|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-432 |
0e+00 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 841.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 1 MAESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGG 80
Cdd:PRK10406 1 MAESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 81 WLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGF 160
Cdd:PRK10406 81 WLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 161 YASFQYVTLIGGQLLALLVVVVLQHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLKGLWR 240
Cdd:PRK10406 161 YASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLKGLWR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 241 NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAA 320
Cdd:PRK10406 241 NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 321 IFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIG 400
Cdd:PRK10406 321 LFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIG 400
|
410 420 430
....*....|....*....|....*....|..
gi 16130512 401 METAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 432
Cdd:PRK10406 401 METAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 432
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
24-427 |
0e+00 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 552.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 24 IVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMM 103
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 104 CFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVL 183
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 184 QHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRAL---KEAGSLKGLWRNRRAFIMVLGFTAAGSLCFY 260
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAEsneASAGTLRELRRHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 261 TFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAF 340
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 341 GLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVS 420
Cdd:cd17367 321 ALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVY 400
|
....*..
gi 16130512 421 LMLHRKG 427
Cdd:cd17367 401 LRMPETR 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
30-418 |
1.23e-159 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 455.58 E-value: 1.23e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 30 GNLVEWFDFYVYSFCSLYFAH-IFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSL 108
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHtFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 109 VIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQHTME 188
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 189 DAALREWGWRIPFALGAVLAVVALWLRRQLDETSQQET---RALKEAGSLKGLWR-NRRAFIMVLGFTAAGSLCFYTFTT 264
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKaqeKHKKKRGPIAETLTkHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 265 YMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVM 344
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130512 345 CALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFL 418
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
23-421 |
3.17e-89 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 276.72 E-value: 3.17e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 23 AIVGASSGNLVEWFDFYVYSFCS-LYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVC 101
Cdd:cd17369 3 VALASLVGTAIEWYDFFIYGTAAaLVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 102 MMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVV 181
Cdd:cd17369 83 LMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 182 VLQHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDET----SQQETRALKEAGSLKGLWRNRRAFIMVLGFTAAGSL 257
Cdd:cd17369 163 LLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETpvfrRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 258 CFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPY 337
Cdd:cd17369 243 LFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 338 AAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSL-KSIGMETAFFWYVTLMAVVA 416
Cdd:cd17369 323 IVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALvAATGSWWPVALYLAALAVIS 402
|
....*
gi 16130512 417 FLVSL 421
Cdd:cd17369 403 LVAAL 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
24-427 |
4.75e-77 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 245.36 E-value: 4.75e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 24 IVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMM 103
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 104 CFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVL 183
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 184 QHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDET--SQQETRALKEAGSLKGLWRNRRAFIMVLGFTAAGSLCFYT 261
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETeaFLERKARPTRRELFALLANNRRIILLGMLLVAGSTVTFYF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 262 FTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFG 341
Cdd:cd17368 241 TTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRLLL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 342 LVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSL-KSIGMETAFFWYVTLMAVVAFLVS 420
Cdd:cd17368 321 VLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLiELTGSPLAPAWYLMGAALLGLLAT 400
|
....*..
gi 16130512 421 LMLHRKG 427
Cdd:cd17368 401 LMLRETA 407
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
24-424 |
6.73e-71 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 228.40 E-value: 6.73e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 24 IVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMM 103
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 104 CFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVL 183
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 184 QHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLdetsqqetralkeagslkglwrnrrafIMVLGFTAAGSLCFYTFT 263
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRPL---------------------------LICIGLVLVFNVTNYMLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 264 TYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRtSMLCFGSLAAI-FTVPILSALQNVSSPYAAFGL 342
Cdd:cd17366 214 SYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRK-PVYAAGLAGLLvLAVPAFLLMNSGSIAAIFIGL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 343 VMCALLIVSFYTSISGILKAeMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSI-GMETAFFWYVTLMAVVAFLVSL 421
Cdd:cd17366 293 LVLGLLLSCYTATMASTLPA-LFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSAtGNPLMPAYYLMVAAVVGLVAVL 371
|
...
gi 16130512 422 MLH 424
Cdd:cd17366 372 FLT 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-421 |
4.63e-67 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 217.47 E-value: 4.63e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 24 IVGASSGNLVEWFDFYVYSFCSLYFAHIFfpsgNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMM 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 104 CFGSLVIACLPGYETIGTWapallllaRLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVL 183
Cdd:cd17316 77 GLATLLIGLLPTPILLLVL--------RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 184 QHTMEDaalrEWGWRIPFALGAVLAVVALWLrrqldetsqqetralkeagslkglwrnRRAFIMVLGFTAAGSLCFYTFT 263
Cdd:cd17316 149 IPLLSG----DWGWRILFLIGALPALLALLL---------------------------RRRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 264 TYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNvsSPYAAFGLV 343
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG--SPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16130512 344 MCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSL 421
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
13-431 |
9.11e-66 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 216.73 E-value: 9.11e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 13 TSSDTRR-RIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHG 91
Cdd:PRK15075 5 TPAASREsKARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 92 RKKSMLLSVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQ------ 165
Cdd:PRK15075 85 RRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQsasqqv 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 166 ---YVTLIGgqllallvvVVLQHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDETsqQETRALKEAGSLKGLWR-- 240
Cdd:PRK15075 165 avvFAALLG---------YLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEET--EEFLARKHRPSMREIFRsl 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 241 --NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHAnvasgimTAALFVFMLIQ-------PLIGALSDKIGRRTS 311
Cdd:PRK15075 234 aaNWRIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSA-------ADSLLVTLCVGvsnfiwlPIGGALSDRIGRRPV 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 312 MLCFGSLAAIFTVPILSALqnVSSPyaAFGLVMCALLIVSF-YTSISGILKA---EMFPAQVRALGVGLSYAVANAIFGG 387
Cdd:PRK15075 307 LIAFTVLAILTAYPALSWL--VAAP--SFARMLAVELWLSFlYGSYNGAMVValtEVMPAEVRTAGFSLAYSLATAIFGG 382
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 16130512 388 SAEYVALSL-KSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMR 431
Cdd:PRK15075 383 FTPAISTWLiHVTGDKAAPGYWLSFAAVCGLIATLVLYRRRGARL 427
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
23-423 |
1.87e-57 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 196.47 E-value: 1.87e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 23 AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCM 102
Cdd:PRK10642 17 AITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 103 MCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVV 182
Cdd:PRK10642 97 MSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 183 LQHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDETS--QQETRALkEAGSLKGLW------------RNRRAFIMV 248
Cdd:PRK10642 177 ISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPafQQHVDKL-EQGDREGLQdgpkvsfkeiatKHWRSLLTC 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 249 LGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCfGSLAAIF-TVPIL 327
Cdd:PRK10642 256 IGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVIL-GSVALFVlAIPAF 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 328 SALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFW 407
Cdd:PRK10642 335 ILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPA-MFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESTQNLMMPAY 413
|
410
....*....|....*.
gi 16130512 408 YVTLMAVVAFLVSLML 423
Cdd:PRK10642 414 YLMVVAVIGLITGVTM 429
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
4-400 |
2.03e-48 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 171.07 E-value: 2.03e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 4 STVTADSKLTSSDTRRriwAIVGASSGNLVEWFDFYVYSF-CSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWL 82
Cdd:PRK09952 7 STRPDEGTLSLSRARR---AALGSFAGAVVDWYDFLLYGItAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 83 FGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYA 162
Cdd:PRK09952 84 FGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 163 SFQYVTLIGGQLLALLVVVVLQHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLK------ 236
Cdd:PRK09952 164 SGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKKripvie 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 237 GLWRNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFG 316
Cdd:PRK09952 244 ALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 317 SLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSL 396
Cdd:PRK09952 324 LIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAAL 403
|
....
