
Cdd:cd19507  73 GESESRLRQMIQTAEAIAPCVLWIDEIEkGFSNADSKGDSGTSSRVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELL 150
                       170
                ....*....|.
gi 17537217 689 RPGRLDKILFV 699
Cdd:cd19507 151 RKGRFDEIFFV 161
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
203-459 5.01e-23

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 103.64  E-value: 5.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   203 VKFEHIGGADRQfLEVCRLAMHLK--RPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPM----------LQL 270
Cdd:TIGR03689 179 VTYADIGGLGSQ-IEQIRDAVELPflHPELYREYGLKPPKGVLLYGPPGCGKTLIAKAVANSLAARIgaegggksyfLNI 257
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   271 AATELVSGVSGETEEKIRRLFDTAKQ----NSPCILILDDIDAIAPRRETA-QREMERRVVSQLCSSLDELvlpprekpl 345
Cdd:TIGR03689 258 KGPELLNKYVGETERQIRLIFQRAREkaseGRPVIVFFDEMDSLFRTRGSGvSSDVETTVVPQLLAEIDGV--------- 328
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   346 kDQLTfgddgsvaiigdsptaagaGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILEKickvNLAGDVTL 425
Cdd:TIGR03689 329 -ESLD-------------------NVIVIGASNREDMIDPAILRPGRLDVKIRIERPDAEAAADIFAK----YLTDDLPL 384
                         250       260       270
                  ....*....|....*....|....*....|....
gi 17537217   426 KQIAKLTPGYVGADLQALIReaakVAIDRVFDTI 459
Cdd:TIGR03689 385 PEDLAAHDGDREATAAALIQ----RVVDALYARS 414
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
210-389 4.77e-20

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 88.51  E-value: 4.77e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 210 GADRQFLEVCRLAMhlKRPKTFATLGVdPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRR 289
Cdd:cd19525  29 FAKKTIKEIVVWPM--LRPDIFTGLRG-PPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRA 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 290 LFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELVLPPREKplkdqltfgddgsvaiigdsptaaga 369
Cdd:cd19525 106 LFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDR-------------------------- 159
                       170       180
                ....*....|....*....|
gi 17537217 370 gVLVIGTTSRPDAVDGGLRR 389
Cdd:cd19525 160 -ILVVGATNRPQEIDEAARR 178
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
238-397 3.81e-19

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 85.42  E-value: 3.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 238 PPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETA 317
Cdd:cd19522  32 PWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 318 -QREMERRVVSQLCSSLDelvlpprekplkdqltfGDDGSVAiiGDSPTAAgagVLVIGTTSRPDAVDGGLRRagRFENE 396
Cdd:cd19522 112 eEHEASRRVKSELLVQMD-----------------GVGGASE--NDDPSKM---VMVLAATNFPWDIDEALRR--RLEKR 167

                .
gi 17537217 397 I 397
Cdd:cd19522 168 I 168
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
567-700 6.50e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 83.96  E-value: 6.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217    567 RPQGILLCGPPGCGKTLLAKAVANE---TGMNFISVKGPELL--------------NMYVGESERAVRTVFQRARDSQPC 629
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARElgpPGGGVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537217    630 VIFFDEIDALVPKRSHGEssggaRLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPgRLDKILFVD 700
Cdd:smart00382  81 VLILDEITSLLDAEQEAL-----LLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
225-397 7.33e-19

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 84.53  E-value: 7.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFaTLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILIL 304
Cdd:cd19521  27 VKFPHLF-TGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFI 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 305 DDIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkdqltfGDDGSvaiigdsptaagaGVLVIGTTSRPDAVD 384
Cdd:cd19521 106 DEVDSLCGTRGEGESEASRRIKTELLVQMNGV---------------GNDSQ-------------GVLVLGATNIPWQLD 157
                       170
                ....*....|...
gi 17537217 385 GGLRRagRFENEI 397
Cdd:cd19521 158 SAIRR--RFEKRI 168
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
208-394 1.57e-18

