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Conserved domains on  [gi|15829589|ref|NP_308362|]
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oxidoreductase [Escherichia coli O157:H7 str. Sakai]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 4-187 4.18e-130

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19133:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 255  Bit Score: 365.36  E-value: 4.18e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19133   1 VTLNNGVEMPILGFGVFQIPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPF 163
Cdd:cd19133  81 KAKKAFERSLKRLGLDYLDLYLIHQPFGDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPF 160

                       170       180
                ....*....|....*....|....
gi 15829589 164 NQQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19133 161 NQQIEAVEFLKKYGVQIEAWGPFA 184
 
Name Accession Description Interval E-value
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 4-187 4.18e-130

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 365.36  E-value: 4.18e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19133   1 VTLNNGVEMPILGFGVFQIPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPF 163
Cdd:cd19133  81 KAKKAFERSLKRLGLDYLDLYLIHQPFGDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPF 160

                       170       180
                ....*....|....*....|....
gi 15829589 164 NQQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19133 161 NQQIEAVEFLKKYGVQIEAWGPFA 184
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 8-187 5.38e-105

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 301.97  E-value: 5.38e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:COG0656   1 NGVEIPALGLGTWQLPGE-EAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAASGVPREELFVTTKVWNDNHGYDDTLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  88 QFERSLNRLQLDYVDLYLIHQPY-GDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQ 166
Cdd:COG0656  80 AFEESLERLGLDYLDLYLIHWPGpGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQ 159

                       170       180
                ....*....|....*....|.
gi 15829589 167 LHAVPWMQSRGIQPEAWAPFA 187
Cdd:COG0656 160 RELLAFCREHGIVVEAYSPLG 180
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
4-190 2.52e-66

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 204.54  E-value: 2.52e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDtsYE 83
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVWQASNE-EVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEASVAREELFITTKLWNDD--HK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   84 GAKAQFERSLNRLQLDYVDLYLIHQP------YGDvhgAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQ 157
Cdd:PRK11565  84 RPREALEESLKKLQLDYVDLYLMHWPvpaidhYVE---AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQ 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 15829589  158 VEVNPFNQQ--LHAvpWMQSRGIQPEAWAPFAVTG 190
Cdd:PRK11565 161 IELHPLMQQrqLHA--WNATHKIQTESWSPLAQGG 193
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 15-187 7.95e-40

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 137.06  E-value: 7.95e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    15 LGFGVFQM------TDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIARNELFVTTKL------WLQD 79
Cdd:pfam00248   1 IGLGTWQLgggwgpISKEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDYPVKRDKVVIATKVpdgdgpWPSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH--GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQ 157
Cdd:pfam00248  81 GSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPieETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQ 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 15829589   158 VEVNPFN--QQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:pfam00248 161 VEYNLLRrrQEEELLEYCKKNGIPLIAYSPLG 192
 
Name Accession Description Interval E-value
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 4-187 4.18e-130

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 365.36  E-value: 4.18e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19133   1 VTLNNGVEMPILGFGVFQIPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPF 163
Cdd:cd19133  81 KAKKAFERSLKRLGLDYLDLYLIHQPFGDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPF 160

                       170       180
                ....*....|....*....|....
gi 15829589 164 NQQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19133 161 NQQIEAVEFLKKYGVQIEAWGPFA 184
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 8-187 5.38e-105

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 301.97  E-value: 5.38e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:COG0656   1 NGVEIPALGLGTWQLPGE-EAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAASGVPREELFVTTKVWNDNHGYDDTLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  88 QFERSLNRLQLDYVDLYLIHQPY-GDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQ 166
Cdd:COG0656  80 AFEESLERLGLDYLDLYLIHWPGpGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQ 159

                       170       180
                ....*....|....*....|.
gi 15829589 167 LHAVPWMQSRGIQPEAWAPFA 187
Cdd:COG0656 160 RELLAFCREHGIVVEAYSPLG 180
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 12-187 9.19e-87

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 255.48  E-value: 9.19e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  12 MPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKAQFER 91
Cdd:cd19071   1 MPLIGLGTYKLKPE-ETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESGVPREELFITTKLWPTDHGYERVREALEE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  92 SLNRLQLDYVDLYLIHQPYGDVHG--------AWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPF 163
Cdd:cd19071  80 SLKDLGLDYLDLYLIHWPVPGKEGgskearleTWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPY 159

                       170       180
                ....*....|....*....|....
gi 15829589 164 NQQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19071 160 LQQKELVEFCKEHGIVVQAYSPLG 183
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 4-190 5.49e-81

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 240.80  E-value: 5.49e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19126   1 VTLNNGTRMPWLGLGVFQTPDGDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRESGVPREELFVTTKLWNDDQRAR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQPYGD-VHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNP 162
Cdd:cd19126  81 RTEDAFQESLDRLGLDYVDLYLIHWPGKDkFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPAVNQVEFHP 160

                       170       180
                ....*....|....*....|....*...
gi 15829589 163 FNQQLHAVPWMQSRGIQPEAWAPFAVTG 190
Cdd:cd19126 161 YLTQKELRGYCKSKGIVVEAWSPLGQGG 188
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 4-185 2.40e-80

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 240.00  E-value: 2.40e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQmTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19127   1 ITLNNGVEMPALGLGVFQ-TPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRSGVDRSDIFVTTKLWISDYGYD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQP----YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVE 159
Cdd:cd19127  80 KALRGFDASLRRLGLDYVDLYLLHWPvpndFDRTIQAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPAVNQVE 159

                       170       180
                ....*....|....*....|....*.
gi 15829589 160 VNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19127 160 LHPYFSQKDLRAFHRRLGIVTQAWSP 185
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 3-185 6.27e-76

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 228.43  E-value: 6.27e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   3 KVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSY 82
Cdd:cd19157   1 TVTLNNGVKMPWLGLGVFKVEEGSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKESGIPREELFITSKVWNADQGY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDV-HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVN 161
Cdd:cd19157  81 DSTLKAFEASLERLGLDYLDLYLIHWPVKGKyKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEFH 160

                       170       180
                ....*....|....*....|....
gi 15829589 162 PFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19157 161 PRLTQKELRDYCKKQGIQLEAWSP 184
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 4-187 1.60e-74

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 224.56  E-value: 1.60e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19131   2 ITLNDGNTIPQLGLGVWQVSND-EAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRASGVPREELFITTKLWNSDQGYD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEV 160
Cdd:cd19131  81 STLRAFDESLRKLGLDYVDLYLIHWPvpaQDKYVETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIEL 160

                       170       180
                ....*....|....*....|....*..
gi 15829589 161 NPFNQQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19131 161 HPRFQQRELRAFHAKHGIQTESWSPLG 187
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 4-185 1.47e-71

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 217.39  E-value: 1.47e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19156   1 VKLANGVEMPRLGLGVWRVQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRESGVPREEVFVTTKLWNSDQGYE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNP 162
Cdd:cd19156  81 STLAAFEESLEKLGLDYVDLYLIHWPVKGKFkDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHP 160

                       170       180
                ....*....|....*....|...
gi 15829589 163 FNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19156 161 LLTQEPLRKFCKEKNIAVEAWSP 183
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 6-185 9.25e-69

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 209.82  E-value: 9.25e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   6 LNNGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGA 85
Cdd:cd19132   1 LNDGTQIPAIGFGTYPLKGD-EGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRRSGVPREELFVTTKLPGRHHGYEEA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  86 KAQFERSLNRLQLDYVDLYLIHQP------YGDvhgAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVE 159
Cdd:cd19132  80 LRTIEESLYRLGLDYVDLYLIHWPnpsrdlYVE---AWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPAVNQIE 156

                       170       180
                ....*....|....*....|....*.
gi 15829589 160 VNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19132 157 LHPYFPQAEQRAYHREHGIVTQSWSP 182
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 12-190 1.85e-66

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 204.40  E-value: 1.85e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  12 MPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQS----GIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:cd19136   1 MPILGLGTFRLRGEEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLlpkyGLSREDIFITSKLAPKDQGYEKARA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  88 QFERSLNRLQLDYVDLYLIH-------QPYGDVH-----GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAV 155
Cdd:cd19136  81 ACLGSLERLGTDYLDLYLIHwpgvqglKPSDPRNaelrrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAV 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15829589 156 NQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFAVTG 190
Cdd:cd19136 161 NQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGD 195
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 4-187 2.38e-66

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 204.10  E-value: 2.38e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMtdAAECERAVIDAI-NTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSY 82
Cdd:cd19135   5 VRLSNGVEMPILGLGTSHS--GGYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAIKESGVPREDLFLTTKLWPSDYGY 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG---------AWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVP 153
Cdd:cd19135  83 ESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGknvketraeTWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVP 162

                       170       180       190
                ....*....|....*....|....*....|....
gi 15829589 154 AVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19135 163 HVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLA 196
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
4-190 2.52e-66

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 204.54  E-value: 2.52e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDtsYE 83
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVWQASNE-EVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEASVAREELFITTKLWNDD--HK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   84 GAKAQFERSLNRLQLDYVDLYLIHQP------YGDvhgAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQ 157
Cdd:PRK11565  84 RPREALEESLKKLQLDYVDLYLMHWPvpaidhYVE---AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQ 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 15829589  158 VEVNPFNQQ--LHAvpWMQSRGIQPEAWAPFAVTG 190
Cdd:PRK11565 161 IELHPLMQQrqLHA--WNATHKIQTESWSPLAQGG 193
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 3-186 2.19e-64