gi 16130512 397 KSIG 400
Cdd:PRK09952 404 VTYF 407
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-429 |
3.93e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.29 E-value: 3.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 18 RRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFfpsGNTTTQLlqtAGVFAAGFLMRPIGGWLFGRIADKHGRKKSML 97
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF---GLSAAQL---GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 98 LSVCMMCFGSLVIACLPGYETIGTWAPallllarlFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLAL 177
Cdd:COG2223 75 IGLLLLGIGLLLLALAVSYWLLLLLGL--------LLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 178 LVVVvlqhtmedAALREWGWRIPF-ALGAVLAVVALWLRRQLDETSQQETRALKEA-GSLKGLWRNRRAFIMVLGFTAAG 255
Cdd:COG2223 147 FLAP--------LLIAAFGWRNAFlILGILLLVVAVLAWLFLRDPPAGAAAAAKASlRDQLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 256 SlCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSS 335
Cdd:COG2223 219 G-SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 336 PYAAFGLVMCALLIV--SFYTSIsgilkAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMA 413
Cdd:COG2223 298 FLVLFLLLGLALGGGngAVFALV-----PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLA 372
|
410
....*....|....*.
gi 16130512 414 VVAFLVSLMLHRKGKG 429
Cdd:COG2223 373 LVALVLTLLLYRRPRR 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-383 |
3.71e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.74 E-value: 3.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 14 SSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSgntttqLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRK 93
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS------PAQAGLVVTAYLLGAALGAPLAGRLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 94 KSMLLSVCMMCFGSLVIACLPGYETIGTWAPallllarlFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQ 173
Cdd:COG2814 76 RVLLLGLLLFALGSLLCALAPSLWLLLAARF--------LQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 174 LLALLVVVVLQHTmedaalreWGWRIPFALGAVLAVVALWL-RRQLDETSQQETRALKeaGSLKGLWRNRRaFIMVLGFT 252
Cdd:COG2814 148 ALGPLLGGLLADL--------FGWRWVFLVNAVLALLALLLlLRLLPESRPAARARLR--GSLRELLRRPR-LLLLLLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 253 AAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLcfgsLAAIFTVPILSALQN 332
Cdd:COG2814 217 FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL----IGLLLLALGLLLLAL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 16130512 333 VSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANA 383
Cdd:COG2814 293 AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-428 |
4.64e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 96.86 E-value: 4.64e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 17 TRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSgntttqLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSM 96
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLS------AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 97 LLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLA 176
Cdd:COG2271 79 AIGLLLWGLATLLFGFATSFWQL--------LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 177 LLVVVvlqhtmedAALREWGWRIPFALGAVLAVVALWLRrqldetsqqetralkeagslkglwrnrraFIMVLGFTAAGS 256
Cdd:COG2271 151 PPLLG--------WLLAAFGWRAAFLILGLPGLLLALLR-----------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 257 LCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFgsLAAIFTVPILSALQNVSSP 336
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA--IGLLLAALALLLLALLPSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 337 YAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVA 416
Cdd:COG2271 272 ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA 351
|
410
....*....|..
gi 16130512 417 FLVSLMLHRKGK 428
Cdd:COG2271 352 LLALLLLRETRK 363
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
27-419 |
1.31e-21 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 96.57 E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 27 ASSGNLVEWFDFYVY-SFCSLYFAHIFFPSGNTTTQL----LQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVC 101
Cdd:pfam00083 5 AALGGFLFGYDTGVIgAFLTLIDFFKNFGLSKSVSSLaalsVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 102 MMCFGSLVIAClpgyeTIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVV 181
Cdd:pfam00083 85 LFVIGAVLQGA-----AKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 182 VLQHTMEdaalrEWGWRIPFALGAVLAVVALWLRRQLDET----------------------SQQETRALKE-------- 231
Cdd:pfam00083 160 GLNKTSN-----SDGWRIPLGLQLVPALLLIIGLLFLPESprwlvekgrleearevlaklrgVPDVDRELDEikdsleag 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 232 -------AGSLKGLWRNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVfmlIQPLIGA-LS 303
Cdd:pfam00083 235 qeaekasWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNF---VFTFIAIfLV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 304 DKIGRRTS-MLCFGSLAAIFTVP-ILSALQNVSSPYAAFGLVMCALLIVSFY----TSISGILKAEMFPAQVRALGVGLS 377
Cdd:pfam00083 312 DRFGRRPLlLLGAAGMAICFVILgIVALLGVSKSDWAGIVAIVFIALFIAFFamgwGPVPWVIVSELFPLSVRSKAMALA 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 16130512 378 YA---VANAIFGGSAEYValsLKSIGMETAFFWYVTLMAVVAFLV 419
Cdd:pfam00083 392 TAanwLANFLIGFLFPII---TDAIGLGYTFFIFAGLLVLFIIFV 433
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
78-423 |
3.17e-21 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 94.68 E-value: 3.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 78 IGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGtwapalllLARLFQGLSVGGEYGTSATYMSEVAVEGR 157
Cdd:cd17371 49 IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLL--------ILRALAGLGFGGEWAAGAALMAEYVPARH 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 158 KGF-YASFQYVTLIGGQLLALLVVVVLQHtmedaALREWGWRIPFALGAVLAVVALWLRRQLDET-----SQQETRALKE 231
Cdd:cd17371 121 RGKaLGYVQSGWAVGWLLATLLAALLFPL-----LPPEIAWRVLFLLGALPALLVLFIRRFVKEPpqwqaARAARRHFAD 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 232 AGSLKGLWR--NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRR 309
Cdd:cd17371 196 RPSLRELFSppLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 310 TSMLCFGSLAAIFTVPILSA-LQNVSSPYAAFGLVMCALLIVSFYtsisGILKAEMFPAQVRALGVGLSYAVANAIFGGS 388
Cdd:cd17371 276 NNFALFALGSAISILLYFFLpLSPTLILILGFPLGFFASGPFSGM----GAYLTELFPTAVRATAQGFCYNVGRIIGALF 351
|
330 340 350
....*....|....*....|....*....|....*
gi 16130512 389 AEYVALSLKSIGMETAFfwyvTLMAVVAFLVSLML 423
Cdd:cd17371 352 PFLVGFLATSGSLGTAI----AVFAAVYYIAGLVL 382
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-324 |
2.15e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 91.03 E-value: 2.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 10 SKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFfpsgNTTTQLLQTagVFAAGFLMRPIGGWLFGRIADK 89
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL----GASSAQLGW--IVSAYLLGRAIGLLLFGRLGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 90 HGRKKSMLLSVCMMCFGSLVIACLPGYETIGTWapallllaRLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTL 169
Cdd:COG0477 76 YGRKRVLLIGLLLFGLASLLCGLAPSPELLIAA--------RALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 170 IGGQLLALLVVVvlqhtmedAALREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLKGLWRNRRAFIMVL 249
Cdd:COG0477 148 GLGLALGPLLGG--------LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALL 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130512 250 GFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTV 324
Cdd:COG0477 220 LLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
62-426 |
1.69e-15 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 78.20 E-value: 1.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 62 LLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGE 141
Cdd:PRK03893 54 TVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTL--------FIARLVIGMGMAGE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 142 YGTSATYMSE---VAVEGR-KGFYAS-FQYVTLIGGQLLALLVVVvlqhtmedaalreWGWRIPFALGAVLAVVALWLRR 216
Cdd:PRK03893 126 YGSSATYVIEswpKHLRNKaSGFLISgFSIGAVVAAQVYSLVVPV-------------WGWRALFFIGILPIIFALWLRK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 217 QLDETSQ-QETRALKEAG--SLKGLWRNRRAFI-MVLGFTAAGSL-----------------------CFYTFT------ 263
Cdd:PRK03893 193 NLPEAEDwKEKHAGKAPVrtMVDILYRGEHRIInILLTLAAAAALwfcfagnlqnaaivavlgllcaaIFISFMvqssgk 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 264 -----------------------TYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAA 320
Cdd:PRK03893 273 rwptgvmlmvvvlfaflyswpiqALLPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQ 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 321 IFTVPILSAlqnvsspYAAFGLVMCALLIVS--FYTSISGILK---AEMFPAQVRALGVGLSYAVAnAIFGGSAEYVALS 395
Cdd:PRK03893 353 LLIIPVFAI-------GGANVWVLGLLLFFQqmLGQGISGLLPkliGGYFDTEQRAAGLGFTYNVG-ALGGALAPILGAL 424
|
410 420 430
....*....|....*....|....*....|...