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 83.57  E-value: 1.57e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 208 IGGADR--QFLEvcrlamhlKRPKTFA----TLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSG 281
Cdd:cd19507   2 VGGLDNlkDWLK--------KRKAAFSkqasAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVG 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 282 ETEEKIRRLFDTAKQNSPCILILDDID-AIAPRRETAQREMERRVVSQLCSSLDElvlppREKPlkdqltfgddgsvaii 360
Cdd:cd19507  74 ESESRLRQMIQTAEAIAPCVLWIDEIEkGFSNADSKGDSGTSSRVLGTFLTWLQE-----KKKP---------------- 132
                       170       180       190
                ....*....|....*....|....*....|....
gi 17537217 361 gdsptaagagVLVIGTTSRPDAVDGGLRRAGRFE 394
Cdd:cd19507 133 ----------VFVVATANNVQSLPPELLRKGRFD 156
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
226-389 1.80e-18

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 83.36  E-value: 1.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 226 KRPKTFATLGVdPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILD 305
Cdd:cd19524  21 LRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFID 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 306 DIDAIAPRRETAQREMERRVVSQLCSSLDELvlpprekplkdqltfgddgsvaiigdsPTAAGAGVLVIGTTSRPDAVD- 384
Cdd:cd19524 100 EVDSLLSERSEGEHEASRRLKTEFLIEFDGV---------------------------QSNGDDRVLVMGATNRPQELDd 152

                ....*
gi 17537217 385 GGLRR 389
Cdd:cd19524 153 AVLRR 157
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
208-399 1.80e-17

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 81.00  E-value: 1.80e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 208 IGGADRQFLEVCR--LAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAgelaiPMLQLAATELVSGVS----- 280
Cdd:cd19504   2 IGGLDKEFSDIFRraFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIG-----KMLNAREPKIVNGPEilnky 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 281 -GETEEKIRRLFDTAKQ-------NSPC-ILILDDIDAIAPRRETAQRE--MERRVVSQLCSSLDELvlpprekplkDQL 349
Cdd:cd19504  77 vGESEANIRKLFADAEEeqrrlgaNSGLhIIIFDEIDAICKQRGSMAGStgVHDTVVNQLLSKIDGV----------EQL 146
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 17537217 350 TfgddgsvaiigdsptaagaGVLVIGTTSRPDAVDGGLRRAGRFENEISL 399
Cdd:cd19504 147 N-------------------NILVIGMTNRKDLIDEALLRPGRLEVQMEI 177
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
208-389 1.11e-16

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 78.24  E-value: 1.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 208 IGGADRQFLEVCRLAMH-LKRPKTFATLGV-DPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEE 285
Cdd:cd19520   2 IGGLDEVITELKELVILpLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 286 KIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELVLPPREKplkdqltfgddgsvaiigdspt 365
Cdd:cd19520  82 LVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCR---------------------- 139
                       170       180
                ....*....|....*....|....
gi 17537217 366 aagagVLVIGTTSRPDAVDGGLRR 389
Cdd:cd19520 140 -----VIVMGATNRPQDLDEAILR 158
ycf46 CHL00195
Ycf46; Provisional
203-458 2.57e-16

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 82.76  E-value: 2.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  203 VKFEHIGGAD--RQFLEvcrlamhlKRPKTFA----TLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELV 276
Cdd:CHL00195 225 EKISDIGGLDnlKDWLK--------KRSTSFSkqasNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLF 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  277 SGVSGETEEKIRRLFDTAKQNSPCILILDDID-AIAPRRETAQREMERRVVSQLCSSLDElvlppREKPlkdqltfgddg 355
Cdd:CHL00195 297 GGIVGESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESKGDSGTTNRVLATFITWLSE-----KKSP----------- 360
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  356 svaiigdsptaagagVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILekicKVNLA-------GDVTLKQI 428
Cdd:CHL00195 361 ---------------VFVVATANNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIF----KIHLQkfrpkswKKYDIKKL 421
                        250       260       270
                 ....*....|....*....|....*....|..
gi 17537217  429 AKLTPGYVGADLQALIREAAKVAID--RVFDT 458
Cdd:CHL00195 422 SKLSNKFSGAEIEQSIIEAMYIAFYekREFTT 453
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
237-400 5.26e-15

