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Conserved domains on  [gi|392890697|ref|NP_495657|]
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MFS domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0114euk super family cl31037
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 198-585 5.99e-16

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


The actual alignment was detected with superfamily member TIGR00894:

Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 80.56  E-value: 5.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQKRSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:TIGR00894  77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKII 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  278 IQWGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALEISLDSVYYIQCGTLAFLTLIWSIFYRDRPQDHPWVSGVELNK 357
Cdd:TIGR00894 157 VKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKY 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  358 IVAGKVNELRSNRALADAyTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSFPFQLLPLSCI 437
Cdd:TIGR00894 237 INSSLQGQKGSTRQSLPI-KAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSI 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  438 IFSSLNVLFKPSTKIVRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLA--IVAGFV-RSLTVVGRVFA 514
Cdd:TIGR00894 316 FAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSsgPLAGVLiNSLDLAPRFLG 395

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392890697  515 eqIVAMCAVPFGLAFSIL-PMVVTYSVTENKLAEWMKVTMFLFFVLSAVAIEFAVFGRGKSASWAASSWDPL 585
Cdd:TIGR00894 396 --FIKGITGLPGFIGGLIaSTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
 
Name Accession Description Interval E-value
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 198-585 5.99e-16

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 80.56  E-value: 5.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQKRSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:TIGR00894  77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKII 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  278 IQWGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALEISLDSVYYIQCGTLAFLTLIWSIFYRDRPQDHPWVSGVELNK 357
Cdd:TIGR00894 157 VKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKY 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  358 IVAGKVNELRSNRALADAyTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSFPFQLLPLSCI 437
Cdd:TIGR00894 237 INSSLQGQKGSTRQSLPI-KAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSI 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  438 IFSSLNVLFKPSTKIVRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLA--IVAGFV-RSLTVVGRVFA 514
Cdd:TIGR00894 316 FAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSsgPLAGVLiNSLDLAPRFLG 395

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392890697  515 eqIVAMCAVPFGLAFSIL-PMVVTYSVTENKLAEWMKVTMFLFFVLSAVAIEFAVFGRGKSASWAASSWDPL 585
Cdd:TIGR00894 396 --FIKGITGLPGFIGGLIaSTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
MFS_1 pfam07690
Major Facilitator Superfamily;
200-508 5.82e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 76.69  E-value: 5.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALeISLDSVYYIqCGTLAFLTLIWSIFYRDRPQDHPWVSGVELNKIV 359
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLI-LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  360 AGKVNELRSNRALadaytslfrslsawSIWTSAFGLFSVTAFFSIYLPSLlaspdvfvVEGLGIHSSFPFQLLPLSCIIF 439
Cdd:pfam07690 191 IVAWKALLRDPVL--------------WLLLALLLFGFAFFGLLTYLPLY--------QEVLGLSALLAGLLLGLGGLLG 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392890697  440 SSLNVLFKPSTKIVRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLAIVAGFVRSLTV 508
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 200-563 3.72e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 71.30  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd06174   34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHY-FHALEISLDSVYYIqCGTLAFLTLIWSIFYRDRPQDHPwvsgvelnki 358
Cdd:cd06174  112 LFPERERGRALGLLQAFGSVGGILGPLLGGIlASSLGFGWRAVFLI-AAALALLAAILLLLVVPDPPESA---------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 359 vaGKVNELRSNRALADAYTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSfpfqllpLSCII 438
Cdd:cd06174  181 --RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS-------LFGLA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 439 FSSLNVLFKPSTKIVRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLAIVAGFVRSLTVVGRVFAEQIV 518
Cdd:cd06174  252 GALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 392890697 519 AMCAVPFGLAFSILPMVVTYSVTENKLAEWMKVTMFLFFVLSAVA 563
Cdd:cd06174  332 GLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
200-520 5.61e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.14  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:COG2814   48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIAD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALeISLDSVYYIqCGTLAFLTLIWSIFYRDRPQDhpwvsgvelnkiv 359
Cdd:COG2814  126 LVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLV-NAVLALLALLLLLRLLPESRP------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 360 agkvnelRSNRALADAYTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASpdvfvVEGLGIHSSFPFQLLPLSCIIF 439
Cdd:COG2814  191 -------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE-----VLGLSASAAGLLLALFGLGGVL 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 440 SSLnvlfkPSTKIV-RILNFTAFAIGAILMIAIVLVASLqtkAGLFSLLLISMLPFGLAIVAGFVRSLTVVGRVFAEQIV 518
Cdd:COG2814  259 GAL-----LAGRLAdRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR 330


