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Conserved domains on  [gi|17506717|ref|NP_492058|]
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putative prefoldin subunit 6 [Caenorhabditis elegans]

Protein Classification

prefoldin subunit 6( domain architecture ID 19227319)

prefoldin subunit 6 (PFDN6) is a beta subunit of prefoldin, a hexameric co-chaperone prefoldin complex that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly

Gene Ontology:  GO:0016272|GO:0061077|GO:0051082|GO:0003714
PubMed:  9630229|11106732|33137104

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 6.45e-33

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


:

Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 111.03  E-value: 6.45e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717  11 VNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEA 90
Cdd:cd23161   1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                        90       100
                ....*....|....*....|.
gi 17506717  91 SISDISKKCTEQRDKVMNMQK 111
Cdd:cd23161  81 QIKDLEKKQEKKREKIAKLQQ 101
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 6.45e-33

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 111.03  E-value: 6.45e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717  11 VNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEA 90
Cdd:cd23161   1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                        90       100
                ....*....|....*....|.
gi 17506717  91 SISDISKKCTEQRDKVMNMQK 111
Cdd:cd23161  81 QIKDLEKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 11-112 2.38e-15

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 66.48  E-value: 2.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717    11 VNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEA 90
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEK 80

                          90       100
                  ....*....|....*....|..
gi 17506717    91 SISDISKKCTEQRDKVMNMQKS 112
Cdd:pfam01920  81 QLEKLEKELEELKEELYKKFGQ 102
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
8-106 3.26e-06

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 42.95  E-value: 3.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717   8 EEEVNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKR 87
Cdd:COG1382  10 QNQLAQLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRLKT 89

                        90
                ....*....|....*....
gi 17506717  88 VEASISDISKKCTEQRDKV 106
Cdd:COG1382  90 LEKQEERLQKQLEELQEKL 108
PRK09343 PRK09343
prefoldin subunit beta; Provisional
 10-101 9.07e-04

prefoldin subunit beta; Provisional


Pssm-ID: 181787 [Multi-domain]  Cd Length: 121  Bit Score: 36.59  E-value: 9.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717   10 EVNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQD-------LEEARSTVEKRLEFID 82
Cdd:PRK09343  12 QLAQLQQLQQQLERLLQQKSQIDLELREINKALEELEKLPDDTPIYKIVGNLLVKVDktkvekeLKERKELLELRSRTLE 91

                         90
                 ....*....|....*....
gi 17506717   83 SETKRVEASISDISKKCTE 101
Cdd:PRK09343  92 KQEKKLREKLKELQAKINE 110
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 11-111 6.45e-33

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 111.03  E-value: 6.45e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717  11 VNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEA 90
Cdd:cd23161   1 SKEFQKLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEK 80

                        90       100
                ....*....|....*....|.
gi 17506717  91 SISDISKKCTEQRDKVMNMQK 111
Cdd:cd23161  81 QIKDLEKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 11-112 2.38e-15

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 66.48  E-value: 2.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717    11 VNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEA 90
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEK 80

                          90       100
                  ....*....|....*....|..
gi 17506717    91 SISDISKKCTEQRDKVMNMQKS 112
Cdd:pfam01920  81 QLEKLEKELEELKEELYKKFGQ 102
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
8-106 3.26e-06

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 42.95  E-value: 3.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717   8 EEEVNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKR 87
Cdd:COG1382  10 QNQLAQLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRLKT 89

                        90
                ....*....|....*....
gi 17506717  88 VEASISDISKKCTEQRDKV 106
Cdd:COG1382  90 LEKQEERLQKQLEELQEKL 108
Prefoldin_beta cd00632
Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, ...
 28-97 8.76e-05

Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467469  Cd Length: 78  Bit Score: 38.48  E-value: 8.76e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717  28 RQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEASISDISK 97
Cdd:cd00632   9 KEELERKINEQKVVLDELSNLKKNRKVYRQQGNIFILASKEETLSELKKTLDHLQKEIKELEQQLKAKEK 78
Prefoldin_beta_GimC cd23162
Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric ...
 9-98 1.65e-04

Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467478 [Multi-domain]  Cd Length: 102  Bit Score: 38.23  E-value: 1.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717   9 EEVNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVR-------QDLEEARSTVEKRLEFI 81
Cdd:cd23162   1 NQLAQLQQLQQQLQAVLLQKQQLEAELREIERALEELEKLPDDAEVYKSVGTILVKvdkeeviKELKERKETLELRLKTL 80

                        90
                ....*....|....*..
gi 17506717  82 DSETKRVEASISDISKK 98
Cdd:cd23162  81 EKQEERLRKQLEELQKK 97
PRK09343 PRK09343
prefoldin subunit beta; Provisional
 10-101 9.07e-04

prefoldin subunit beta; Provisional


Pssm-ID: 181787 [Multi-domain]  Cd Length: 121  Bit Score: 36.59  E-value: 9.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717   10 EVNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQD-------LEEARSTVEKRLEFID 82
Cdd:PRK09343  12 QLAQLQQLQQQLERLLQQKSQIDLELREINKALEELEKLPDDTPIYKIVGNLLVKVDktkvekeLKERKELLELRSRTLE 91

                         90
                 ....*....|....*....
gi 17506717   83 SETKRVEASISDISKKCTE 101
Cdd:PRK09343  92 KQEKKLREKLKELQAKINE 110
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 44-101 6.02e-03

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 34.06  E-value: 6.02e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17506717  44 ELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRVEASISDISKKCTE 101
Cdd:cd23165  38 ELELADDDEPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEIEKLEEEIDEIEEEMKE 95
Prefoldin_2 cd23163
prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic ...
 9-105 7.13e-03

prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467479  Cd Length: 100  Bit Score: 33.64  E-value: 7.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506717   9 EEVNKLRTLEKDREKYFTSRQEMEMRLTESKNVKAELDLMESDSKVYKLIGAVLVRQDLEEARSTVEKRLEFIDSETKRV 88
Cdd:cd23163   1 EVVAQYNQLRQEQQQLASKIAELEQELNEHKLVIDTLKPLDPDRKCFRLVGGVLVERTVGEVLPALEENKENLEEVIEQL 80

                        90
                ....*....|....*..
gi 17506717  89 EASISDISKKCTEQRDK 105
Cdd:cd23163  81 NEQLEEKEKELNEFREK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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