gi 16130512 396 L-KSIGMETAFF-WYVTLMAVVAFLVSLMLHRK 426
Cdd:PRK03893 425 IaQRLDLGTALAsLSFSLTFVVILLIGLDMPSR 457
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
36-423 |
2.19e-15 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 77.32 E-value: 2.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 36 FDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAgVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPG 115
Cdd:cd17364 13 YDLFSISLVTKILGRLYYGGKGSLPSGVSGL-VNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 116 YETIGtwAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKG----FYASFQYVTLIGGQLLALLVVVVLQHTMEDAA 191
Cdd:cd17364 92 STPLG--VMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGaliaAVFAMQGFGILAGAIVTLILSAIFEHPLPAGT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 192 LR--EWGWRIPFALGAVLAVVALWLRRQLDETSqqetralkeagslkGLWrnrraFIMVLGFTAAGSLCFYTFTTYMQKY 269
Cdd:cd17364 170 YHhaDLVWRIVLGLGAIPALSVLYFRKHLLGTA--------------GTW-----FLLDIAFYGQNLFQSTIISAIGFSK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 270 LVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRR-TSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALL 348
Cdd:cd17364 231 TMNAYQELFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKkIQMMGFFGMTIFLLILAGPYDHWKISTIGFFVLYGLTFF 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16130512 349 IVSF-YTSISGILKAEMFPAQVRALGVGLSYAV--ANAIFGGsaeYVALSLKSIGMETAFFWYVTLMAVVAFLVSLML 423
Cdd:cd17364 311 FSNFgPNTTTFIVPAEVFPARVRSTCHGISAASgkIGAIVGS---FLFLSLTQNIGVRNVLIILAGVALLGIILTLLF 385
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
78-418 |
1.54e-13 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 71.83 E-value: 1.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 78 IGGWLFGRIADKHGRKKSMLLSVCMMCFGSL------VIACLPGYETIGtwapallllarlfqGLSVGGEYGTSATYMSE 151
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALgsafspNFTIFIIARIIG--------------GLAVGGASALVPMYIAE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 152 VAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDETSqqetRALKE 231
Cdd:cd17359 117 VAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESP----RWLVS 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 232 AGslkglwrnRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANvASGIMTAALFVFMLIQPLIG-ALSDKIGRRT 310
Cdd:cd17359 193 KG--------KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSEN-AALLQTIGIGVVNVIFTIIAiLLVDKVGRKP 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 311 SMLcFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALL---IVSFYTSISGI---LKAEMFPAQVRALGVGLSYAV---A 381
Cdd:cd17359 264 LLL-IGSIGMAISLLLIGTAFYFAPGSQASGIVALVLIllfVAFFAMSWGPVtwvLLSEIFPNRIRGLAMGIAVFFlwiA 342
|
330 340 350
....*....|....*....|....*....|....*..
gi 16130512 382 NAIFGGSaeyVALSLKSIGMETAFFWYVtLMAVVAFL 418
Cdd:cd17359 343 NFLVSLT---FPILLAAFGLAFTFLIFA-VICVLAFL 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
64-421 |
8.34e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 69.38 E-value: 8.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 64 QTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYG 143
Cdd:cd06174 32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLL--------LLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 144 TSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLqhtmedAALREWGWRIPFALGAVLAVVALWLRRQLDETSQ 223
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL------ASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 224 QETRALKEA-------GSLKGLWRNRRAFIMVLGFTAAGSLcFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQ 296
Cdd:cd06174 178 ESARAKNEEassksvlKLLKRVLKNPGLWLLLLAIFLVNLA-YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 297 PLIGALSDK-IGRRTSMLCFGSLAAIFTVPILSAlqnvSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVG 375
Cdd:cd06174 257 LLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 16130512 376 LSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSL 421
Cdd:cd06174 333 LLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
63-423 |
1.08e-12 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 69.19 E-value: 1.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 63 LQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSlviaclpGYETIGTwAPALLLLARLFQGLSVGGEY 142
Cdd:PRK12307 53 MEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGT-------GLSGLAS-GVIMLTLSRFIVGMGMAGEY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 143 GTSATYmsevAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQHTMEDAalreWGWRIPFALGAVLAVVALWLRRQLDETS 222
Cdd:PRK12307 125 ACASTY----AVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEA----YGWRAAFFVGLLPVLLVIYIRARAPESK 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 223 QQETRALKEAG------------SLKGLWRNRR------AFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAgmhanVASGI 284
Cdd:PRK12307 197 EWEEAKLSGKGkhsqsawsvfslSMKGLFNRAQfpltlcVFIVLFSIFGANWPIFGLLPTYLAGEGFDTG-----VVSNL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 285 MTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAA--FGLVMCALlivsfytSISGILKA 362
Cdd:PRK12307 272 MTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGAclFGLMATNV-------GVGGLVPK 344
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130512 363 ---EMFPAQVRALGVGLSYAVANAifGGSAEYVALSLKSIGMETAffwyVTLMAVVAFLVSLML 423
Cdd:PRK12307 345 flyDYFPLEVRGLGTGLIYNLAAT--SGTFNSMAATWLGITMGLG----AALTFIVAFWTATIL 402
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
63-423 |
1.84e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.37 E-value: 1.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 63 LQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEY 142
Cdd:cd17325 31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL--------LLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 143 GTSATYMSEVAVEGRKG-FYASFQYVTLIGGQLLALLVVVVLQHtmedaalreWGWRIPFALGAVLAVVALWLR-RQLDE 220
Cdd:cd17325 103 PAAMALIADIAPPEERGrAMGIFSSAIGLGFLIGPLLGGLLADA---------LGYRAPFLVCAALALLALVLAlLLLPE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 221 TSQQETRALKEAGSLKGLWR---NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQP 297
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLRlllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 298 LIGALSDKIGRRTsMLCFGSLAAIFTVPILSAlqnVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLS 377
Cdd:cd17325 254 PAGKLSDRIGRKP-LILIGLLLSAVALLLLPL---ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 16130512 378 YAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLML 423
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
68-386 |
2.52e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 68.15 E-value: 2.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 68 VFAAGFLMRPIGGWLFGRIADKHGRKKsmLLSVCMMCFGSLVIAClpgyetIGTWAPALLLLARLFQGLSVGGEYGTSAT 147
Cdd:TIGR00895 57 LFSAGLIGMAFGALFFGPLADRIGRRR--VLLWSILLFSVFTLLC------ALATNVTQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 148 YMSEVAVEGRKGFYASFQYVTL-IGGQLLALLVVVVLQHtmedaalreWGWRIPFALGAVLAVVALWL------------ 214
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYpIGAAVGGFLAGWLIPV---------FGWRSLFYVGGIAPLLLLLLlmrflpesidfl 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 215 --------------------RRQLDETSQQETRALKEAGSLKGLWRNRRAFIMVL--GFTAAGSLCFYTFTTYMQKyLVN 272
Cdd:TIGR00895 200 vskrpetvrrivnaiapqmqAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLlwLLYFMLLVGVYFLTNWLPK-LMV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 273 TAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLcFGSLAAIFTVpilSALQNVSSPYAAFGLVMCALLIVSF 352
Cdd:TIGR00895 279 ELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTAL-LLLLGAVFAV---LVGSTLFSPTLLLLLGAIAGFFVNG 354
|
330 340 350
....*....|....*....|....*....|....*.
