|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
812-1137 |
2.05e-79 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
:
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 263.45 E-value: 2.05e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 812 LTRYLKRLKLGTLRAGRLLELLHCaheTQEPGIWKHVSHQlpGHLSFLGTRLTAP--DVYVLGRALETASqdfslDLRQT 889
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 890 GIEPSRLGDLVGLSCVTSFRASLS-DTMALWESLQH---QGETQLLQAAEEKfTIEPFKAKSPKDV-EDLDSLVQTQRLR 964
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 965 N--PSADAAKDLPAIRDLKKLEFALGPvLGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 1042
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 1043 LNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLqKC 1122
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 399154119 1123 PQVETLAMWTPTIPF 1137
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
440-611 |
1.15e-50 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 175.96 E-value: 1.15e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 440 QVVAVLGKAGQGKSHWARTVSHIWAQGQLPQY-DFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMDDEVIDHIVRQPD 518
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 519 RVLLILDAFEELEAQDSLLHGpcgplspePCSLRGLLAGLFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 596
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 399154119 597 TKQAQIYMRHYFENS 611
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
736-841 |
1.43e-05 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 45.36 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 736 LQCFLGAVWLAQCnEMKDKELPQYLALTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAmaaV 804
Cdd:pfam17776 4 FQEFFAALFYVLS-FKEEKSNPLKEFFGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCK---L 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 399154119 805 ADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQE 841
Cdd:pfam17776 80 SSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
812-1137 |
2.05e-79 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 263.45 E-value: 2.05e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 812 LTRYLKRLKLGTLRAGRLLELLHCaheTQEPGIWKHVSHQlpGHLSFLGTRLTAP--DVYVLGRALETASqdfslDLRQT 889
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 890 GIEPSRLGDLVGLSCVTSFRASLS-DTMALWESLQH---QGETQLLQAAEEKfTIEPFKAKSPKDV-EDLDSLVQTQRLR 964
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 965 N--PSADAAKDLPAIRDLKKLEFALGPvLGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 1042
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 1043 LNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLqKC 1122
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 399154119 1123 PQVETLAMWTPTIPF 1137
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
440-611 |
1.15e-50 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 175.96 E-value: 1.15e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 440 QVVAVLGKAGQGKSHWARTVSHIWAQGQLPQY-DFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMDDEVIDHIVRQPD 518
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 519 RVLLILDAFEELEAQDSLLHGpcgplspePCSLRGLLAGLFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 596
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 399154119 597 TKQAQIYMRHYFENS 611
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
999-1150 |
1.76e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.38 E-value: 1.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 999 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALaKSLLRLSLYNNC 1078
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 399154119 1079 ICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1150
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
438-667 |
2.55e-07 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 55.20 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 438 ETQVVAVLGKAGQGKSHWAR-TVSHIWAQGQLPQYDFVFYVPCQCLDRPGDtyhLRDLLCPPNLQPLAMDDEVIDHIVRQ 516
Cdd:COG5635 179 KKKRLLILGEPGSGKTTLLRyLALELAERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKRGGEPEDALERLLRN 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 517 pDRVLLILDAFEELEAQDSLLHgpcgplspepcsLRGLLAGLFQRklLRGCTLLLTARPRGRLAQSLSKADaIFEVPSFS 596
Cdd:COG5635 256 -GRLLLLLDGLDEVPDEADRDE------------VLNQLRRFLER--YPKARVIITSRPEGYDSSELEGFE-VLELAPLS 319
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 399154119 597 TKQAQIYMRHYFENSGTAGshDKALGLLEGQPFLLTHSHSPVLCSAVCQLSKalldqgAEAQLPCTLTGLY 667
Cdd:COG5635 320 DEQIEEFLKKWFEATERKA--ERLLEALEENPELRELARNPLLLTLLALLLR------ERGELPDTRAELY 382
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
736-841 |
1.43e-05 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 45.36 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 736 LQCFLGAVWLAQCnEMKDKELPQYLALTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAmaaV 804
Cdd:pfam17776 4 FQEFFAALFYVLS-FKEEKSNPLKEFFGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCK---L 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 399154119 805 ADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQE 841
Cdd:pfam17776 80 SSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1067-1093 |
2.46e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.31 E-value: 2.46e-04
10 20
....*....|....*....|....*..
