|
Name |
Accession |
Description |
Interval |
E-value |
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
1-490 |
0e+00 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 924.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 1 MSSQYLRIFQQPRSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRR 80
Cdd:PRK11010 1 MSSQYLRIFQQPNSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFLGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 81 RGWLLATQILLLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSG 160
Cdd:PRK11010 81 RGWLLATQLLLLVAIAAMGFLEPGTQLRWLAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 161 GLALWLADKWLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAF 240
Cdd:PRK11010 161 GLALWLADRYLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 241 AMSLTTTFLIRGVGFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYSMG 320
Cdd:PRK11010 241 AMSLTTTFLIRGVGFDAGEVGLVNKTLGLLATIVGALYGGILMQRLSLFRALMIFGILQGVSNAGYWLLSITDKNLYSMG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 321 AAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILLL 400
Cdd:PRK11010 321 AAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWPTFYLFSVAAAVPGLLLLL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 401 VCRQTLEYTRVNDNFISRTAYPAGYAFAMWTLAAGVSLLAVWLLLLTMDALDLTHFSFLP-ALLEVGVLVALSGVVLGGL 479
Cdd:PRK11010 401 VCRQTLEYTQKTDNFIPRTEYPAGYRFALRLLLAGVSLLAVWLLLLTMNALDLTHFSFLPaTLLEVGVLVALSGIVLGGL 480
|
490
....*....|.
gi 16128418 480 LDYLALRKTHL 490
Cdd:PRK11010 481 LDYLALRKTHL 491
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
15-407 |
0e+00 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 527.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVA 94
Cdd:PRK11902 2 GAMLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 95 IAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADKWLGWQ 174
Cdd:PRK11902 82 IAAMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADRVLGWG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 175 GMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVG 254
Cdd:PRK11902 162 NTYLLMAGLMLAGALTTLWAPEPEVPARPPRSLGEAVVGPLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIRGAG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 255 FDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYSMGAAVFFENLCGGMGT 334
Cdd:PRK11902 242 FSAGEVGIVNKTLGLAATIVGALAGGTLMVRLGLYRSLMLFGVLQAVSNLGYWVLAVTPKHLWTMALAIGIENLCGGMGT 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128418 335 SAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILLLVCRQTLE 407
Cdd:PRK11902 322 AAFVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGWPGFYLMTVVIALPGLALLWLMRGTIG 394
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
17-402 |
1.58e-154 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 444.73 E-value: 1.58e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 17 LLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVAIA 96
Cdd:cd17486 1 ILLLGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRYSTPFLGRRRGWILLTQILLMAALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 97 AMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADkWLGWQGM 176
Cdd:cd17486 81 ALAFLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLAD-SLSWSAV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 177 YWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQ---AVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGv 253
Cdd:cd17486 160 YLIMAALMGPGILATLFAPEPPRTDPPANSLSEtvvAFFAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLLDL- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 254 GFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYSMGAAVFFENLCGGMG 333
Cdd:cd17486 239 GFTKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILQALSNLGFIYLAHAGPNLTLLVAAVAVENFGGGLG 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128418 334 TSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILLLVC 402
Cdd:cd17486 319 TTAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGWTGFFLLTTLAAIPGLLLLLKV 387
|
|
| 2A0125 |
TIGR00901 |
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions] |
25-363 |
1.27e-133 |
|
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
Pssm-ID: 273329 [Multi-domain] Cd Length: 356 Bit Score: 390.60 E-value: 1.27e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 25 GLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVAIAAMGFLEPG 104
Cdd:TIGR00901 1 GLPLGLVGNTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTVYLPFFGRRRSWLVLTQVLLLSLLLILSFLVPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 105 TQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADKWLG-------WQGMY 177
Cdd:TIGR00901 81 TDLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASPEFAntglitlWGYIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 178 WLMAALLIPCIIATL-LAPEPTDTIPVPKTLEQAVVAPLRDFFGRNN---AWLILLLIVLYKLGDAFAMSLTTTFLIRgV 253
Cdd:TIGR00901 161 FWTALLILPGLLVTLfLAKEPQEDASVPKPLTQAVLKPIREFFQRKNmiqALLLLLLIVLYKLGDSAATVLTTLFLLD-M 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 254 GFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLS-------ITDKHLYSMGAAVFFE 326
Cdd:TIGR00901 240 GFSKEEIALVAKINGLLGAILGGLIGGIIMQPLNILYALLLFGIVQALTNAGFVWLAsnghhdgITFPHLLMLFLTITLE 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 16128418 327 NLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAV 363
Cdd:TIGR00901 320 AVTGGLGTVAFVAFLSKLSNPKFGATQMALLSSLSAL 356
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
16-400 |