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 199.82  E-value: 2.19e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   3 KVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNAL----KQSGIARNELFVTTKLWLQ 78
Cdd:cd19116   2 TIKLNDGNEIPAIALGTWKLKDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIrekiAEGVVKREDLFITTKLWNS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  79 DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19116  82 YHEREQVEPALRESLKRLGLDYVDLYLIHWPVAfkenndsesngdgslsdiDYLETWRGMEDLVKLGLTRSIGVSNFNSE 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15829589 141 RLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19116 162 QINRLLSNCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPF 207
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 6-185 2.94e-61

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 190.89  E-value: 2.94e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   6 LNNGIEMPLLGFGVFQMTDAAEcERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGA 85
Cdd:cd19130   4 LNDGNSIPQLGYGVFKVPPADT-QRAVATALEVGYRHIDTAAIYGNEEGVGAAIAASGIPRDELFVTTKLWNDRHDGDEP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  86 KAQFERSLNRLQLDYVDLYLIHQPY---GDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNP 162
Cdd:cd19130  83 AAAFAESLAKLGLDQVDLYLVHWPTpaaGNYVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQIELHP 162

                       170       180
                ....*....|....*....|...
gi 15829589 163 FNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19130 163 AYQQRTIRDWAQAHDVKIEAWSP 185
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 5-186 1.60e-60

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 189.86  E-value: 1.60e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   5 KLNNGIEMPLLGFGVFQmTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALK---QSGIA-RNELFVTTKLWLQDT 80
Cdd:cd19125   4 KLNTGAKIPAVGLGTWQ-ADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKklfEDGVVkREDLFITSKLWCTDH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  81 SYEGAKAQFERSLNRLQLDYVDLYLIHQPYG----------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19125  83 APEDVPPALEKTLKDLQLDYLDLYLIHWPVRlkkgahmpepeevlppDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLED 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15829589 145 LIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19125 163 LLAVARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPL 204
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 12-187 2.18e-60

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 188.25  E-value: 2.18e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  12 MPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKAQFER 91
Cdd:cd19073   1 IPALGLGTWQLRGD-DCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAESGVPREDLFITTKVWRDHLRPEDLKKSVDR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  92 SLNRLQLDYVDLYLIHQPYGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHA 169
Cdd:cd19073  80 SLEKLGTDYVDLLLIHWPNPTVPLEetLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAVNQVEFHPFLYQAEL 159

                       170
                ....*....|....*...
gi 15829589 170 VPWMQSRGIQPEAWAPFA 187
Cdd:cd19073 160 LEYCRENDIVITAYSPLA 177
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 9-185 4.75e-60

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 188.21  E-value: 4.75e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGV----FQMTDAA---ECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTS 81
Cdd:cd19120   1 GSKIPAIAFGTgtawYKSGDDDiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKESGVPREDLFITTKVSPGIKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  82 YEGAkaqFERSLNRLQLDYVDLYLIHQPY------GDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAV 155
Cdd:cd19120  81 PREA---LRKSLAKLGVDYVDLYLIHSPFfakeggPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAV 157

                       170       180       190
                ....*....|....*....|....*....|..
gi 15829589 156 NQVEVNPF--NQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19120 158 NQIEFHPYlyPQQPALLEYCREHGIVVSAYSP 189
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 4-188 1.58e-59

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 186.60  E-value: 1.58e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19134   3 VTLNDDNTMPVIGLGVGELSDD-EAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIPRGELFVTTKLATPDQGFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVH---GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEV 160
Cdd:cd19134  82 ASQAACRASLERLGLDYVDLYLIHWPAGREGkyvDSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTFFTPAVNQIEL 161

                       170       180
                ....*....|....*....|....*...
gi 15829589 161 NPFNQQLHAVPWMQSRGIQPEAWAPFAV 188
Cdd:cd19134 162 HPLLNQAELRKVNAQHGIVTQAYSPLGV 189
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 5-190 5.26e-57

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 180.77  E-value: 5.26e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   5 KLNNGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWlqDTSYEG 84
Cdd:cd19117   7 KLNTGAEIPAVGLGTWQSKPN-EVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIKDSGVPREEIFITTKLW--CTWHRR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  85 AKAQFERSLNRLQLDYVDLYLIHQPYG-----------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDR 141
Cdd:cd19117  84 VEEALDQSLKKLGLDYVDLYLMHWPVPldpdgndflfkkddgtkdhepdwDFIKTWELMQKLPATGKVKAIGVSNFSIKN 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 15829589 142 LADLIA--FNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFAVTG 190
Cdd:cd19117 164 LEKLLAspSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGSTN 214
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 4-191 2.93e-54

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 174.52  E-value: 2.93e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTdAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQ---SGI-ARNELFVTTKLWLQD 79
Cdd:cd19154   4 ITLSNGVKMPLIGLGTWQSK-GAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAElleEGVvKREDLFITTKLWTHE 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG---------------------DVHGAWRAMEELQQAGKIRAIGVSNFH 138
Cdd:cd19154  83 HAPEDVEEALRESLKKLQLEYVDLYLIHAPAAfkddegesgtmengmsihdavDVEDVWRGMEKVYDEGLTKAIGVSNFN 162

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 15829589 139 PDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFAVTGR 191
Cdd:cd19154 163 NDQIQRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSPGR 215
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 1-185 7.34e-54

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 173.37  E-value: 7.34e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKLNNGIEMPLLGFGVFQmTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNAL----KQSGIARNELFVTTKLW 76
Cdd:cd19123   1 MKTLPLSNGDLIPALGLGTWK-SKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALaevfKEGKVKREDLWITSKLW 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  77 LQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGA--------------------WRAMEELQQAGKIRAIGVSN 136
Cdd:cd19123  80 NNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKGVgfpesgedllslspipledtWRAMEELVDKGLCRHIGVSN 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15829589 137 FHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19123 160 FSVKKLEDLLATARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSP 208
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 1-190 6.72e-53

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 170.40  E-value: 6.72e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKLNNGIEMPLLGFGVFQmTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQS---GIARNELFVTTKLWl 77
Cdd:cd19121   1 MTSFKLNTGASIPAVGLGTWQ-AKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAiagGVKREDLFVTTKLW- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  78 qDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP-------------------------YGDVHGaWRAMEELQQAGKIRAI 132
Cdd:cd19121  79 -STYHRRVELCLDRSLKSLGLDYVDLYLVHWPvllnpngnhdlfptlpdgsrdldwdWNHVDT-WKQMEKVLKTGKTKAI 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15829589 133 GVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFAVTG 190
Cdd:cd19121 157 GVSNYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGSTG 214
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 8-166 6.78e-53

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 169.36  E-value: 6.78e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:cd19140   4 NGVRIPALGLGTYPLTGE-ECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIAASGVPRDELFLTTKVWPDNYSPDDFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  88 QFERSLNRLQLDYVDLYLIHQPYGDVHGAW--RAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQ 165
Cdd:cd19140  83 SVEESLRKLRTDYVDLLLLHWPNKDVPLAEtlGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFTNQVEYHPYLD 162


                .
gi 15829589 166 Q 166
Cdd:cd19140 163 Q 163
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 8-185 2.26e-52

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 168.99  E-value: 2.26e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFGVF-QMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQ---SG--IARNELFVTTKLWLQDTS 81
Cdd:cd19124   1 SGQTMPVIGMGTAsDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEalrLGlvKSRDELFVTSKLWCSDAH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  82 YEGAKAQFERSLNRLQLDYVDLYLIHQPYG------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:cd19124  81 PDLVLPALKKSLRNLQLEYVDLYLIHWPVSlkpgkfsfpieeedflpfDIKGVWEAMEECQRLGLTKAIGVSNFSCKKLQ 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15829589 144 DLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19124 161 ELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSP 202
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 6-185 4.36e-51

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 166.41  E-value: 4.36e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   6 LNNGIEMPLLGFGVFQmTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQS-----GIARNELFVTTKLWLQDT 80
Cdd:cd19106   1 LHTGQKMPLIGLGTWK-SKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKvgpgkAVPREDLFVTSKLWNTKH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  81 SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG---------------------AWRAMEELQQAGKIRAIGVSNFHP 139
Cdd:cd19106  80 HPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGdnpfpknpdgtirydsthykeTWKAMEKLVDKGLVKAIGLSNFNS 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15829589 140 DRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19106 160 RQIDDILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSP 205
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 9-191 8.16e-51

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 164.98  E-value: 8.16e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGVFQMTdAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALK---QSG-IARNELFVTTKLWLQDTSYEG 84
Cdd:cd19111   1 GFPMPVIGLGTYQSP-PEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKwwlKNGkLKREEVFITTKLPPVYLEFKD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  85 AKAQFERSLNRLQLDYVDLYLIHQPYG---------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFN 149
Cdd:cd19111  80 TEKSLEKSLENLKLPYVDLYLIHHPCGfvnkkdkgerelassDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYA 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15829589 150 NVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFAVTGR 191
Cdd:cd19111 160 KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSPGR 201
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 6-186 1.42e-49

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 161.81  E-value: 1.42e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   6 LNNGIEMPLLGFGVFQmTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQS-----GIARNELFVTTKLWLQDT 80
Cdd:cd19118   1 LNTGNKIPAIGLGTWQ-AEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELlkeepGVKREDLFITSKLWNNSH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  81 SYEGAKAQFERSLNRLQLDYVDLYLIH-----QPYGDVHG---------------------AWRAMEELQQAGKIRAIGV 134
Cdd:cd19118  80 RPEYVEPALDDTLKELGLDYLDLYLIHwpvafKPTGDLNPltavptnggevdldlsvslvdTWKAMVELKKTGKVKSIGV 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15829589 135 SNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19118 160 SNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPL 211
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 4-185 4.58e-49