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 72.95  E-value: 5.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 237 DPPRGFIVHGPPGCGKTMFAQAVAGELAI---PMLQLAATELVSGVSGETEEK---IRRLFDTAKQNSPCILILDDIDAI 310
Cdd:cd00009  17 PPPKNLLLYGPPGTGKTTLARAIANELFRpgaPFLYLNASDLLEGLVVAELFGhflVRLLFELAEKAKPGVLFIDEIDSL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 311 APRRETAQREMerrvvsqlcssLDELVLPPREKplkdqltfgddgsvaiigdsptaagAGVLVIGTTSRPDAVDGGLRRA 390
Cdd:cd00009  97 SRGAQNALLRV-----------LETLNDLRIDR-------------------------ENVRVIGATNRPLLGDLDRALY 140
                       170
                ....*....|
gi 17537217 391 GRFENEISLG 400
Cdd:cd00009 141 DRLDIRIVIP 150
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
225-397 1.44e-13

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 68.92  E-value: 1.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 225 LKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATElvsgvSGETEEKIRRLFDTAKQNSpcILIL 304
Cdd:cd19510   9 IKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSE-----VVLTDDRLNHLLNTAPKQS--IILL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 305 DDIDAiaprretaqremerrvvsqlcssldelVLPPREKPLKDQLTFGDDGSVAIIG-----DSPTAAGAGVLVIgTTSR 379
Cdd:cd19510  82 EDIDA---------------------------AFESREHNKKNPSAYGGLSRVTFSGllnalDGVASSEERIVFM-TTNH 133
                       170
                ....*....|....*...
gi 17537217 380 PDAVDGGLRRAGRFENEI 397
Cdd:cd19510 134 IERLDPALIRPGRVDMKI 151
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
227-389 2.26e-13

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 68.76  E-value: 2.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 227 RPKTFATLgVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDD 306
Cdd:cd19523  22 RPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKILQASFLAARCRQPSVLFISD 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 307 IDAIAPRRETAQREMErRVVSQLCSSLDELVlpprekplkdqltfgddgsvaiigdspTAAGAGVLVIGTTSRPDAVDGG 386
Cdd:cd19523 101 LDALLSSQDDEASPVG-RLQVELLAQLDGVL---------------------------GSGEDGVLVVCTTSKPEEIDES 152

                ...
gi 17537217 387 LRR 389
Cdd:cd19523 153 LRR 155
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
553-694 4.48e-12

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 64.68  E-value: 4.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 553 IKRADDFAALGIDCRpQGILLCGPPGCGKTLLAKAVANETGMNFI------SVKGPELLNmyvgeseRAVRTVFQRArds 626
Cdd:cd19510   9 IKNEDWYNDRGIPYR-RGYLLYGPPGTGKSSFIAALAGELDYDICdlnlseVVLTDDRLN-------HLLNTAPKQS--- 77
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17537217 627 qpcVIFFDEIDALV-----PKRSHGESSGGARL-VNQLLTEMDGV---EGRQKVFligATNRPDIVDAAILRPGRLD 694
Cdd:cd19510  78 ---IILLEDIDAAFesrehNKKNPSAYGGLSRVtFSGLLNALDGVassEERIVFM---TTNHIERLDPALIRPGRVD 148
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
571-697 1.51e-11

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 62.93  E-value: 1.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 571 ILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYvGESERAVRTVFQRARDSQPCVIFF-DEIDALVPKRSHGESS 649
Cdd:cd19512  25 ILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAIHKVFDWANTSRRGLLLFvDEADAFLRKRSTEKIS 103
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 17537217 650 GGAR-LVNQLLTEMDgvEGRQKVFLIGATNRPDIVDAAIlrPGRLDKIL 697
Cdd:cd19512 104 EDLRaALNAFLYRTG--EQSNKFMLVLASNQPEQFDWAI--NDRIDEMV 148
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
571-699 6.76e-11

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 62.46  E-value: 6.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 571 ILLCGPPGCGKTLLAKAVANETGMN---------FISVKGPELLNMYVGESERAVRTVFQRAR---DSQPCVIF--FDEI 636
Cdd:cd19508  55 VLLHGPPGTGKTSLCKALAQKLSIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQeliDDKDALVFvlIDEV 134
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17537217 637 DALVPKR----SHGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILrpGRLDKILFV 699
Cdd:cd19508 135 ESLAAARsassSGTEPSDAIRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAFV--DRADIKQYI 199
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
422-459 4.08e-10