gi 16130512 353 YTSISGILKAEMFPAQVRALGVGLSYAV--ANAIFG 386
Cdd:TIGR00895 355 GQSGLYALMALFYPTAIRATGVGWAIGIgrLGAIIG 390
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
64-428 |
7.47e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.42 E-value: 7.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 64 QTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGTWapallllaRLFQGLSVGGEYG 143
Cdd:COG0738 44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLA--------LFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 144 TSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQHTMEDAalrewgWRIPF-ALGAVLAVVALWL-RRQLDET 221
Cdd:COG0738 116 AANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS------WHLPYlILAVLLLLLALLFlRSKLPEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 222 SQQETRALKEAGSLKGLWRNRRAFIMVLGFTAAGsLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGA 301
Cdd:COG0738 190 EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYV-GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 302 LSDKIGRRTSMLCFGSLAAIFtvpILSALQNVSSPYAAFGLVMCALLIVSFYTSI--SGILKAEMFPAQVRALGVGLSY- 378
Cdd:COG0738 269 LLKRFGPVRLLRLSALLAAVG---LLLALLAPGPWLALIGLALVGLGLSLMFPTIfsLALDGLGKRTAAAVSAVLIMGIv 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 16130512 379 --AVANAIFGGSAEYVALSlksigmetAFFWYVTLMAVVAFLVSLMLHRKGK 428
Cdd:COG0738 346 ggAIGPPLIGFLADAFGLR--------AAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
195-423 |
9.80e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.46 E-value: 9.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 195 WGWRIPFALGAVLAVVA-LWLRRQLDETSQQETRALKEAGSLKGLWRNRrAFIMVLGFTAAGSLCFYTFTTYMQKYLVNT 273
Cdd:COG2211 180 LGYRLTALIFAVLGLLAfLLTFFGTKERPVPEEEKVSLKESLKALLKNR-PFLLLLLAYLLFFLALALVAALLLYYFKYV 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 274 AGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPIlsALQNVSSPYAAFGLVMCALLIVSFY 353
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL--FFLGPGNLWLLLVLAALAGIGLGAI 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 354 TSISGILKAEMFPAQ--------------VRALGVGLSYAVANAIFG---GSAEYVALSLKSIGMETAFFWYVTLMAVVA 416
Cdd:COG2211 337 LVLPWAMLADVVDYDewktgrrreglyfgIFTFAIKLGQALAGALAGlllALFGYVAGAAQSPSALTGIRLLFFLLPAVL 416
|
....*..
gi 16130512 417 FLVSLML 423
Cdd:COG2211 417 LLLAALL 423
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
68-382 |
3.81e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.98 E-value: 3.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 68 VFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSAT 147
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL--------LVLRVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 148 YMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVvlqhtmedAALREWGWRIPFALGAVLAVVA-----LWLRRQLDETS 222
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGG--------LLASLFGWRAAFLILAILSLLAavlllLPRPPPESKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 223 QQETRALKEAGSLKGLWRNRRAFIMVLGFtAAGSLCFYTFTTYMQKYlVNTAGMHANVASGIMTAALFVFMLIQPLIGAL 302
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 303 SDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILkAEMFPAQVRALGVGLSYAVAN 382
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV-SDLAPKEERGTASGLYNTAGS 337
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-427 |
5.88e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 63.37 E-value: 5.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 64 QTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGTWapallllaRLFQGLSVGGEYG 143
Cdd:cd17365 35 QLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--------RFLTGLGLGAAMP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 144 TSATYMSEVAVEGRKGFYASFQYVTL-IGGQLLALLVVVVLQHtmedaalreWGWRIPFALGAVLAVVALWLRRqldets 222
Cdd:cd17365 107 NAITLVSEYAPARRRSLAVTLMFCGYpLGAALGGFLAAALIPA---------FGWRSVFLLGGVPPLILLPLLR------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 223 qqetralkeaGSLKgLWrnrRAFIMVLgftaagsLCFYTFTTYMQKyLVNTAGMHANVASGIMTAALFVFMLIQPLIGAL 302
Cdd:cd17365 172 ----------GTLL-LW---VTFFMGL-------LLVYLLNSWLPK-LMVEAGYSLSQALTITLLLNIGGVIGSLLLGWL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 303 SDKIGRRTSMLCFGSLAAIFTVPILSALqnvSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVAn 382
Cdd:cd17365 230 ADRFGPKRVLALFFALGAVSLALLGVSP---ASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVG- 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 16130512 383 aiFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKG 427
Cdd:cd17365 306 --RLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
78-421 |
1.17e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.57 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 78 IGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEGR 157
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL--------LLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 158 KGFYASFQYVTLIGGQLLALLVVVVlqhtMEDAalreWGWRIPF-ALGAVLAVVALWLRRQLDETSQQETRALKEAGSLK 236
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGGL----LGQL----LGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 237 GLWRNRRAFiMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFG 316
Cdd:cd17324 193 LLLRNPRLR-LAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 317 SLAAIFTVPILSAlqnvssPYAAFGLVMCALL-IVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALS 395
Cdd:cd17324 272 LLAAALLLLTLLG------PSPLLLLVGLVLWgLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLV 345
|
330 340
....*....|....*....|....*.
gi 16130512 396 LKSIGMeTAFFWYVTLMAVVAFLVSL 421
Cdd:cd17324 346 LDHGGW-AGVGWVGAALLLLALLLAL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
82-421 |
2.50e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.80 E-value: 2.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 82 LFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGTwapallllARLFQGLSVGGEYGTSATYMSEVAvEGRKGFY 161
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL--------LVALAGIGSAAFHPEGARLASQAA-GGRRGLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 162 ASFqYVTliGGQLLALLVVVVLQHTMEDAALREWGWRipFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLKglWRN 241
Cdd:cd17478 121 MSI-FSV--GGNLGFALGPLIAAALVALFGGLGLLIL--LIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTL--KGV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 242 RRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGmhANVASGIMtaaLFVFMLI----QPLIGALSDKIGRRTSMlcfgs 317
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGY--SLVFAGLL---LSLFLFAgaigTLIGGPLSDRFGRRRVI----- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 318 LAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVrALGVGLSYAVANAIFGGSAEYVALSLK 397
Cdd:cd17478 264 IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALAD 342
|
330 340
....*....|....*....|....
gi 16130512 398 SIGMETAfFWYVTLMAVVAFLVSL 421
Cdd:cd17478 343 AFGLESV-LLILALLPLLGALLAF 365
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
27-423 |
1.53e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 59.12 E-value: 1.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 27 ASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFlmrpIGGWLFGRIADKHGRKKSMLLSVCMMCFG 106
Cdd:cd17315 2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAA----IGSLFGGPLADRFGRRKSLLIAAVLYVIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 107 SLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLqht 186
Cdd:cd17315 78 ALLSALAPNVWVL--------IVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLAL--- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 187 medAALREWGWRIPFALGAVLAVVALWLRRQLdetsqQETRALKEAGSLKGLwrnrrafimvLGFTAAGSLCFYTfTTYM 266
Cdd:cd17315 147 ---SLSPPGWWRLMFALAAVPALLQLLLMFFL-----PESRALLVGVGLQLL----------QQLTGINAVMYYA-PTIF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 267 QKYLVNTAGMHANVASG-IMTAALFVFMLiqpligaLSDKIGRRTSMLC--FGSLAAIFTVPILSALQNVSSPYAAFGLV 343
Cdd:cd17315 208 KSAGGGTASILASIIVGvVNLLATLVAIR-------LVDKVGRRPLLLIgfAGMAASLLLLAIAFLLPALAKAAGWLALL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 344 MCALLIVSFYTS---ISGILKAEMFPAQVRALGVGLSYAV---ANAIFGGSAEYValsLKSIGMETAFFWYvTLMAVVAF 417
Cdd:cd17315 281 GILLYIAAFAMGagpVPWLLLSEIFPLRIRGKGMAIATLVnwiFNFIVGLTFLIM---VSTIGLAGVFIFF-AAVCLLAL 356
|
....*.
