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Conserved domains on  [gi|31981509|ref|NP_473439|]
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metalloreductase STEAP4 [Mus musculus]

Protein Classification

COG2085 and Ferric_reduct domain-containing protein( domain architecture ID 11946522)

COG2085 and Ferric_reduct domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
24-190 1.75e-43

Predicted dinucleotide-binding enzyme [General function prediction only];


:

Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 151.86  E-value: 1.75e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509  24 IFGTGDFGKSLGLKMLQCGYSIVFGSRNPQ-----VSSLLPrGAEVLSYSEAASKSDIIILAMHREHYDSLTELV-DYLK 97
Cdd:COG2085   3 IIGTGNIGSALARRLAAAGHEVVIGSRDPEkaaalAAELGP-GARAGTNAEAAAAADVVVLAVPYEAVPDVLESLgDALA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509  98 GKVLVDVSN------NRKINQYPE-SNAEYLAQLEPGAHVVKAFNTISAWALQSGTLDAS--RQVFVCGNDSKAKQRVMD 168
Cdd:COG2085  82 GKIVIDATNplperdGFILDPPGGgSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVVAA 161

                       170       180
                ....*....|....*....|..
gi 31981509 169 IARTLGLTPLDQGSLMAASEIE 190
Cdd:COG2085 162 LIEDLGFDPVDAGPLANARRLE 183
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 249-394 3.15e-03

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


:

Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 37.63  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509   249 ITALILLALVYLPGILAAILQLYRGTKYrrfpnwlDHWMLCRKQLGLVALGFAFLHVIYTLVIPIRYYVRwrlrnatitq 328
Cdd:pfam01794   3 ILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLE---------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31981509   329 altnkdspfITSYAWINDSYLALGILGFFLFLLLGITSLPSVSNMvNWREFRFVQSKLGYLTLVLC 394
Cdd:pfam01794  66 ---------GILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRL-SYELFLYLHILLAVAFLLLV 121
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
24-190 1.75e-43

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 151.86  E-value: 1.75e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509  24 IFGTGDFGKSLGLKMLQCGYSIVFGSRNPQ-----VSSLLPrGAEVLSYSEAASKSDIIILAMHREHYDSLTELV-DYLK 97
Cdd:COG2085   3 IIGTGNIGSALARRLAAAGHEVVIGSRDPEkaaalAAELGP-GARAGTNAEAAAAADVVVLAVPYEAVPDVLESLgDALA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509  98 GKVLVDVSN------NRKINQYPE-SNAEYLAQLEPGAHVVKAFNTISAWALQSGTLDAS--RQVFVCGNDSKAKQRVMD 168
Cdd:COG2085  82 GKIVIDATNplperdGFILDPPGGgSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVVAA 161

                       170       180
                ....*....|....*....|..
gi 31981509 169 IARTLGLTPLDQGSLMAASEIE 190
Cdd:COG2085 162 LIEDLGFDPVDAGPLANARRLE 183
npdG TIGR01915
NADPH-dependent F420 reductase; This model represents a subset of a parent family described by ...
 26-190 1.40e-19

NADPH-dependent F420 reductase; This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport]


Pssm-ID: 273873  Cd Length: 219  Bit Score: 87.16  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509    26 GTGDFGKSLGLKMLQCGYSIVFGSRNPQVSS---------LLPRGAEV----LSYSEAASKSDIIILAMHREHY-DSLTE 91
Cdd:TIGR01915   8 GTGDQGKGLALRLAKAGNKIIIGSRDLEKAEeaaakaleeLGHGGSDIkvtgADNAEAAKRADVVILAVPWDHVlKTLES 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509    92 LVDYLKGKVLVD-----VSNNRKINQY--PE--SNAEYLAQLEP-GAHVVKAFNTISAWALQSGTLDASRQVFVCGNDSK 161
Cdd:TIGR01915  88 LRDELSGKLVISpvvplASDGGKGARYlpPEegSAAEQAAALLPeTSRVVAAFHNLSAVLLQDVDDEVDCDVLVCGDDEE 167

                         170       180       190
                  ....*....|....*....|....*....|
gi 31981509   162 AKQRVMDIARTL-GLTPLDQGSLMAASEIE 190
Cdd:TIGR01915 168 AKEVVAELAGRIdGLRALDAGPLENAAIVE 197
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
23-107 2.97e-18

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 79.58  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509    23 CIFGTGDFGKSLGLKMLQCG-YSIVFG-SRNPQ-VSSLLPR---GAEVLSYSEAASKSDIIILAMHREHYDS-LTELVDY 95
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGpHEVVVAnSRNPEkAEELAEEygvGATAVDNEEAAEEADVVFLAVKPEDAPDvLSELSDL 80