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 161.11  E-value: 4.58e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMtDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNAL----KQSGIARNELFVTTKLWlqD 79
Cdd:cd19112   3 ITLNSGHKMPVIGLGVWRM-EPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALaeafKTGLVKREDLFITTKLW--N 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-------------------------GAWRAMEELQQAGKIRAIGV 134
Cdd:cd19112  80 SDHGHVIEACKDSLKKLQLDYLDLYLVHFPVATKHtgvgttgsalgedgvldidvtisleTTWHAMEKLVSAGLVRSIGI 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 15829589 135 SNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19112 160 SNYDIFLTRDCLAYSKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTP 210
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 4-186 1.29e-47

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 157.61  E-value: 1.29e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMtDAAECERAVIDAINTGYRLIDTAASYQNEPQVGN----ALKQSGIARNELFVTTKLWLQD 79
Cdd:cd19113   3 IKLNSGYKMPSVGFGCWKL-DNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEgvnrAIDEGLVKREELFLTSKLWNNF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQP-------------------------YGDVH--GAWRAMEELQQAGKIRAI 132
Cdd:cd19113  82 HDPKNVETALNKTLSDLKLDYVDLFLIHFPiafkfvpieekyppgfycgdgdnfvYEDVPilDTWKALEKLVDAGKIKSI 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15829589 133 GVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19113 162 GVSNFPGALILDLLRGATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSF 215
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 7-185 1.95e-45

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 151.46  E-value: 1.95e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   7 NNGIEMPLLGFGVFqMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQ----SGIARNELFVTTKLWLQDTSY 82
Cdd:cd19129   1 NGSGAIPALGFGTL-IPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEvfkaGKIRREDLFVTTKLWNTNHRP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  83 EGAKAQFERSLNRLQLDYVDLYLIHQPYG----------DVHGA------------WRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19129  80 ERVKPAFEASLKRLQLDYLDLYLIHTPFAfqpgdeqdprDANGNviyddgvtlldtWRAMERLVDEGRCKAIGLSDVSLE 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15829589 141 RLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19129 160 KLREIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAP 204
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 5-186 6.94e-45

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 150.08  E-value: 6.94e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   5 KLNNGIEMPLLGFGVFQMTDA-AECERAVIDAINTGYRLIDTAASYQNEPQVGNALK-----QSGIARNELFVTTKLWLQ 78
Cdd:cd19122   2 TLNNGVKIPAVGFGTFANEGAkGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRdflkeNPSVKREDLFICTKVWNH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  79 DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG-------------------------DVHGAWRAMEELQQAGKIRAIG 133
Cdd:cd19122  82 LHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAaekndqrspklgpdgkyvilkdlteNPEPTWRAMEEIYESGKAKAIG 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 15829589 134 VSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19122 162 VSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPL 214
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 9-186 8.82e-44

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 147.70  E-value: 8.82e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGVFQMtDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALK---QSGIA-RNELFVTTKLWLQDTSYEG 84
Cdd:cd19114   1 GDKMPLVGFGTAKI-KANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRkaiQEGLVkREDLFIVTKLWNNFHGKDH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  85 AKAQFERSLNRLQLDYVDLYLIHQP----YGD-----------------------VHGAWRAMEELQQAGKIRAIGVSNF 137
Cdd:cd19114  80 VREAFDRQLKDYGLDYIDLYLIHFPipaaYVDpaenypflwkdkelkkfpleqspMQECWREMEKLVDAGLVRNIGIANF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15829589 138 HPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19114 160 NVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSF 208
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 4-191 2.00e-43

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 146.90  E-value: 2.00e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNALK---QSG-IARNELFVTTKLWLQD 79
Cdd:cd19155   4 VTFNNGEKMPVVGLGTWQSSPE-EIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKkwiDSGkVKREELFIVTKLPPGG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG-----------------------DVHGAWRAMEELQQAGKIRAIGVSN 136
Cdd:cd19155  83 NRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGslskeddsgkldptgehkqdyttDLLDIWKAMEAQVDQGLTRSIGLSN 162

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15829589 137 FHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFAVTGR 191
Cdd:cd19155 163 FNREQMARILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSPGA 217
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 12-188 3.35e-43

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 144.42  E-value: 3.35e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  12 MPLLGFGVFQMTDAAeCERAVIDAINTGYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKAQFER 91
Cdd:cd19139   1 IPAFGLGTFRLKDDV-VIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLSKDKLLPSLEE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  92 SLNRLQLDYVDLYLIH--QPYG--DVHGAWRAMEELQQAGKIRAIGVSNF---HPDRLADLIAFNNVvpAVNQVEVNPFN 164
Cdd:cd19139  80 SLEKLRTDYVDLTLIHwpSPNDevPVEEYIGALAEAKEQGLTRHIGVSNFtiaLLDEAIAVVGAGAI--ATNQIELSPYL 157

                       170       180
                ....*....|....*....|....
gi 15829589 165 QQLHAVPWMQSRGIQPEAWAPFAV 188
Cdd:cd19139 158 QNRKLVAHCKQHGIHVTSYMTLAY 181
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 9-185 1.14e-42

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 143.52  E-value: 1.14e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFG----VFQMTDAAECERAVIDAINT----GYRLIDTAASYQN---EPQVGNALKqsGIARNELFVTTKLWL 77
Cdd:cd19072   1 GEEVPVLGLGtwgiGGGMSKDYSDDKKAIEALRYaielGINLIDTAEMYGGghaEELVGKAIK--GFDREDLFITTKVSP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  78 QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP--YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAF-NNVVPA 154
Cdd:cd19072  79 DHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPnpSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYlKKGPIV 158

                       170       180       190
                ....*....|....*....|....*....|...
gi 15829589 155 VNQVEVNPFNQ--QLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19072 159 ANQVEYNLFDReeESGLLPYCQKNGIAIIAYSP 191
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 2-186 1.25e-42

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 144.87  E-value: 1.25e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   2 QKVKLNNGIEMPLLGFGVFQMTDAAeCERAVIDAINTGYRLIDTAASYQNEPQVGN----ALKQSGIARNELFVTTKLWL 77
Cdd:cd19115   3 PTVKLNSGYDMPLVGFGLWKVNNDT-CADQVYNAIKAGYRLFDGACDYGNEVEAGQgvarAIKEGIVKREDLFIVSKLWN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  78 QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP----YGD----------------------VHGAWRAMEELQQAGKIRA 131
Cdd:cd19115  82 TFHDGERVEPICRKQLADWGIDYFDLFLIHFPialkYVDpavryppgwfydgkkvefsnapIQETWTAMEKLVDKGLARS 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15829589 132 IGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19115 162 IGVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSF 216
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 4-186 2.38e-42

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 143.79  E-value: 2.38e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   4 VKLNNGIEMPLLGFGVFQ-MTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQS----GIARNELFVTTKLWlq 78
Cdd:cd19119   4 FKLNTGASIPALGLGTASpHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAiddgSIKREELFITTKVW-- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  79 DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPY---------------------------GDVHGAWRAMEELQQAGKIRA 131
Cdd:cd19119  82 PTFYDEVERSLDESLKALGLDYVDLLLVHWPVcfekdsddsgkpftpvnddgktryaasGDHITTYKQLEKIYLDGRAKA 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15829589 132 IGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19119 162 IGVSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPL 216
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 2-191 1.19e-41

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 140.85  E-value: 1.19e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   2 QKVKLNNGIEMPLLGFGVFQM----TDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQSgiaRNELFVTTK 74
Cdd:cd19138   1 RTVTLPDGTKVPALGQGTWYMgedpAKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR---RDKVFLVSK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  75 LWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPyGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLADLIAF---N 149
Cdd:cd19138  78 VLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWR-GGVPLAetVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVpggG 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 15829589 150 NVvpAVNQVEVNPFNQ--QLHAVPWMQSRGIQPEAWAPFAVTGR 191
Cdd:cd19138 157 NC--AANQVLYNLGSRgiEYDLLPWCREHGVPVMAYSPLAQGGL 198
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 13-185 1.53e-41

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 141.12  E-value: 1.53e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  13 PLLGFGVFQMTDAaECERAVIDAINTGYRLIDTAASYQNEPQVGNAL----KQSGIARNELFVTTKLWLQDTSYEGAKAQ 88
Cdd:cd19128   2 PRLGFGTYKITES-ESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFseifKDGGVKREDLFITSKLWPTMHQPENVKEQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  89 FERSLNRLQLDYVDLYLIHQPYGDVHGA---------------------WRAMEELQQAGKIRAIGVSNFHPDRLADLIA 147
Cdd:cd19128  81 LLITLQDLQLEYLDLFLIHWPLAFDMDTdgdprddnqiqslskkpledtWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLN 160

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15829589 148 FNNVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19128 161 YCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRP 198
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 9-186 5.32e-41

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 140.63  E-value: 5.32e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGVFQmTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNA----LKQSGIARNELFVTTKLWlqDTSYEG 84
Cdd:cd19107   1 GAKMPILGLGTWK-SPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAiqekIKEQVVKREDLFIVSKLW--CTFHEK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  85 A--KAQFERSLNRLQLDYVDLYLIHQPYGDVHG---------------------AWRAMEELQQAGKIRAIGVSNFHPDR 141
Cdd:cd19107  78 GlvKGACQKTLSDLKLDYLDLYLIHWPTGFKPGkelfpldesgnvipsdttfldTWEAMEELVDEGLVKAIGVSNFNHLQ 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15829589 142 LADLIAFNNV--VPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPF 186
Cdd:cd19107 158 IERILNKPGLkyKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPL 204
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 1-187 1.98e-40

