NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|16129445|ref|NP_416003|]
View 

putative D,D-dipeptide ABC transporter membrane subunit DdpB [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

ABC transporter permease( domain architecture ID 11427312)

ABC transporter permease similar to ABC oligopeptide transporter permease proteins (OppB, AppB, and AmiC), the transmembrane subunits (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters which generally bind type 2 PBPs

Gene Ontology:  GO:0055085
PubMed:  18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 6-337 3.97e-111

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 325.87  E-value: 3.97e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   6 ILRqRCWGLVLVVAGVCVITFIISHLIPGDPARLLAGDRASDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRT 85
Cdd:COG0601   5 ILR-RLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTSFVY 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  86 GRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILP 165
Cdd:COG0601  84 GRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLGWLP 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 166 GGGRLDDWldppthvtgfylldallegngEVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLP 245
Cdd:COG0601 164 VSGRVSPW---------------------EDFLDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLS 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 246 GWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDL 325
Cdd:COG0601 223 ERRVLLRHALRNALIPVVTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDL 302

                       330
                ....*....|..
gi 16129445 326 LYLWIDPRIGRG 337
Cdd:COG0601 303 LYALLDPRIRLG 314
 
Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 6-337 3.97e-111

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 325.87  E-value: 3.97e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   6 ILRqRCWGLVLVVAGVCVITFIISHLIPGDPARLLAGDRASDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRT 85
Cdd:COG0601   5 ILR-RLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTSFVY 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  86 GRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILP 165
Cdd:COG0601  84 GRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLGWLP 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 166 GGGRLDDWldppthvtgfylldallegngEVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLP 245
Cdd:COG0601 164 VSGRVSPW---------------------EDFLDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLS 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 246 GWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDL 325
Cdd:COG0601 223 ERRVLLRHALRNALIPVVTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDL 302

                       330
                ....*....|..
gi 16129445 326 LYLWIDPRIGRG 337
Cdd:COG0601 303 LYALLDPRIRLG 314
PRK10914 PRK10914
dipeptide ABC transporter permease DppB;
10-334 1.32e-74

dipeptide ABC transporter permease DppB;


Pssm-ID: 182834 [Multi-domain]  Cd Length: 339  Bit Score: 233.55  E-value: 1.32e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   10 RCWGLVL-VVAGVCVITFIISHLIPGDPARLLAGDRA-SDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGR 87
Cdd:PRK10914   7 RRLGLVIpTFIGITLLTFAFVHMIPGDPVMIMAGERGiSPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGISLKSRI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   88 PVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILPGG 167
Cdd:PRK10914  87 PVWDEFVPRFKATLELGVCAMIFAVAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  168 GRLDD--WLDPPTHVTGFYLLDALLEGNGEVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLP 245
Cdd:PRK10914 167 GRVSDmvFLDDSNPLTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTARAKGLT 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  246 GWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDL 325
Cdd:PRK10914 247 RMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILVNLLVDL 326


                 ....*....
gi 16129445  326 LYLWIDPRI 334
Cdd:PRK10914 327 LYGVVNPRI 335
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 115-336 1.45e-24

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 98.53  E-value: 1.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   115 GIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFyghlqilpgggrlddwldppthvtgfylldallegng 194
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIA------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   195 evFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDLL 274
Cdd:pfam00528  44 --ILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGAL 121

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16129445   275 YGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYLWIDPRIGR 336
Cdd:pfam00528 122 GGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 114-315 2.51e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.39  E-value: 2.51e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 114 IGIPLGILSAvWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQilpgggrlddwldppthvtgfylldallegn 193
Cdd:cd06261  18 LGLLLGIILA-RKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG------------------------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 194 gevfFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDL 273
Cdd:cd06261  66 ----WGILPGLGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARA 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 16129445 274 LYGAVLTETVFA----WPGMGAWVVTSIQALDFPAVMGFAVVVSFA 315
Cdd:cd06261 142 LGEFALVSFLGGgeapGPGTGLLLIFAILFPGDLGVAAAVALILLL 187
 
Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 6-337 3.97e-111

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 325.87  E-value: 3.97e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   6 ILRqRCWGLVLVVAGVCVITFIISHLIPGDPARLLAGDRASDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRT 85
Cdd:COG0601   5 ILR-RLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTSFVY 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  86 GRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILP 165
Cdd:COG0601  84 GRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLGWLP 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 166 GGGRLDDWldppthvtgfylldallegngEVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLP 245
Cdd:COG0601 164 VSGRVSPW---------------------EDFLDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLS 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 246 GWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDL 325
Cdd:COG0601 223 ERRVLLRHALRNALIPVVTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDL 302