                          90
                  ....*....|..
gi 31981509    96 LKGKVLVDVSNN 107
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 249-394 3.15e-03

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 37.63  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509   249 ITALILLALVYLPGILAAILQLYRGTKYrrfpnwlDHWMLCRKQLGLVALGFAFLHVIYTLVIPIRYYVRwrlrnatitq 328
Cdd:pfam01794   3 ILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLE---------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31981509   329 altnkdspfITSYAWINDSYLALGILGFFLFLLLGITSLPSVSNMvNWREFRFVQSKLGYLTLVLC 394
Cdd:pfam01794  66 ---------GILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRL-SYELFLYLHILLAVAFLLLV 121
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
24-190 1.75e-43

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 151.86  E-value: 1.75e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509  24 IFGTGDFGKSLGLKMLQCGYSIVFGSRNPQ-----VSSLLPrGAEVLSYSEAASKSDIIILAMHREHYDSLTELV-DYLK 97
Cdd:COG2085   3 IIGTGNIGSALARRLAAAGHEVVIGSRDPEkaaalAAELGP-GARAGTNAEAAAAADVVVLAVPYEAVPDVLESLgDALA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509  98 GKVLVDVSN------NRKINQYPE-SNAEYLAQLEPGAHVVKAFNTISAWALQSGTLDAS--RQVFVCGNDSKAKQRVMD 168
Cdd:COG2085  82 GKIVIDATNplperdGFILDPPGGgSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVVAA 161

                       170       180
                ....*....|....*....|..
gi 31981509 169 IARTLGLTPLDQGSLMAASEIE 190
Cdd:COG2085 162 LIEDLGFDPVDAGPLANARRLE 183
npdG TIGR01915
NADPH-dependent F420 reductase; This model represents a subset of a parent family described by ...
 26-190 1.40e-19

NADPH-dependent F420 reductase; This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport]


Pssm-ID: 273873  Cd Length: 219  Bit Score: 87.16  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509    26 GTGDFGKSLGLKMLQCGYSIVFGSRNPQVSS---------LLPRGAEV----LSYSEAASKSDIIILAMHREHY-DSLTE 91
Cdd:TIGR01915   8 GTGDQGKGLALRLAKAGNKIIIGSRDLEKAEeaaakaleeLGHGGSDIkvtgADNAEAAKRADVVILAVPWDHVlKTLES 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509    92 LVDYLKGKVLVD-----VSNNRKINQY--PE--SNAEYLAQLEP-GAHVVKAFNTISAWALQSGTLDASRQVFVCGNDSK 161
Cdd:TIGR01915  88 LRDELSGKLVISpvvplASDGGKGARYlpPEegSAAEQAAALLPeTSRVVAAFHNLSAVLLQDVDDEVDCDVLVCGDDEE 167

                         170       180       190
                  ....*....|....*....|....*....|
gi 31981509   162 AKQRVMDIARTL-GLTPLDQGSLMAASEIE 190
Cdd:TIGR01915 168 AKEVVAELAGRIdGLRALDAGPLENAAIVE 197
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
23-107 2.97e-18

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 79.58  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509    23 CIFGTGDFGKSLGLKMLQCG-YSIVFG-SRNPQ-VSSLLPR---GAEVLSYSEAASKSDIIILAMHREHYDS-LTELVDY 95
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGpHEVVVAnSRNPEkAEELAEEygvGATAVDNEEAAEEADVVFLAVKPEDAPDvLSELSDL 80

                          90
                  ....*....|..
gi 31981509    96 LKGKVLVDVSNN 107
Cdd:pfam03807  81 LKGKIVISIAAG 92
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 22-106 2.87e-03

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 38.22  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509    22 VCIFGTGDFGKSLGLKMLQCGYSIVFGSRNPQ-VSSLLPRGAEVL-SYSEAASKSDIIILaM--HREHYDSLTE---LVD 94
Cdd:pfam03446   2 IGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEkVEELVAAGAIAAaSPAEFVAGLDVVIT-MvpAGAAVDAVIFgegLLP 80

                          90
                  ....*....|...
gi 31981509    95 YL-KGKVLVDVSN 106
Cdd:pfam03446  81 GLkPGDIIIDGST 93
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 249-394 3.15e-03

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 37.63  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981509   249 ITALILLALVYLPGILAAILQLYRGTKYrrfpnwlDHWMLCRKQLGLVALGFAFLHVIYTLVIPIRYYVRwrlrnatitq 328
Cdd:pfam01794   3 ILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLE---------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31981509   329 altnkdspfITSYAWINDSYLALGILGFFLFLLLGITSLPSVSNMvNWREFRFVQSKLGYLTLVLC 394
Cdd:pfam01794  66 ---------GILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRL-SYELFLYLHILLAVAFLLLV 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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