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 139.16  E-value: 1.98e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKL-NNGIEMPLLGFGVFQM------TDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKqsGIARNELF 70
Cdd:COG0667   1 MEYRRLgRSGLKVSRLGLGTMTFggpwggVDEAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALK--GRPRDDVV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  71 VTTKL--------WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:COG0667  79 IATKVgrrmgpgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTpiEETLGALDELVREGKIRYIGVSNYSAE 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 15829589 141 RLADL--IAFNNVVPAVNQVEVNPFNQQLHA--VPWMQSRGIQPEAWAPFA 187
Cdd:COG0667 159 QLRRAlaIAEGLPPIVAVQNEYSLLDRSAEEelLPAARELGVGVLAYSPLA 209
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 2-166 3.12e-40

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 138.13  E-value: 3.12e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   2 QKVKLNNGIEMPLLGFGVF--QMTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALkQSGIA-----RNELFVTTK 74
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYapEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAI-RSKIAdgtvkREDIFYTSK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  75 LWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG----------DVHG-----------AWRAMEELQQAGKIRAIG 133
Cdd:cd19108  80 LWCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVAlkpgeelfpkDENGklifdtvdlcaTWEAMEKCKDAGLAKSIG 159

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 15829589 134 VSNFHpDRLADLIaFN----NVVPAVNQVEVNPFNQQ 166
Cdd:cd19108 160 VSNFN-RRQLEMI-LNkpglKYKPVCNQVECHPYLNQ 194
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 15-187 7.95e-40

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 137.06  E-value: 7.95e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    15 LGFGVFQM------TDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIARNELFVTTKL------WLQD 79
Cdd:pfam00248   1 IGLGTWQLgggwgpISKEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDYPVKRDKVVIATKVpdgdgpWPSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH--GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQ 157
Cdd:pfam00248  81 GSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPieETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQ 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 15829589   158 VEVNPFN--QQLHAVPWMQSRGIQPEAWAPFA 187
Cdd:pfam00248 161 VEYNLLRrrQEEELLEYCKKNGIPLIAYSPLG 192
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
12-188 8.90e-40

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 136.31  E-value: 8.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   12 MPLLGFGVFQMTDaaeceRAVIDAINT----GYRLIDTAASYQNEPQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:PRK11172   3 IPAFGLGTFRLKD-----QVVIDSVKTalelGYRAIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLAKDKLIP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   88 QFERSLNRLQLDYVDLYLIHQPY-GDVHGAWRAMEELQQA---GKIRAIGVSNFHPDRLADLIAfnnVVP----AVNQVE 159
Cdd:PRK11172  78 SLKESLQKLRTDYVDLTLIHWPSpNDEVSVEEFMQALLEAkkqGLTREIGISNFTIALMKQAIA---AVGaeniATNQIE 154

                        170       180
                 ....*....|....*....|....*....
gi 15829589  160 VNPFNQQLHAVPWMQSRGIQPEAWAPFAV 188
Cdd:PRK11172 155 LSPYLQNRKVVAFAKEHGIHVTSYMTLAY 183
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 15-187 9.57e-38

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 129.95  E-value: 9.57e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQM---TDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIaRNELFVTTKL---WLQDTSYEGA 85
Cdd:cd06660   3 LGLGTMTFggdGDEEEAFALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGRGN-RDDVVIATKGghpPGGDPSRSRL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  86 -----KAQFERSLNRLQLDYVDLYLIHQPygD----VHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIA----FNNVV 152
Cdd:cd06660  82 spehiRRDLEESLRRLGTDYIDLYYLHRD--DpstpVEETLEALNELVREGKIRYIGVSNWSAERLAEALAyakaHGLPG 159

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15829589 153 PAVNQVEVNPFNQQLH---AVPWMQSRGIQPEAWAPFA 187
Cdd:cd06660 160 FAAVQPQYSLLDRSPMeeeLLDWAEENGLPLLAYSPLA 197
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 3-178 9.97e-37

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 127.60  E-value: 9.97e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   3 KVKL-NNGIEMPLLGFG--VFQMTDAAECERAVIDAINTGYRLIDTAASYQN-EPQVGNALKQSgiaRNELFVTTKLWlq 78
Cdd:cd19100   1 YRRLgRTGLKVSRLGFGggPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKGR---RDKVFLATKTG-- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  79 DTSYEGAKAQFERSLNRLQLDYVDLYLIH---------QPYGDvHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLI--- 146
Cdd:cd19100  76 ARDYEGAKRDLERSLKRLGTDYIDLYQLHavdteedldQVFGP-GGALEALLEAKEEGKIRFIGISGHSPEVLLRALetg 154

                       170       180       190
                ....*....|....*....|....*....|..
gi 15829589 147 AFNNVVPAVNQVEVNPFNQQLHAVPWMQSRGI 178
Cdd:cd19100 155 EFDVVLFPINPAGDHIDSFREELLPLAREKGV 186
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
1-148 1.47e-36

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 130.32  E-value: 1.47e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKL-NNGIEMPLLGFGV--FQMTDAAECERaVID-AINTGYRLIDTAASY-QNEPQVGNALKQsgiARNELFVTTKL 75
Cdd:COG1453   1 MQYRRLgKTGLEVSVLGFGGmrLPRKDEEEAEA-LIRrAIDNGINYIDTARGYgDSEEFLGKALKG---PRDKVILATKL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  76 --WLQDtsYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH--------GAWRAMEELQQAGKIRAIGVSnFHpDRLADL 145
Cdd:COG1453  77 ppWVRD--PEDMRKDLEESLKRLQTDYIDLYLIHGLNTEEDlekvlkpgGALEALEKAKAEGKIRHIGFS-TH-GSLEVI 152


                ...
gi 15829589 146 IAF 148
Cdd:COG1453 153 KEA 155
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 11-190 1.32e-32

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 118.52  E-value: 1.32e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  11 EMPLLGFGVFQMTdAAECERAVIDAINTGYRLIDTAASYQNEPQVGNAL----KQSGIARNELFVTTKLWLQDTSYEGAK 86
Cdd:cd19110   3 DIPAVGLGTWKAS-PGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIrekiKEGVVRREDLFIVSKLWCTCHKKSLVK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  87 AQFERSLNRLQLDYVDLYLIHQPYG---------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADL 145
Cdd:cd19110  82 TACTRSLKALKLNYLDLYLIHWPMGfkpgepdlpldrsgmvipsdtDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLERL 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15829589 146 IAFNN--VVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAPFAVTG 190
Cdd:cd19110 162 LNKPGlrVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGSC 208
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 15-191 1.85e-32

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 117.69  E-value: 1.85e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQM--------TDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQSgiaRNELFVTTKLWLQDTSYE 83
Cdd:cd19085   4 LGLGCWQFgggywwgdQDDEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKGR---RDDVVIATKVSPDNLTPE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVpaVNQVEVN 161
Cdd:cd19085  81 DVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEetMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGRID--SNQLPYN 158

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15829589 162 PFNQQLHA--VPWMQSRGIQPEAWAPFA---VTGR 191
Cdd:cd19085 159 LLWRAIEYeiLPFCREHGIGVLAYSPLAqglLTGK 193
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 1-135 2.07e-31

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 114.22  E-value: 2.07e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKL-NNGIEMPLLGFGVfqMTDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKqsGIARNELFVTTKLW 76
Cdd:cd19105   1 MPYRTLgKTGLKVSRLGFGG--GGLPRESPELLRRALDLGINYFDTAEGYGNgnsEEIIGEALK--GLRRDKVFLATKAS 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15829589  77 LQD--TSYEGAKAQFERSLNRLQLDYVDLYLIHQP----YGDVHGAW-RAMEELQQAGKIRAIGVS 135
Cdd:cd19105  77 PRLdkKDKAELLKSVEESLKRLQTDYIDIYQLHGVdtpeERLLNEELlEALEKLKKEGKVRFIGFS 142
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 15-187 1.24e-30

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 111.94  E-value: 1.24e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQ------MTDAAECERAVIDAINTGYRLIDTAASYQN-EPQVGNALkqSGIARNELFVTTKLW--------LQD 79
Cdd:cd19095   3 LGLGTSGigrvwgVPSEAEAARLLNTALDLGINLIDTAPAYGRsEERLGRAL--AGLRRDDLFIATKVGthgeggrdRKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDrLADLIAfNNVVPAVnQ 157
Cdd:cd19095  81 FSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDEltGEVLETLEDLKAAGKVRYIGVSGDGEE-LEAAIA-SGVFDVV-Q 157

                       170       180       190
                ....*....|....*....|....*....|.
gi 15829589 158 VEVNPFNQQL-HAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19095 158 LPYNVLDREEeELLPLAAEAGLGVIVNRPLA 188
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 15-165 1.97e-30

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 111.03  E-value: 1.97e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQM-------TDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQSgiaRNELFVTTKL--------- 75
Cdd:cd19086   6 IGFGTWGLggdwwgdVDDAEAIRALRAALDLGINFFDTADVYGDghsERLLGKALKGR---RDKVVIATKFgnrfdggpe 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  76 WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVv 152
Cdd:cd19086  83 RPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPpdeVLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALRRGGI- 161

                       170
                ....*....|...
gi 15829589 153 pAVNQVEVNPFNQ 165
Cdd:cd19086 162 -DVVQVIYNLLDQ 173
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 9-185 2.51e-30

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 112.59  E-value: 2.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGVFQ---MTDAAECERAVIDAINTGYRLIDTAASYQNEPQVGNALKQS----GIARNELFVTTKLWLQDTS 81
Cdd:cd19109   1 GNSIPIIGLGTYSepkTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKiaegKVKREDIFYCGKLWNTCHP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  82 YEGAKAQFERSLNRLQLDYVDLYLIHQPYG---------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19109  81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAfkpgdeiyprdengkwlyhktNLCATWEALEACKDAGLVKSIGVSNFNRR 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15829589 141 RLaDLIaFN----NVVPAVNQVEVNPFNQQLHAVPWMQSRGIQPEAWAP 185
Cdd:cd19109 161 QL-ELI-LNkpglKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSP 207
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 15-191 7.61e-30