                 ..
gi 392890697 519 AM 520
Cdd:COG2814  331 GR 332
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 197-340 7.47e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 42.60  E-value: 7.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  197 LQRGLLFAASGLGVIFGSFVTINLIKK---FGVRKVFSICMvqsTILILLFLYVQkrSYIFLLLTRFLLGFsFSSVFPVM 273
Cdd:PRK08633  269 FQVQYLLAASAIGIGIGSLLAGRLSGRhieLGLVPLGALGL---ALSLFLLPTAP--SLASVLVLFFLFGF-SAGLFIVP 342

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392890697  274 GNLLIQWGPLKEQLIFI---------TSMFMFLSIGPVVSWpiahyfhaLEISLDSVYYIqCGTLAFLTLIWSIFY 340
Cdd:PRK08633  343 LNALIQFRAPEKELGKVlaannflqnVGMLLFLALTTLFSG--------LGLSPAGLFYL-IALVTLIGTLYTLLL 409
 
Name Accession Description Interval E-value
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 198-585 5.99e-16

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 80.56  E-value: 5.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQKRSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:TIGR00894  77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKII 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  278 IQWGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALEISLDSVYYIQCGTLAFLTLIWSIFYRDRPQDHPWVSGVELNK 357
Cdd:TIGR00894 157 VKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKY 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  358 IVAGKVNELRSNRALADAyTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSFPFQLLPLSCI 437
Cdd:TIGR00894 237 INSSLQGQKGSTRQSLPI-KAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSI 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  438 IFSSLNVLFKPSTKIVRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLA--IVAGFV-RSLTVVGRVFA 514
Cdd:TIGR00894 316 FAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSsgPLAGVLiNSLDLAPRFLG 395

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392890697  515 eqIVAMCAVPFGLAFSIL-PMVVTYSVTENKLAEWMKVTMFLFFVLSAVAIEFAVFGRGKSASWAASSWDPL 585
Cdd:TIGR00894 396 --FIKGITGLPGFIGGLIaSTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
MFS_1 pfam07690
Major Facilitator Superfamily;
200-508 5.82e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 76.69  E-value: 5.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALeISLDSVYYIqCGTLAFLTLIWSIFYRDRPQDHPWVSGVELNKIV 359
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLI-LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  360 AGKVNELRSNRALadaytslfrslsawSIWTSAFGLFSVTAFFSIYLPSLlaspdvfvVEGLGIHSSFPFQLLPLSCIIF 439
Cdd:pfam07690 191 IVAWKALLRDPVL--------------WLLLALLLFGFAFFGLLTYLPLY--------QEVLGLSALLAGLLLGLGGLLG 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392890697  440 SSLNVLFKPSTKIVRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLAIVAGFVRSLTV 508
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 200-563 3.72e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 71.30  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd06174   34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHY-FHALEISLDSVYYIqCGTLAFLTLIWSIFYRDRPQDHPwvsgvelnki 358
Cdd:cd06174  112 LFPERERGRALGLLQAFGSVGGILGPLLGGIlASSLGFGWRAVFLI-AAALALLAAILLLLVVPDPPESA---------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 359 vaGKVNELRSNRALADAYTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSfpfqllpLSCII 438
Cdd:cd06174  181 --RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS-------LFGLA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 439 FSSLNVLFKPSTKIVRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLAIVAGFVRSLTVVGRVFAEQIV 518
Cdd:cd06174  252 GALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 392890697 519 AMCAVPFGLAFSILPMVVTYSVTENKLAEWMKVTMFLFFVLSAVA 563
Cdd:cd06174  332 GLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 198-570 9.10e-11

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 64.18  E-value: 9.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQKRSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:cd17318   57 TQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALW 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 278 IQWGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFhALEISLDSVYYIQCGtlafLTLIWSIFYrdrpqdhpwvsgvelnk 357
Cdd:cd17318  137 AKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFL-CESLGWPSIFYIFGG----LGLLWCLLW----------------- 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 358 ivagkvnelrsnraladaytsLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSFPFQLLPLSCI 437
Cdd:cd17318  195 ---------------------FFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSI 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 438 IFSSLNVLFKpSTKIVRILN----FTAFAIGaILMIAIVLVASLQTKAGLFSLLLISMLPFGLAIVAGFVRSLTVVGRVF 513
Cdd:cd17318  254 VGGYLADWLR-SRGILSTTTvrklFTSIGFL-GPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNY 331