gi 16130512 418 LVSLML 423
Cdd:cd17315 357 VFVFFF 362
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
78-419 |
2.53e-09 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 58.44 E-value: 2.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 78 IGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEGR 157
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL--------IVGRVLVGLGVGIASMTVPLYIAEAAPPRI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 158 KGFYASFQYVTLIGGQLLALLVVVVLQHTmedaalrEWGWRIPFALGAVLAVVALWLRRQLDETSQqetralkeagslkg 237
Cdd:cd17360 122 RGRLVTINVLFITGGQFVAYVINGAFSYL-------PGGWRWMLGLAAVPAVLQFIGLLFLPESPR-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 238 lWR-NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHAN---VASGIMTAAL-FVFMLIQPLigaLSDKIGRRTSM 312
Cdd:cd17360 181 -WPsTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNqnaIWLSLIVAGTnFIFTIVGMY---LIDKFGRRKLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 313 L--CFGSLAAIFTVPILSAlqnvsspyaafgLVMCALLIVSF---YTSISGILKAEMFPAQVRALGVGLSyAVANAIFGG 387
Cdd:cd17360 257 LisLFGVIVALVVLAVWLA------------LVGLILYLAFFapgMGPVPWTVNSEIYPLWARGTGGGCA-AAVNWVFNL 323
|
330 340 350
....*....|....*....|....*....|...
gi 16130512 388 SAEYVALSL-KSIGMETAFFWYVTLMAVVAFLV 419
Cdd:cd17360 324 LVSQTFLTLtQAIGPYGTFLLFAGLAVLGLIFI 356
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
84-432 |
5.18e-09 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 57.75 E-value: 5.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 84 GRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYAS 163
Cdd:cd17362 60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVL--------LVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 164 FQYVTLIGGQLLALLVVVVLQHTMedaalreWGWRIPFALGAVLAVV---ALWLrrqldetsqqetraLKEAGSLKGlwR 240
Cdd:cd17362 132 LKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAAPPALLlgiGMWF--------------LPPSPRWQG--N 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 241 NRRAFIMVLG------FTAAGSLCFYTFTTYmqkylvNTAGMHANVASGIMTAALFVFMLIQPLIG-ALSDKIGRRTSML 313
Cdd:cd17362 189 YRKPLIIGLGlvlfqqITGQPSVLYYAATIF------KSAGFSAASDATLVSVGLGVFKLLMTIVAvLLVDKLGRRPLLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 314 --CFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYT----SISGILKAEMFPAQVRALGVGLSYAV---ANAI 384
Cdd:cd17362 263 ggVSGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQisfgPISWLMVSEIFPLRVRGRAIALAVLVnfgSNAL 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 16130512 385 fggsaeyVALSL----KSIGMETAFFWYvTLMAVVAFLVSLMLHRKGKGMRL 432
Cdd:cd17362 343 -------VSLAFlplqELIGLPGTFLGF-GVIGVLALLFIYFTVPETKGLSL 386
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
205-419 |
1.44e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 205 AVLAVVALWLRRQLDETSQqETRALKEAGSLKGLwrnRRAFIMVLGFTAAGSLCFYTFTTYMqkYLVNTAGMHANVASGI 284
Cdd:cd17370 166 ALLALLILLFVVKEYPRPP-KLRKKSKKTSLKKL---PKAFWLYLLAVALFALGNFSFAFLI--LRAQELGLSAALIPLL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 285 MTAALFVFMLIQPLIGALSDKIGRRTsMLCFGSLAAIFTvpiLSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEM 364
Cdd:cd17370 240 YALFNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALA---YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADL 315
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 16130512 365 FPAQVRALGVGLSYA-VANAIFGGSAEYVALsLKSIGMETAfFWYVTLMAVVAFLV 419
Cdd:cd17370 316 VPAELRGTAYGLFNTvVGIGWLLASLIAGYL-WDLISPSAA-FLFSAVLALIALLL 369
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
12-221 |
5.28e-08 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 54.73 E-value: 5.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 12 LTSSDTRRRIW----AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAgVFAAGFLMRPIGGWLFGRIA 87
Cdd:TIGR00887 2 LEEADTAPFGWqhfrAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVSAA-VNGSASIGTLAGQLFFGWLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 88 DKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGtwAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKG-FYAS--- 163
Cdd:TIGR00887 81 DKLGRKRVYGMELIIMIIATVASGLSPGSSPKS--VMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGaMMAAvfa 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16130512 164 FQYVTLIGGQLLALLVVVVLQHTMEDAALRE-----------WGWRIPFALGAVLAVVALWLRRQLDET 221
Cdd:TIGR00887 159 MQGFGILAGAIVALIVLAGFKHSLEAAADEAsctgscvpavdYMWRILIGFGAVPALLALYFRLTIPET 227
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
56-321 |
3.06e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.18 E-value: 3.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 56 GNTTTQLLQTAGVFAAGflmrpIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYET--IGTwapallllarLF 133
Cdd:COG2807 51 SATQAGLLTTLPLLAFG-----LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALllAGT----------AL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 134 QGLSVGGEYGTSATYMSEVAVEgRKGFYASFQYVTLIGGQLLALLVVVvlqhtmedAALREWGWRIPFALGAVLAVVALW 213
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTV--------PLAAALGWRGALAVWALLALLALL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 214 LRRQLDETSQQETRALKEAGSLKGLWRNRRAFIMVLGFtAAGSLCFYTFTTYMQKYLVnTAGMHANVASGIMTAALFVFM 293
Cdd:COG2807 187 LWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFF-GLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGI 264
|
250 260
....*....|....*....|....*...
gi 16130512 294 LIQPLIGALSDKIGRRTSMLCFGSLAAI 321
Cdd:COG2807 265 PGSLLVPLLADRLGDRRPLLLLLGLLGL 292
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
242-431 |
3.24e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 242 RRAFIMVLGFTAAGSLCFYTFTTY--MQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLA 319
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWsvLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 320 AIFTvpILSALQNVSSPYAAFGLVMCALLIVSFYTSISGIlkAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSI 399
Cdd:COG2223 81 GIGL--LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALV--SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190
....*....|....*....|....*....|..
gi 16130512 400 GMETAFFWYVTLMAVVAFLVSLMLHRKGKGMR 431
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGAA 188
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
65-426 |
4.06e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 51.88 E-value: 4.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 65 TAGVFAAGFLmrpIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIAC---LPGYETIGTWAPALlllarlfqGLSVGGE 141
Cdd:cd17357 54 IVSIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLsksAKSPELLIFGRFLV--------GIACGLS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 142 YGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVvvvlqhTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDET 221
Cdd:cd17357 123 TGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVF------GLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPES 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 222 SQ-------QETRALK-----------------------------EAGSLKGLWRN---RRAFIMVLGFTAAGSLC---- 258
Cdd:cd17357 197 PKflliskgDEEEAEKslkflrgieddvdqeleeikkeseqmgdqKQVSLMQLLRDpslRLPLLLVLVVSASQQFSgina 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 259 --FYTFTTYMQkylvntAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSML--CFGSLAAIFTVPILSALQNVS 334
Cdd:cd17357 277 ifFYSTFIFEN------AGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLisLSVCAVALLLMSVFLFLSEQN 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 335 SPYAAFGLVMCALLIVSFYTS---ISGILKAEMFPAQVRALGVGLSYAVaNAIFGGSAEYVALSLKSIGmetaFFWYVTL 411
Cdd:cd17357 351 SWMSYGCIVAIFLFIFFFAIGlgpIPWFIGAELFPQAPRSAAQSLGSSV-NWTSNFIVGMAFPPLQSIG----GGFVFII 425
|
410
....*....|....*
gi 16130512 412 MAVVAFLVSLMLHRK 426
Cdd:cd17357 426 FAIPCALFLLYLYRY 440
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
77-423 |
7.11e-07 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 51.04 E-value: 7.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 77 PIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEG 156
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWML--------YLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 157 RKGFYASFQYVTLIGGQLLALLVVVVLqhtmedaalrewGWRIPFALGAVLAVVAL------------------------ 212
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLGYVLGSFL------------PWRTLALIGAIPPVVFLillffipesprwlakkgreeeaek 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 213 ---WLRRQLDETS---------QQETRALKEAGSLKGLW--RNRRAFIMVLGFTAAGSLC-FYTFTTYMQKYLVNTagmH 277
Cdd:cd17358 195 slqFLRGKDADISkeaaeiqeeLAELEKEAKESSFSDLFqrKYLKPLVIGLGLMLFQQLSgINAVIFYASSIFDEA---G 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 278 ANVASGIMTAALFVFMLIQPLIGA-LSDKIGRRtSMLCFGSLAAIFTVPILSA---LQNVSSPYAAFG---LVMCALLIV 350
Cdd:cd17358 272 SGLDPNTATIIIGVVQVVGTLVATlLVDRLGRR-PLLLVSAIGMGIGLLALGLyfyLQEHGALLSSVSwlpLVGLVIYII 350
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130512 351 SF---YTSISGILKAEMFPAQVRALGVGLSYAVaNAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLML 423
Cdd:cd17358 351 SFsigLGPLPWVIMSEIFPAKIKGLAGSLVTLV-NWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLF 425
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
196-377 |
2.69e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.16 E-value: 2.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 196 GWRIPFALGAVLAVVA-----LWLRRQLDETSQQEtRALKEAGSLKGLWRNRrafIMVLGFTAAGSLCF--YTFTTYMQK 268
Cdd:cd17475 148 GWRAAFVVAGLVSILAavlfwLFYREPPAASAATE-SASTLLRSLKEVLRNR---DVWLIAIAGALLVApqFALLTFLLL 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 269 YLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIG---RRTSMLCFGSLAAIFTVpiLSALQNVSSPYAAFGLVMC 345
Cdd:cd17475 224 FLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALL--VLSLLSPGTPLWLLVLLLI 301
|
170 180 190
....*....|....*....|....*....|...