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 111.08  E-value: 7.61e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQMTDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKqsGIaRNELFVTTKLWLQ---------DTSY 82
Cdd:cd19084  14 IGGTWWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALK--GR-RDDVVIATKCGLRwdggkgvtkDLSP 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVpaVNQVEV 160
Cdd:cd19084  91 ESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTpiEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGPIV--SLQPPY 168

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15829589 161 NPFNQQL--HAVPWMQSRGIQPEAWAPFA---VTGR 191
Cdd:cd19084 169 SMLEREIeeELLPYCRENGIGVLPYGPLAqglLTGK 204
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 11-191 2.11e-28

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 107.31  E-value: 2.11e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  11 EMPLLGFGVFQMTD----------AAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGiARNELFVTTKL-- 75
Cdd:cd19093   1 EVSPLGLGTWQWGDrlwwgygeygDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKELG-DRDEVVIATKFap 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  76 ----WLQDTSYEGAKAqferSLNRLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRL---ADL 145
Cdd:cd19093  80 lpwrLTRRSVVKALKA----SLERLGLDSIDLYQLHWPgpwYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLrraHKA 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15829589 146 IAFNNVVPAVNQVEVN-----PFNQQLhaVPWMQSRGIQPEAWAPFAV---TGR 191
Cdd:cd19093 156 LKERGVPLASNQVEYSllyrdPEQNGL--LPACDELGITLIAYSPLAQgllTGK 207
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 9-187 3.23e-28

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 106.12  E-value: 3.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGVFQM-----TDAAECERAV---IDAINTGYRLIDTAASY---QNEPQVGNALKQsgIARNELFVTTKLWL 77
Cdd:cd19137   1 GEKIPALGLGTWGIggfltPDYSRDEEMVellKTAIELGYTHIDTAEMYgggHTEELVGKAIKD--FPREDLFIVTKVWP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  78 QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAV 155
Cdd:cd19137  79 TNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIplEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQTPIVC 158

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15829589 156 NQVEVNPFNQQLH---AVPWMQSRGIQPEAWAPFA 187
Cdd:cd19137 159 NQVKYNLEDRDPErdgLLEYCQKNGITVVAYSPLR 193
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 7-187 3.61e-27

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 103.79  E-value: 3.61e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   7 NNGIEMPLLGFGVFQMTD----AAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQSGIARNELFVTTK----- 74
Cdd:cd19092   1 PEGLEVSRLVLGCMRLADwgesAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALNPGLREKIEIQTKcgirl 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  75 ------LWLQ--DTSYEGAKAQFERSLNRLQLDYVDLYLIHQP-----YGDVHgawRAMEELQQAGKIRAIGVSNFHPDR 141
Cdd:cd19092  81 gddprpGRIKhyDTSKEHILASVEGSLKRLGTDYLDLLLLHRPdplmdPEEVA---EAFDELVKSGKVRYFGVSNFTPSQ 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15829589 142 LADLIAFNNVVPAVNQVEVNPFNQQLHA---VPWMQSRGIQPEAWAPFA 187
Cdd:cd19092 158 IELLQSYLDQPLVTNQIELSLLHTEAIDdgtLDYCQLLDITPMAWSPLG 206
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 13-169 7.45e-26

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 99.56  E-value: 7.45e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  13 PLLGFGV--FQMT-----DAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGiaRNELFVTTKL-WLQDTS 81
Cdd:cd19096   1 SVLGFGTmrLPESdddsiDEEKAIEMIRYAIDAGINYFDTAYGYgggKSEEILGEALKEGP--REKFYLATKLpPWSVKS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  82 YEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-------GAWRAMEELQQAGKIRAIGVSnFH--PDRLADLIAFNNVv 152
Cdd:cd19096  79 AEDFRRILEESLKRLGVDYIDFYLLHGLNSPEWlekarkgGLLEFLEKAKKEGLIRHIGFS-FHdsPELLKEILDSYDF- 156

                       170
                ....*....|....*..
gi 15829589 153 pAVNQVEVNPFNQQLHA 169
Cdd:cd19096 157 -DFVQLQYNYLDQENQA 172
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
 15-149 6.92e-25

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 97.62  E-value: 6.92e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQMTDAAECER-----AVID-AINTGYRLIDTAASYQN-EPQVGNALKqsGIARNELFVTTKL-----WLQDTSY 82
Cdd:cd19090   3 LGLGTAGLGGVFGGVDddeavATIRaALDLGINYIDTAPAYGDsEERLGLALA--ELPREPLVLSTKVgrlpeDTADYSA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15829589  83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-------GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFN 149
Cdd:cd19090  81 DRVRRSVEESLERLGRDRIDLLMIHDPERVPWvdilapgGALEALLELKEEGLIKHIGLGGGPPDLLRRAIETG 154
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 3-187 1.92e-24

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 97.10  E-value: 1.92e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   3 KVKL-NNGIEMPLLGFG--------VFQMTDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKqsGIARNELF 70
Cdd:cd19083   1 KVKLgKSDIDVNPIGLGtnavgghnLYPNLDEEEGKDLVREALDNGVNLLDTAFIYglgRSEELVGEVLK--EYNRNEVV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  71 VTTKLWLQ--------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19083  79 IATKGAHKfggdgsvlNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETpkAEAVGALQELKDEGKIRAIGVSNFSLE 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15829589 141 RLADLIAFNNVvpAVNQVEVNPFNQQL--HAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19083 159 QLKEANKDGYV--DVLQGEYNLLQREAeeDILPYCVENNISFIPYFPLA 205
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 23-178 7.89e-24

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 95.45  E-value: 7.89e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  23 TDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIaRNELFVTTKLWLQ---------DTSYEGAKAQFE 90
Cdd:cd19148  22 TDEKEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKALKEYGK-RDRVVIATKVGLEwdeggevvrNSSPARIRKEVE 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  91 RSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLAdliAFNNVVP-AVNQVEVNPFNQQL 167
Cdd:cd19148 101 DSLRRLQTDYIDLYQVHWPDPLVpiEETAEALKELLDEGKIRAIGVSNFSPEQME---TFRKVAPlHTVQPPYNLFEREI 177

                       170
                ....*....|...
gi 15829589 168 HA--VPWMQSRGI 178
Cdd:cd19148 178 EKdvLPYARKHNI 190
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 2-142 2.48e-23

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 93.82  E-value: 2.48e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   2 QKVKL-NNGIEMPLLGFGVFQMTDA-----AECERAVID-AINTGYRLIDTAASYQ---NEPQVGNALKQsgiARNELFV 71
Cdd:cd19076   1 PTRKLgTQGLEVSALGLGCMGMSAFygpadEEESIATLHrALELGVTFLDTADMYGpgtNEELLGKALKD---RRDEVVI 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  72 TTKLWLQ----------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHP 139
Cdd:cd19076  78 ATKFGIVrdpgsgfrgvDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVpiEETVGAMAELVEEGKVRYIGLSEASA 157


                ...
gi 15829589 140 DRL 142
Cdd:cd19076 158 DTI 160
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 23-143 1.08e-22

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 92.35  E-value: 1.08e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  23 TDAAECERAVIDAintGYRLIDTAASY---QNEPQVGNALKQsgiARNELFVTTK---LW------LQDTSYEGAKAQFE 90
Cdd:cd19102  26 RDSIAAIRAALDL---GINWIDTAAVYglgHSEEVVGRALKG---LRDRPIVATKcglLWdeegriRRSLKPASIRAECE 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15829589  91 RSLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:cd19102 100 ASLRRLGVDVIDLYQIHWPDPDepIEEAWGALAELKEEGKVRAIGVSNFSVDQMK 154
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 22-179 3.00e-22

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 90.28  E-value: 3.00e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  22 MTDAAECERAVIDAINTGYRLIDTAASYqnepqvGNALK---QSGIARNELFVTTKL----WLQDTSYEGAKAQFERSLN 94
Cdd:cd19097  22 KPSEKEAKKILEYALKAGINTLDTAPAY------GDSEKvlgKFLKRLDKFKIITKLpplkEDKKEDEAAIEASVEASLK 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  95 RLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNvvPAVNQVEVNPFNQQLHAVP 171
Cdd:cd19097  96 RLKVDSLDGLLLHNPddlLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALESFK--IDIIQLPFNILDQRFLKSG 173

                       170
                ....*....|.
gi 15829589 172 W---MQSRGIQ 179
Cdd:cd19097 174 LlakLKKKGIE 184
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 15-143 4.33e-22

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 90.84  E-value: 4.33e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQM----TDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQS----GIARNELFVTTK--------- 74
Cdd:cd19099   6 LGLGTYRGdsddETDEEYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELiekgGIKRDEVVIVTKagyipgdgd 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  75 ------LWLQ-------DTSYEGA-----------KAQFERSLNRLQLDYVDLYLIHQP------------YGDVHGAWR 118
Cdd:cd19099  86 eplrplKYLEeklgrglIDVADSAglrhcispaylEDQIERSLKRLGLDTIDLYLLHNPeeqllelgeeefYDRLEEAFE 165

                       170       180
                ....*....|....*....|....*
gi 15829589 119 AMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:cd19099 166 ALEEAVAEGKIRYYGISTWDGFRAP 190
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 7-151 9.44e-22

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 90.02  E-value: 9.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   7 NNGIEMPLLGFGVFQM--------TDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQSgiaRNELFVTTKL 75
Cdd:cd19149   6 KSGIEASVIGLGTWAIgggpwwggSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGR---RDKVVLATKC 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  76 WL-------------------QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGV 134
Cdd:cd19149  83 GLrwdreggsfffvrdgvtvyKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVEtpIEETMEALEELKRQGKIRAIGA 162

