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Conserved domains on  [gi|24655024|ref|NP_476827|]
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lysozyme E [Drosophila melanogaster]

Protein Classification

LYZ_C_invert domain-containing protein( domain architecture ID 13014106)

LYZ_C_invert domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 19-139 6.08e-62

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


:

Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 185.89  E-value: 6.08e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024  19 RTLDRCSLAREMSNLGVPRDQLARWACIAEHESSYRTGVVGPENYNGSNDYGIFQINNYYWCAPPSGrfSYNECGLSCNA 98
Cdd:cd16899   1 KIFTRCELARELRKLGVPRSQLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGG--SGNGCNVKCED 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24655024  99 LLTDDITHSVRCAQKVLSQQGWSAWSTW-HYCSGW-LPSIDGC 139
Cdd:cd16899  79 LLDDDISDDVKCAKKIYKEQGFNAWVGWkNKCKGKnLPSYSDC 121
 
Name Accession Description Interval E-value
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 19-139 6.08e-62

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 185.89  E-value: 6.08e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024  19 RTLDRCSLAREMSNLGVPRDQLARWACIAEHESSYRTGVVGPENYNGSNDYGIFQINNYYWCAPPSGrfSYNECGLSCNA 98
Cdd:cd16899   1 KIFTRCELARELRKLGVPRSQLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGG--SGNGCNVKCED 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24655024  99 LLTDDITHSVRCAQKVLSQQGWSAWSTW-HYCSGW-LPSIDGC 139
Cdd:cd16899  79 LLDDDISDDVKCAKKIYKEQGFNAWVGWkNKCKGKnLPSYSDC 121
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 19-139 2.62e-61

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 184.16  E-value: 2.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024    19 RTLDRCSLAREMSNLGVP---RDQLARWACIAEHESSYRTGVVGPENynGSNDYGIFQINNYYWCAPPSGRFSYNECGLS 95
Cdd:pfam00062   1 KQFTRCELARELKKLGMDgyrGISLAEWVCLAFHESGYDTQAIVYNN--GSTDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24655024    96 CNALLTDDITHSVRCAQKVLSQQGWSAWSTW-HYCSGWLPSIDGC 139
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKILDPQGIDAWLAWkPHCSEDLEQWIGC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
19-140 4.09e-57

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 173.63  E-value: 4.09e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024     19 RTLDRCSLAREMSNL---GVPRDQLARWACIAEHESSYRTGVVGPENyNGSNDYGIFQINNYYWCAPPSGRFSYNECGLS 95
Cdd:smart00263   1 KVFTRCELARELKRLgldGYRGISLANWVCLAFHESGYNTQATNYNN-GGSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 24655024     96 CNALLTDDITHSVRCAQKVLSQQGWSAWSTWH-YCSG--WLPSIDGCF 140
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSDQGIDAWVAWKnHCQGedLSQWIRGCG 127
 
Name Accession Description Interval E-value
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 19-139 6.08e-62

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 185.89  E-value: 6.08e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024  19 RTLDRCSLAREMSNLGVPRDQLARWACIAEHESSYRTGVVGPENYNGSNDYGIFQINNYYWCAPPSGrfSYNECGLSCNA 98
Cdd:cd16899   1 KIFTRCELARELRKLGVPRSQLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGG--SGNGCNVKCED 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24655024  99 LLTDDITHSVRCAQKVLSQQGWSAWSTW-HYCSGW-LPSIDGC 139
Cdd:cd16899  79 LLDDDISDDVKCAKKIYKEQGFNAWVGWkNKCKGKnLPSYSDC 121
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 19-139 2.62e-61

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 184.16  E-value: 2.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024    19 RTLDRCSLAREMSNLGVP---RDQLARWACIAEHESSYRTGVVGPENynGSNDYGIFQINNYYWCAPPSGRFSYNECGLS 95
Cdd:pfam00062   1 KQFTRCELARELKKLGMDgyrGISLAEWVCLAFHESGYDTQAIVYNN--GSTDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24655024    96 CNALLTDDITHSVRCAQKVLSQQGWSAWSTW-HYCSGWLPSIDGC 139
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKILDPQGIDAWLAWkPHCSEDLEQWIGC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
19-140 4.09e-57

