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Conserved domains on  [gi|17136470|ref|NP_476722|]
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shotgun [Drosophila melanogaster]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182814)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1127-1294 3.74e-28

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 111.36  E-value: 3.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470 1127 SVAFYGSGYA-FYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRHQ 1205
Cdd:cd00110    1 GVSFSGSSYVrLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNG------GDFLALELEDGRLVLRYDLGSGSLVLSSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470 1206 HIkmVAD-RTYQLDIILQRTSIEMTVDNCRLSTcqtlGAPIGPNEFLNVNAPLQLGGTPVDLEQlgrqlnwTHVPNQKGF 1284
Cdd:cd00110   75 TP--LNDgQWHSVSVERNGRSVTLSVDGERVVE----SGSPGGSALLNLDGPLYLGGLPEDLKS-------PGLPVSPGF 141

                        170
                 ....*....|
gi 17136470 1285 FGCIRNLTIN 1294
Cdd:cd00110  142 VGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 1430-1489 1.11e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 106.85  E-value: 1.11e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   1430 CDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYG 1489
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 93-191 5.91e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 5.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   93 YAPKVKEEQPENTYVLTVEAVDPD--PDQVIRYSIVQSPfERPKFFINPSTGVIFTTHTFDRDEPiheKFVFVTVQATDN 170
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGN-EDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 17136470  171 GLPPLDDVCTFNVTIEDINDN 191
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 531-619 6.59e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 6.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  531 RLLEDANTNTEVIEVKAEDED--NASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDGIYD---D 605
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPplsS 84

                         90
                 ....*....|....
gi 17136470  606 YTTVVIKIEDVNDN 619
Cdd:cd11304   85 TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 417-518 4.61e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 4.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  417 SGTILENEPPGTPVMQVRAFDMDgTSANNIVSFELA--DNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNspss 494
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG---- 77

                         90       100
                 ....*....|....*....|....
gi 17136470  495 lfdNGEPNRGHQVFRISIGDKNDH 518
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 200-292 4.90e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 4.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  200 YDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPdP 279
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-P 80

                         90
                 ....*....|...
gi 17136470  280 PQDAQIEVRIRVV 292
Cdd:cd11304   81 PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 627-729 2.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  627 YSVTILEETTYDDCILTVEAYDPDIkdrNADQHIVYSIHQNDGNRW-TID-NSGCLRLVKTLDRDPpngHKNWQVLIKAn 704
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEDGLfSIDpSTGEITTAKPLDREE---QSSYTLTVTA- 74

                         90       100
                 ....*....|....*....|....*
gi 17136470  705 dEDGVGTTVSTVKEVTVTLKDINDN 729
Cdd:cd11304   75 -TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 736-834 7.10e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.88  E-value: 7.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  736 EMPVYWQENRNPGHVV-QLQANDYDDTPGaGNFTFGIDSeatPDIKTKFSMDGDY--LHANVQFDREAQKEYFIPIRISD 812
Cdd:cd11304    1 SYEVSVPENAPPGTVVlTVSATDPDSGEN-GEVTYSIVS---GNEDGLFSIDPSTgeITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 17136470  813 SGVPRQSAVSILHLVIGDVNDN 834
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 332-410 3.66e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 3.66e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     332 PDKPE---VIFELNTGrteqtNSKNTFVFNQIGNEVTISlgKTLDYEAITDYTLTMIVRN--THELGTEHQIKIQVEDVN 406
Cdd:smart00112    5 ADSGEngkVTYSILSG-----NDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDggGPPLSSTATVTITVLDVN 77


                    ....
gi 17136470     407 DNIP 410
Cdd:smart00112   78 DNAP 81
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1127-1294 3.74e-28

