Histidine triad nucleotide-binding protein 1 [Caenorhabditis elegans]
histidine triad nucleotide-binding protein( domain architecture ID 10101095)
histidine triad nucleotide-binding protein of the histidine triad family of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides
List of domain hits
Name | Accession | Description | Interval | E-value | |||
PKCI_related | cd01276 | Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ... |
20-122 | 3.51e-57 | |||
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members. : Pssm-ID: 238607 [Multi-domain] Cd Length: 104 Bit Score: 172.75 E-value: 3.51e-57
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Name | Accession | Description | Interval | E-value | |||
PKCI_related | cd01276 | Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ... |
20-122 | 3.51e-57 | |||
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members. Pssm-ID: 238607 [Multi-domain] Cd Length: 104 Bit Score: 172.75 E-value: 3.51e-57
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HinT | COG0537 | Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ... |
19-123 | 5.82e-37 | |||
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only]; Pssm-ID: 440303 [Multi-domain] Cd Length: 133 Bit Score: 122.36 E-value: 5.82e-37
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HIT | pfam01230 | HIT domain; |
28-125 | 7.83e-36 | |||
HIT domain; Pssm-ID: 395984 [Multi-domain] Cd Length: 98 Bit Score: 118.57 E-value: 7.83e-36
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PRK10687 | PRK10687 | purine nucleoside phosphoramidase; Provisional |
18-125 | 4.93e-34 | |||
purine nucleoside phosphoramidase; Provisional Pssm-ID: 182648 [Multi-domain] Cd Length: 119 Bit Score: 114.60 E-value: 4.93e-34
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Name | Accession | Description | Interval | E-value | |||
PKCI_related | cd01276 | Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ... |
20-122 | 3.51e-57 | |||
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members. Pssm-ID: 238607 [Multi-domain] Cd Length: 104 Bit Score: 172.75 E-value: 3.51e-57
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HinT | COG0537 | Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ... |
19-123 | 5.82e-37 | |||
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only]; Pssm-ID: 440303 [Multi-domain] Cd Length: 133 Bit Score: 122.36 E-value: 5.82e-37
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HIT | pfam01230 | HIT domain; |
28-125 | 7.83e-36 | |||
HIT domain; Pssm-ID: 395984 [Multi-domain] Cd Length: 98 Bit Score: 118.57 E-value: 7.83e-36
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PRK10687 | PRK10687 | purine nucleoside phosphoramidase; Provisional |
18-125 | 4.93e-34 | |||
purine nucleoside phosphoramidase; Provisional Pssm-ID: 182648 [Multi-domain] Cd Length: 119 Bit Score: 114.60 E-value: 4.93e-34
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HINT_subgroup | cd01277 | HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the ... |
20-119 | 3.14e-28 | |||
HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression. Pssm-ID: 238608 [Multi-domain] Cd Length: 103 Bit Score: 99.22 E-value: 3.14e-28
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DcpS_C | pfam11969 | Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA ... |
23-121 | 1.02e-23 | |||
Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. Pssm-ID: 463415 [Multi-domain] Cd Length: 114 Bit Score: 88.05 E-value: 1.02e-23
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HIT_like | cd00468 | HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH ... |
36-121 | 1.12e-20 | |||
HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified in the literacture into three major branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Further sequence analysis reveals several new closely related, yet uncharacterized subgroups. Pssm-ID: 238263 [Multi-domain] Cd Length: 86 Bit Score: 79.82 E-value: 1.12e-20
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FHIT | cd01275 | FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH ... |
23-120 | 2.66e-14 | |||
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours. Pssm-ID: 238606 [Multi-domain] Cd Length: 126 Bit Score: 64.23 E-value: 2.66e-14
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aprataxin_related | cd01278 | aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia ... |
27-120 | 5.09e-06 | |||
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are predominantly eukaryotic in origin. Pssm-ID: 238609 [Multi-domain] Cd Length: 104 Bit Score: 42.37 E-value: 5.09e-06
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Blast search parameters | ||||
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