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Conserved domains on  [gi|55926203|ref|NP_446033|]
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isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1 precursor [Rattus norvegicus]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
47-380 1.70e-175

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 491.51  E-value: 1.70e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203    47 GAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIYTPMEyKGELA 126
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   127 SYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYAT 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   207 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGY 366
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 55926203   367 STTTDFIKSVIGHL 380
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 47-380 1.70e-175

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 491.51  E-value: 1.70e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203    47 GAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIYTPMEyKGELA 126
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   127 SYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYAT 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   207 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGY 366
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 55926203   367 STTTDFIKSVIGHL 380
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 50-380 3.63e-128

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 372.66  E-value: 3.63e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   50 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIYTPMeyKGELASYD 129
Cdd:PLN00123  32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  130 MQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKG 209
Cdd:PLN00123 106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  210 RSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
Cdd:PLN00123 186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  290 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGY 366
Cdd:PLN00123 266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGS 345

                        330
                 ....*....|....
gi 55926203  367 STTTDFIKSVIGHL 380
Cdd:PLN00123 346 STTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 49-380 8.50e-101

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 302.32  E-value: 8.50e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  49 FPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIYTP- 118
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGPk 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 119 MEYKGELASYDMQLRRKLDLFANVVHVKSLPGYKTRH-----NNLDLVIIREQTEGEYSSLEHESARG----VIECLKIV 189
Cdd:COG0473  78 WDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 190 TRTKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVM 269
Cdd:COG0473 158 TRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 270 PNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMI 345
Cdd:COG0473 237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAI 312

                       330       340       350
                ....*....|....*....|....*....|....*
gi 55926203 346 ADAvKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
Cdd:COG0473 313 EAA-VEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
51-376 1.94e-88

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 270.70  E-value: 1.94e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203    51 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFKEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIYTPMEYKGEL 125
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   126 ASYD--MQLRRKLDLFANVVHVKSLPG------YKTRHNNLDLVIIREQTEGEYSSLEHE---SARGVIECLKIVTRTKS 194
Cdd:pfam00180  82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   195 QRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 274
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   275 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSSMIADAvKK 351
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA-VL 318

                         330       340
                  ....*....|....*....|....*...
gi 55926203   352 VIKVGKVRTRDMGG---YSTTTDFIKSV 376
Cdd:pfam00180 319 KVLESGIRTGDLAGsatYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 47-380 1.70e-175

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 491.51  E-value: 1.70e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203    47 GAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIYTPMEyKGELA 126
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   127 SYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYAT 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   207 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGY 366
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 55926203   367 STTTDFIKSVIGHL 380
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 50-380 3.63e-128

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 372.66  E-value: 3.63e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   50 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIYTPMeyKGELASYD 129
Cdd:PLN00123  32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  130 MQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKG 209
Cdd:PLN00123 106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  210 RSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
Cdd:PLN00123 186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  290 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGY 366
Cdd:PLN00123 266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGS 345

                        330
                 ....*....|....
gi 55926203  367 STTTDFIKSVIGHL 380
Cdd:PLN00123 346 STTQEVVDAVIANL 359
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 47-380 1.48e-124

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 363.82  E-value: 1.48e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   47 GAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSE-----VQNMASEEKLEqvlsSMKENKVAIIGKIYTPMEy 121
Cdd:PLN00118  40 TPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTtvdprTGSFLTWESLE----SVRRNKVGLKGPMATPIG- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  122 KGElASYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFA 201
Cdd:PLN00118 115 KGH-RSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  202 FDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLA 281
Cdd:PLN00118 194 FHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLC 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  282 AGLVGGAGVVP-GESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVR 359
Cdd:PLN00118 274 AGLIGGLGLTPsCNIGENGLALAE--AVHGSAPDIaGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYR 351

                        330       340
                 ....*....|....*....|.
gi 55926203  360 TRDMGGYSTTTDFIKSVIGHL 380
Cdd:PLN00118 352 TADLGGSSTTTDFTKAICDHL 372
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 51-380 2.20e-102

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 305.87  E-value: 2.20e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFKehhLSEVQNMASEEKLE----QVLSSMKENKVAIIGKIYTPMeykGE-L 125
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYE---FADAGLTALEKHGEllpqRTLDLIEKNKIALKGPLTTPV---GEgF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  126 ASYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHE-SARG-VIECLKIVTRTKSQRIAKFAFD 203
Cdd:PRK08997  79 TSINVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  204 YATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAG 283
Cdd:PRK08997 159 LARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  284 LVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRD 362
Cdd:PRK08997 239 LVGGLGMAPGANIGRDAAIFE--AVHGSAPDIaGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRD 316