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 111.36  E-value: 3.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470 1127 SVAFYGSGYA-FYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRHQ 1205
Cdd:cd00110    1 GVSFSGSSYVrLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNG------GDFLALELEDGRLVLRYDLGSGSLVLSSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470 1206 HIkmVAD-RTYQLDIILQRTSIEMTVDNCRLSTcqtlGAPIGPNEFLNVNAPLQLGGTPVDLEQlgrqlnwTHVPNQKGF 1284
Cdd:cd00110   75 TP--LNDgQWHSVSVERNGRSVTLSVDGERVVE----SGSPGGSALLNLDGPLYLGGLPEDLKS-------PGLPVSPGF 141

                        170
                 ....*....|
gi 17136470 1285 FGCIRNLTIN 1294
Cdd:cd00110  142 VGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 1430-1489 1.11e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 106.85  E-value: 1.11e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   1430 CDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYG 1489
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
LamG smart00282
Laminin G domain;
1148-1296 2.82e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.20  E-value: 2.82e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    1148 KISLEITPQIDQGLIMYLGPLNFnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIE 1227
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17136470    1228 MTVDNCRLSTCQTLgapiGPNEFLNVNAPLQLGGTPVDLEqlgrqlnWTHVPNQKGFFGCIRNLTINEQ 1296
Cdd:smart00282   75 LSVDGGNRVSGESP----GGLTILNLDGPLYLGGLPEDLK-------LPPLPVTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 93-191 5.91e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 5.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   93 YAPKVKEEQPENTYVLTVEAVDPD--PDQVIRYSIVQSPfERPKFFINPSTGVIFTTHTFDRDEPiheKFVFVTVQATDN 170
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGN-EDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 17136470  171 GLPPLDDVCTFNVTIEDINDN 191
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 531-619 6.59e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 6.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  531 RLLEDANTNTEVIEVKAEDED--NASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDGIYD---D 605
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPplsS 84

                         90
                 ....*....|....
gi 17136470  606 YTTVVIKIEDVNDN 619
Cdd:cd11304   85 TATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1155-1296 2.08e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 2.08e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   1155 PQIDQGLIMYLGPLNfnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCR 1234
Cdd:pfam02210    3 TRQPNGLLLYAGGGG-------SDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136470   1235 LSTcqtlGAPIGPNEFLNVNAPLQLGGTPVDleqlgrqLNWTHVPNQKGFFGCIRNLTINEQ 1296
Cdd:pfam02210   76 VVS----SLPPGESLLLNLNGPLYLGGLPPL-------LLLPALPVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 417-518 4.61e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 4.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  417 SGTILENEPPGTPVMQVRAFDMDgTSANNIVSFELA--DNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNspss 494
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG---- 77

                         90       100
                 ....*....|....*....|....
gi 17136470  495 lfdNGEPNRGHQVFRISIGDKNDH 518
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 200-292 4.90e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 4.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  200 YDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPdP 279
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-P 80

                         90
                 ....*....|...
gi 17136470  280 PQDAQIEVRIRVV 292
Cdd:cd11304   81 PLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 548-621 8.05e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 8.05e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136470     548 EDEDNASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDG---IYDDYTTVVIKIEDVNDNPP 621
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 112-193 1.75e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.75e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     112 AVDPD--PDQVIRYSIVQSPfERPKFFINPSTGVIFTTHTFDRDEpihEKFVFVTVQATDNGLPPLDDVCTFNVTIEDIN 189
Cdd:smart00112    2 ATDADsgENGKVTYSILSGN-DDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 17136470     190 DNAP 193
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
97-186 4.90e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 4.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     97 VKEEQPENTYVLTVEAVDPD--PDQVIRYSIVQSPfERPKFFINPSTGVIFTTHTFDRDEPihEKFVfVTVQATDNGLPP 174
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGG-PGGNFRIDPDTGDISTTKPLDRESI--GEYE-LTVEATDSGGPP 80

                           90
                   ....*....|..
gi 17136470    175 LDDVCTFNVTIE 186
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
417-500 1.11e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 1.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    417 SGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADNRE-YFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSL 495
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81


                   ....*
gi 17136470    496 FDNGE 500
Cdd:pfam00028   82 SSTAT 86
Cadherin pfam00028
Cadherin domain;
531-614 3.81e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 3.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    531 RLLEDANTNTEVIEVKAEDEDNA--SQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFD-GIY--DD 605
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPplSS 83