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 55.62  E-value: 4.08e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17537217   422 DVTLKQIAKLTPGYVGADLQALIREAAKVAIDRVFDTI 459
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAV 38
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
238-324 6.89e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 58.15  E-value: 6.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217    238 PPRGFIVHGPPGCGKTMFAQAVAGELAIP-----------------MLQLAATELVSGVSGETEEKIRRLFDTAKQNSPC 300
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggviyidgedileevlDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80
                           90       100
                   ....*....|....*....|....
gi 17537217    301 ILILDDIDAIAPRRETAQREMERR 324
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEE 104
Nucleolin_bd pfam16725
Nucleolin binding domain; This domain adopts a three helix fold resembling part of a winged ...
5-65 1.55e-08

Nucleolin binding domain; This domain adopts a three helix fold resembling part of a winged helix motif. It binds nucleolin.


Pssm-ID: 465247  Cd Length: 70  Bit Score: 51.86  E-value: 1.55e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537217     5 MGFPSDPALLPRVQAHIRKFPGTKYFKPELVAYDLQQEHPEYQRKNHKVFMGMVREALERI 65
Cdd:pfam16725   4 SGYFSDPRLVPRVEQYLEDNSDSTYVDVDAMADELQRQYREYGRRKRNAFRIQVEKAYEII 64
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
571-682 2.43e-08

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 57.55  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   571 ILLCGPPGCGKTLLAKAVANE-TGM------NFISVKGPELLNMYVGESERAVRTVFQRARDSqpcVIFFDEIDALVPKR 643
Cdd:TIGR03922 315 MLFAGPPGTGKTTIARVVAKIyCGLgvlrkpLVREVSRADLIGQYIGESEAKTNEIIDSALGG---VLFLDEAYTLVETG 391
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 17537217   644 SHGESSGGARLVNQLLTEMDGveGRQKVFLIGATNRPDI 682
Cdd:TIGR03922 392 YGQKDPFGLEAIDTLLARMEN--DRDRLVVIGAGYRKDL 428
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
567-641 4.17e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 56.22  E-value: 4.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 567 RPQGILLCGPPGCGKTLLAKAVANETGMNFISvkgpelLNmyvgeserAV-------RTVFQRARD----SQPCVIFFDE 635
Cdd:COG2256  48 RLSSMILWGPPGTGKTTLARLIANATDAEFVA------LS--------AVtsgvkdiREVIEEARErrayGRRTILFVDE 113
                        90
                ....*....|....
gi 17537217 636 I--------DALVP 641
Cdd:COG2256 114 IhrfnkaqqDALLP 127
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
571-680 7.25e-08

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 52.53  E-value: 7.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 571 ILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGES--ERAVRTVFQRARDSQPCVIFFDEIDAL----VPKRS 644
Cdd:cd19506  29 LLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTfykkVPKTE 108
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17537217 645 hgESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRP 680
Cdd:cd19506 109 --KQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRP 142
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
571-677 1.21e-07

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 54.71  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  571 ILLCGPPGCGKTLLAKAVANETGMNFI-------SVKgpellnmyvgeserAVRTVFQRARDS----QPCVIFFDEI--- 636
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEalsavtsGVK--------------DLREVIEEARQRrsagRRTILFIDEIhrf 104
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 17537217  637 -----DALVPkrshgessggarlvnqlltemdGVEgRQKVFLIGAT 677
Cdd:PRK13342 105 nkaqqDALLP----------------------HVE-DGTITLIGAT 127
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
242-307 4.72e-07

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 52.78  E-value: 4.72e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  242 FIVHGPPGCGKTMFAQAVAGELAIPMLQLAATelVSGVsgeteEKIRRLFDTAKQNS----PCILILDDI 307
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSAV--TSGV-----KDLREVIEEARQRRsagrRTILFIDEI 101
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
567-637 1.18e-06

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 49.12  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   567 RPQG-ILLCGPPGCGKTLLAKAVANETGM---NFISVKGPELL-----NM-------YVGESERAVRTVFQRARdsQPCV 630
Cdd:pfam07724   1 RPIGsFLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYMeehsvSRligappgYVGYEEGGQLTEAVRRK--PYSI 78

                  ....*..
gi 17537217   631 IFFDEID 637
Cdd:pfam07724  79 VLIDEIE 85
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
568-697 4.17e-06