4.35e-69 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 225.57 E-value: 4.35e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 16 ILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVAI 95
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 96 AAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADKWlGWQG 175
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLI-GWQS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 176 MYWLMAALLIPCIIATLLAPEPTDT-IPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIrGVG 254
Cdd:cd17485 160 LLLSLAALYLLLLLPVLFLRELELPqQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLV-DRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 255 FDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSI--TDKHLYSMGAAVFFENLCGGM 332
Cdd:cd17485 239 FSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALggSGLNWVLLLASLALLHLVGGM 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128418 333 GTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILLL 400
Cdd:cd17485 319 ITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
15-398 |
1.17e-28 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 116.92 E-value: 1.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVA 94
Cdd:TIGR02718 4 ITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSWRLGRRRSWVLPMQCLVSAC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 95 IAAMGFLEPG-TQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADKwLGW 173
Cdd:TIGR02718 84 LASLALVGPDvAGAGWAVGLLACASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGK-FGQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 174 QGMYWLMAAL-LIPCIIATLLAPEPTDTIPVPKtleqAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRG 252
Cdd:TIGR02718 163 RPAFLLVACVpLASLVCVLWLKDRAVASPEAPL----ARRASLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 253 vGFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGAS------NAGYWLLSitdkHLYSMGAAVFFE 326
Cdd:TIGR02718 239 -GWPLEWIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTFILGVGLAGSLallwfaQAAFWLAP----GIAVAWSCSAFG 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128418 327 NLCGGMGTSAFVALLMTLCNKSFSA-TQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLIL 398
Cdd:TIGR02718 314 SLITGITSVAIYTAFMRFAGDGDQAgTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILL 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-400 |
2.37e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 86.71 E-value: 2.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 17 LLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQ--AYVFKFLWSPLMDRYtppffgRRRGWLLATQILLLVA 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSlgYALLQPLAGLLADRF------GRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 95 IAAMGFLepgTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLAD-KWLGW 173
Cdd:cd06174 75 ALLFAFA---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASsLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 174 QGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQA---VVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLI 250
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASsksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 251 RGVGFDAGEVGVVnKTLGLLATIVGALYGGILMQR-LSLFRALLIFGILQGASNAGYWLLSitdkHLYSMGAAVFFENLC 329
Cdd:cd06174 232 DLGGLSVAVAGLL-LSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAP----SLLLLLLLLLLLGFG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128418 330 GGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWF-VEAHGWSTFYLFSVAAAVPGLILLL 400
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-366 |
8.74e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 75.53 E-value: 8.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 17 LLILGFASGLPLALTSGTLQAWMTVE-NIDLKTIGFFSLVGQ--AYVFKFLWSPLMDRytppfFGRRRgWLLATQILLLV 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSlgYALAQPLAGRLSDR-----FGRRR-VLLIGLLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 94 AIAAMGFlepGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADkWLGW 173
Cdd:pfam07690 75 GLLLLLF---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 174 QGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGV 253
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 254 GFDAGEVGVVnKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYSMGAAVFFeNLCGGMG 333
Cdd:pfam07690 231 GLSALLAGLL-LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL-GFGFGLV 308
|
330 340 350
....*....|....*....|....*....|...
gi 16128418 334 TSAFVALLMTLCNKSFSATQFALLSALSAVGRV 366
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-364 |
1.12e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 69.23 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQ--AYVFKFLWSPLMDRytppfFGRRRgWLLATQILLL 92
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLlgAALGAPLAGRLADR-----FGRRR-VLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 93 VAIAAMGFLepgTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADkWLG 172
Cdd:COG2814 87 LGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 173 WQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLeqavvAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRG 252
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLR-----GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 253 VGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSitdkHLYSMGAAVFFENLCGGM 332
Cdd:COG2814 238 LGLSASAAGLLL-ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|..