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 392890697 514 AEQIVAMCAVPFGLAFSILPMVVTYSVT-ENKLAEWMKVTMFLFFVLSAVAIEFAVFG 570
Cdd:cd17318  332 AGTLMGITNTAATIAGIISPLIVGAIVKnDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
200-520 5.61e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.14  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:COG2814   48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIAD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALeISLDSVYYIqCGTLAFLTLIWSIFYRDRPQDhpwvsgvelnkiv 359
Cdd:COG2814  126 LVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLV-NAVLALLALLLLLRLLPESRP------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 360 agkvnelRSNRALADAYTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASpdvfvVEGLGIHSSFPFQLLPLSCIIF 439
Cdd:COG2814  191 -------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE-----VLGLSASAAGLLLALFGLGGVL 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 440 SSLnvlfkPSTKIV-RILNFTAFAIGAILMIAIVLVASLqtkAGLFSLLLISMLPFGLAIVAGFVRSLTVVGRVFAEQIV 518
Cdd:COG2814  259 GAL-----LAGRLAdRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR 330


                 ..
gi 392890697 519 AM 520
Cdd:COG2814  331 GR 332
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
198-580 7.18e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.05  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:COG2223   41 QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV--SYWLLLLLGLLLGIGGGGSFAVGIALV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 278 IQWGPlKEQLIFITSMF-MFLSIGPVVSWPIAHYFHALeISLDSVYYIQCGTLAFLTLIWSIFYRDRPQDHPWVSGVELN 356
Cdd:COG2223  119 SKWFP-PDRRGLALGLAaGGGNLGAAVAAFLAPLLIAA-FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 357 kivagkvnelrsnraladAYTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLAS-PDVFVVEGLGIHSSFPFqLLPLS 435
Cdd:COG2223  197 ------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFAL-LGALG 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 436 CIIFSSLnvlfkpSTKIVRILnfTAFAIGAILMIAIVLVASLQTKAGLFSLLLISM---LPFGLAIVAGFVRslTVVGRV 512
Cdd:COG2223  258 RPLGGWL------SDRIGGRR--VLLIVFALMALGLLLLALALGSLWLFLVLFLLLglaLGGGNGAVFALVP--DIFPTK 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392890697 513 FAEQIVAMCAVPFGLAFSILPMVVTYSVTenkLAEWMKVTMFLFFVLSAVAIEFAVFGRGKSASWAAS 580
Cdd:COG2223  328 NAGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
198-520 1.37e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.27  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:COG2271   46 QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 278 IQWGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALeISLDSVYYIqcgtLAFLTLIWSIfyrdrpqdhpwvsgvelnk 357
Cdd:COG2271  124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA-FGWRAAFLI----LGLPGLLLAL------------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 358 ivagkvnelrsnraladaytslfrsLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSFPFQLLPLSCI 437
Cdd:COG2271  180 -------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 438 IFSSLNVLFKPSTKIVRILnftAFAIGAILMIAIVLVASLQtkaglfsLLLISMLPFGLAIVAGFVRSLTVVGRVFAEQI 517
Cdd:COG2271  235 LGGWLSDRLGRRRKLVLAI---GLLLAALALLLLALLPSPA-------LAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304


                 ...
gi 392890697 518 VAM 520
Cdd:COG2271  305 RGT 307
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 200-410 1.67e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVqkRSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd17325   34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA--TSYWQLLLARFLQGLASAAVWPAAMALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALeISLDSVYYIqCGTLAFLTLIWSIFYRDRPQDHPWvSGVELNKIV 359
Cdd:cd17325  112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA-LGYRAPFLV-CAALALLALVLALLLLPEPRPPPN-KRAVSAARL 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 392890697 360 AGKVNELRSNRALADAYTSLFrslsawsIWTSAFGLFSvtAFFSIYLPSLL 410
Cdd:cd17325  189 RSGLRLLLRDRRLLALFLAIF-------VLAFAFGALE--PFLPLYAAELG 230
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 198-406 1.38e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 50.70  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:cd17475   32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG--SYPVLLVLLFLVGAGYGSVQPGGGRAI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 278 IQWGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFhALEISLDSVYYIQCGTLAFLTLIWSIFYRDRPQdhpwvsgvelNK 357
Cdd:cd17475  110 MRWFPPRERGLAMGIRQTGVPLGGALAAALLPPL-ALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA----------AS 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 392890697 358 IVAGKVNELRSNRaladayTSLFRSLSAWSIWTSAFGL----FSVTAFFSIYL 406
Cdd:cd17475  179 AATESASTLLRSL------KEVLRNRDVWLIAIAGALLvapqFALLTFLLLFL 225
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 208-522 2.65e-06