                   ....*....
gi 17136470    606 YTTVVIKIE 614
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
200-291 1.45e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 1.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    200 YDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPdP 279
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-P 79

                           90
                   ....*....|..
gi 17136470    280 PQDAQIEVRIRV 291
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 627-729 2.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  627 YSVTILEETTYDDCILTVEAYDPDIkdrNADQHIVYSIHQNDGNRW-TID-NSGCLRLVKTLDRDPpngHKNWQVLIKAn 704
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEDGLfSIDpSTGEITTAKPLDREE---QSSYTLTVTA- 74

                         90       100
                 ....*....|....*....|....*
gi 17136470  705 dEDGVGTTVSTVKEVTVTLKDINDN 729
Cdd:cd11304   75 -TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 736-834 7.10e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.88  E-value: 7.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  736 EMPVYWQENRNPGHVV-QLQANDYDDTPGaGNFTFGIDSeatPDIKTKFSMDGDY--LHANVQFDREAQKEYFIPIRISD 812
Cdd:cd11304    1 SYEVSVPENAPPGTVVlTVSATDPDSGEN-GEVTYSIVS---GNEDGLFSIDPSTgeITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 17136470  813 SGVPRQSAVSILHLVIGDVNDN 834
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 218-299 1.28e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 1.28e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     218 SASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPdPPQDAQIEVRIRVVESSIK 297
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDN 79


                    ..
gi 17136470     298 PP 299
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 434-520 9.92e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 9.92e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     434 RAFDMDgTSANNIVSFELADNRE--YFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEpnrghqvFRIS 511
Cdd:smart00112    1 SATDAD-SGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT-------VTIT 72


                    ....*....
gi 17136470     512 IGDKNDHKP 520
Cdd:smart00112   73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 760-835 2.87e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 2.87e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136470     760 DTPGAGNFTFGIDSEATPDIktkFSMD--GDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNA 835
Cdd:smart00112    6 DSGENGKVTYSILSGNDDGL---FSIDpeTGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 652-731 4.69e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 4.69e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     652 KDRNADQHIVYSIHQNDGNRW-TID-NSGCLRLVKTLDRDPpngHKNWQVLIKAndEDGVGTTVSTVKEVTVTLKDINDN 729
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDGLfSIDpETGEITTTKPLDREE---QPEYTLTVEA--TDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 17136470     730 AP 731
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 332-410 3.66e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 3.66e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     332 PDKPE---VIFELNTGrteqtNSKNTFVFNQIGNEVTISlgKTLDYEAITDYTLTMIVRN--THELGTEHQIKIQVEDVN 406
Cdd:smart00112    5 ADSGEngkVTYSILSG-----NDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDggGPPLSSTATVTITVLDVN 77


                    ....
gi 17136470     407 DNIP 410
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
743-828 7.66e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 7.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    743 ENRNPG-HVVQLQANDYDDTPgAGNFTFGIDSEATPDIktkFSMDGD--YLHANVQFDREAQKEYFIPIRISDSGVPRQS 819
Cdd:pfam00028    7 ENAPVGtEVLTVTATDPDLGP-NGRIFYSILGGGPGGN---FRIDPDtgDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 17136470    820 AVSILHLVI 828
Cdd:pfam00028   83 STATVTITV 91
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1127-1294 3.74e-28

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 111.36  E-value: 3.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470 1127 SVAFYGSGYA-FYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRHQ 1205
Cdd:cd00110    1 GVSFSGSSYVrLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNG------GDFLALELEDGRLVLRYDLGSGSLVLSSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470 1206 HIkmVAD-RTYQLDIILQRTSIEMTVDNCRLSTcqtlGAPIGPNEFLNVNAPLQLGGTPVDLEQlgrqlnwTHVPNQKGF 1284
Cdd:cd00110   75 TP--LNDgQWHSVSVERNGRSVTLSVDGERVVE----SGSPGGSALLNLDGPLYLGGLPEDLKS-------PGLPVSPGF 141

