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Conserved domains on  [gi|17136906|ref|NP_476979|]
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peter pan [Drosophila melanogaster]

Protein Classification

Brix domain-containing protein( domain architecture ID 10657984)

Brix domain-containing protein similar to Drosophila melanogaster protein Peter pan which is required for initiation of larval growth and normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication

CATH:  3.40.50.10480
Gene Ontology:  GO:0019843|GO:0006364
PubMed:  11406393
SCOP:  4004748

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Brix smart00879
The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from ...
31-212 1.32e-30

The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.


:

Pssm-ID: 214879 [Multi-domain]  Cd Length: 180  Bit Score: 116.68  E-value: 1.32e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906     31 FVIHRGLACPYITDLTLDFRRIMEPFTASNLREKRMNRIKDFVSLSsfFHVSHMGIFNKAST--QLSFKVVRLPRGPSLT 108
Cdd:smart00879   1 LITTSRKPSKRTRQLAKDLRRLFPPSTKINRGKNKLNELLEFASEK--GNTDLLVVFESSSKgrPLNLTIYRLPNGPTLD 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906    109 FKVHQFTLARDVislsKKQMIDNDHFKHAPLVIMNNFSGDGKHLklMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDT 188
Cdd:smart00879  79 FKILNVSLRKEL----KGFKTGNCLTGSRPLLIFNNFFTELGKL--IKELFQDLFPGPPEHKKSLPGLRRVVTFSNQDDY 152
                          170       180
                   ....*....|....*....|....
gi 17136906    189 klVEMRHYSVQVVPVGLKRAVQKI 212
Cdd:smart00879 153 --IFFRHYRIKFGKKKPRVELQEI 174
Brix super family cl00935
The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from ...
215-295 1.22e-03

The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.


The actual alignment was detected with superfamily member COG5154:

Pssm-ID: 469999  Cd Length: 283  Bit Score: 40.76  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906 215 GTVPNLGKCNEVVDFVTKDGYAseseaeDDeqshVVLAQTLKSKGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVL 294
Cdd:COG5154 161 GIPKGARRSKPFIDKVLCFFIL------DG----KIWVRCYEIGRENEDKSKDVKLEEIGPRFVMTVIKILEGSFGGPAI 230

                .
gi 17136906 295 Y 295
Cdd:COG5154 231 Y 231
 
Name Accession Description Interval E-value
Brix smart00879
The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from ...
31-212 1.32e-30

The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.


Pssm-ID: 214879 [Multi-domain]  Cd Length: 180  Bit Score: 116.68  E-value: 1.32e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906     31 FVIHRGLACPYITDLTLDFRRIMEPFTASNLREKRMNRIKDFVSLSsfFHVSHMGIFNKAST--QLSFKVVRLPRGPSLT 108
Cdd:smart00879   1 LITTSRKPSKRTRQLAKDLRRLFPPSTKINRGKNKLNELLEFASEK--GNTDLLVVFESSSKgrPLNLTIYRLPNGPTLD 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906    109 FKVHQFTLARDVislsKKQMIDNDHFKHAPLVIMNNFSGDGKHLklMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDT 188
Cdd:smart00879  79 FKILNVSLRKEL----KGFKTGNCLTGSRPLLIFNNFFTELGKL--IKELFQDLFPGPPEHKKSLPGLRRVVTFSNQDDY 152
                          170       180
                   ....*....|....*....|....
gi 17136906    189 klVEMRHYSVQVVPVGLKRAVQKI 212
Cdd:smart00879 153 --IFFRHYRIKFGKKKPRVELQEI 174
Brix pfam04427
Brix domain;
42-283 1.36e-24

Brix domain;


Pssm-ID: 461304 [Multi-domain]  Cd Length: 180  Bit Score: 99.96  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906    42 ITDLTLDFRRIMEPFTASNLReKRMNRIKDfvslssffhVSHMGIFNKaSTQLSFKVVRL-----PRGPSLTFKVHQFTL 116
Cdd:pfam04427   8 LRQLLKDLRSLMKPHTASFLK-RNSNPLED---------VTHLEFLSE-KNDCSLFVFGShskkrPNGPTLEFGVENYSL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906   117 ARDVislskkQMIDNDHFKHAPLVIMNNFSGDGKHLKLMATTFQNMF--PSINLAtvnigTIRRCVLFS-YNPDTKLVEM 193
Cdd:pfam04427  77 MKDL------KGTGNCLKGSRPLLVFNGSFFSDPNFKLLKSLFQDLFrvPPINLK-----GIDRVILFSaYDNQPDKIWF 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906   194 RHYSVqvvpvglkravqkivkgtvpnlgkcnevvdfvtkdgyaseseaeddeqshvvlaqTLKSKGNLEDKKSSIKLHEI 273
Cdd:pfam04427 146 RHYQI-------------------------------------------------------RLKEKKKSGTKLPRVELVEI 170
                         250
                  ....*....|
gi 17136906   274 GPRLTMQLIK 283
Cdd:pfam04427 171 GPRFDLKLRR 180
BRX1 COG5154
RNA-binding protein required for 60S ribosomal subunit biogenesis [Translation, ribosomal ...
215-295 1.22e-03