                       330
                ....*....|..
gi 16129445 326 LYLWIDPRIGRG 337
Cdd:COG0601 303 LYALLDPRIRLG 314
PRK10914 PRK10914
dipeptide ABC transporter permease DppB;
10-334 1.32e-74

dipeptide ABC transporter permease DppB;


Pssm-ID: 182834 [Multi-domain]  Cd Length: 339  Bit Score: 233.55  E-value: 1.32e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   10 RCWGLVL-VVAGVCVITFIISHLIPGDPARLLAGDRA-SDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGR 87
Cdd:PRK10914   7 RRLGLVIpTFIGITLLTFAFVHMIPGDPVMIMAGERGiSPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGISLKSRI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   88 PVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILPGG 167
Cdd:PRK10914  87 PVWDEFVPRFKATLELGVCAMIFAVAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  168 GRLDD--WLDPPTHVTGFYLLDALLEGNGEVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLP 245
Cdd:PRK10914 167 GRVSDmvFLDDSNPLTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTARAKGLT 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  246 GWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDL 325
Cdd:PRK10914 247 RMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILVNLLVDL 326


                 ....*....
gi 16129445  326 LYLWIDPRI 334
Cdd:PRK10914 327 LYGVVNPRI 335
PRK15081 PRK15081
glutathione ABC transporter permease GsiC; Provisional
 9-314 7.27e-69

glutathione ABC transporter permease GsiC; Provisional


Pssm-ID: 185039 [Multi-domain]  Cd Length: 306  Bit Score: 217.66  E-value: 7.27e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445    9 QRCWGLVLVVAGVCVITFIISHLIPGDPARLLAGDRASDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGRP 88
Cdd:PRK15081   7 KRLLGLIPTLLIVAVLVFLFVHLLPGDPARLAAGPEADAQVVALVRQQLGLDQPLPHQFWHYISNALQGDFGTSMVSRRP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   89 VLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILPGGG 168
Cdd:PRK15081  87 VSEEIASRFMPTLWLTITSMVWAVIFGMAIGIASAVWRNRWPDRLGMTLAVSGISFPAFALGMLLMQVFSVELGWLPTVG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  169 RlDDWldppthvtgfylldallegngevffnalQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWY 248
Cdd:PRK15081 167 A-DSW----------------------------QHYILPSLTLGAAVAAVMARFTRASFVEVLSEDYMRTARAKGVSETW 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16129445  249 IVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSF 314
Cdd:PRK15081 218 VVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEVLLFSL 283
SapB COG4168
ABC-type antimicrobial peptide export system, permease component SapB [Defense mechanisms];
3-313 5.03e-63

ABC-type antimicrobial peptide export system, permease component SapB [Defense mechanisms];


Pssm-ID: 443329 [Multi-domain]  Cd Length: 321  Bit Score: 203.15  E-value: 5.03e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   3 FWSILRqRCWGLVLVVAGVCVITFIISHLIPGDPARllagdrasdaivenirqqlglDQPLYVQFYRYVSDLFHGDLGTS 82
Cdd:COG4168   2 LIYLLR-RLNLLLITLLILSLISFSLLYRDPLNPLS---------------------DASLFSGYLFYLQNLLQGDFGIS 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  83 IRTGRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQ 162
Cdd:COG4168  60 SINGEPILEQLLTVFPATLELCFLAFLLALLIGIPLGILAGIYRGKWLDKLISSLSLLGFSIPVFWLALLLILFFSLNLG 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 163 ILPGGGRLdDWLDPPTHVTGFYLLDALLEGNG---EVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTA 239
Cdd:COG4168 140 WLPVSGRY-NLLYEIPPVTGFALIDAWLSDSPyrlKAIQSALQHLILPTLVLAVAPTTEVIRLTRQSTEEVMNQNYIKAA 218