                        170
                 ....*....|
gi 17136470 1285 FGCIRNLTIN 1294
Cdd:cd00110  142 VGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 1430-1489 1.11e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 106.85  E-value: 1.11e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   1430 CDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYG 1489
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
LamG smart00282
Laminin G domain;
1148-1296 2.82e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.20  E-value: 2.82e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    1148 KISLEITPQIDQGLIMYLGPLNFnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIE 1227
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17136470    1228 MTVDNCRLSTCQTLgapiGPNEFLNVNAPLQLGGTPVDLEqlgrqlnWTHVPNQKGFFGCIRNLTINEQ 1296
Cdd:smart00282   75 LSVDGGNRVSGESP----GGLTILNLDGPLYLGGLPEDLK-------LPPLPVTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 93-191 5.91e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 5.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   93 YAPKVKEEQPENTYVLTVEAVDPD--PDQVIRYSIVQSPfERPKFFINPSTGVIFTTHTFDRDEPiheKFVFVTVQATDN 170
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGN-EDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 17136470  171 GLPPLDDVCTFNVTIEDINDN 191
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 531-619 6.59e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 6.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  531 RLLEDANTNTEVIEVKAEDED--NASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDGIYD---D 605
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPplsS 84

                         90
                 ....*....|....
gi 17136470  606 YTTVVIKIEDVNDN 619
Cdd:cd11304   85 TATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1155-1296 2.08e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 2.08e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   1155 PQIDQGLIMYLGPLNfnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCR 1234
Cdd:pfam02210    3 TRQPNGLLLYAGGGG-------SDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136470   1235 LSTcqtlGAPIGPNEFLNVNAPLQLGGTPVDleqlgrqLNWTHVPNQKGFFGCIRNLTINEQ 1296
Cdd:pfam02210   76 VVS----SLPPGESLLLNLNGPLYLGGLPPL-------LLLPALPVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 417-518 4.61e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 4.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  417 SGTILENEPPGTPVMQVRAFDMDgTSANNIVSFELA--DNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNspss 494
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG---- 77

                         90       100
                 ....*....|....*....|....
gi 17136470  495 lfdNGEPNRGHQVFRISIGDKNDH 518
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 200-292 4.90e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 4.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  200 YDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPdP 279
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-P 80

                         90
                 ....*....|...
gi 17136470  280 PQDAQIEVRIRVV 292
Cdd:cd11304   81 PLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 548-621 8.05e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 8.05e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136470     548 EDEDNASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDG---IYDDYTTVVIKIEDVNDNPP 621
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 112-193 1.75e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.75e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     112 AVDPD--PDQVIRYSIVQSPfERPKFFINPSTGVIFTTHTFDRDEpihEKFVFVTVQATDNGLPPLDDVCTFNVTIEDIN 189
Cdd:smart00112    2 ATDADsgENGKVTYSILSGN-DDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 17136470     190 DNAP 193
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
97-186 4.90e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 4.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     97 VKEEQPENTYVLTVEAVDPD--PDQVIRYSIVQSPfERPKFFINPSTGVIFTTHTFDRDEPihEKFVfVTVQATDNGLPP 174
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGG-PGGNFRIDPDTGDISTTKPLDRESI--GEYE-LTVEATDSGGPP 80

                           90
                   ....*....|..
gi 17136470    175 LDDVCTFNVTIE 186
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
417-500 1.11e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 1.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    417 SGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADNRE-YFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSL 495
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81


                   ....*
gi 17136470    496 FDNGE 500
Cdd:pfam00028   82 SSTAT 86
Cadherin pfam00028
Cadherin domain;
531-614 3.81e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 3.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    531 RLLEDANTNTEVIEVKAEDEDNA--SQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFD-GIY--DD 605
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPplSS 83


                   ....*....
gi 17136470    606 YTTVVIKIE 614
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
200-291 1.45e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 1.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    200 YDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPdP 279
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-P 79