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 49.94  E-value: 2.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 208 LGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVqkRSYIFLLLTRFLLGFSFSSVFPVMGNLLIQWGPLKEQL 287
Cdd:cd17327   52 VGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 288 IFITSMFMFLSIGPVVSWPIA----HYFHALEISLDSVYYIQCGTLAFLTLIWSIFY-RDRPQDHPWVSGVElnKIVAGK 362
Cdd:cd17327  130 KRIAFFYAAAGLGSIFGGLLAygvfKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWlPDNPSKAWFLTEEE--KELAVE 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 363 VNElRSNRALADAYTSLFRSLSA---WSIWTSAFGLFS---VTAFFSIYLPSLLASpDVFVVEGLGIHSSFPFQLLPLSC 436
Cdd:cd17327  208 RLR-ANQTGKGDQKFKWKQIKEAfkdPRTWLLFLFFFCsqiTNNGISNFLPLILKS-LGFYSLQTNLLSVPIGALGAVSL 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 437 IIFSSLNVLFKPstkivRILNFTAFAIGAILMIAIVLVASLQTKAGLFSLLLISMLPFGLAIVAGFVRSLT--VVGRVFA 514
Cdd:cd17327  286 LIAALLSDRFKK-----RGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCagYTKRATV 360


                 ....*...
gi 392890697 515 EQIVAMCA 522
Cdd:cd17327  361 LAIMLIFY 368
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 193-270 3.06e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.86  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 193 LPLRLQR--------GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGF 264
Cdd:cd17477   19 LSLRLERegvstaliGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD--SPWVWFLLRFVMGI 96


                 ....*.
gi 392890697 265 SFSSVF 270
Cdd:cd17477   97 GLAGLF 102
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
200-513 3.95e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:COG2807   56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQL---IFITSMFMFLSIGPVVSWPIAHYFH---ALEIsldsvyyiqCGTLAFLTLI-WSIFYRDRPQDHPWVSG 352
Cdd:COG2807  134 WFPDRVGLmtgLYTAAMGLGAALAAGLTVPLAAALGwrgALAV---------WALLALLALLlWLPLLRRRPAAAAAAPA 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 353 velnkivagkvnelrsnralADAYTSLFRSLSAWSIwTSAFGLFSVTAFFSI-YLPSLLASPDVFVVEGLGIHSsfPFQL 431
Cdd:COG2807  205 --------------------AASLRSLWRSPLAWLL-TLFFGLQSLLYYAVVaWLPPILRDAGLSAATAGLLLS--LFQL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 432 LPL-SCIIFSSLNVLFKPstkiVRILNFTAFAIGAILMIAIVLVASlqtkaglfSLLLISMLPFGLAIVAGFVRSLTVVG 510
Cdd:COG2807  262 AGIpGSLLVPLLADRLGD----RRPLLLLLGLLGLAGLLGLLLAPG--------SLPWLWAVLLGLGQGGLFPLALTLIG 329


                 ...
gi 392890697 511 RVF 513
Cdd:COG2807  330 LRA 332
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 200-501 4.98e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.11  E-value: 4.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd17319   41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAE 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFhALEISLDSVYYIqcgtLAFLTLIWSIFYrdrpqdhpwvsgvelnkiv 359
Cdd:cd17319  119 WFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFII----EGLLGLLLAVLW------------------- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 360 agkvnelrsnraladaytsLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSFPFQLLPLSCIIF 439
Cdd:cd17319  175 -------------------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILG 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392890697 440 SSLNVLFKPSTKivRILNFTAFAIGAILMIAIVLVASLqtkagLFSLLLISMLPFGLAIVAG 501
Cdd:cd17319  236 GRLSDRLLRGAR--RLVIIIGLLLAAVGLLLAYLTTSP-----VVAVILLSLAGFGIGAASP 290
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
200-300 1.59e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:COG2814  246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAE 323

                         90       100
                 ....*....|....*....|.
gi 392890697 280 WGPLKEQLIFITSMFMFLSIG 300
Cdd:COG2814  324 LAPPEARGRASGLYNSAFFLG 344
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
200-277 5.23e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 5.23e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQKRSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:COG2211  267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAML 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 192-341 7.60e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 7.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 192 TLPLRLQR---------GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVqkRSYIFLLLTRFLL 262
Cdd:cd17325  221 FLPLYAAElgglspaqiGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALL 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 263 GFSFSSVFPVMGNLLIQWGPLKEQ----LIFITSMFMFLSIGPVVSWPIAHYFhaleiSLDSVYYIqCGTLAFLTLIWSI 338
Cdd:cd17325  299 GLGLGLVFPATLALLADIVPPEGRgtamGLFNTAFSLGMVLGPLLGGFLYDAF-----GFATPFLA-AAALLLLAAVLFL 372