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 47.37  E-value: 4.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 568 PQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLN--------------MYVGESERAVRTVFQRARDSQPCVIFF 633
Cdd:cd19505  12 SKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYnkpdfgnddwidgmLILKESLHRLNLQFELAKAMSPCIIWI 91
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17537217 634 DEIDALVPKRSHGESSGG----ARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKIL 697
Cdd:cd19505  92 PNIHELNVNRSTQNLEEDpkllLGLLLNYLSRDFEKSSTRNILVIASTHIPQKVDPALIAPNRLDTCI 159
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
726-779 1.25e-05

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 42.91  E-value: 1.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17537217   726 DIDFHEIAQlpELAGFTGADLAALIHESSLLALQarvlendESVKGVGMRHFRE 779
Cdd:pfam17862   1 DVDLEELAE--RTEGFSGADLEALCREAALAALR-------RGLEAVTQEDLEE 45
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
242-307 1.64e-05

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 48.13  E-value: 1.64e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 242 FIVHGPPGCGKTMFAQAVAGELAIPMLQLAATelVSGVSgeteeKIRRLFDTAKQNS----PCILILDDI 307
Cdd:COG2256  52 MILWGPPGTGKTTLARLIANATDAEFVALSAV--TSGVK-----DIREVIEEARERRaygrRTILFVDEI 114
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
531-735 1.77e-05

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 47.68  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   531 SWDDIGALVEVRKQLEWSILypikraddfAALGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPellnmyvg 610
Cdd:TIGR00635   2 LLAEFIGQEKVKEQLQLFIE---------AAKMRQEALDHLLLYGPPGLGKTTLAHIIANEMGVNLKITSGP-------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   611 eseravrtVFQRARD--------SQPCVIFFDEIDALvpkrshgessggARLVNQLLT------EMDGVEGR-------- 668
Cdd:TIGR00635  65 --------ALEKPGDlaailtnlEEGDVLFIDEIHRL------------SPAVEELLYpamedfRLDIVIGKgpsarsvr 124
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   669 ---QKVFLIGATNRPDIVDAAiLRpGRLDKILFVDFPSVEDRVDILRKSTKngtrpMLGEDIDFHEIAQL 735
Cdd:TIGR00635 125 ldlPPFTLVGATTRAGMLTSP-LR-DRFGIILRLEFYTVEELAEIVSRSAG-----LLNVEIEPEAALEI 187
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
571-641 2.04e-05

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 47.43  E-value: 2.04e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17537217  571 ILLCGPPGCGKTLLAKAVANETGMNFISVKGPellnmyvgeseravrtVFQRARD--------SQPCVIFFDEIDALVP 641
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGP----------------ALEKPGDlaailtnlEEGDVLFIDEIHRLSP 116
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
571-636 2.13e-05

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 45.57  E-value: 2.13e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537217   571 ILLCGPPGCGKTLLAKAVANETGMNFISVKGPELlnmyvgesER-----AVRTVFQrARDsqpcVIFFDEI 636
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI--------ERpgdlaAILTNLE-PGD----VLFIDEI 93
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
240-336 4.22e-05

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 45.13  E-value: 4.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 240 RGFIVHGPPGCGKTMFAQAVAGELAI---------PMLQLAATELVSGVSGETEEKIRRLFD------TAKQNSPCILIl 304
Cdd:cd19508  53 RLVLLHGPPGTGKTSLCKALAQKLSIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQkiqeliDDKDALVFVLI- 131
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17537217 305 DDIDAIAPRRETAQREMER----RVVSQLCSSLDEL 336
Cdd:cd19508 132 DEVESLAAARSASSSGTEPsdaiRVVNAVLTQIDRI 167
PLN00020 PLN00020
ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional
188-318 8.81e-05

ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional


Pssm-ID: 215031 [Multi-domain]  Cd Length: 413  Bit Score: 45.86  E-value: 8.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  188 GLGAVSDTISPRESHVK---FEHIGG----ADRqFLEvcRLAMHLKrpKTFATLG-VDPPRGFIVHGPPGCGKTMFAQAV 259
Cdd:PLN00020  94 GLGTDSDIASSYDYLQRtrsFDNLVGgyyiAPA-FMD--KVAVHIA--KNFLALPnIKVPLILGIWGGKGQGKSFQCELV 168
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17537217  260 AGELAIPMLQLAATELVSGVSGETEEKIRRLFDTA-----KQNSPCILILDDIDAIAPRRETAQ 318
Cdd:PLN00020 169 FKKMGIEPIVMSAGELESENAGEPGKLIRQRYREAadiikKKGKMSCLFINDLDAGAGRFGTTQ 232
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
234-307 8.87e-05