gi 16128418 333 GTSAFVALLMTLCNKSFSATQFALLSALSAVG 364
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-380 |
1.55e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.16 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 19 ILGFASG-LPLALTSGTLQAWM-----TVENIDLKTIGFFSLVgqAYVFKFLWSPLM----DRyTPPFFGRRRGWLLATQ 88
Cdd:COG2211 12 KLAYGLGdLGLNLAFGLLSAYLlyfytDVLGLSAALVGLILLV--ARLWDAITDPLIgalsDR-TRTRWGRRRPWILIGA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 89 ILLLVAIAAMGF---LEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLP-AEERGAGAAISVLGYRLGMLVSGGLAL 164
Cdd:COG2211 89 IPLALSFVLLFTapdLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 165 WLADKW-----LGWQGMYWLMAALLIPCIIATLLApepTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDA 239
Cdd:COG2211 169 PLVAAFggdaaLGYRLTALIFAVLGLLAFLLTFFG---TKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 240 FAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDkhLYSM 319
Cdd:COG2211 246 LVAALLLYYFKYVLGLSAALVGLLL-ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN--LWLL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128418 320 GAAVFFENLCGGMGTSAFVALLMTLC-------NKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHG 380
Cdd:COG2211 323 LVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
77-403 |
5.81e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 64.13 E-value: 5.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 77 FGRRRgWLLATQILLLVAIAAMGFLEPGTQLrwmAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGM 156
Cdd:COG2223 67 FGPRR-VLLIGLLLLGIGLLLLALAVSYWLL---LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 157 LVSGGLALWLADKWlGWQGMYWLMA-ALLIPCIIATLLAPEPTDTIPVPktlEQAVVAPLRDFFGRNNAWLILLLIVLYK 235
Cdd:COG2223 143 AVAAFLAPLLIAAF-GWRNAFLILGiLLLVVAVLAWLFLRDPPAGAAAA---AKASLRDQLEALRDPRFWLLSLLYFGTF 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 236 LGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGasnAGYWLLSITDKH 315
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLA-ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA---LGLLLLALALGS 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 316 LYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHG-WSTFYLFSVAAAVP 394
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALV 374
|
....*....
gi 16128418 395 GLILLLVCR 403
Cdd:COG2223 375 ALVLTLLLY 383
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
67-401 |
5.34e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.09 E-value: 5.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 67 PLMDRYtppffgRRRGWLLATQIL--LLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAG 144
Cdd:cd06173 56 VLADRF------DRRRLLILADLLraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 145 AAISVLGYRLGMLVSGGLALWLADkWLGWQGMYWLMAALLIPCIIATLL--APEPTDTIPVPKTLEQAVVAPLRDFFGRN 222
Cdd:cd06173 130 NALNSLATQLARIIGPALGGLLVA-LLGPGGAFAINALSFLLSALLLLFirRPPPAAPGESSSLLLRDLREGLRYLRRSP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 223 NAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGLlATIVGALYGGILMQRLSLFRALLIFGILQGAS 302
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 303 NAGYWLLSitdkHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWS 382
Cdd:cd06173 288 LLVLGLSP----SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
330
....*....|....*....
gi 16128418 383 TFYLFSVAAAVPGLILLLV 401
Cdd:cd06173 364 AVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-403 |
2.06e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 2.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 60 VFKFLWSPLMDRYtppffGRRRGWLLATqILLLVAIAAMGFlepGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAE 139
Cdd:cd17325 46 LFSPPAGRLSDRF-----GRKRLLLLGL-LLLAVSTLLFAF---ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 140 ERGAGAAISVLGYRLGMLVSGGLALWLADkWLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFF 219
Cdd:cd17325 117 ERGRAMGIFSSAIGLGFLIGPLLGGLLAD-ALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 220 GRN-NAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSlFRALLIFGIL 298
Cdd:cd17325 196 LRDrRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF-GAQGLASALSQPPAGKLSDRIG-RKPLILIGLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 299 QGAsnAGYWLLSITDkHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVyVGP-VAGWFVE 377
Cdd:cd17325 274 LSA--VALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMV-LGPlLGGFLYD 349
|
330 340
....*....|....*....|....*.
