BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057   128 YEKMFSPSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLF----AKQADTGILIEGVTYDEFGLLMSTIYPEMVLStDKT 203
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFsgqeSESSVSEITLDDVSPEDFEALLEFMYTGKLIS-EEN 79

                          90       100
                  ....*....|....*....|....*.
gi 17534057   204 AELLLRLGDRFKMPAVMHHVETRLIE 229
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057   128 YEKMFSPSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLF----AKQADTGILIEGVTYDEFGLLMSTIYPEMVLStDKT 203
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFsgqeSESSVSEITLDDVSPEDFEALLEFMYTGKLIS-EEN 79

                          90       100
                  ....*....|....*....|....*.
gi 17534057   204 AELLLRLGDRFKMPAVMHHVETRLIE 229
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 138 SDAVLLVGDKKLHVNKAFLSCHSTYFRSLFAKQADTG----ILIEGVTYDEFGLLMSTIYPEMVLSTDKTAELLLRLGDR 213
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESssseIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

                .
gi 17534057 214 F 214
Cdd:cd18186  82 L 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057   128 YEKMFSPSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLF----AKQADTGILIEGVTYDEFGLLMSTIYPEMVLStDKT 203
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFsgqeSESSVSEITLDDVSPEDFEALLEFMYTGKLIS-EEN 79

                          90       100
                  ....*....|....*....|....*.
gi 17534057   204 AELLLRLGDRFKMPAVMHHVETRLIE 229
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 138 SDAVLLVGDKKLHVNKAFLSCHSTYFRSLFAKQADTG----ILIEGVTYDEFGLLMSTIYPEMVLSTDKTAELLLRLGDR 213
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESssseIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

                .
gi 17534057 214 F 214
Cdd:cd18186  82 L 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 126 RLYEKMFSPSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLFA---KQADTG-ILIEGVTYDEFGLLMSTIY---PEMVL 198
Cdd:cd18297   1 RIDPHYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSsgsTEAQTPvIEIPDIRYDIFQLMMQYLYtggVESLD 80

                        90       100
                ....*....|....*....|....*....
gi 17534057 199 STDKTAELLLRLGDRFKMPAVMHHVETRL 227
Cdd:cd18297  81 VAQDDALELLRAASFFQLDGLKRHCEILL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 139 DAVLLVGDKKLHVNKAFLSCHSTYFRSLFAKQADTG---ILIEGVTYDEFGLLMSTIYPEMVLSTDKTAELLLRLGDRFK 215
Cdd:cd18212  25 DITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGqsiYMLEGMVAETFGALLEFIYTGCLQVGEKSLEQILATAQFLK 104

                ..
gi 17534057 216 MP 217
Cdd:cd18212 105 VN 106

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 130 KMFSPSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLF----AKQADTGILIEGVTYDEFGLLMSTIYPEmVLSTDKTAE 205
Cdd:cd18286  10 QLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLsgswAESNSSEITLTGVSHAAVSFVLLFIYGG-VLDLPDDVN 88

                ....*....
gi 17534057 206 L--LLRLGD 212
Cdd:cd18286  89 LgeLLSLAD 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17534057 141 VLLVGDKKLHVNKAFLSCHSTYFRSLFA-KQADTG---ILIEGVTYDEFGLLMSTIYPEMVLSTDKTAELLLRLGDRF 214
Cdd:cd01165   2 VLVVEGEKFHVNKELLAQSSEYFRALFRgGFRESGqaeINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 132 FSPSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLFAKQADTG----ILIEGVTYDEFGLLMSTIYPEMVLSTDKTAELL 207
Cdd:cd18314   1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESnlkeVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDL 80

                        90
                ....*....|.
gi 17534057 208 LRLGDRFKMPA 218
Cdd:cd18314  81 LMLASKYQVPD 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 139 DAVLLVGDKKLHVNKAFLSCHSTYFRSLFA----KQADTGILIEGVTYDEFGLLMSTIY-PEMVLSTDKTAELLLRlGDR 213
Cdd:cd18251  25 DVVLVVEGKPIEAHRILLAASCDYFRGMFAgglrEMQQTEVLIHGVSYNAMCKILDFIYtSELELSLDNVQETLTA-ACQ 103

                        90
                ....*....|....*...
gi 17534057 214 FKMPAVMHHVETRLIEWT 231
Cdd:cd18251 104 LQIPEVIGFCCDFLMSWV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 130 KMFSPSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRslFAKQADTGIL-IEGVTYDEFGLLMSTIYpemvlstdkTAELLL 208
Cdd:cd18303  11 SLFDKELYSDITIKLADKSIPAHKFVLAARSEKWS--NENLASTNELdLSDISYEVVLALLRWLY---------TDELDL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 17534057 209 RLGDRFkmpavmhhvetrLIEwtqltdqkLMFLADKFKLQKLLERTIS 256
Cdd:cd18303  80 TLDDEF------------LLE--------LMKAAKRFQLTDLVERCER 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 138 SDAVLLVGDKKLHVNKAFLSCHSTYFRSLFAKQADTGI----LIEGVTYDEFGLLMSTIYPEMVLSTDKTAELLLRLGDR 213
Cdd:cd18332  20 TDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVsvltLPSGLEARGFQLLLDFMYTSRLPLTPRTVPAVLAAATY 99

                        90
                ....*....|..
gi 17534057 214 FKMPavmHHVET 225
Cdd:cd18332 100 LQME---HVVET 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17534057 136 EQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLF----AKQADTGILIEGVTYDEFGLLMSTIYPEMVLSTDKTAELLL 208
Cdd:cd18249  22 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgelAESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534057 139 DAVLLVGDKKLHVNKAFLSCHSTYFRSLFAKQAD-TGIL---IEGVTYDEFGLLMSTIY-------PEMVLSTDKTAEll 207
Cdd:cd18306  20 DVILQVGGHEIPAHRAVLACASPYLFELFSSDSDgESILtvkLDGLDPDAVEVLVNYAYtsrlevpADLVKSVYSAAK-- 97

                        90       100
                ....*....|....*....|..
gi 17534057 208 lrlgdRFKMPAVMHHVETRLIE 229
Cdd:cd18306  98 -----KLKMDRVKKACGDFLLE 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 17534057 123 CLHRLYEKmfspSEQSDAVLLVGDKKLHVNKAFLSCHSTYFRSLF 167
Cdd:cd18238   5 VLHQFYEN----GELCDVTLKVGEKSIHCHRLVLACVSPYFRAMF 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|..
gi 17534057 139 DAVLLVGDKKLHVNKAFLSCHSTYFRSLFAKQ 170
Cdd:cd18209  20 DVLLIVGDQKFRAHKNVLAASSEYFQSLFTEK 51