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 43.52  E-value: 8.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 234 LGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATEL---------VSGVSGETEEKIRRL-----FDTAKQNSP 299
Cdd:cd19505   7 LGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLlynkpdfgnDDWIDGMLILKESLHrlnlqFELAKAMSP 86

                ....*...
gi 17537217 300 CILILDDI 307
Cdd:cd19505  87 CIIWIPNI 94
PRK04195 PRK04195
replication factor C large subunit; Provisional
571-659 1.71e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 44.91  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  571 ILLCGPPGCGKTLLAKAVANEtgMNFisvkgpELLNM-------------YVGESERaVRTVFQRARDsqpcVIFFDEID 637
Cdd:PRK04195  42 LLLYGPPGVGKTSLAHALAND--YGW------EVIELnasdqrtadvierVAGEAAT-SGSLFGARRK----LILLDEVD 108
                         90       100
                 ....*....|....*....|..
gi 17537217  638 ALVPKrshgESSGGARLVNQLL 659
Cdd:PRK04195 109 GIHGN----EDRGGARAILELI 126
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
571-739 2.05e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 44.00  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 571 ILLCGPPGCGKTLLAKAVANETGMNFISVKG-PELL-------NMYVGESERAV---RTVFQRardsqpcVIFFDEIDal 639
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALARALGLPFIRIQFtPDLLpsdilgtYIYDQQTGEFEfrpGPLFAN-------VLLADEIN-- 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 640 vpkRShgessgGARLVNQLLTEMD----GVEGR----QKVFLIGAT-NRPDIVD-----AAILRpgRLDKILFVDFPSVE 705
Cdd:COG0714 105 ---RA------PPKTQSALLEAMEerqvTIPGGtyklPEPFLVIATqNPIEQEGtyplpEAQLD--RFLLKLYIGYPDAE 173
                       170       180       190
                ....*....|....*....|....*....|....
gi 17537217 706 DRVDILRkSTKNGTRPMLGEDIDFHEIAQLPELA 739
Cdd:COG0714 174 EEREILR-RHTGRHLAEVEPVLSPEELLALQELV 206
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
568-651 2.58e-04

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 42.75  E-value: 2.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 568 PQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNM-YVGeseravRTVFQRARDSQPCVIFFDEIDALVPKrshG 646
Cdd:cd19498  46 PKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEVgYVG------RDVESIIRDLVEGIVFIDEIDKIAKR---G 116

                ....*
gi 17537217 647 ESSGG 651
Cdd:cd19498 117 GSSGP 121
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
567-637 2.61e-04

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 42.55  E-value: 2.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 567 RPQG-ILLCGPPGCGKTLLAKAVA---NETGMNFISVKGPELLNM------------YVGESERAvrTVFQRARDSQPCV 630
Cdd:cd19499  39 RPIGsFLFLGPTGVGKTELAKALAellFGDEDNLIRIDMSEYMEKhsvsrligappgYVGYTEGG--QLTEAVRRKPYSV 116

                ....*..
gi 17537217 631 IFFDEID 637
Cdd:cd19499 117 VLLDEIE 123
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
240-316 3.67e-04

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 41.74  E-value: 3.67e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17537217 240 RGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATElVSGVSGETEEKIRRLFDTA-KQNSPCILILDDIDAIAPRRET 316
Cdd:cd19512  23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKRST 99
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
571-634 3.98e-04

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 40.28  E-value: 3.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17537217   571 ILLCGPPGCGKTL----LAKAVANETGMNFISV----KGPELLNMYVGeseravrtvfqrardsQPCVIFFD 634
Cdd:pfam00910   1 IWLYGPPGCGKSTlakyLARALLKKLGLPKDSVysrnPDDDFWDGYTG----------------QPVVIIDD 56
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
571-602 5.48e-04