gi 16128418 378 AHGWSTFYLFSVAAAVPGLILLLVCR 403
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
60-401 |
2.54e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.73 E-value: 2.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 60 VFKFLWSPLMDRytppfFGRRRGWLLATqILLLVAIAAMGFlepGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAE 139
Cdd:COG2271 60 LGQIPAGLLADR-----FGRRRVLAIGL-LLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 140 ERGAGAAISVLGYRLGMLVSGGLALWLADkWLGWQGMYWLMAALLIPCIIATLlapeptdtipvpktleqavvaplrdff 219
Cdd:COG2271 131 ERGRALGIFNAGGPLGGALAPPLLGWLLA-AFGWRAAFLILGLPGLLLALLRF--------------------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 220 grnnaWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQ 299
Cdd:COG2271 183 -----WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL-SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 300 GASnAGYWLLSITDkHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAH 379
Cdd:COG2271 257 LAA-LALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
330 340
....*....|....*....|..
gi 16128418 380 GWSTFYLFSVAAAVPGLILLLV 401
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALL 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-403 |
2.81e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 2.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQA--YVFKFLWSPLMDRytppfFGRRRGWLLAtqiLLL 92
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLgyLLASLPAGRLIDR-----FGYKRGLLLG---LLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 93 VAIAAMGFLEpGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVlpaEERGAGAAISVLG--YRLGMLVSGGLALWLADKW 170
Cdd:COG0738 83 MALGLLLFAL-APSYPLLLLALFLLGLGLGLLDVAANPYVAAL---GPETAASRLNLLHafFSLGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 171 LG--WQGMYWLMAALLIpcIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTF 248
Cdd:COG0738 159 LSlsWHLPYLILAVLLL--LLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 249 LIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGasnAGYWLLSITDKHLYSMGAAVFFenl 328
Cdd:COG0738 237 LKDVLGLSEATAALGL-SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAA---VGLLLALLAPGPWLALIGLALV--- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 329 cgGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGrvYVG-----PVAGWFVEAHGWSTFYLFSVAAAVPGLILLLVCR 403
Cdd:COG0738 310 --GLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG--IVGgaigpPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
16-159 |
3.64e-08 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 55.83 E-value: 3.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 16 ILLILGFASGLPLALTSGT----LQAwmTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQI-- 89
Cdd:pfam13000 3 LLVALYFLQGIPVGLAFGTipflLKS--MAKETSFTSLGIFSMATYPYSLKILWSPIVDSIYSKKIGRRRSWIIPVQLvs 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 90 -LLLVAIAAM---GFLEPG------------------TQLRWMAALAVviaFCSASQDIVFDAWKTDVLPAEERGAGAAI 147
Cdd:pfam13000 81 gIMLIILGYCiskGLIFPGvddafhgrlskgvlnvniTTLTWYFGILV---FLCATQDIAVDGWALTILSKQSLSYASTA 157
|
170
....*....|..
gi 16128418 148 SVLGYRLGMLVS 159
Cdd:pfam13000 158 QTVGLNTGYFLS 169
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
77-400 |
3.36e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.05 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 77 FGRRRGWLLAtqilLLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGM 156
Cdd:cd17489 58 FGRKRLLLIG----LLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 157 LVSGGLALWLADkWLGWQGMYWLMAALLIPCIIATLLAPEPtdtiPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYkl 236
Cdd:cd17489 134 ALGPALGLFLYQ-HLGFAVLFIVAAVLALLALLLVFLVKDP----PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLA-- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 237 gdAFAMSLTTTFLirgvGFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSL---FRALLIFGILQGAsnAGYWLLSITD 313
Cdd:cd17489 207 --SIAYGAISTFL----PLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDrkgPKTVIIPGLLLLA--LGLLLLSFAG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 314 KHLYSMGAAVFFeNLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAV 393
Cdd:cd17489 279 SPWMLLLAAVLY-GLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
....*..
gi 16128418 394 PGLILLL 400
Cdd:cd17489 358 LALVLYI 364
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
64-400 |
3.98e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.62 E-value: 3.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 64 LWSPLMDRytppfFGRRRgwLLATQILLLVAIAAMGFLEPGtqLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGA 143
Cdd:cd17324 53 LLGPLSDR-----IERRR--LLLVLLLLFILGNLLAALAPS--FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 144 GAAISVLGYRLGMLVSGGLALWLADkWLGWQGMYWLMAALLIPCIIATLLAPEPtdtIPVPKTLEQAVVAPLRDFFGRNN 223
Cdd:cd17324 124 AIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAAFLAIAVLALLAALLLWRLLPS---LPPKKPGSLGLLSSLLLLLRNPR 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 224 AWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGlLATIVGALYGGILMQRLsLFRALLIFGILQGASn 303
Cdd:cd17324 200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFG-VAGVVGSPLAGRLADRG-GRRALLIALLLLAAA- 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 304 agYWLLSITDKHLYSMGAAVFFENLCGGMGTSAFVALLMTLcNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWST 383
Cdd:cd17324 277 --LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAG 353
|
330
....*....|....*..