                 ...
gi 392890697 339 FYR 341
Cdd:cd17325  373 LLR 375
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 196-519 1.99e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 44.27  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  196 RLQRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGN 275
Cdd:TIGR00895  51 PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT--NVTQLLILRFLAGLGLGGLMPNLNA 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  276 LLIQWGPLKEQLIFITSMFMFLSIGPVV-----SWPIAHYfhaleiSLDSVYYIqcGTLAFLTLIW--------SIFY-- 340
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVggflaGWLIPVF------GWRSLFYV--GGIAPLLLLLllmrflpeSIDFlv 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  341 RDRPQDHPWVSGVELNKIVAGKVNELRSNRALADAYTSLF-------RSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASP 413
Cdd:TIGR00895 201 SKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMVEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  414 DVFVVEGLGIHSSFPFQLLpLSCIIFSSLNVLFKPSTkivrilnftafaIGAILMIAIVLVASLQTKAGLFSLLLISMLP 493
Cdd:TIGR00895 281 GFSLSLAATGGALFNFGGV-IGSIIFGWLADRLGPRV------------TALLLLLGAVFAVLVGSTLFSPTLLLLLGAI 347

                         330       340
                  ....*....|....*....|....*.
gi 392890697  494 FGLAIVAGFVRSLTVVGRVFAEQIVA 519
Cdd:TIGR00895 348 AGFFVNGGQSGLYALMALFYPTAIRA 373
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 200-336 4.55e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.95  E-value: 4.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVF---SICMVQSTILILLFLYVQKRSYIFLLLTRFLLGFSFSSVFPVMGNL 276
Cdd:cd17320  240 GLLFALNAIALILGSLLNGRLVRRFGPRRLLrlgLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL 319

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392890697 277 LIQwgPLKEQLIFITSMFMFL--SIGPVVSWPIAHyFHALEISLDSVYYIQCGTLAFLTLIW 336
Cdd:cd17320  320 ALE--PFPHVAGTASALLGFLqfLIGALAGALVGL-LPNGTALPMGLLILVLGLLALLLLIL 378
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 197-340 7.47e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 42.60  E-value: 7.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  197 LQRGLLFAASGLGVIFGSFVTINLIKK---FGVRKVFSICMvqsTILILLFLYVQkrSYIFLLLTRFLLGFsFSSVFPVM 273
Cdd:PRK08633  269 FQVQYLLAASAIGIGIGSLLAGRLSGRhieLGLVPLGALGL---ALSLFLLPTAP--SLASVLVLFFLFGF-SAGLFIVP 342

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392890697  274 GNLLIQWGPLKEQLIFI---------TSMFMFLSIGPVVSWpiahyfhaLEISLDSVYYIqCGTLAFLTLIWSIFY 340
Cdd:PRK08633  343 LNALIQFRAPEKELGKVlaannflqnVGMLLFLALTTLFSG--------LGLSPAGLFYL-IALVTLIGTLYTLLL 409
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
200-499 9.79e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 9.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVqkRSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA--PSYPLLLLALFLLGLGLGLLDVAANPYVAA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIfITSMFMFLSIGPVVSWPIAHYFHALEISLD-SVYYIQCGTLAFLTLIWSIFYRdrpqdhpwvsgvelnki 358
Cdd:COG0738  124 LGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSwHLPYLILAVLLLLLALLFLRSK----------------- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 359 VAGKVNELRSNRALADAYTSLFRSLSAWSIWTSAFGLFSVTAFFSIYLPSLLASPDVFVVEGLGIHSSFPFQLLPLSCII 438
Cdd:COG0738  186 LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFL 265