gi 399154119 1067 KSLLRLSLYNNCICDEGAKSLARVLPD 1093
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
812-1137 |
2.05e-79 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 263.45 E-value: 2.05e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 812 LTRYLKRLKLGTLRAGRLLELLHCaheTQEPGIWKHVSHQlpGHLSFLGTRLTAP--DVYVLGRALETASqdfslDLRQT 889
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 890 GIEPSRLGDLVGLSCVTSFRASLS-DTMALWESLQH---QGETQLLQAAEEKfTIEPFKAKSPKDV-EDLDSLVQTQRLR 964
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 965 N--PSADAAKDLPAIRDLKKLEFALGPvLGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 1042
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 1043 LNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLqKC 1122
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 399154119 1123 PQVETLAMWTPTIPF 1137
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
440-611 |
1.15e-50 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 175.96 E-value: 1.15e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 440 QVVAVLGKAGQGKSHWARTVSHIWAQGQLPQY-DFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMDDEVIDHIVRQPD 518
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 519 RVLLILDAFEELEAQDSLLHGpcgplspePCSLRGLLAGLFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 596
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 399154119 597 TKQAQIYMRHYFENS 611
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
999-1150 |
1.76e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.38 E-value: 1.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 999 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALaKSLLRLSLYNNC 1078
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 399154119 1079 ICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1150
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
991-1128 |
1.34e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 77.52 E-value: 1.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 991 LGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALpALAKSLL 1070
Cdd:COG5238 248 IGDEGVIALAEALKNNTTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLH 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 399154119 1071 RLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETL 1128
Cdd:COG5238 324 TLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1010-1145 |
2.30e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 73.67 E-value: 2.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 1010 QHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALpALAKSLLRLSLYNNCICDEGAKSLAR 1089
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 1090 VLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETLAMWTPTIPF----GVQEHLQQ 1145
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
998-1128 |
2.54e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.18 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 998 TLAKILPAFSSLQHLDldsLSENKIGDkgvskLSATFPQLKALETLNLSQNSITDvgackLAEALPALaKSLLRLSLYNN 1077
Cdd:COG4886 127 DLPEELANLTNLKELD---LSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNL-TNLKELDLSNN 192
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 399154119 1078 CIcdegaKSLARVLPDMVSLRVMDVQFNKFTAvgaqqLTSSLQKCPQVETL 1128
Cdd:COG4886 193 QI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETL 233
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1003-1128 |
5.20e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 59.95 E-value: 5.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 1003 LPAFSSLQHLDLdslSENKIGDkgvskLSATFPQLKALETLNLSQNSITDvgackLAEALPALaKSLLRLSLYNNCIcde 1082
Cdd:COG4886 109 LSNLTNLESLDL---SGNQLTD-----LPEELANLTNLKELDLSNNQLTD-----LPEPLGNL-TNLKSLDLSNNQL--- 171
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 399154119 1083 gaKSLARVLPDMVSLRVMDVQFNKFTavgaqQLTSSLQKCPQVETL 1128
Cdd:COG4886 172 --TDLPEELGNLTNLKELDLSNNQIT-----DLPEPLGNLTNLEEL 210
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
438-667 |
2.55e-07 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 55.20 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 438 ETQVVAVLGKAGQGKSHWAR-TVSHIWAQGQLPQYDFVFYVPCQCLDRPGDtyhLRDLLCPPNLQPLAMDDEVIDHIVRQ 516
Cdd:COG5635 179 KKKRLLILGEPGSGKTTLLRyLALELAERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKRGGEPEDALERLLRN 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 517 pDRVLLILDAFEELEAQDSLLHgpcgplspepcsLRGLLAGLFQRklLRGCTLLLTARPRGRLAQSLSKADaIFEVPSFS 596
Cdd:COG5635 256 -GRLLLLLDGLDEVPDEADRDE------------VLNQLRRFLER--YPKARVIITSRPEGYDSSELEGFE-VLELAPLS 319
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 399154119 597 TKQAQIYMRHYFENSGTAGshDKALGLLEGQPFLLTHSHSPVLCSAVCQLSKalldqgAEAQLPCTLTGLY 667
Cdd:COG5635 320 DEQIEEFLKKWFEATERKA--ERLLEALEENPELRELARNPLLLTLLALLLR------ERGELPDTRAELY 382
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
998-1120 |
3.18e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.17 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 998 TLAKILPAFSSLQHLDLdslSENKIGDkgvskLSATFPQLKALETLNLSQNSITDvgacklaeaLPALA--KSLLRLSLY 1075
Cdd:COG4886 196 DLPEPLGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQLTD---------LPELGnlTNLEELDLS 258
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 399154119 1076 NNCICDegakslarvLPD---MVSLRVMDVQFNKFTAVGAQQLTSSLQ 1120
Cdd:COG4886 259 NNQLTD---------LPPlanLTNLKTLDLSNNQLTDLKLKELELLLG 297
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
736-841 |
1.43e-05 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 45.36 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154119 736 LQCFLGAVWLAQCnEMKDKELPQYLALTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAmaaV 804
Cdd:pfam17776 4 FQEFFAALFYVLS-FKEEKSNPLKEFFGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCK---L 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 399154119 805 ADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQE 841
Cdd:pfam17776 80 SSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1067-1093 |
2.46e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.31 E-value: 2.46e-04
10 20
....*....|....*....|....*..
gi 399154119 1067 KSLLRLSLYNNCICDEGAKSLARVLPD 1093
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1008-1080 |
1.95e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.95e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 399154119 1008 SLQHLDLdslSENKIGDkgVSKLSAtfpqLKALETLNLSQNSITDVGAckLAEALPALaKSLLRLSLYNNCIC 1080
Cdd:cd21340 121 SLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDLEE--LLDLLSSW-PSLRELDLTGNPVC 181
|
|
| |