                        330
                 ....*....|....*...
gi 55926203  363 MGGYSTTTDFIKSVIGHL 380
Cdd:PRK08997 317 LGGTHGTTDFTQAVIDRL 334
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 49-380 8.50e-101

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 302.32  E-value: 8.50e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  49 FPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIYTP- 118
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGPk 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 119 MEYKGELASYDMQLRRKLDLFANVVHVKSLPGYKTRH-----NNLDLVIIREQTEGEYSSLEHESARG----VIECLKIV 189
Cdd:COG0473  78 WDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 190 TRTKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVM 269
Cdd:COG0473 158 TRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 270 PNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMI 345
Cdd:COG0473 237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAI 312

                       330       340       350
                ....*....|....*....|....*....|....*
gi 55926203 346 ADAvKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
Cdd:COG0473 313 EAA-VEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
51-376 1.94e-88

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 270.70  E-value: 1.94e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203    51 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFKEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIYTPMEYKGEL 125
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   126 ASYD--MQLRRKLDLFANVVHVKSLPG------YKTRHNNLDLVIIREQTEGEYSSLEHE---SARGVIECLKIVTRTKS 194
Cdd:pfam00180  82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   195 QRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 274
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   275 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSSMIADAvKK 351
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA-VL 318

                         330       340
                  ....*....|....*....|....*...
gi 55926203   352 VIKVGKVRTRDMGG---YSTTTDFIKSV 376
Cdd:pfam00180 319 KVLESGIRTGDLAGsatYVSTSEFGEAV 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
50-348 2.79e-88

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 274.85  E-value: 2.79e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   50 PVTMLPGDGVGPELMHAVKEVFKAAAVPVE----------FKEHHLSEVqnmaSEEKLEqvlsSMKENKVAIIGKIYTPM 119
Cdd:PRK09222   6 PITVAYGDGIGPEIMEAVLKILEAAGAPLEietieigekvYKKGWTSGI----SPSAWE----SIRRTKVLLKAPITTPQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  120 E--YKgelaSYDMQLRRKLDLFANVVHVKSL-PGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQR 196
Cdd:PRK09222  78 GggYK----SLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  197 IAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNI 276
Cdd:PRK09222 154 IIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDI 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55926203  277 IDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 348
Cdd:PRK09222 234 LSDIAAEISGSVGLAGSANIGEEYAMFE--AVHGSAPDIaGKNIANPSGLLNAAVMMLVHIGQFDIAELIENA 304
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 51-380 1.61e-78

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 244.66  E-value: 1.61e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFkehhlseVQNMASEEKLEQVLSSMKENKVAIIGKI-YTPMEYKGEL-ASY 128
Cdd:PRK14025   4 ICVIEGDGIGKEVVPAALHVLEATGLPFEF-------VYAEAGDEVFEKTGKALPEETIEAAKEAdAVLFGAAGETaADV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  129 DMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKK 208
Cdd:PRK14025  77 IVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKRR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  209 ----GRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGL 284
Cdd:PRK14025 157 kkmgKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  285 VGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVrTRDM 363
Cdd:PRK14025 237 VGGLGLAPSANIGDKYGLFE--PVHGSApDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLT-TPDL 313

                        330
                 ....*....|....*..
gi 55926203  364 GGYSTTTDFIKSVIGHL 380
Cdd:PRK14025 314 GGNLSTMEMAEEVAKRV 330
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 51-380 4.89e-52

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 177.22  E-value: 4.89e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   51 VTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEHHLS-----EVQNMASEEKLEQVLSSMkenkvAII-GKIYTPme 120
Cdd:PRK00772   5 IAVLPGDGIGPEVMAEAVKVLDAVAekfgFDFEFEEALVGgaaidAHGVPLPEETLEACRAAD-----AVLlGAVGGP-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  121 yKGELASYDMQ-------LRRKLDLFANVVHVKSLPGYKT-------RHNNLDLVIIREQTEGEYS------SLEHESAR 180
Cdd:PRK00772  78 -KWDNLPPDVRpergllaLRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYFgeprgrEGLGGEER 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  181 GVIEClkIVTRTKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN 260
Cdd:PRK00772 157 AFDTM--VYTREEIERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  261 PYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFETGarHPFA-QAVGRNIANPTAMLLSASNMLRH-LN 337
Cdd:PRK00772 233 PKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI--HGSApDIAGKGIANPIATILSAAMMLRYsLG 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 55926203  338 LEYHSSMIADAvKKVIKVGKVRTRDM---GGYSTTTDFIKSVIGHL 380
Cdd:PRK00772 311 LEEAADAIEAA-VEKVLAQGYRTADIaegGGKVSTSEMGDAILAAL 355
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 53-369 6.51e-43