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16129445 240 RASGLPGWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVS 313
Cdd:COG4168 219 ATRGLSRFTIIRRHVLRNALPPIIPQLGLQFSTMLTLAMITEVVFSWPGIGRWLINAIRQQDYAAISAGVIVIG 292
PRK10352 PRK10352
nickel transporter permease NikB; Provisional
 14-339 1.76e-61

nickel transporter permease NikB; Provisional


Pssm-ID: 182400 [Multi-domain]  Cd Length: 314  Bit Score: 198.77  E-value: 1.76e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   14 LVLVVAGVCVITFIISHLIPGDPArlLAGDRAS-----DAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGRP 88
Cdd:PRK10352  12 LIPMLLAASVIIFLMLRLGTGDPA--LDYLRLSnlpptPEMLASTRTMLGLDQPLYVQYGTWLWKALHLDFGISFATQRP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   89 VLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILPGGG 168
Cdd:PRK10352  90 VLDDLLNFLPATLELAGAALVLILLTSVPLGIWAARHRDRLPDFAVRFIAFLGVSMPNFWLAFLLVMAFSVYLQWLPAMG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  169 RlddwldppthvtgfylldallegngevffNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWY 248
Cdd:PRK10352 170 Y-----------------------------GGWQHIILPAVSIAFMSLAINARLLRASMLEVAGQRHVTWARLRGLSERQ 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  249 IVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYL 328
Cdd:PRK10352 221 VERRHILRNASLPMITAVGMHIGELIGGTMIIENIFAWPGVGRYAVSAIFNRDYPVIQCFTLMMVVVFVVCNLIVDLLNA 300

                        330
                 ....*....|.
gi 16129445  329 WIDPRIGRGGG 339
Cdd:PRK10352 301 ALDPRIRRHEG 311
PRK15110 PRK15110
peptide ABC transporter permease SapB;
70-312 2.23e-47

peptide ABC transporter permease SapB;


Pssm-ID: 185065 [Multi-domain]  Cd Length: 321  Bit Score: 162.55  E-value: 2.23e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   70 YVSDLFHGDLGTSIRTGRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWL 149
Cdd:PRK15110  47 WFNGLLHWDFGVSSINGQPISEQLKEVFPATMELCILAFGFALLVGIPVGIIAGVTRHKWQDNLISALALLGFSIPVFWL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  150 GLGVIVLFYGHLQILPGGGRLdDWLDPPTHVTGFYLLDALLEGN---GEVFFNALQHLILPALTLAFVHLGIVARQIRSA 226
Cdd:PRK15110 127 ALLLTLFFSLTLGWLPVSGRF-DLLYEVKPVTGFALIDAWLSDSpwrDEMIMSAIRHMILPVITLAVAPTTEVIRLMRIS 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  227 MLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVM 306
Cdd:PRK15110 206 TIEVYDQNYVKAAATRGLSRFTILRRHVLHNALPPVIPRLGLQFSTMLTLAMITEMVFSWPGLGRWLINAIRQQDYAAIS 285


                 ....*.
gi 16129445  307 GFAVVV 312
Cdd:PRK15110 286 AGVMVV 291
oppB PRK09471
oligopeptide ABC transporter permease OppB;
24-334 9.41e-37

oligopeptide ABC transporter permease OppB;


Pssm-ID: 181886 [Multi-domain]  Cd Length: 306  Bit Score: 134.04  E-value: 9.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   24 ITFIISHLIPGDParlLAGDRA-SDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGRPVLEEL-RIFFPATL 101
Cdd:PRK09471  22 ISFFMMRLAPGSP---FTGERTlPPEVMANIEAKYHLNDPIMTQYFSYLKQLAHGDFGPSFKYKDYSVNDLvASSFPVSA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  102 ELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILPGGGrlddWLDppthvt 181
Cdd:PRK09471  99 KLGAAAFFLAVILGVSAGVIAALKQNTKWDYTVMGFAMTGVVIPSFVVAPLLVLIFAITLHWLPGGG----WNG------ 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  182 gfylldallegngevffNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIP 261
Cdd:PRK09471 169 -----------------GALKFMILPMVALSLAYIASIARITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALKPALLP 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16129445  262 SITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYLWIDPRI 334
Cdd:PRK09471 232 VLSYMGPAFVGIITGSMVIETIFGLPGIGQLFVNGALNRDYSLVLSLTILVGALTILFNAIVDVLYAVIDPKI 304
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 115-336 1.45e-24

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 98.53  E-value: 1.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   115 GIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFyghlqilpgggrlddwldppthvtgfylldallegng 194
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIA------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   195 evFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDLL 274
Cdd:pfam00528  44 --ILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGAL 121

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16129445   275 YGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYLWIDPRIGR 336
Cdd:pfam00528 122 GGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 114-315 2.51e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.39  E-value: 2.51e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 114 IGIPLGILSAvWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQilpgggrlddwldppthvtgfylldallegn 193
Cdd:cd06261  18 LGLLLGIILA-RKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG------------------------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 194 gevfFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDL 273
Cdd:cd06261  66 ----WGILPGLGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARA 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 16129445 274 LYGAVLTETVFA----WPGMGAWVVTSIQALDFPAVMGFAVVVSFA 315
Cdd:cd06261 142 LGEFALVSFLGGgeapGPGTGLLLIFAILFPGDLGVAAAVALILLL 187
BPD_transp_1_N pfam19300
Binding-prot-dependent transport system membrane comp, N-term; This is the N-terminal ...
 14-100 1.35e-11

Binding-prot-dependent transport system membrane comp, N-term; This is the N-terminal transmembrane domain of the Binding-protein-dependent transport system inner membrane component.