                       170
                ....*....|....*..
gi 15829589 135 SNFHPDRLADLIAFNNV 151
Cdd:cd19149 163 SNVSVEQIKEYVKAGQL 179
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
 1-135 1.63e-21

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 88.76  E-value: 1.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKL-NNGIEMPLLGFG------VFQMTDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKqsGIARNELF 70
Cdd:cd19163   1 MKYRKLgKTGLKVSKLGFGasplggVFGPVDEEEAIRTVHEALDSGINYIDTAPWYgqgRSETVLGKALK--GIPRDSYY 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15829589  71 VTTK------LWLQ--DTSYEGAKAQFERSLNRLQLDYVDLYLIH----QPYGD--VHGAWRAMEELQQAGKIRAIGVS 135
Cdd:cd19163  79 LATKvgryglDPDKmfDFSAERITKSVEESLKRLGLDYIDIIQVHdiefAPSLDqiLNETLPALQKLKEEGKVRFIGIT 157
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 15-148 4.43e-21

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 87.61  E-value: 4.43e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVF----QMTDAAECERAVIDAintGYRLIDTAASYQN-------EPQVGNALKQSGIaRNELFVTTK-----LWLQ 78
Cdd:cd19082   5 LGTADFgtriDEEEAFALLDAFVEL---GGNFIDTARVYGDwvergasERVIGEWLKSRGN-RDKVVIATKgghpdLEDM 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15829589  79 DTSYEGAK---AQFERSLNRLQLDYVDLYLIH-----QPYGDVHGAwraMEELQQAGKIRAIGVSNFHPDRLADLIAF 148
Cdd:cd19082  81 SRSRLSPEdirADLEESLERLGTDYIDLYFLHrddpsVPVGEIVDT---LNELVRAGKIRAFGASNWSTERIAEANAY 155
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
 23-137 5.79e-20

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 84.93  E-value: 5.79e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  23 TDAAEcERAVID-AINTGYRLIDTAASYQN---EPQVGNALKQSgiaRNELFVTTK--------LWLQDTSYEGAKAQFE 90
Cdd:cd19087  27 TDEET-SFAIMDrALDAGINFFDTADVYGGgrsEEIIGRWIAGR---RDDIVLATKvfgpmgddPNDRGLSRRHIRRAVE 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15829589  91 RSLNRLQLDYVDLYLIHQPYGDVHG--AWRAMEELQQAGKIRAIGVSNF 137
Cdd:cd19087 103 ASLRRLQTDYIDLYQMHHFDRDTPLeeTLRALDDLVRQGKIRYIGVSNF 151
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 9-165 8.63e-20

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 84.62  E-value: 8.63e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFG------VFQMTDAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQsgiARNELFVTTKLWLQD 79
Cdd:cd19104   9 GLKVSELTFGgggiggLMGRTTREEQIAAVRRALDLGINFFDTAPSYgdgKSEENLGRALKG---LPAGPYITTKVRLDP 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 TSYEGAKAQFER----SLNRLQLDYVDLYLIHQ-------PYGDVH----------GAWRAMEELQQAGKIRAIGVSNF- 137
Cdd:cd19104  86 DDLGDIGGQIERsvekSLKRLKRDSVDLLQLHNrigderdKPVGGTlsttdvlglgGVADAFERLRSEGKIRFIGITGLg 165

                       170       180
                ....*....|....*....|....*...
gi 15829589 138 HPDRLADLIAFNnvVPAVNQVEVNPFNQ 165
Cdd:cd19104 166 NPPAIRELLDSG--KFDAVQVYYNLLNP 191
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
 24-191 4.91e-19

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 82.25  E-value: 4.91e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  24 DAAECERAVIDAintGYRLIDTAASY---QNEPQVGNALKqsGIARNELFVTTKL-W-LQDTSYE---GAK---AQFERS 92
Cdd:cd19074  23 DAKACVRKAYDL---GINFFDTADVYaagQAEEVLGKALK--GWPRESYVISTKVfWpTGPGPNDrglSRKhifESIHAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  93 LNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIA----FNNVVPAVNQVEVNPFNQQ 166
Cdd:cd19074  98 LKRLQLDYVDIYYCHRYDPETplEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDlarqFGLIPPVVEQPQYNMLWRE 177

                       170       180       190
                ....*....|....*....|....*....|
gi 15829589 167 LHA--VPWMQSRGIQPEAWAPFA---VTGR 191
Cdd:cd19074 178 IEEevIPLCEKNGIGLVVWSPLAqglLTGK 207
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 7-143 9.06e-19

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 81.88  E-value: 9.06e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   7 NNGIEMPLLGFGVfqMTDAAECER----AVIDA-INTGYRLIDTAASY----------QNEPQVGNALKQSGiARNELFV 71
Cdd:cd19081   4 RTGLSVSPLCLGT--MVFGWTADEetsfALLDAfVDAGGNFIDTADVYsawvpgnaggESETIIGRWLKSRG-KRDRVVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  72 TTKL-WLQDTSYEGA-----KAQFERSLNRLQLDYVDLYLIHQPYGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:cd19081  81 ATKVgFPMGPNGPGLsrkhiRRAVEASLRRLQTDYIDLYQAHWDDPATPLEetLGALNDLIRQGKVRYIGASNYSAWRLQ 160
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
 8-187 1.28e-17

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 78.66  E-value: 1.28e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFG---VFQMTDAAECERAVID-AINTGYRLIDTAASYQN---EPQVGNALKQSGIARNELFVTTKLWLQDT 80
Cdd:cd19142   9 SGLRVSNVGLGtwsTFSTAISEEQAEEIVTlAYENGINYFDTSDAFTSgqaETELGRILKKKGWKRSSYIVSTKIYWSYG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  81 SYEGAKAQ------FERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLI----AF 148
Cdd:cd19142  89 SEERGLSRkhiiesVRASLRRLQLDYIDIVIIHKadPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVEIMEAFsiarQF 168

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15829589 149 NNVVPAVNQVEVNPFNQ---QLHAVPWMQSRGIQPEAWAPFA 187
Cdd:cd19142 169 NCPTPICEQSEYHMFCRekmELYMPELYNKVGVGLITWSPLS 210
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 9-135 2.22e-17

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 77.66  E-value: 2.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGVFQMT-------DAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQsgiARNELFVTTKLWLQ 78
Cdd:cd19078   1 GLEVSAIGLGCMGMShgygpppDKEEMIELIRKAVELGITFFDTAEVYgpyTNEELVGEALKP---FRDQVVIATKFGFK 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15829589  79 -----------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQ-----PYGDVHGawrAMEELQQAGKIRAIGVS 135
Cdd:cd19078  78 idggkpgplglDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRvdpnvPIEEVAG---TMKELIKEGKIRHWGLS 147
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 1-137 5.37e-17

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 76.88  E-value: 5.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKL-NNGIEMPLLGFGVfqMT--------------DAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQs 62
Cdd:cd19091   1 MEYRTLgRSGLKVSELALGT--MTfgggggffgawggvDQEEADRLVDIALDAGINFFDTADVYsegESEEILGKALKG- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  63 giARNELFVTTKLWLQ--------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAI 132
Cdd:cd19091  78 --RRDDVLIATKVRGRmgegpndvGLSRHHIIRAVEASLKRLGTDYIDLYQLHGfdALTPLEETLRALDDLVRQGKVRYI 155


                ....*
gi 15829589 133 GVSNF 137
Cdd:cd19091 156 GVSNF 160
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 1-163 5.46e-17

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 77.10  E-value: 5.46e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   1 MQKVKL-NNGIEMPLLGFG-----VFQMTDAAECER-AVID-AINTGYRLIDTAASYQ-NEPQVGNALKQSGIARNELFV 71
Cdd:cd19144   1 IPTRTLgRNGPSVPALGFGamglsAFYGPPKPDEERfAVLDaAFELGCTFWDTADIYGdSEELIGRWFKQNPGKREKIFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  72 TTK-----------LWLqDTSYEGAKAQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFH 138
Cdd:cd19144  81 ATKfgieknvetgeYSV-DGSPEYVKKACETSLKRLGVDYIDLYYQHRvdGKTPIEKTVAAMAELVQEGKIKHIGLSECS 159

                       170       180
                ....*....|....*....|....*
gi 15829589 139 PDRLADLIAFNNVVpAVnQVEVNPF 163
Cdd:cd19144 160 AETLRRAHAVHPIA-AV-QIEYSPF 182
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 15-190 1.06e-16

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 75.83  E-value: 1.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQMTDAAECERAVIDA-INTGYRLIDTAASY----------QNEPQVGNALKQSGiARNELFVTTKL-------W 76
Cdd:cd19752   5 LGTMYFGTRTDEETSFAILDRyVAAGGNFLDTANNYafwteggvggESERLIGRWLKDRG-NRDDVVIATKVgagprdpD 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  77 LQDTSYEGA-----KAQFERSLNRLQLDYVDLYLIH--QPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRL--ADLIA 147
Cdd:cd19752  84 GGPESPEGLsaetiEQEIDKSLRRLGTDYIDLYYAHvdDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLerARQIA 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 15829589 148 FNNVVPAVNQVevnpfnQQLHAVpwmqsrgIQPEAWAPFAVTG 190
Cdd:cd19752 164 RQQGWAEFSAI------QQRHSY-------LRPRPGADFGVQR 193
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
 13-135 1.18e-16