gi 16128418 384 FYLFSVAAAVPGLILLL 400
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
133-401 |
5.62e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 45.25 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 133 TDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADkWLGWQGMYWLMAAL-LIPCIIATLLAPeptdtipvpktleqav 211
Cdd:cd17319 117 AEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-LFGWRWAFIIEGLLgLLLAVLWWFYLR---------------- 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 212 vaplrdffgrnNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRA 291
Cdd:cd17319 180 -----------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLA-AIPFLAGAIGMILGGRLSDRLLRGAR 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 292 LLIFGILqGASNAGYWLLSITDKHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPV 371
Cdd:cd17319 248 RLVIIIG-LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
250 260 270
....*....|....*....|....*....|.
gi 16128418 372 AGWFVEA-HGWSTFYLFSVAAAVPGLILLLV 401
Cdd:cd17319 327 IGYLVDAtGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-399 |
8.24e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.86 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 15 AILLILGFASGLPLALTSgtlqAWMTVENIDLKTIGFFSLVgqAYVFKFLWSPLMDRYTppffgRRRGWLLATQILLLVA 94
Cdd:cd17477 3 LSVALLGLGSGLLLPLLS----LRLEREGVSTALIGLVASA--YYLGILLGSPLVPRLI-----RRVGHIRAFAAGAAIT 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 95 IAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVsGGLALWLADKwLGWQ 174
Cdd:cd17477 72 AVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVGT-AGAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 175 gMYWLMAALLIPCIIATLLAPEPtdtipvPKTLEQAVVAPLRDFFGRnnAWLILLLIVLYKLGDAFAMSLTTTFLIRgVG 254
Cdd:cd17477 150 -PFLIAAVLLLLALVPLLLTRRA------APEIEEAESISLRRLLRI--APLALLGAFVAGFLEGAFYSLLPLYGLR-LG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 255 FDAGEVGVVnKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYsmgaAVFFenLCGGMGT 334
Cdd:cd17477 220 LSVAQAALL-LAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL----VLLF--LWGGAAG 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128418 335 SAFvALLMTLCNKSFSATQF----ALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILL 399
Cdd:cd17477 293 PLY-TLALALAGDRLPGDELvaanAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
223-400 |
2.59e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 223 NAWLILLLIVLYKLGDAFAMSLTTTFL---IRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQ 299
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALpliAADLGASPAQAGLVV-TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 300 GASNAGYWLLSitdkHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAH 379
Cdd:COG2814 86 ALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|.
gi 16128418 380 GWSTFYLFSVAAAVPGLILLL 400
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLL 182
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
76-401 |
9.13e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.44 E-value: 9.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 76 FFGRRRGWLLATQILLLVAIAAMGFLEPGtqlrWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLG 155
Cdd:cd17490 57 RIGKRKLFIIIGLLFTVLASLIMILFPSP----WGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 156 MLVSGGLALWLADKWlGWQGMYWLMAALLIPCIIATLLAPEPtdtiPVPKTLEQAVVAPLRDFFGRNNAWLI-LLLIVLY 234
Cdd:cd17490 133 QLIAFLIGGLIAEHF-GMRAPFLLAALAGVLGFILSLFIKEE----RREKKPVLTELKELLSVLKDKKLLFFsLLAILQQ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 235 KLGDAFAMSLTTTFLiRGVGFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSitdk 314
Cdd:cd17490 208 MITFSTTFGFTPLIA-KQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAP---- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 315 HLYsmgaAVFFENLCGGMGTSAFVALLMTLCNKSFS----ATQFALLSALSAVGrVYVGPV-AGWFVEAHGWSTFYLFSV 389
Cdd:cd17490 283 NLT----LLYLLQALNGFGTGILFPLLMSLSIEGVPaeqrSTAMGFFQAIYALG-MFLGPVlVGIISEAFGLQTGFFVIG 357
|
330
....*....|..