Pssm-ID: 437132 [Multi-domain]  Cd Length: 114  Bit Score: 60.70  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445    14 LVLVVAGVCVITFIIS-------HLIPGDPARLLAGDRASDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGD-------- 78
Cdd:pfam19300   5 LVRRTLGAVVILLIISavtfflfYAIPRDPARLACGKNCTPETLALIRHNLGLDKPIPVQYWHFLSGIFAGRdfgavghc 84

                          90       100
                  ....*....|....*....|....*.
gi 16129445    79 ----LGTSIRTGRPVLEELRIFFPAT 100
Cdd:pfam19300  85 papcLGYSFANNEPVWDTIMDRFPTT 110
YejB COG4174
ABC-type microcin C transport system, permease component YejB [Secondary metabolites ...
 48-334 6.12e-11

ABC-type microcin C transport system, permease component YejB [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443333 [Multi-domain]  Cd Length: 363  Bit Score: 62.90  E-value: 6.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  48 AIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRN 127
Cdd:COG4174  81 EFIAELEKQYGFDKPAHERFLLMLKNYLRFDFGESYFRDISVIDLILEKLPVSISLGLWSTLLTYLISIPLGIRKAVRDG 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 128 RWLDHLVRIMAITGISTPAFWLGLGVIVLFYG--HLQILPGGGRL-DDW--LDPPTHVTGFylldallegngevffnaLQ 202
Cdd:COG4174 161 SRFDVWTSTVIIVGYAIPGFLFAILLIVLFAGgsYFDWFPLRGLTsDNWdqLSWWGKILDY-----------------LW 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 203 HLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVL-GLALGDLLYGAVLTE 281
Cdd:COG4174 224 HLTLPVTAMVIGGFATLTLLTKNSFLDEIRKQYVLTARAKGLSERRVLYGHVFRNAMLIVIAGFpAAFIGAFFTGSLLIE 303

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 16129445 282 TVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYLWIDPRI 334
Cdd:COG4174 304 TIFSLDGLGLLGFEAVVNRDYPVVFGTLYIFTLIGLVLKLISDLTYVLVDPRI 356
PRK15133 PRK15133
microcin C ABC transporter permease YejB; Provisional
 42-334 4.85e-10

microcin C ABC transporter permease YejB; Provisional


Pssm-ID: 185087 [Multi-domain]  Cd Length: 364  Bit Score: 60.15  E-value: 4.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445   42 GDRASDA-IVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGRPVLEELRIFFPATLELAFGALLLALLIGIPLGI 120
Cdd:PRK15133  77 GGRGLDPeVIAEITHRYGFDKPLHERYFKMLWDYIRFDFGDSLFRSASVLTLIKDSLPVSITLGLWSTLIIYLVSIPLGI 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  121 LSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFyghlqilpGGGRLDDWldppthvtgfYLLDALLEGNGEVF--- 197
Cdd:PRK15133 157 RKAVRNGSRFDVWSSAFIIIGYAIPAFLFAILLIVFF--------AGGSYFDL----------FPLRGLVSANFDSLpwy 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445  198 ---FNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDLL 274
Cdd:PRK15133 219 qkiTDYLWHITLPVLATVIGGFAALTMLTKNSFLDEIRKQYVVTARAKGVSEKNILWKHVFRNAMLLVIAGFPATFISMF 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16129445  275 Y-GAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYLWIDPRI 334
Cdd:PRK15133 299 FtGSLLIEVMFSLNGLGLLGYEATVSRDYPVMFGTLYIFTLIGLLLNIVSDISYTLVDPRI 359
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 208-291 3.99e-07

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 3.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129445 208 ALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGdllyGAVLTETVFAWP 287
Cdd:COG1173 145 ILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIA----SAILAEAGLSFL 220


                ....
gi 16129445 288 GMGA 291
Cdd:COG1173 221 GLGV 224
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 206-270 8.78e-03

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 37.66  E-value: 8.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16129445  206 LPALTLAFVHLGIVArQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLAL 270
Cdd:PRK15021 206 LLAITVLFGWMSLVG-VVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFIL 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH