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Conserved domains on  [gi|16080896|ref|NP_391724|]
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transcriptional regulator controlling expression of tyrZ [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

MarR family transcriptional regulator( domain architecture ID 12204203)

MarR family transcriptional regulator is a winged helix-turn-helix domain-containing protein, named for an Escherichia coli regulator of an operon that encodes a drug efflux pump

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  10498949

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
54-154 9.30e-27

helix_turn_helix multiple antibiotic resistance protein;


:

Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 96.89  E-value: 9.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896     54 EVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTRDRRLVFVSITDSGKQAIEE 133
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 16080896    134 LYPEFHKGETELIAGMTKDEQ 154
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
54-154 9.30e-27

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 96.89  E-value: 9.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896     54 EVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTRDRRLVFVSITDSGKQAIEE 133
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 16080896    134 LYPEFHKGETELIAGMTKDEQ 154
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
35-167 5.36e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 88.49  E-value: 5.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896  35 SIATNLYRSAQRLRVKMEtEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTR 114
Cdd:COG1846  11 RLGLLLRRLARALRRALD-RALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 16080896 115 DRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGLLRKVADN 167
Cdd:COG1846  90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 61-119 2.78e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 61.02  E-value: 2.78e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16080896    61 LSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTRDRRLV 119
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 79-168 8.13e-04

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 38.19  E-value: 8.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896   79 ETRKI--AELS---GISTATASNVIKTLEKKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDE 153
Cdd:PRK10870  68 ENHSIqpSELScalGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTE 147

                         90
                 ....*....|....*
gi 16080896  154 QKILTGLLRKVADNL 168
Cdd:PRK10870 148 KDQLEQITRKLLSRL 162
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 42-127 3.56e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.56  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896    42 RSAQRLRVKMETEVLSTYN----------LSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCrKSI 111
Cdd:TIGR01884 112 VKTVVFRVYYESEELISFIdldlvpllagLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV-EQK 190

                          90
                  ....*....|....*.
gi 16080896   112 DTRDRRlvfVSITDSG 127
Cdd:TIGR01884 191 GRKGKR---YSLTKLG 203
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 46-125 3.77e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 36.59  E-value: 3.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896  46 RLRVKMETEVLSTYN----------LSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCrKSIDTRD 115
Cdd:cd09655 112 VVRVEYESEEEIDFIeldlvpllagLSREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLV-EQKGTKG 190

                        90
                ....*....|
gi 16080896 116 RRlvfVSITD 125
Cdd:cd09655 191 KR---YSLTK 197
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
54-154 9.30e-27

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 96.89  E-value: 9.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896     54 EVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTRDRRLVFVSITDSGKQAIEE 133
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 16080896    134 LYPEFHKGETELIAGMTKDEQ 154
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
35-167 5.36e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 88.49  E-value: 5.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896  35 SIATNLYRSAQRLRVKMEtEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTR 114
Cdd:COG1846  11 RLGLLLRRLARALRRALD-RALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 16080896 115 DRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGLLRKVADN 167
Cdd:COG1846  90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 61-119 2.78e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 61.02  E-value: 2.78e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16080896    61 LSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTRDRRLV 119
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 79-168 8.13e-04

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 38.19  E-value: 8.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896   79 ETRKI--AELS---GISTATASNVIKTLEKKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDE 153
Cdd:PRK10870  68 ENHSIqpSELScalGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTE 147

                         90
                 ....*....|....*
gi 16080896  154 QKILTGLLRKVADNL 168
Cdd:PRK10870 148 KDQLEQITRKLLSRL 162
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 42-127 3.56e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.56  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896    42 RSAQRLRVKMETEVLSTYN----------LSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCrKSI 111
Cdd:TIGR01884 112 VKTVVFRVYYESEELISFIdldlvpllagLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV-EQK 190

                          90
                  ....*....|....*.
gi 16080896   112 DTRDRRlvfVSITDSG 127
Cdd:TIGR01884 191 GRKGKR---YSLTKLG 203
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 46-125 3.77e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 36.59  E-value: 3.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896  46 RLRVKMETEVLSTYN----------LSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLEKKSFCrKSIDTRD 115
Cdd:cd09655 112 VVRVEYESEEEIDFIeldlvpllagLSREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLV-EQKGTKG 190

                        90
                ....*....|
gi 16080896 116 RRlvfVSITD 125
Cdd:cd09655 191 KR---YSLTK 197
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
72-148 6.88e-03

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 35.40  E-value: 6.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080896   72 LWVWGALETRKIAELSG---ISTATASNVIKTLEKKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAG 148
Cdd:PRK13777  51 LWIAYHLKGASISEIAKfgvMHVSTAFNFSKKLEERGYLTFSKKEDDKRNTYIELTEKGEELLLETMEEYDPENNSVFNG 130
HTH_27 pfam13463
Winged helix DNA-binding domain;
79-127 8.84e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 33.42  E-value: 8.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 16080896    79 ETRKIAELSGISTATASNVIKTLEKKSFCRKSIDTRDRRLVFVSITDSG 127
Cdd:pfam13463  20 TLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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