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Conserved domains on  [gi|17137784|ref|NP_477498|]
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fushi tarazu [Drosophila melanogaster]

Protein Classification

FTZ and homeodomain domain-containing protein( domain architecture ID 11145931)

FTZ and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTZ pfam03867
Fushi tarazu (FTZ), N-terminal region; This region contains the important motif (LXXLL) ...
 1-248 2.35e-102

Fushi tarazu (FTZ), N-terminal region; This region contains the important motif (LXXLL) necessary for the interaction of FTZ with the nuclear receptor FTZ-F1. FTZ is thought to represents a category of LXXLL motif-dependent co-activators for nuclear receptors.


:

Pssm-ID: 397787  Cd Length: 269  Bit Score: 304.73  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784     1 MATTNSQSHYSYADNMnmYNMYHPHSLPPTYYDNSGSNAYYQNT------------SNYQGYYPQESYSESCYYYNNQEQ 68
Cdd:pfam03867   1 MAATNSHSHYYYADSM--YNMYHHHALPPTYYDNTSSNSYYQNSssasswpasyqpSSYAGYYPQESYSESCYYSNHQQQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784    69 VTTQTVPPVQPTTPPP-------------KATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVK 135
Cdd:pfam03867  79 EQVQQQQEVPPVPEPAplpsyqqptpappKSRKRKAEESAADIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTFEQVK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784   136 KAPaVSTKVT--ASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTqklKNGDFA----TPPPTTPTSLPPLEGISTPP 209
Cdd:pfam03867 159 KAP-VSTKSTsaGSPAPSYEQDYVAVPTPSASEDVDYLDVYSPRKQA---KNGDFVtpppATTPTTPTSLPPVEGISTPP 234

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 17137784   210 QSPGEKSssavSQEINHRIVTAPNGAGDFNWSHIEETLA 248
Cdd:pfam03867 235 QSPAEKS----SNEINHRIVTAANAANDFNWSHIEETLA 269
Homeodomain pfam00046
Homeodomain;
255-311 1.28e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 1.28e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137784   255 KRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK 311
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
KLF1_2_4_N super family cl41729
N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel ...
 321-404 6.97e-05

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.


The actual alignment was detected with superfamily member cd22056:

Pssm-ID: 425360 [Multi-domain]  Cd Length: 339  Bit Score: 44.65  E-value: 6.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784 321 HCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQHQCSYQ 400
Cdd:cd22056 199 GGGGFMGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQ 278


                ....
gi 17137784 401 QHPQ 404
Cdd:cd22056 279 FHGQ 282
 
Name Accession Description Interval E-value
FTZ pfam03867
Fushi tarazu (FTZ), N-terminal region; This region contains the important motif (LXXLL) ...
 1-248 2.35e-102

Fushi tarazu (FTZ), N-terminal region; This region contains the important motif (LXXLL) necessary for the interaction of FTZ with the nuclear receptor FTZ-F1. FTZ is thought to represents a category of LXXLL motif-dependent co-activators for nuclear receptors.


Pssm-ID: 397787  Cd Length: 269  Bit Score: 304.73  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784     1 MATTNSQSHYSYADNMnmYNMYHPHSLPPTYYDNSGSNAYYQNT------------SNYQGYYPQESYSESCYYYNNQEQ 68
Cdd:pfam03867   1 MAATNSHSHYYYADSM--YNMYHHHALPPTYYDNTSSNSYYQNSssasswpasyqpSSYAGYYPQESYSESCYYSNHQQQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784    69 VTTQTVPPVQPTTPPP-------------KATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVK 135
Cdd:pfam03867  79 EQVQQQQEVPPVPEPAplpsyqqptpappKSRKRKAEESAADIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTFEQVK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784   136 KAPaVSTKVT--ASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTqklKNGDFA----TPPPTTPTSLPPLEGISTPP 209
Cdd:pfam03867 159 KAP-VSTKSTsaGSPAPSYEQDYVAVPTPSASEDVDYLDVYSPRKQA---KNGDFVtpppATTPTTPTSLPPVEGISTPP 234

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 17137784   210 QSPGEKSssavSQEINHRIVTAPNGAGDFNWSHIEETLA 248
Cdd:pfam03867 235 QSPAEKS----SNEINHRIVTAANAANDFNWSHIEETLA 269
Homeodomain pfam00046
Homeodomain;
255-311 1.28e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 1.28e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137784   255 KRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK 311
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 254-310 4.01e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 4.01e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137784    254 SKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSK 310
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 255-311 2.92e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.92  E-value: 2.92e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137784 255 KRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK 311
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
243-313 5.96e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 66.31  E-value: 5.96e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17137784 243 IEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDR 313
Cdd:COG5576  40 KLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 321-404 6.97e-05

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 44.65  E-value: 6.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784 321 HCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQHQCSYQ 400
Cdd:cd22056 199 GGGGFMGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQ 278


                ....
gi 17137784 401 QHPQ 404
Cdd:cd22056 279 FHGQ 282
 
Name Accession Description Interval E-value
FTZ pfam03867
Fushi tarazu (FTZ), N-terminal region; This region contains the important motif (LXXLL) ...
 1-248 2.35e-102

Fushi tarazu (FTZ), N-terminal region; This region contains the important motif (LXXLL) necessary for the interaction of FTZ with the nuclear receptor FTZ-F1. FTZ is thought to represents a category of LXXLL motif-dependent co-activators for nuclear receptors.


Pssm-ID: 397787  Cd Length: 269  Bit Score: 304.73  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784     1 MATTNSQSHYSYADNMnmYNMYHPHSLPPTYYDNSGSNAYYQNT------------SNYQGYYPQESYSESCYYYNNQEQ 68
Cdd:pfam03867   1 MAATNSHSHYYYADSM--YNMYHHHALPPTYYDNTSSNSYYQNSssasswpasyqpSSYAGYYPQESYSESCYYSNHQQQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784    69 VTTQTVPPVQPTTPPP-------------KATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVK 135
Cdd:pfam03867  79 EQVQQQQEVPPVPEPAplpsyqqptpappKSRKRKAEESAADIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTFEQVK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784   136 KAPaVSTKVT--ASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTqklKNGDFA----TPPPTTPTSLPPLEGISTPP 209
Cdd:pfam03867 159 KAP-VSTKSTsaGSPAPSYEQDYVAVPTPSASEDVDYLDVYSPRKQA---KNGDFVtpppATTPTTPTSLPPVEGISTPP 234

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 17137784   210 QSPGEKSssavSQEINHRIVTAPNGAGDFNWSHIEETLA 248
Cdd:pfam03867 235 QSPAEKS----SNEINHRIVTAANAANDFNWSHIEETLA 269
Homeodomain pfam00046
Homeodomain;
255-311 1.28e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 1.28e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137784   255 KRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK 311
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 254-310 4.01e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 4.01e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137784    254 SKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSK 310
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 255-311 2.92e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.92  E-value: 2.92e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137784 255 KRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK 311
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
243-313 5.96e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 66.31  E-value: 5.96e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17137784 243 IEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDR 313
Cdd:COG5576  40 KLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 321-404 6.97e-05

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 44.65  E-value: 6.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137784 321 HCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQHQCSYQ 400
Cdd:cd22056 199 GGGGFMGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQ 278


                ....
gi 17137784 401 QHPQ 404
Cdd:cd22056 279 FHGQ 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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