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392890697 439 FSSLNVLFKPsTKIVRIlnftaFAIGAILMIAIVLVASlqtkAGLFSLLLISMLPFGLAIV 499
Cdd:COG0738  266 GGFLLKRFGP-VRLLRL-----SALLAAVGLLLALLAP----GPWLALIGLALVGLGLSLM 316
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 200-512 1.47e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--SFALLLLARALAGLAHGGFWAIAAAYAAD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 280 WGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFhALEISLDSVYYIQcGTLAFLTLIWSIFYRDRPQDHPwvsgvelnkiv 359
Cdd:cd17324  115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL-GQLLGWRAAFLAI-AVLALLAALLLWRLLPSLPPKK----------- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 360 agkvnelRSNRALADAYTSLFRSLSAWSI-WTSAFGLFSVTAFFSiYLPSLLASPDVFVVEGLGIHssfpFQLLPLSCII 438
Cdd:cd17324  182 -------PGSLGLLSSLLLLLRNPRLRLAyLITFLLFGGFFALYT-YLAPFLTDVPGFSSSAIIGL----LLLFGVAGVV 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392890697 439 FSSLnvlfkpSTKIV-RILNFTAFAIGAILMIAIVLVASLqtkAGLFSLLLISMLPFGLAIVAGFVRSLTVVGRV 512
Cdd:cd17324  250 GSPL------AGRLAdRGGRRALLIALLLLAAALLLLTLL---GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 208-303 1.57e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697  208 LGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYvqKRSYIFLLLTRFLLGFSFSSVFPVMGNLLIQWGPLKEQL 287
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAF--SPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRA 215

                          90
                  ....*....|....*.
gi 392890697  288 IFITSMFMFLSIGPVV 303
Cdd:TIGR00898 216 IVGTLIQVFFSLGLVL 231
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 200-336 3.55e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVqkRSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd06173  247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS--PSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392890697 280 WGPlKEQL-----IFITSMFMFLSIGPVVSWPIAHYFhaleiSLDSVYYIQCGTLAFLTLIW 336
Cdd:cd06173  325 RVP-DELRgrvfsVYNALNSGAMPLGALLAGLLADAL-----GLSAVFLLAGALLLLAALLL 380
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 200-341 3.73e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 3.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd17489  230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG--SPWMLLLAAVLYGLGFGLLFPALQALAVD 307

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392890697 280 WGPlKEQL-----IFITSMFMFLSIGPVVSWPIAHYFhaleiSLDSVYYIqCGTLAFLTLIWSIFYR 341
Cdd:cd17489  308 LVP-PHRRgaangTFFIFFDLGIGLGGLLLGLVAELF-----GYRAMFLL-AAVVVLLALVLYIFLL 367
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 193-277 4.83e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.90  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 193 LPLRLQRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQKRSYIFLLLTRFLLGFSFSSVFPV 272
Cdd:cd17332  252 LGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLL 331


                 ....*
gi 392890697 273 MGNLL 277
Cdd:cd17332  332 PWAML 336
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 197-339 4.90e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 197 LQRGLLFAASGLGVIFGSFVTINLI-KKFGVRKVFSICMVQSTILILLFLYVqkRSYIFLLLTRFLLGFSFSSVFPVMGN 275
Cdd:cd17474  234 IIIGLLFAGWSVLLALGSLFVGRLLkKRFGARRILVIGLLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLPLLTT 311

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392890697 276 LLIQWGPlKEQLIFITSMFMFL-----SIGPVVSWPIAHYFhaleiSLDSVYYIqcGTLAFLTLIWSIF 339
Cdd:cd17474  312 LVTELAP-EEERGTASSLYNFVrflgqAVGPLLFGLLLEIF-----GLSAPFLV--GAAIALAAAVLLA 372
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 198-354 5.44e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.59  E-value: 5.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 198 QRGLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLL 277
Cdd:cd06180   35 QAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTS--GFAALLALRFLAGAASAFVFVFGSNLV 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392890697 278 IQWGPLKEQLIFITSMFMFLSIGPVVSWPIAHYFHALEISLDSVYYIQCGTLAFLTLIWSIFYRDRPQDHPWVSGVE 354
Cdd:cd06180  113 LHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAE 189
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 200-339 8.76e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.78  E-value: 8.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392890697 200 GLLFAASGLGVIFGSFVTINLIKKFGVRKVFSICMVQSTILILLFLYVQkrSYIFLLLTRFLLGFSFSSVFPVMGNLLIQ 279
Cdd:cd17391  243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQ--TPWQLGILRFLLGLATGGLLPAINSLLAK 320

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392890697 280 WGP-LKEQLIF-ITSMFMFL--SIGPVVSWPIAHYFhaleiSLDSVYYIQCGTLaFLTLIWSIF 339
Cdd:cd17391  321 ITPkEVAGRIFgYNQSFQYLgnVAGPLLGSAIAAHF-----GYRAVFVVTALLV-LLNAIWSFI 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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