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 75.86  E-value: 1.18e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  13 PLLGFGVFQMTDAAECER----AVID-AINTGYRLIDTAASY---QNEPQVGNALKqsGIARNELFVTTKL--------- 75
Cdd:cd19162   1 PRLGLGAASLGNLARAGEdeaaATLDaAWDAGIRYFDTAPLYglgLSERRLGAALA--RHPRAEYVVSTKVgrllepgaa 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15829589  76 -------WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH----GAWRAMEELQQAGKIRAIGVS 135
Cdd:cd19162  79 grpagadRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDRHLLqaltDAFPALEELRAEGVVGAIGVG 149
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 16-166 4.63e-16

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 74.13  E-value: 4.63e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  16 GFGVFQMTDAAECERAVIDAI-NTGYRLIDTAASYQN---EPQVGNAlkqsGIARNELFVTTKL--WLQDT-SYEGAKAQ 88
Cdd:cd19075   9 TFGSQGRFTTAEAAAELLDAFlERGHTEIDTARVYPDgtsEELLGEL----GLGERGFKIDTKAnpGVGGGlSPENVRKQ 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  89 FERSLNRLQLDYVDLYLIHQPygD----VHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAF---NN-VVPAVNQVEV 160
Cdd:cd19075  85 LETSLKRLKVDKVDVFYLHAP--DrstpLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEIckeNGwVLPTVYQGMY 162


                ....*.
gi 15829589 161 NPFNQQ 166
Cdd:cd19075 163 NAITRQ 168
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 15-166 1.04e-15

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 72.64  E-value: 1.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  15 LGFGVFQMT---------DAAECERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQsgiARNELFVTTKL------- 75
Cdd:cd19088   4 LGYGAMRLTgpgiwgppaDREEAIAVLRRALELGVNFIDTADSYgpdVNERLIAEALHP---YPDDVVIATKGglvrtgp 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  76 --WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNV 151
Cdd:cd19088  81 gwWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRidPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRI 160

                       170
                ....*....|....*
gi 15829589 152 VpAVnQVEVNPFNQQ 166
Cdd:cd19088 161 V-SV-QNRYNLANRD 173
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
 18-146 2.89e-15

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 72.18  E-value: 2.89e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  18 GVFQMTDAA-ECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQSGIARNELFVTTKL-----WLQDTSYEGAKAQ 88
Cdd:cd19153  24 GVYGDGLEQdEAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAALQVPRSSYTVATKVgryrdSEFDYSAERVRAS 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15829589  89 FERSLNRLQLDYVDLYLIH-----QPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLI 146
Cdd:cd19153 104 VATSLERLHTTYLDVVYLHdiefvDYDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRAT 166
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
 13-187 6.03e-15

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 71.10  E-value: 6.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  13 PLLGFG------VFQMTDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKqsGIARNELFVTTKL-WL----- 77
Cdd:cd19152   1 PKLGFGtaplgnLYEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALR--ELGREDYVISTKVgRLlvplq 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  78 -------------------QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP----YGDVH---------GAWRAMEELQQ 125
Cdd:cd19152  79 eveptfepgfwnplpfdavFDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPdedlAGAESdehfaqaikGAFRALEELRE 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589 126 AGKIRAIGV-SNFHP--DRLADLIAFNNVVPA-----VNQVEVNPFNQQLHAvpwmqsRGIQPEAWAPFA 187
Cdd:cd19152 159 EGVIKAIGLgVNDWEviLRILEEADLDWVMLAgrytlLDHSAARELLPECEK------RGVKVVNAGPFN 222
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 35-145 1.53e-14

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 69.92  E-value: 1.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  35 AINTGYRLIDTAASYQN---EPQVGNALKqSGIARNELFVTTKLWLQ---DTSYEGAK-----AQFERSLNRLQLDYVDL 103
Cdd:cd19079  44 ALDLGINFFDTANVYSGgasEEILGRALK-EFAPRDEVVIATKVYFPmgdGPNGRGLSrkhimAEVDASLKRLGTDYIDL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15829589 104 YLIHQpygdvhgaW----------RAMEELQQAGKIRAIGVSNFHPDRLADL 145
Cdd:cd19079 123 YQIHR--------WdyetpieetlEALHDVVKSGKVRYIGASSMYAWQFAKA 166
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 30-137 5.14e-14

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 68.51  E-value: 5.14e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  30 RAVID-AINTGYRLIDTAASY---QNEPQVGNALKQsgIARNELFVTTKLWLQ--DTSYEGAKAQFERSLNRLQLDYVDL 103
Cdd:cd19103  35 KAVFDkAMAAGLNLWDTAAVYgmgASEKILGEFLKR--YPREDYIISTKFTPQiaGQSADPVADMLEGSLARLGTDYIDI 112

                        90       100       110
                ....*....|....*....|....*....|....
gi 15829589 104 YLIHQPyGDVHGAWRAMEELQQAGKIRAIGVSNF 137
Cdd:cd19103 113 YWIHNP-ADVERWTPELIPLLKSGKVKHVGVSNH 145
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 22-137 4.05e-13

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 66.09  E-value: 4.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  22 MTDAAECeRAVIDA-INTGYRLIDTAASYQN---EPQVGNALKQSgiaRNELFVTTKLWL----QDTSYEG--AKA---Q 88
Cdd:cd19080  27 GADREEA-RAMFDAyVEAGGNFIDTANNYTNgtsERLLGEFIAGN---RDRIVLATKYTMnrrpGDPNAGGnhRKNlrrS 102

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15829589  89 FERSLNRLQLDYVDLYLIHQPYG--DVHGAWRAMEELQQAGKIRAIGVSNF 137
Cdd:cd19080 103 VEASLRRLQTDYIDLLYVHAWDFttPVEEVMRALDDLVRAGKVLYVGISDT 153
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
 17-145 2.46e-12

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 63.84  E-value: 2.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  17 FGVFQMTDAAEC--ERAVIDAINTGYRLIDTAASYQN-EPQVGNALK--QSGIARNELFVTTK-----LWLQDTSYEGAK 86
Cdd:cd19164  23 FSYQYTTDPESIppVDIVRRALELGIRAFDTSPYYGPsEIILGRALKalRDEFPRDTYFIITKvgrygPDDFDYSPEWIR 102

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15829589  87 AQFERSLNRLQLDYVDLYLIHQ----PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADL 145
Cdd:cd19164 103 ASVERSLRRLHTDYLDLVYLHDvefvADEEVLEALKELFKLKDEGKIRNVGISGYPLPVLLRL 165
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 3-140 2.55e-12

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 63.99  E-value: 2.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   3 KVKL-NNGIEMPLLGFGVFQMT---DAAECERAVID----AINTGYRLIDTAASY---QNEPQVGNALKqsGIARNELFV 71
Cdd:cd19145   2 RVKLgSQGLEVSAQGLGCMGLSgdyGAPKPEEEGIAlihhAFNSGVTFLDTSDIYgpnTNEVLLGKALK--DGPREKVQL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  72 TTKLWLQDTSYEG---------AKAQFERSLNRLQLDYVDLYLIHQ-----PYGDVHGawrAMEELQQAGKIRAIGVSNF 137
Cdd:cd19145  80 ATKFGIHEIGGSGvevrgdpayVRAACEASLKRLDVDYIDLYYQHRidttvPIEITMG---ELKKLVEEGKIKYIGLSEA 156


                ...
gi 15829589 138 HPD 140
Cdd:cd19145 157 SAD 159
PLN02587 PLN02587
L-galactose dehydrogenase
 7-135 3.28e-12

L-galactose dehydrogenase


Pssm-ID: 178198 [Multi-domain]  Cd Length: 314  Bit Score: 63.64  E-value: 3.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    7 NNGIEMPLLGFG------VFQMTDAAECERAVIDAINTGYRLIDTAASYQN---EPQVGNALKQSGIARNELFVTTKLWL 77
Cdd:PLN02587   6 STGLKVSSVGFGasplgsVFGPVSEEDAIASVREAFRLGINFFDTSPYYGGtlsEKVLGKALKALGIPREKYVVSTKCGR 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15829589   78 Q----DTSYEGAKAQFERSLNRLQLDYVDLYLIHQ-PYGD----VHGAWRAMEELQQAGKIRAIGVS 135
Cdd:PLN02587  86 YgegfDFSAERVTKSVDESLARLQLDYVDILHCHDiEFGSldqiVNETIPALQKLKESGKVRFIGIT 152
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 35-136 6.07e-12

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 62.97  E-value: 6.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  35 AINTGYRLIDTAASY----QNEPQ------VGNALKQSGiARNELFVTTKL--------WLQDT----SYEGAKAQFERS 92
Cdd:cd19094  27 AFDEGVNFIDTAEMYpvppSPETQgrteeiIGSWLKKKG-NRDKVVLATKVagpgegitWPRGGgtrlDRENIREAVEGS 105

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15829589  93 LNRLQLDYVDLYLIHQP-----------YGDVHGAW---------RAMEELQQAGKIRAIGVSN 136
Cdd:cd19094 106 LKRLGTDYIDLYQLHWPdrytplfgggyYTEPSEEEdsvsfeeqlEALGELVKAGKIRHIGLSN 169
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 7-165 9.41e-12

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 62.27  E-value: 9.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   7 NNGIEMPLLGFGVFQ----MTDAAECERAVIDAINTGYRLIDTAASYQNEPQ-----VGNALKQSGIA-RNELFVTTKlw 76
Cdd:cd19089   6 RSGLHLPAISLGLWHnfgdYTSPEEARELLRTAFDLGITHFDLANNYGPPPGsaeenFGRILKRDLRPyRDELVISTK-- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  77 lqdTSYE---------GAK----AQFERSLNRLQLDYVDLYLIHQPYGDVhgawrAMEELQQA-------GKIRAIGVSN 136
Cdd:cd19089  84 ---AGYGmwpgpygdgGSRkyllASLDQSLKRMGLDYVDIFYHHRYDPDT-----PLEETMTAladavrsGKALYVGISN 155

                       170       180       190
                ....*....|....*....|....*....|..
gi 15829589 137 FHPDRLADLIAFNN---VVPAVNQVEVNPFNQ 165
Cdd:cd19089 156 YPGAKARRAIALLRelgVPLIIHQPRYSLLDR 187
tas PRK10625
putative aldo-keto reductase; Provisional
 10-136 1.39e-11

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 61.79  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   10 IEMPLLGFGVfqMT--------DA-AECERAVIDAINtgyrLIDTAASYQNEPQ----------VGNALKQSGiARNELF 70
Cdd:PRK10625  11 LEVSTLGLGT--MTfgeqnseaDAhAQLDYAVAQGIN----LIDVAEMYPVPPRpetqgltetyIGNWLAKRG-SREKLI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   71 VTTKLW------------LQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP------YGDVHGAW-------------RA 119
Cdd:PRK10625  84 IASKVSgpsrnndkgirpNQALDRKNIREALHDSLKRLQTDYLDLYQVHWPqrptncFGKLGYSWtdsapavslletlDA 163

                        170
                 ....*....|....*..
gi 15829589  120 MEELQQAGKIRAIGVSN 136
Cdd:PRK10625 164 LAEQQRAGKIRYIGVSN 180
AKR_KCAB1B_AKR6A3-like cd19159
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ...
 8-191 1.40e-11

voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.