                           90
                   ....*....|..
gi 17136470    280 PQDAQIEVRIRV 291
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 627-729 2.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 2.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  627 YSVTILEETTYDDCILTVEAYDPDIkdrNADQHIVYSIHQNDGNRW-TID-NSGCLRLVKTLDRDPpngHKNWQVLIKAn 704
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEDGLfSIDpSTGEITTAKPLDREE---QSSYTLTVTA- 74

                         90       100
                 ....*....|....*....|....*
gi 17136470  705 dEDGVGTTVSTVKEVTVTLKDINDN 729
Cdd:cd11304   75 -TDGGGPPLSSTATVTITVLDVNDN 98
Laminin_G_1 pfam00054
Laminin G domain;
1159-1299 6.99e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 70.04  E-value: 6.99e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470   1159 QGLIMYLGPLNFnpllaiSDFLALELDNGYPVLTVDYGSGAIRIRH-------QHIKMVADRTyqldiilqRTSIEMTVD 1231
Cdd:pfam00054    7 SGLLLYNGTQTE------RDFLALELRDGRLEVSYDLGSGAAVVRSgdklndgKWHSVELERN--------GRSGTLSVD 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136470   1232 NCRLStcqTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQlnwthvPNQKGFFGCIRNLTINEQTYN 1299
Cdd:pfam00054   73 GEARP---TGESPLGATTDLDVDGPLYVGGLPSLGVKKRRL------AISPSFDGCIRDVIVNGKPLD 131
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 736-834 7.10e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.88  E-value: 7.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470  736 EMPVYWQENRNPGHVV-QLQANDYDDTPGaGNFTFGIDSeatPDIKTKFSMDGDY--LHANVQFDREAQKEYFIPIRISD 812
Cdd:cd11304    1 SYEVSVPENAPPGTVVlTVSATDPDSGEN-GEVTYSIVS---GNEDGLFSIDPSTgeITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 17136470  813 SGVPRQSAVSILHLVIGDVNDN 834
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 218-299 1.28e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 1.28e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     218 SASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPdPPQDAQIEVRIRVVESSIK 297
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDN 79


                    ..
gi 17136470     298 PP 299
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 434-520 9.92e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 9.92e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     434 RAFDMDgTSANNIVSFELADNRE--YFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEpnrghqvFRIS 511
Cdd:smart00112    1 SATDAD-SGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT-------VTIT 72


                    ....*....
gi 17136470     512 IGDKNDHKP 520
Cdd:smart00112   73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 760-835 2.87e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 2.87e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136470     760 DTPGAGNFTFGIDSEATPDIktkFSMD--GDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNA 835
Cdd:smart00112    6 DSGENGKVTYSILSGNDDGL---FSIDpeTGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 652-731 4.69e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 4.69e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     652 KDRNADQHIVYSIHQNDGNRW-TID-NSGCLRLVKTLDRDPpngHKNWQVLIKAndEDGVGTTVSTVKEVTVTLKDINDN 729
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDGLfSIDpETGEITTTKPLDREE---QPEYTLTVEA--TDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 17136470     730 AP 731
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 332-410 3.66e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 3.66e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470     332 PDKPE---VIFELNTGrteqtNSKNTFVFNQIGNEVTISlgKTLDYEAITDYTLTMIVRN--THELGTEHQIKIQVEDVN 406
Cdd:smart00112    5 ADSGEngkVTYSILSG-----NDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDggGPPLSSTATVTITVLDVN 77


                    ....
gi 17136470     407 DNIP 410
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
743-828 7.66e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 7.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136470    743 ENRNPG-HVVQLQANDYDDTPgAGNFTFGIDSEATPDIktkFSMDGD--YLHANVQFDREAQKEYFIPIRISDSGVPRQS 819
Cdd:pfam00028    7 ENAPVGtEVLTVTATDPDLGP-NGRIFYSILGGGPGGN---FRIDPDtgDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 17136470    820 AVSILHLVI 828
Cdd:pfam00028   83 STATVTITV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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