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 152.77  E-value: 6.51e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   53 MLPGDGVGPELMH-AVKeVFKAAA---VPVEFKEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIYTP------MEy 121
Cdd:PRK03437   9 VIPGDGIGPEVVAeALK-VLDAVAaggPGVETTEYDLGARRYLRTGETLpDSVLAELRQHDAILLGAIGDPsvpsgvLE- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  122 KGELasydMQLRRKLDLFANVVHVKSLPGYKTRHNN---LDLVIIREQTEGEYSS--------LEHESARGVieclKIVT 190
Cdd:PRK03437  87 RGLL----LKLRFALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHEVATEV----SVNT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  191 RTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270
Cdd:PRK03437 159 AFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEYA---VFE-TGARHPfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIA 346
Cdd:PRK03437 239 NLFGDIITDLAAAVTGGIGLAASGNINPTGTnpsMFEpVHGSAP--DIAGQGIADPTAAILSVALLLDHLGEEDAAARIE 316

                        330       340
                 ....*....|....*....|...
gi 55926203  347 DAvkkviKVGKVRTRDMGGYSTT 369
Cdd:PRK03437 317 AA-----VEADLAERGKMGRSTA 334
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 49-380 1.33e-39

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 144.09  E-value: 1.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   49 FPVTMLPGDGVGPELMHAVKEVFKAAA-----VPVEFKEHHLS-----EVQNMASEEKLEQvlssMKENKVAIIGKIYTP 118
Cdd:PRK08194   4 FKIAVIPGDGVGKEVVPAAVRVLKAVAevhggLKFEFTEFPWSceyylEHGEMMPEDGLEQ----LKQFDAIFLGAVGNP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  119 MEYKGELASYDM--QLRRKLDLFANVVHVKSLPGYK---TRHNNLDLVIIREQTEGEYSSLEHESARGVIECL---KIVT 190
Cdd:PRK08194  80 KLVPDHISLWGLliKIRREFEQVINIRPAKQLRGIKsplANPKDFDLLVVRENSEGEYSEVGGRIHRGEDEIAiqnAVFT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  191 RTKSQRIAKFAFDYATKKgRSKVTAVHKAN----IMKLGDGLFlqccEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDV 266
Cdd:PRK08194 160 RKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTRPEEFDV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  267 LVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE--Y-AVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHS 342
Cdd:PRK08194 235 IVASNLFGDILTDIGAAIMGSIGIAPAANINVNgkYpSMFE--PVHGSApDIAGKGIANPIGQIWTAKLMLDHFGEEELG 312

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 55926203  343 SMIADAvKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
Cdd:PRK08194 313 SHLLDV-IEDVTEDGIKTPDIGGRATTDEVTDEIISRL 349
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
56-348 3.27e-37

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 139.20  E-value: 3.27e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   56 GDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASE--EKL------EQVLSSMKENKVAIIGKIYTPMEyKGeLAS 127
Cdd:PRK06451  31 GDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDkaEKLtgnrfpKESEELIEKYRVLLKGPLETPIG-KG-WKS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  128 YDMQLRRKLDLFANVVHVKSLPGYKT--RH-NNLDLVIIREQTEGEYSSLEH----ESARGVIECL-------------- 186
Cdd:PRK06451 109 INVAIRLMLDLYANIRPVKYIPGIESplKNpEKIDLIIFRENTDDLYRGIEYpydsEEAKKIRDFLrkelgveveddtgi 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  187 --KIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCC---------------EEVAELYP------KI 243
Cdd:PRK06451 189 giKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAyevalkefrdyvvteEEVTKNYNgvppsgKV 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  244 KFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANP 322
Cdd:PRK06451 269 IINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--AIHGTApKYAGKNVANP 346

                        330       340
                 ....*....|....*....|....*.
gi 55926203  323 TAMLLSASNMLRHLNLEYHSSMIADA 348
Cdd:PRK06451 347 TGIIKGGELMLRFMGWDKAADLIDKA 372
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 56-336 9.40e-35