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 173.63  E-value: 4.09e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024     19 RTLDRCSLAREMSNL---GVPRDQLARWACIAEHESSYRTGVVGPENyNGSNDYGIFQINNYYWCAPPSGRFSYNECGLS 95
Cdd:smart00263   1 KVFTRCELARELKRLgldGYRGISLANWVCLAFHESGYNTQATNYNN-GGSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 24655024     96 CNALLTDDITHSVRCAQKVLSQQGWSAWSTWH-YCSG--WLPSIDGCF 140
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSDQGIDAWVAWKnHCQGedLSQWIRGCG 127
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 19-139 1.50e-32

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 111.51  E-value: 1.50e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024  19 RTLDRCSLAREMSNLGVPR-DQLARWACIAEHESSYRTGVVGpENYNGSNDYGIFQINNYYWCAPPSGRFSYNECGLSCN 97
Cdd:cd00119   1 KVFTRCELARLLKDIGGYGgISLPNWVCLMKHESGYDTQATN-ENNNGSTDYGLFQINSRYWCKDGQTPGARNICDISCS 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24655024  98 ALLTDDITHSVRCAQKVLSQQGWSAWSTW-HYCSGWLPSIDGC 139
Cdd:cd00119  80 KLLTDDITDAIMCAKKIVDDKGIDAWVAWkNHCQNKLRQYVSC 122
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 20-139 4.32e-30

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 105.04  E-value: 4.32e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024  20 TLDRCSLAREMSNLGVPRDQ---LARWACIAEHESSYRTGVVGpENYNGSNDYGIFQINNYYWCAPPSGRfSYNECGLSC 96
Cdd:cd16897   2 IFSRCELARILKRGGLDGYRgysLANWVCLAYYESGFNTRATN-ENPDGSTDYGIFQINSRYWCNDGKTP-SKNLCHISC 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24655024  97 NALLTDDITHSVRCAQKVLSQ-QGWSAWSTW-HYCSG-----WLpsiDGC 139
Cdd:cd16897  80 SDLLNDDITDDIKCAKKIVKDpQGMGAWVAWrLHCEGrdlsrWL---DGC 126
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 19-133 3.61e-24

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 90.19  E-value: 3.61e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024  19 RTLDRCSLAREMSNLGVPRDQ---LARWACIAEHESSYRTGVVgpENYNGSNDYGIFQINNYYWCAPPSGRFSYNECGLS 95
Cdd:cd16898   1 IIFTKCELSQILKEHGLDGFNgisLPEWICVTFHTSGYDTQAL--VYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGIS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 24655024  96 CNALLTDDITHSVRCAQKVLSQ-QGWSAWSTWH-YCSGWL 133
Cdd:cd16898  79 CSKLLDDDITDDIACAKKILAIpKGIDYWKAHKpFCREDL 118
SLT_3 pfam18896
Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla ...
 32-125 1.41e-04

Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla radiation bacteria. The domain contains several conserved cysteine and histidine residues suggesting that it may bind to zinc.


Pssm-ID: 436815 [Multi-domain]  Cd Length: 89  Bit Score: 38.16  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655024    32 NLGVPRDQLARWACIAEHESSYRTGVVG-PENYNGSNDYGIFQINNYYwcapPSGRFSYNEC--GLSCNALLTDDIthsv 108
Cdd:pfam18896   6 AAGFTGDDAVTAVAVAMAESGGDPSAVGdLANTKGSPSRGLWQINSLA----HPEVTGPDACayDPQCNAKAAYAI---- 77

                          90
                  ....*....|....*....
gi 24655024   109 rcaqkvlSQQG--WSAWST 125
Cdd:pfam18896  78 -------SSGGtnWSPWST 89
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 43-92 6.41e-04

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 35.85  E-value: 6.41e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24655024  43 WACIAEHESSYRTGVVGPenyNGSNDYGIFQINNYYWCA----PPSGRFSYNEC 92
Cdd:cd00442   2 LAAIIGQESGGNKPANAG---SGSGAAGLFQFMPGTWKAygknSSSDLNDPEAS 52
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 46-75 9.32e-04

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 36.35  E-value: 9.32e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 24655024  46 IAEHESSYRTGVVGPeNYNGSNDYGIFQIN 75
Cdd:cd13400  11 IAKVESGFNPNAINR-NKNGSYDIGLMQIN 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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