RNA-binding protein required for 60S ribosomal subunit biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227483  Cd Length: 283  Bit Score: 40.76  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906 215 GTVPNLGKCNEVVDFVTKDGYAseseaeDDeqshVVLAQTLKSKGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVL 294
Cdd:COG5154 161 GIPKGARRSKPFIDKVLCFFIL------DG----KIWVRCYEIGRENEDKSKDVKLEEIGPRFVMTVIKILEGSFGGPAI 230

                .
gi 17136906 295 Y 295
Cdd:COG5154 231 Y 231
 
Name Accession Description Interval E-value
Brix smart00879
The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from ...
31-212 1.32e-30

The Brix domain is found in a number of eukaryotic proteins; Members include SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.


Pssm-ID: 214879 [Multi-domain]  Cd Length: 180  Bit Score: 116.68  E-value: 1.32e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906     31 FVIHRGLACPYITDLTLDFRRIMEPFTASNLREKRMNRIKDFVSLSsfFHVSHMGIFNKAST--QLSFKVVRLPRGPSLT 108
Cdd:smart00879   1 LITTSRKPSKRTRQLAKDLRRLFPPSTKINRGKNKLNELLEFASEK--GNTDLLVVFESSSKgrPLNLTIYRLPNGPTLD 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906    109 FKVHQFTLARDVislsKKQMIDNDHFKHAPLVIMNNFSGDGKHLklMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDT 188
Cdd:smart00879  79 FKILNVSLRKEL----KGFKTGNCLTGSRPLLIFNNFFTELGKL--IKELFQDLFPGPPEHKKSLPGLRRVVTFSNQDDY 152
                          170       180
                   ....*....|....*....|....
gi 17136906    189 klVEMRHYSVQVVPVGLKRAVQKI 212
Cdd:smart00879 153 --IFFRHYRIKFGKKKPRVELQEI 174
Brix pfam04427
Brix domain;
42-283 1.36e-24

Brix domain;


Pssm-ID: 461304 [Multi-domain]  Cd Length: 180  Bit Score: 99.96  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906    42 ITDLTLDFRRIMEPFTASNLReKRMNRIKDfvslssffhVSHMGIFNKaSTQLSFKVVRL-----PRGPSLTFKVHQFTL 116
Cdd:pfam04427   8 LRQLLKDLRSLMKPHTASFLK-RNSNPLED---------VTHLEFLSE-KNDCSLFVFGShskkrPNGPTLEFGVENYSL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906   117 ARDVislskkQMIDNDHFKHAPLVIMNNFSGDGKHLKLMATTFQNMF--PSINLAtvnigTIRRCVLFS-YNPDTKLVEM 193
Cdd:pfam04427  77 MKDL------KGTGNCLKGSRPLLVFNGSFFSDPNFKLLKSLFQDLFrvPPINLK-----GIDRVILFSaYDNQPDKIWF 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906   194 RHYSVqvvpvglkravqkivkgtvpnlgkcnevvdfvtkdgyaseseaeddeqshvvlaqTLKSKGNLEDKKSSIKLHEI 273
Cdd:pfam04427 146 RHYQI-------------------------------------------------------RLKEKKKSGTKLPRVELVEI 170
                         250
                  ....*....|
gi 17136906   274 GPRLTMQLIK 283
Cdd:pfam04427 171 GPRFDLKLRR 180
BRX1 COG5154
RNA-binding protein required for 60S ribosomal subunit biogenesis [Translation, ribosomal ...
215-295 1.22e-03

RNA-binding protein required for 60S ribosomal subunit biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227483  Cd Length: 283  Bit Score: 40.76  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136906 215 GTVPNLGKCNEVVDFVTKDGYAseseaeDDeqshVVLAQTLKSKGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVL 294
Cdd:COG5154 161 GIPKGARRSKPFIDKVLCFFIL------DG----KIWVRCYEIGRENEDKSKDVKLEEIGPRFVMTVIKILEGSFGGPAI 230

                .
gi 17136906 295 Y 295
Cdd:COG5154 231 Y 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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