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 132.16  E-value: 9.40e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  56 GDGVGPELMHAVKEVFKAA-------AVPVEFKEHHLSEvqnMASEEKLEQV----LSSMKENKVAIIGKIYTPMEykGE 124
Cdd:COG0538  26 GDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDAGE---KARDETGDWLpdetAEAIKEYGVGIKGPLTTPVG--GG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 125 LASYDMQLRRKLDLFAN---VVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHES----ARGVIECL----------- 186
Cdd:COG0538 101 WRSLNVTIRQILDLYVCrrpVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAgspeALKLIFFLedemgvtvirf 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 187 --------KIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAE--------------LYP--- 241
Cdd:COG0538 181 pedsgigiKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEeefgdkfitegpweKYKgpk 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203 242 ---KIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGE--SYSAeYAVFE----TGARHpfa 312
Cdd:COG0538 261 pagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGAniGDDG-GAEFEathgTAPKY--- 336

                       330       340
                ....*....|....*....|....
gi 55926203 313 qaVGRNIANPTAMLLSASNMLRHL 336
Cdd:COG0538 337 --AGKDSTNPGSLILSGTMMLRHR 358
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 56-337 4.31e-34

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 130.57  E-value: 4.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   56 GDGVGPELMHAVKEVFKAAavpVEF-----KEHHLSEVqnMASEEKL----------EQVLSSMKENKVAIIGKIYTPMe 120
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAA---VEKaykgeRKISWMEI--YAGEKATkvygedvwlpEETLDLIREYRVAIKGPLTTPV- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  121 yKGELASYDMQLRRKLDLFA---NVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHES----ARGVIECL------- 186
Cdd:PRK07006 101 -GGGIRSLNVALRQELDLYVclrPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvk 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  187 ------------KIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAEL-----------YPKI 243
Cdd:PRK07006 180 kirfpetsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEefgdelidggpWDKI 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  244 K---------FETMIIDNCCMQLVQNPYQFDVLVMPNLYGNII-DNLAAGlVGGAGVVPGESYSAEYAVFEtgARHPFA- 312
Cdd:PRK07006 260 KnpetgkeiiVKDSIADAFLQQILLRPAEYDVIATMNLNGDYIsDALAAQ-VGGIGIAPGANINDGHAIFE--ATHGTAp 336

                        330       340
                 ....*....|....*....|....*
gi 55926203  313 QAVGRNIANPTAMLLSASNMLRHLN 337
Cdd:PRK07006 337 KYAGLDKVNPGSVILSAEMMLRHMG 361
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 45-348 7.89e-27

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 110.55  E-value: 7.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   45 VEGAFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEHHLSEVQ-NMASEEKLEQVLSSMKENKVAIIGKI---- 115
Cdd:PLN02329  43 GKKRYNIALLPGDGIGPEVISVAKNVLQKAGslegLEFDFQEMPVGGAAlDLVGVPLPEETFTAAKQSDAILLGAIggyk 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  116 --YTPMEYKGELASydMQLRRKLDLFANVVHVKSLPGY-------KTRHNNLDLVIIREQTEGEYSSLE-----HESARG 181
Cdd:PLN02329 123 wdKNEKHLRPEMAL--FYLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPrgitiNENGEE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  182 VIECLKIVTRTKSQRIAKFAFDYATKKgRSKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNP 261
Cdd:PLN02329 201 VGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDP 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  262 YQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRH-LNLEY 340
Cdd:PLN02329 279 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEK 358


                 ....*...
gi 55926203  341 HSSMIADA 348
Cdd:PLN02329 359 AAKRIEDA 366
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
56-336 8.07e-19

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 87.85  E-value: 8.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203   56 GDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEKL----------EQVLSSMKENKVAIIGKIYTPMeyKGEL 125
Cdd:PRK07362  36 GDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACdlygtyqylpEDTLEAIREYGVAIKGPLTTPI--GGGI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  126 ASYDMQLRRKLDLFANVVHVKSLPGYKTRHNN---LDLVIIREQTEGEYSSLEHES----ARGVIECL------------ 186
Cdd:PRK07362 114 RSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNpekLDVIVYRENTEDIYMGIEWEAgdeiGDKLIKHLneevipaspelg 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  187 ------------KIVTRTKSQRIAKFAFDYATK--KGRSKVTAVHKANIMKLGDGLF----------------------- 229
Cdd:PRK07362 194 krqiplgsgigiKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIMKYTEGAFrdwgyelattefrdecvteresw 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926203  230 --------------------------------LQCCEEVAELYPKI-------KFETMII------DNCCMQLVQNPYQF 264
Cdd:PRK07362 274 ilsnkeknpnisiednarmiepgydsltpekkAAICAEVKEVLDSIwsshgngKWKEKVLvddriaDSIFQQIQTRPQEY 353

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55926203  265 DVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHL 336
Cdd:PRK07362 354 SILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFE--ATHGTApKHAGLDRINPGSVILSGVMMLEYL 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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