gi 16128418 390 AAAVPGLILLLV 401
Cdd:cd17490 358 VIALLAAILSLA 369
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
78-343 |
1.68e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 40.76 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 78 GRRRGWLLATQILLLVAIAAM---GFLEPGTQLRWMAALAVVIAFCSASQDIVFDAW---KTDvlPAEER----GAGAAI 147
Cdd:pfam13347 65 GRRRPWLLLSAIILAVSFILLftpPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLgpeLTR--DYDERtsltSYRSFF 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 148 SVLGYRLGMLVSGGLALWLADKWL---GWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFG---R 221
Cdd:pfam13347 143 SVGGGLLAAALAFPLVLILGGTGLerkGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKevfR 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 222 NNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGA 301
Cdd:pfam13347 223 NRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFP-LVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIA 301
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 16128418 302 SNAGYWLLSITDkhLYSMGAAVFFENLCGGMGTSAFVALLMT 343
Cdd:pfam13347 302 GFALALLLGPNN--TLLFLVLYIIIGFGYGSSFFLPWSMLAD 341
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
80-400 |
1.76e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.61 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 80 RRGWLLATQILLLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVS 159
Cdd:cd17471 62 RKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 160 GGLALWLADKWlGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRdffgRNNAWLILLLIVLYKLGDA 239
Cdd:cd17471 142 PPLAFLLLDVL-GFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPV----NRRLLLLFAAFTLLFAANS 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 240 FAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLfRALLIFGILQGasnAGYWLLSITDKHLYSM 319
Cdd:cd17471 217 MYIIAMPLYVTNELGGSESWVGLLF-GLAAALEIPIMLLAGLLAKRFGK-RRLLLAGFLAG---VLFYLGLALATSLWQL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 320 GAAVFFEnlcgGMGTSAFVALLMTLC-----NKSFSATqfALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVP 394
Cdd:cd17471 292 IALQLLN----AIFIGITAGLGISYFqdlmpGQPGLAT--TLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
|
....*.
gi 16128418 395 GLILLL 400
Cdd:cd17471 366 ALVLLL 371
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
78-287 |
2.03e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.52 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 78 GRRRGWLLATQILLLVAIAAMGFLEPGTQlrWMAALAVVIAFCSASQDIVF-DAWKTDVLPAEERGagaAISVLGYRLGM 156
Cdd:COG2270 80 GRKKPFLAFFTLLGVLATAALFFVAPGGL--WLGLLLFVLANIGFEGSLVFyNAFLPDIATPEEIG---RVSGLGWALGY 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 157 LVSG-----GLALWLADKWLGWQGMYW------LMAAL--LIPCIIATLLAPEPtdTIPVPKTLEQAVVAPLRDFFG--- 220
Cdd:COG2270 155 LGGVlllliNLALFLKPEAFGLPDAGEavrisfLLTALwwLLFALPLFLFLPER--PRPGPAPPRGAVRAGFRELRRtlr 232
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16128418 221 --RNNAWLILLLIV--LYKLGDAFAMSLTTTFLIRGVGFDAGEVGVvnktLGLLATIVGALyGGILMQRLS 287
Cdd:COG2270 233 elRRYRDLLRFLLAyfFYRDGVQTVIAFAGIYAAGVLGFSTTELIV----FGLLVQIVAAL-GALLFGRLD 298
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-401 |
2.70e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 227 ILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGY 306
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLL-TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 307 WLLSitdkHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYL 386
Cdd:pfam07690 80 LFAS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170
....*....|....*
gi 16128418 387 FSVAAAVPGLILLLV 401
Cdd:pfam07690 156 ILAILSLLAAVLLLL 170
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
68-393 |
3.60e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 68 LMDRYTPpffgrrRGWLLATQILLLVAIAAMGFLEPGTQLrwMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAI 147
Cdd:cd17355 61 LLDRFGP------RRVMLLGLLLLAAGLVLLALATSLWQL--YLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 148 SVLGYRLGMLVSGGLALWLADkWLGWQGMYWLMAALLIPCIIATLLA----PEPTDTIPVPKTLEQAVVAPLRDFFGRNN 223
Cdd:cd17355 133 LTAGGGLGSLVFLPLGAALIE-AFGWRTALLVLALLALLVLVPVLLLlrrrPADLALRAYDDASPASPGSTLKEALRSAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 224 AWLILLLIVLYKLGDAFaMSLTTTFLIRGVGFDAGEVGVVNKTLGLLAtIVGALYGGILMQRLSLFRALLIFGILQGASN 303