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 43.15  E-value: 5.48e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 17537217 571 ILLCGPPGCGKTLLAKAVANETGMNFISVKGP 602
Cdd:COG2255  57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGP 88
PRK04195 PRK04195
replication factor C large subunit; Provisional
238-313 5.55e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 43.37  E-value: 5.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  238 PPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAAtelvsgvSGE-TEEKIRR----------LFDTAKQnspcILILDD 306
Cdd:PRK04195  38 PKKALLLYGPPGVGKTSLAHALANDYGWEVIELNA-------SDQrTADVIERvageaatsgsLFGARRK----LILLDE 106

                 ....*..
gi 17537217  307 IDAIAPR 313
Cdd:PRK04195 107 VDGIHGN 113
PRK08116 PRK08116
hypothetical protein; Validated
570-606 8.94e-04

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 41.93  E-value: 8.94e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 17537217  570 GILLCGPPGCGKTLLAKAVANETGMNFISVKG---PELLN 606
Cdd:PRK08116 116 GLLLWGSVGTGKTYLAACIANELIEKGVPVIFvnfPQLLN 155
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
570-617 9.73e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 42.65  E-value: 9.73e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 17537217 570 GILLCGPPGCGKTLLAKAVANETGMN--FISVKGPELLNMYVGESE---RAVR 617
Cdd:COG1224  66 GILIVGPPGTGKTALAVAIARELGEDtpFVAISGSEIYSAELKKTEflmQALR 118
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
571-597 9.99e-04

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 40.62  E-value: 9.99e-04
                        10        20
                ....*....|....*....|....*..
gi 17537217 571 ILLCGPPGCGKTLLAKAVANETGMNFI 597
Cdd:cd00464   2 IVLIGMMGAGKTTVGRLLAKALGLPFV 28
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
242-326 1.02e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 39.79  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 242 FIVHGPPGCGKTMFAQAVAGELAIPMLQLAateLVSGVSGEteekIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREM 321
Cdd:cd01120   1 ILITGPPGSGKTTLLLQFAEQALLSDEPVI---FISFLDTI----LEAIEDLIEEKKLDIIIIDSLSSLARASQGDRSSE 73

                ....*
gi 17537217 322 ERRVV 326
Cdd:cd01120  74 LLEDL 78
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
242-312 2.47e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 39.49  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   242 FIVHGPPGCGKTMFAQAVAGELAI---PMLQLAATEL-----VS----------GV--SGETEEKIRRlfdtakqNSPCI 301
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYmeehsVSrligappgyvGYeeGGQLTEAVRR-------KPYSI 78
                          90
                  ....*....|.
gi 17537217   302 LILDDIDAIAP 312
Cdd:pfam07724  79 VLIDEIEKAHP 89
PRK13341 PRK13341
AAA family ATPase;
572-641 2.57e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 41.19  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  572 LLCGPPGCGKTLLAKAVANETGMNFISvkgpelLNMYV-GESEraVRTVFQRARDS-----QPCVIFFDEI--------D 637
Cdd:PRK13341  56 ILYGPPGVGKTTLARIIANHTRAHFSS------LNAVLaGVKD--LRAEVDRAKERlerhgKRTILFIDEVhrfnkaqqD 127

                 ....
gi 17537217  638 ALVP 641
Cdd:PRK13341 128 ALLP 131
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
240-289 2.59e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 40.76  E-value: 2.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 17537217   240 RGFIVHGPPGCGKTMFAQAVAGELA--IPMLQLAATELVSGVSGETE---EKIRR 289
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKELGedTPFTSISGSEVYSLEMKKTEaltQAFRK 105
PRK08116 PRK08116
hypothetical protein; Validated
196-309 2.68e-03