gi 16130512 346 AL-LIVSFYTSISGILKAEMFPAQVRALGVGLS 377
Cdd:cd17475 302 LLgLFAIGWNGLYLTLVAESAGPEQAGTALGLA 334
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
66-354 |
2.93e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 66 AGVFAAGFLmrpIGGWLFGRIADKHGRKKSMLLsvcMMCFGSLVIACLPGYETIGTWAPALLllarlFQGLSVGGEYGTS 145
Cdd:cd17477 37 ASAYYLGIL---LGSPLVPRLIRRVGHIRAFAA---GAAITAVSVLLLALTDSPWVWFLLRF-----VMGIGLAGLFVVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 146 ATYMSEVAVEGRKG----FYASFQYVTLIGGQLLALLVVVVLQhtmedaalrewgwrIPFALGAVLAVVAL----WLRRQ 217
Cdd:cd17477 106 ESWLNALATNENRGrvlgLYSTVLGLGFALGPLLLALVGTAGA--------------LPFLIAAVLLLLALvpllLTRRA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 218 LDETSQQETRALKEAgslkgLWRNRRAFIMVL--GFTAAGSLCFYTFttymqkYLVNtAGMHANVASGIMTAALFVFMLI 295
Cdd:cd17477 172 APEIEEAESISLRRL-----LRIAPLALLGAFvaGFLEGAFYSLLPL------YGLR-LGLSVAQAALLLAAFVLGGLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 16130512 296 QPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQnvSSPYAAFGLVMCALLIVSFYT 354
Cdd:cd17477 240 QWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPG--LPLALLVLLFLWGGAAGPLYT 296
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
47-432 |
4.65e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 48.40 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 47 YFAHIFFPSGNTTTQLLQTAGVFAAGFLMrpiGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIAClpgyeTIGTWAPAL 126
Cdd:cd17356 32 YFADNTGTYYPSSSRQGLIVSIVNLGSFF---GALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVA-----AIGKWYQLI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 127 LLLArlFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQHTMEDAAlrewgWRIPFALGAV 206
Cdd:cd17356 104 VGRI--IAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLGLQIV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 207 LAVVALWLRRQLDEtsqqetralkeagSLKGLWRnrraFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHAN---VASG 283
Cdd:cd17356 177 WGLLLLIGMFFLPE-------------SPRWLYR----TILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSsplLTSI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 284 IMTAALFVFMLIQPLigaLSDKIGRRTS--------MLCFGSLAAIF-TVPILSALQNVSSPYAAFG-LVMCALLIVSFY 353
Cdd:cd17356 240 ILYIVNFVSTIPGLF---FVDKFGRRTClligaagmSICLFIYAAVGvRYLIPNPQSGTSNKSAGNGmIVFICLFIFSFA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 354 TSISGI---LKAEMFPAQVRALGVGLSyAVANAIFG-GSAEYVALSLKSIGMETAFFWyvTLMAVVAFLVSLMLHRKGKG 429
Cdd:cd17356 317 TTWGPIawvYVAEVFPLRVRSKGMALA-TAFNWLWNfLISFFTPFIIGSIGFKYYYIF--AGCNLLAFIVVFFFVPETKG 393
|
...
gi 16130512 430 MRL 432
Cdd:cd17356 394 LTL 396
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
64-423 |
1.07e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.19 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 64 QTAGVFAAGFLmrpIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYG 143
Cdd:cd17320 38 LTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL--------LIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 144 TSATYMSEVaVEGRKGFYAsFQYVT-----------LIGGQLLALlvvvvlqhtmedaalreWGWRIPFALGAVLAVVAL 212
Cdd:cd17320 107 VARAIVRDL-YSGAELAKI-FSLLMmilaiapalapLLGGLLLLF-----------------FGWRAIFVFLALLGLLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 213 -WLRRQLDETSQQETRALKEAGSLKG---LWRNRR--AFIMVLGFTAAGSLCFYTFTTYMqkyLVNTAGMHANVASGIMT 286
Cdd:cd17320 168 lLVLLFLPETLPEEKRKPLLSSLLRAykrVLKNRRflGYALALGLSFAGLFAYLAAAPFI---YIEQLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 287 AALFVFMLIQPLIGALSDKIG-RRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMF 365
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 16130512 366 PaQVRALGVGLSYAVANAIFGGSAEYVALSlkSIGMETAFFWYVTLMAVVAFLVSLML 423
Cdd:cd17320 325 P-HVAGTASALLGFLQFLIGALAGALVGLL--PNGTALPMGLLILVLGLLALLLLILL 379
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
22-419 |
2.67e-05 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 46.18 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 22 WAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLM-RPIGGWLFGRIADKHGRKKSMLLSV 100
Cdd:TIGR00879 29 LSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVgGFIGALFAGWLSDRFGRKKSLLIIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 101 CMMCFGSLVIAClpgyeTIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVV 180
Cdd:TIGR00879 109 LLFVIGAILMGL-----AAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 181 vvlqhTMEDAALREWGWRIPFAL---GAVLAVVALW---------------------LRRQLDETS-----QQETRALKE 231
Cdd:TIGR00879 184 -----SGKVSLNNTLGWRIPLGLqliPAGLLFLGLFflpesprwlvgkgrveearksLARLRGTSGedkelLDELELIDI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 232 AGSLKGLWRN-------------RRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMhANVASGIMTAALFVFMLIQPL 298
Cdd:TIGR00879 259 KRSIEKRSVQpswgslfsstrriRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGV-STDHAFLVSIIVGAVNFAFTF 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 299 IGA-LSDKIGRRTSML--CFGSLAAIFTVPILSALQNVSSPYAAFG--LVMCALLIVSFYTSISGI---LKAEMFPAQVR 370
Cdd:TIGR00879 338 VAIfLVDRFGRRPLLLigAAGMAICLFVLGILGASFVTGSSKSSGNvaIVFILLFIAFFAMGWGPVpwvIVSEIFPLSLR 417
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 16130512 371 ALgvGLSYAVANAIFGG---SAEYVALsLKSIGMETAFFWYVTLMAVVAFLV 419
Cdd:TIGR00879 418 PK--GISIAVAANWLANfivGFLFPTM-LESIGVGGVFIFFGGLNVLGLIFV 466
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
78-418 |
3.46e-05 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 45.86 E-value: 3.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 78 IGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEGR 157
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVL--------MVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 158 KGFYASFQYVTL-IG---GQLLALLVVVVLQHTmedaalrewGWRIPFALGAVLAVVALWLRRQLDEtSQQETRALkeag 233
Cdd:cd17437 119 RGFLTSFPEIFInIGillGYVSNYAFSGLPLHV---------GWRLMLGVGAVPSLFLAIGVLAMPE-SPRWTPAV---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 234 slkglwrnRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMH-------ANVASGIMTAALFVFMLIqpligaLSDKI 306
Cdd:cd17437 185 --------RRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKskdklllATVAVGVTKTLFILVATF------LLDKV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 307 GRRTSMLC--FGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTS-------ISGILKAEMFPAQVRALGVGLS 377
Cdd:cd17437 251 GRRPLLLTstGGMTLSLTALATSLTFIDRNGGGLTWALVLAITAVCSFVAFfsigagpITWVYSSEIFPLRLRAQGASLG 330
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 16130512 378 YAVaNAIFGGSAEYVALSL-KSIGMETAFFwyvtLMAVVAFL 418
Cdd:cd17437 331 VVV-NRLMSGTVSMTFLSMsKAITTGGTFF----LFAGVAAA 367
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
64-380 |
1.12e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.18 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 64 QTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMmcFGSLVIAclpgyeTIGTWAPALLLLARLFQGLSVGGEYG 143
Cdd:PRK11551 51 QMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVAL--FGLFSLA------TAQAWDFPSLLVARLLTGVGLGGALP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 144 TSATYMSEVAVEGRKGFYASFQYVTL-IGGQLLALLVVVVLQHTmedaalrewGWRIPFALGAV--LAVVALwLRRQLDE 220
Cdd:PRK11551 123 NLIALTSEAVGPRLRGTAVSLMYCGVpFGGALASVIGVLAAGDA---------AWRHIFYVGGVgpLLLVPL-LMRWLPE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 221 TS---QQETRALKEAGSLKGLWRNRRAFIMVLGFTAagslCFYTFTT-YM--------------QKYLVNTAGMHANVAS 282
Cdd:PRK11551 193 SRafaQAAGAGKQRAPVLRALFGEGRATATLLLWIS----YFFTLIVlYFllnwlpsllvgqglSRSQAGLVQIAFNIGG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 283 GIMTAalfvfmliqpLIGALSDKIGRRTSMLCF--GSLAAIFTVPILSALqnVSSPYAAFGLVMCalliVSFYTSISGIL 360
Cdd:PRK11551 269 ALGSL----------LIGALMDRLRPRRVVLLIyaGILASLAALAAAPSF--AGMLLAGFAAGLF----VVGGQSVLYAL 332
|
330 340
....*....|....*....|
gi 16130512 361 KAEMFPAQVRALGVGLSYAV 380
Cdd:PRK11551 333 APLFYPTQVRGTGVGAAVAV 352
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
62-419 |
1.18e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 62 LLQTAGVFAAGFLMRPIGgwlfgRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGTWAPallllarlFQGLSVGGE 141
Cdd:cd17474 38 LLITAFTLPAAVLMPVAG-----VLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRA--------LQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 142 YGTSATYMSEVAVEGRK----GFYASFQYVT-----LIGGqllallvvvvlqhtmedaALREWGWRIPFALGAVLAVVAL 212
Cdd:cd17474 105 GPLALTLIGDLFEGGERakamGLYEAALGLGiavgpLLGG------------------LLAAISWRYPFFLLAALIPVAF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 213 WLRRQLDETSQQETRALKEAGSLKGLWRNRRAFIMVLGFTAA-GSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFV 291
Cdd:cd17474 167 LAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFlYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 292 FMLIQPLIGALSDK-IGRRTSML-CFGSLAAIFTV-PILSALQNVSSPYAAFGLVMcALLIVSFYTSIsgilkAEMFPAQ 368
Cdd:cd17474 247 LALGSLFVGRLLKKrFGARRILViGLLLYALSLLLlGFVPSLALLLIAIVLFGLGL-GLNLPLLTTLV-----TELAPEE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 16130512 369 VRALGVGLsYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLV 419
Cdd:cd17474 321 ERGTASSL-YNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
195-423 |
1.24e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.10 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 195 WGWRIPFALGAVLAVVALWLrrqldetsqqetralkeagslkgLWRNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTA 274
Cdd:cd17319 154 FGWRWAFIIEGLLGLLLAVL-----------------------WWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQAR 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 275 GMHaNVASGIMTAALFVFMLI-QPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFY 353
Cdd:cd17319 211 GFS-LKQVGLLAAIPFLAGAIgMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAAS 289
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 354 TSISGILkAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLML 423
Cdd:cd17319 290 PVFWSLP-ADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
195-384 |
1.39e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.76 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 195 WGWRIPFALGAVLAVVALWL-----RRQLDETSQQETRALKEAGSLKGLWRNRRAFIMVLGFTA----AGSLCFyTFTTY 265
Cdd:cd17328 155 WAFRVTGVLGVLLAILLLLFvreppRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAvsfvTGALAF-WAPTF 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 266 MQKYLVNTAGMHANVaSGIMTAALFVFMLIQPLIGA-LSDKIGRRTS----MLC-FGSLAAIFTVpILSALQNVSSPYAA 339
Cdd:cd17328 234 FLRAFGVGDLSSADV-GLIFGAITCIAGVLGVLLGGiLADRLRRKTPradpLVCaVGLLAAAPFL-FLALVLALSNLLLA 311
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 16130512 340 FGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAI 384
Cdd:cd17328 312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLL 356
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
280-426 |
1.52e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.80 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 280 VASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVpILSALQNVSSPYAAFGLVMCALLIVSFYTSISGI 359
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV-LLALATSLWQLYLLWGLLGGGGAGTLAAVAFATV 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16130512 360 LKAEMFPAQVRALGVGLSYAVANAIFGgsAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRK 426
Cdd:cd17355 118 AAWWFERRRGLALGILTAGGGLGSLVF--LPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRR 182
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
195-348 |
1.82e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.44 E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 195 WGWRIPFALGAVLAVVALWLRRQLDETS--QQETRALKEAGSLKGLWRNRRAFIMVLGFTAAGSlcFYTFTTYMQKYLVN 272
Cdd:TIGR00886 165 WGWAFVIVPAGILLLPALLIFFVGADTPpgKPATGKLSFKEALKVFGNRHTWILALLYSVTFGS--FLGVSSIFAMLFKD 242
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130512 273 TAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALL 348
Cdd:TIGR00886 243 QFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFF 318
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
202-419 |
4.11e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 42.49 E-value: 4.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 202 ALGAVLAVVALWLRRQLDETSQQETRALKE-AGSLKGLWRNRRAFIMVLgFTAAGSLCFYTFTTYMQKYLVNTAGMHANV 280
Cdd:cd17337 167 ALGGLIALFLVRDRTGEQPLANPSEEPLKElLSGITILFRNPKIAIGGI-VRIINTLSQFGFPVFMPLYFTDTGGFSTSQ 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 281 ASGIMTAALFVFMLIQPLIGALSDKIG-RRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLI-VSFYTSISG 358
Cdd:cd17337 246 WLQIWGIIFLVNIFFNLIFGILGDKIGwRRTVRWFGGVGCAISTLLFYYVPQLFGHNYWAALIAAILFGIgLAGFVPLSA 325
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16130512 359 IlkaemFPAQ----------VRALGVGLSYAVANAIfggsaeyVALSLKSIGMETAFFWYVTLMAVVAFLV 419
Cdd:cd17337 326 L-----MPSLapehkgaamsILNLGAGLSNFVGPAI-------VTLFLGSFGAGGVVWIFAGLYLLSAVLT 384
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
64-423 |
1.14e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 64 QTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIAclpgyetIGTWAPALLLLARLFQGLSVGGEYG 143
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLA-------LATSLWQLYLLWGLLGGGGAGTLAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 144 TSATYMSEVAVEGRKGFYASFqyVTLIGGQLLALLVVVVlqhtmeDAALREWGWRIPF-----ALGAVLAVVALWLRRQL 218
Cdd:cd17355 112 VAFATVAAWWFERRRGLALGI--LTAGGGLGSLVFLPLG------AALIEAFGWRTALlvlalLALLVLVPVLLLLRRRP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 219 DETSQQETRALKEAG---SLKGLWRNRRAFIMVLGFTAAGsLCFYTFTTYMQKYLVNtAGMHANVASGIMtAALFVFMLI 295