Cdd:cd17355 212 FWLLALAFFLCGFAVVG-LIVHLVPYLADRGISPAAAAVALALIGLFN-IVGRLLSGWLGDRYSPRRLLAASYALRALGL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 304 AGYWLLSITDKHLYsmGAAVFFENLCGGMGTSAfVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHG--- 380
Cdd:cd17355 290 ALLLLLPFPPLALL--LFAALFGLGWGATVPLT-AALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsyt 366
|
330
....*....|....*
gi 16128418 381 --WSTFYLFSVAAAV 393
Cdd:cd17355 367 aaWALAVALGLIAAL 381
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
63-400 |
3.79e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 63 FLWSPLMDRYtppffGRRRGwLLATQILLLVAIAAMGFLepgTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERG 142
Cdd:cd17316 54 LLFGYLGDRI-----GRKKA-LILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 143 AGAAISVLGYRLGMLVSGGLALWLAD---KWLGWQGMYWLMAallIPCIIATLLapeptdtipvpktleqavvaplrdff 219
Cdd:cd17316 125 FALGLLQSGWALGALLAALVASLLIPllsGDWGWRILFLIGA---LPALLALLL-------------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 220 gRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQ 299
Cdd:cd17316 176 -RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYL-LLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 300 GASnaGYWLLSITDKHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAH 379
Cdd:cd17316 254 GIL--ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
330 340
....*....|....*....|..
gi 16128418 380 G-WSTFYLFSVAAAVPGLILLL 400
Cdd:cd17316 332 GgTGVPALILALLAIVALIVAL 353
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
58-193 |
3.89e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.43 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 58 AYVFKFLWSPLMDRytppfFGRRRGWLLATQILLLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLP 137
Cdd:cd17369 277 AAITIPLFGWLSDR-----VGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFP 351
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 138 AEERGAGAAisvLGYRLGMLVSGGL----ALWLADKWLGWQGMYWLMAALLIPCIIATLL 193
Cdd:cd17369 352 TRVRYTGAS---LGYQLGAILGGGFapliATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
139-401 |
4.11e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 139 EERGAGAAISVLGYRLGMLVSGGL-ALWLADKWLGWQGMYWLMAALLIPCIIATLLA-PEPTDTIPVPKTLEQAVVAPLR 216
Cdd:cd17353 123 DKRGLATGIVIAGFGLGSLIFSPLiAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRdPPKGWVPPGVDPLANNAENSPR 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 217 DFFGRNNA-----WLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGLlATIVGALYGGILMQRLSLFRA 291
Cdd:cd17353 203 DYTPREMLrtptfWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSI-FNGGGRPFWGWLSDKIGRKNT 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 292 LLIFGILQGAsnaGYWLLSITDKHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPV 371
Cdd:cd17353 282 LSIAFLIQGV---AMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPII 358
|
250 260 270
....*....|....*....|....*....|.
gi 16128418 372 AGWFVEAHGW-STFYLFSVAAAVPGLILLLV 401
Cdd:cd17353 359 AAYVLYTGGYnAAFIIAAALSLVALALALLL 389
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|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
77-401 |
4.55e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 77 FGRRRgWLLATQILLLVAIAAMGFLEpgtQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGM 156
Cdd:cd17329 62 FGRKP-VMLAGLLLRALGFALLGFAH---SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGV 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 157 LVSGGLALWLADkwLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEqAVVAPLRDFFGRNNAWLILLLIVLYKL 236
Cdd:cd17329 138 AIGPLLGGLLLL--YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKT-EILRGYKIVLRDRAFLLFLLASFLISL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 237 GDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLsitdKHL 316
Cdd:cd17329 215 IYFQLESTLPVYVVEILGLGESLLGLLL-ALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFA----NTL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128418 317 YSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVyVGPVAGWFVEAHgWSTFYLFSVAAAVPGL 396
Cdd:cd17329 290 AVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRA-IGPLVGGLLLDL-LGPGLPWLILAALGLI 367
|
....*
gi 16128418 397 ILLLV 401
Cdd:cd17329 368 AAALL 372
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