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 40.39  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217  196 ISPRESHVKFEH--IGGADRQFLEVCRlamhlKRPKTFATLGVDPpRGFIVHGPPGCGKTMFAQAVAGEL---AIPML-- 268
Cdd:PRK08116  75 LDEKFRNSTFENflFDKGSEKAYKIAR-----KYVKKFEEMKKEN-VGLLLWGSVGTGKTYLAACIANELiekGVPVIfv 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 17537217  269 -------QLAATelVSGVSGETEEKIRRLFDTAKqnspcILILDDIDA 309
Cdd:PRK08116 149 nfpqllnRIKST--YKSSGKEDENEIIRSLVNAD-----LLILDDLGA 189
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
567-659 2.86e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 40.15  E-value: 2.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 567 RPQGILLCGPPGCGKTLLAKAVANETGMNFISVK---GPELLN-MYVGESERAVRTVFQRARdSQPCVIfFDEIdALVPK 642
Cdd:COG1484  98 RGENLILLGPPGTGKTHLAIALGHEACRAGYRVRfttAPDLVNeLKEARADGRLERLLKRLA-KVDLLI-LDEL-GYLPL 174
                        90
                ....*....|....*..
gi 17537217 643 rshgeSSGGARLVNQLL 659
Cdd:COG1484 175 -----DAEGAELLFELI 186
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
571-698 3.38e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 38.25  E-value: 3.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 571 ILLCGPPGCGKTLLAKAVANetgmNFISVKGPELLNMYVgesERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSg 650
Cdd:cd01120   1 ILITGPPGSGKTTLLLQFAE----QALLSDEPVIFISFL---DTILEAIEDLIEEKKLDIIIIDSLSSLARASQGDRSS- 72
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 17537217 651 gaRLVNQLLTEMDG-VEGRQKVFLIGATNRPDIVDAAILRPGRLDKILF 698
Cdd:cd01120  73 --ELLEDLAKLLRAaRNTGITVIATIHSDKFDIDRGGSSNDERLLKSLR 119
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
571-625 4.15e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 38.44  E-value: 4.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17537217   571 ILLCGPPGCGKTLLAKAVANETGMNFIS---------VKGPELLNMYVGESERAVRTVFQRARD 625
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSsdderkrlfGEGRPSISYYTDATDRTYERLHELARI 65
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
570-623 4.25e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 40.37  E-value: 4.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17537217   570 GILLCGPPGCGKTLLAKAVANETG--MNFISVKGPELLNMYVGESErAVRTVFQRA 623
Cdd:pfam06068  52 AVLIAGPPGTGKTALAIAISKELGedTPFTSISGSEVYSLEMKKTE-ALTQAFRKA 106
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
570-689 5.10e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.04  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217   570 GILLCGPPGCGKTLLAK------------AVANETGMNFISVKGPelLNMYVGESERAVRTVFQRARDSqpCVIFFDEID 637
Cdd:pfam07728   1 GVLLVGPPGTGKTELAErlaaalsnrpvfYVQLTRDTTEEDLFGR--RNIDPGGASWVDGPLVRAAREG--EIAVLDEIN 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17537217   638 alvpkrsHGESSGGARLvNQLLTE-----MDGVE----GRQKVFLIGATNRPDI----VDAAILR 689
Cdd:pfam07728  77 -------RANPDVLNSL-LSLLDErrlllPDGGElvkaAPDGFRLIATMNPLDRglneLSPALRS 133
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
571-597 6.71e-03

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 38.19  E-value: 6.71e-03
                        10        20
                ....*....|....*....|....*..
gi 17537217 571 ILLCGPPGCGKTLLAKAVANETGMNFI 597
Cdd:COG0703   1 IVLIGMMGAGKSTVGRLLAKRLGLPFV 27
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
205-307 8.33e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 38.61  E-value: 8.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537217 205 FEHIGGADRqflevcRLAMHLkrpktfATLG-VDPPRGFIVHGPPGCGKTMFAQAVAGELA--------IPMLQLaATEL 275
Cdd:COG1484  76 FDAQPGLDR------RQILEL------ATLDfIERGENLILLGPPGTGKTHLAIALGHEACragyrvrfTTAPDL-VNEL 142
                        90       100       110
                ....*....|....*....|....*....|...
gi 17537217 276 VSG-VSGETEEKIRRLfdtakqNSPCILILDDI 307
Cdd:COG1484 143 KEArADGRLERLLKRL------AKVDLLILDEL 169
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
240-289 9.16e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 39.18  E-value: 9.16e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17537217 240 RGFIVHGPPGCGKTMFAQAVAGELA--IPMLQLAATELVSGVSGETE---EKIRR 289
Cdd:COG1224  65 KGILIVGPPGTGKTALAVAIARELGedTPFVAISGSEIYSAELKKTEflmQALRK 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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