Cdd:cd17355 184 ADLALRAYDDASPASpgsTLKEALRSASFWLLALAFFLCG-FAVVGLIVHLVPYLAD-RGISPAAAAVAL-ALIGLFNIV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 296 -QPLIGALSDKIGRRTsmlcfgSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGI---LKAEMFPAQVRA 371
Cdd:cd17355 261 gRLLSGWLGDRYSPRR------LLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLtaaLAARYFGARSYG 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 16130512 372 LGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLML 423
Cdd:cd17355 335 TLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
257-426 |
1.54e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.49 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 257 LCFYTFTTYMQKYLVNTA--------GMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILS 328
Cdd:cd06174 1 LLLGFFLTGLARGLISPLlpallqsfGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 329 AlqnVSSPYAAFGLVMCALLIVSFYTSISGILkAEMFPAQVRALGVGLSYAVANA--IFGGSAEYVALSLKSIGMETAFF 406
Cdd:cd06174 81 A---PSFWLLLLGRFLLGLGSGLIDPAVLALI-ADLFPERERGRALGLLQAFGSVggILGPLLGGILASSLGFGWRAVFL 156
|
170 180
....*....|....*....|
gi 16130512 407 WYVTLMAVVAFLVSLMLHRK 426
Cdd:cd06174 157 IAAALALLAAILLLLVVPDP 176
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
82-423 |
1.56e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 82 LFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSATYMSEVAVEGRK--- 158
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL--------LASRALLGIGVAGIMTLATALIGDYFEGEERakm 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 159 -GFYASFQYV-----TLIGGqllallvvvvlqhtmedaALREWGWRIPFAL----GAVLAVVALWLRRQLDETSQQETRA 228
Cdd:cd17473 126 lGLQSAAMSLggvvfLLLGG------------------ALAEIGWRAPFLVyllaLPVLILVLLFLPEPARKSKSAASPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 229 LKEAGSLKglwrnRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGR 308
Cdd:cd17473 188 AATAAALP-----WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 309 RTSMLCFGSLAAI--FTVPILSALQNVSSPYAAFGLVmCALLIVSFYTSISGILkaemfPAQVRALGVGLsyaVANAIFG 386
Cdd:cd17473 263 RRLLAIGFALMALgfLLLALASGLWVVLLGAILAGLG-FGLLLPTLNSWAMSLV-----PPELRGRAMGI---VTSAFFL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 16130512 387 G---SAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLML 423
Cdd:cd17473 334 GqflSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
78-384 |
1.75e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 78 IGGWLFGRIADKHGRKKSMLLS--VCMMCFGSLVIACLPGYETIGtwapallllaRLFQGLSVGGEYGTSATYMSEVAVE 155
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGllLRALGFALLGFAHSPWLFAIA----------LVLTGFGGGLFEPASEAMIADVTTP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 156 GRKGFYASFQYV---------TLIGGqllallvvvvlqhtmedaALREWGWRIPFALGAVLAVV-ALWLRRQLDETsQQE 225
Cdd:cd17329 120 ENRTRAFSLLYWainlgvaigPLLGG------------------LLLLYSFRLLFLAAAVLFLLaALVLLFLLPET-RPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 226 TRALKEAGSLKGLWR--NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALS 303
Cdd:cd17329 181 RRAAEKTEILRGYKIvlRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 304 DKIGRRTSMLCFGSLAAIFTVPILSAlqnvSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRAL---GVGLSYAV 380
Cdd:cd17329 261 ERFRLRKILMIGILLFAIGFAVLAFA----NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSymgFYALAWGL 336
|
....
gi 16130512 381 ANAI 384
Cdd:cd17329 337 GRAI 340
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
68-423 |
5.95e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 5.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 68 VFAAGFLMrpiggwLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIgtwapallLLARLFQGLSVGGEYGTSAT 147
Cdd:cd17321 42 LAFAALLL------LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--------IAARALQGIGAAAIMPASLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 148 YMSEVAVEGRK----GFYASFQYVT-----LIGGqllallvvvvlqhtmedAALREWGWRIPFALGAVLAVVALWLrrql 218
Cdd:cd17321 108 LIAATFPGERRgralGLWGAVVGIGaalgpLLGG-----------------LLLELFGWRWIFLINVPIGLVALLL---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 219 detsqqetralkeagslkglwrnRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPL 298
Cdd:cd17321 167 -----------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 299 IGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQ---------- 368
Cdd:cd17321 224 AGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKagaasgilnt 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130512 369 VRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAF-----------FWYVTLMAVVAFLVSLML 423
Cdd:cd17321 304 ARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAaaafaagfhlaFLVAAALALLAALLALLL 369
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
133-423 |
6.01e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 38.77 E-value: 6.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 133 FQGLSVGGEYGTSATYMSEVA-VEGRKGFYASFQYVTLIGGQLLALLVVVVLQHtmedaalREWGWRIPFALGAVLAVVA 211
Cdd:cd17361 113 LLGFGVGFGNQAVPLYLSEMApAKLRGALNIGFQLAITIGILIANLINYGTSKI-------KPNGWRLSLGLAAVPALIL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 212 LWLRRQLDET--SQQETRALkeagslkglwrnrrAFIMVLGFTAAGSLCFYT---FTTymqkylVNTAGMHANVASGIMT 286
Cdd:cd17361 186 LLGSLFLPETpnSPQLVIAI--------------LIPFFQQLTGINVIMFYApvlFQT------LGFGSDASLISAVITG 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 287 AALFVFMLIQPLigaLSDKIGRRT-------SMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSF---YTSI 356
Cdd:cd17361 246 AVNVVSTLVSIY---LVDRFGRRFllleggvQMLASQVAIGILLAVKFGDGGELPKAYAIAVVVLICLYVAAFawsWGPL 322
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16130512 357 SGILKAEMFPAQVRALGVGLSYAVaNAIFGGSAEYVALSlksigMETAFFWYVTLMAvvAFLVSLML 423
Cdd:cd17361 323 GWLVPSEIFPLETRSAGQSLTVAV-NFLFTFVIAQAFLS-----MLCAMKFGIFLFF--AGWVVVMS 381
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
195-296 |
7.48e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 38.33 E-value: 7.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 195 WGWRIPFALGAVLAVVAL--WLRRQLDetsQQETRALKEAGSLKGLWRNRRAFiMVLGFTAAGSLCFYTFTTYMQKYLVN 272
Cdd:cd17339 150 GGWRGALAIWALPALLALliWLPQLRR---RKRAAAAAAPLTKISVWRSPLAW-QVTLFMGLQSLLFYTLMAWLPTILID 225
|
90 100
....*....|....*....|....
gi 16130512 273 tAGMHANVASGImtaaLFVFMLIQ 296
Cdd:cd17339 226 -AGLSAATAGWL----LSLFQLVG 244
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
279-428 |
9.09e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 37.94 E-value: 9.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130512 279 NVASGIMTAALFVFMLI-QPLIGALSDKIGRRTSMLcfGSLAAIFTVPILSALqnVSSPYAAFGLVMCALLIVSFYTSIS 357
Cdd:cd17325 30 VAQIGLIVAAYALAQLLfSPPAGRLSDRFGRKRLLL--LGLLLLAVSTLLFAF--ATSYWQLLLARFLQGLASAAVWPAA 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16130512 358 GILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGK 428
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRP 176
|
|
| |