Pssm-ID: 381385 [Multi-domain]  Cd Length: 323  Bit Score: 61.98  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFGVF-----QMTDAAeCERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIARNELFVTTKLwlqd 79
Cdd:cd19159   9 SGLRVSCLGLGTWvtfggQISDEV-AERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKKGWRRSSLVITTKL---- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 tsYEGAKAQFER-------------SLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19159  84 --YWGGKAETERglsrkhiieglkgSLQRLQLEYVDVVFANRPDSNtpMEEIVRAMTHVINQGMAMYWGTSRWSAMEIME 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15829589 145 LIA----FNNVVPAVNQVEVNPFNQQLHAV--PWMQSR-GIQPEAWAPFA---VTGR 191
Cdd:cd19159 162 AYSvarqFNMIPPVCEQAEYHLFQREKVEVqlPELYHKiGVGAMTWSPLAcgiISGK 218
Aldo_ket_red_shaker cd19141
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ...
 9-191 8.75e-11

Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381367 [Multi-domain]  Cd Length: 310  Bit Score: 59.38  E-value: 8.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGVF-----QMTDAAeCERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIARNELFVTTKLwlqdt 80
Cdd:cd19141   9 GLRVSCLGLGTWvtfgsQISDEV-AEELVTLAYENGINLFDTAEVYaagKAEIVLGKILKKKGWRRSSYVITTKI----- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  81 sYEGAKAQFER-------------SLNRLQLDYVDLYLIHQPygDVHgawRAMEELQQA-------GKIRAIGVSNFHPD 140
Cdd:cd19141  83 -FWGGKAETERglsrkhiieglkaSLERLQLEYVDIVFANRP--DPN---TPMEEIVRAfthvinqGMAMYWGTSRWSAM 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15829589 141 RLADLIA----FNNVVPAVNQVEVNPFNQ---QLHAVPWMQSRGIQPEAWAPFA---VTGR 191
Cdd:cd19141 157 EIMEAYSvarqFNLIPPIVEQAEYHLFQRekvEMQLPELFHKIGVGAMTWSPLAcgiLSGK 217
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
 25-166 5.87e-10

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 57.22  E-value: 5.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  25 AAECERAVIDAintGYRLIDTAASYQN---EPQVGNALKQSGIARNELFVTTKL-W------LQDTS------YEGAKAq 88
Cdd:cd19143  33 AKECMKAAYDA---GVNFFDNAEVYANgqsEEIMGQAIKELGWPRSDYVVSTKIfWggggppPNDRGlsrkhiVEGTKA- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  89 ferSLNRLQLDYVDLYLIHQPygDVHG----AWRAMEELQQAGKIRAIGVSNF------HPDRLAD---LIAfnnvvPAV 155
Cdd:cd19143 109 ---SLKRLQLDYVDLVFCHRP--DPATpieeTVRAMNDLIDQGKAFYWGTSEWsaqqieEAHEIADrlgLIP-----PVM 178

                       170
                ....*....|.
gi 15829589 156 NQVEVNPFNQQ 166
Cdd:cd19143 179 EQPQYNLFHRE 189
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 24-179 9.46e-10

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 56.45  E-value: 9.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  24 DAAECERAVIDAINTGYRLIDTAASYQN-EPQVG---NALKQSGIARNELFVTTKL----WLQDTSYEGAKAQFERSLNR 95
Cdd:cd19101  21 DEDAAVRAMAAYVDAGLTTFDCADIYGPaEELIGefrKRLRRERDAADDVQIHTKWvpdpGELTMTRAYVEAAIDRSLKR 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  96 LQLDYVDLYLIH-QPYGD---VHGAwRAMEELQQAGKIRAIGVSNFHPDRLADLIafNNVVPAV-NQVEVNPFNQ--QLH 168
Cdd:cd19101 101 LGVDRLDLVQFHwWDYSDpgyLDAA-KHLAELQEEGKIRHLGLTNFDTERLREIL--DAGVPIVsNQVQYSLLDRrpENG 177

                       170
                ....*....|.
gi 15829589 169 AVPWMQSRGIQ 179
Cdd:cd19101 178 MAALCEDHGIK 188
AKR_KCAB3B_AKR6A9-like cd19160
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ...
 8-191 1.02e-09

voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.


Pssm-ID: 381386 [Multi-domain]  Cd Length: 325  Bit Score: 56.53  E-value: 1.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFGVF-----QMTDAAeCERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIARNELFVTTKLwlqd 79
Cdd:cd19160  11 SGLRVSCLGLGTWvtfgsQISDET-AEDLLTVAYEHGVNLFDTAEVYaagKAERTLGNILKSKGWRRSSYVVTTKI---- 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 tsYEGAKAQFER-------------SLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19160  86 --YWGGQAETERglsrkhiieglrgSLDRLQLEYVDIVFANRsdPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAMEIME 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15829589 145 LIA----FNNVVPAVNQVEVNPFNQQL--HAVPWMQSR-GIQPEAWAPFA---VTGR 191
Cdd:cd19160 164 AYSvarqFNLIPPVCEQAEYHLFQREKveMQLPELYHKiGVGSVTWSPLAcglITGK 220
AKR_AKR15A1 cd19161
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ...
 30-133 1.34e-09

Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.


Pssm-ID: 381387 [Multi-domain]  Cd Length: 310  Bit Score: 56.18  E-value: 1.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  30 RAVID-AINTGYRLIDTAASYQN---EPQVGNALKQSGiaRNELFVTTKL-----------------WLQ--------DT 80
Cdd:cd19161  23 DATLDaAWDSGIRYFDTAPMYGHglaEHRLGDFLREKP--RDEFVLSTKVgrllkparegsvpdpngFVDplpfeivyDY 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15829589  81 SYEGAKAQFERSLNRLQLDYVDLYLIHQ--PY--GDVH----------GAWRAMEELQQAGKIRAIG 133
Cdd:cd19161 101 SYDGIMRSFEDSLQRLGLNRIDILYVHDigVYthGDRKerhhfaqlmsGGFKALEELKKAGVIKAFG 167
AKR_KCAB2B_AKR6A1-like cd19158
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ...
 8-187 3.78e-09

voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.


Pssm-ID: 381384 [Multi-domain]  Cd Length: 324  Bit Score: 54.71  E-value: 3.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   8 NGIEMPLLGFGVF-----QMTDAAeCERAVIDAINTGYRLIDTAASY---QNEPQVGNALKQSGIARNELFVTTKLwlqd 79
Cdd:cd19158   9 SGLRVSCLGLGTWvtfggQITDEM-AEHLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKKKGWRRSSLVITTKI---- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  80 tsYEGAKAQFER-------------SLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19158  84 --FWGGKAETERglsrkhiieglkaSLERLQLEYVDVVFANRPDPNtpMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 15829589 145 LIA----FNNVVPAVNQVEVNPFNQQLHAV---PWMQSRGIQPEAWAPFA 187
Cdd:cd19158 162 AYSvarqFNLIPPICEQAEYHMFQREKVEVqlpELFHKIGVGAMTWSPLA 211
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
 8-191 5.74e-09

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 54.23  E-value: 5.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589    8 NGIEMPLLGFGV---FQMTDAAECERAVI-DAINTGYRLIDTAASY-----QNEPQVGNALKQSGIA-RNELFVTTK--- 74
Cdd:PRK09912  21 SGLRLPALSLGLwhnFGHVNALESQRAILrKAFDLGITHFDLANNYgpppgSAEENFGRLLREDFAAyRDELIISTKagy 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   75 -LWLQDTSYEGAK----AQFERSLNRLQLDYVDLYLIHQ-----PYGDVHGawrAMEELQQAGKIRAIGVSNFHPDR--- 141
Cdd:PRK09912 101 dMWPGPYGSGGSRkyllASLDQSLKRMGLEYVDIFYSHRvdentPMEETAS---ALAHAVQSGKALYVGISSYSPERtqk 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15829589  142 LADLIAFNNVVPAVNQVEVNPFNQ---QLHAVPWMQSRGIQPEAWAPFA---VTGR 191
Cdd:PRK09912 178 MVELLREWKIPLLIHQPSYNLLNRwvdKSGLLDTLQNNGVGCIAFTPLAqglLTGK 233
AKR_AKR14A2 cd19151
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ...
 7-147 5.61e-08

Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).


Pssm-ID: 381377 [Multi-domain]  Cd Length: 309  Bit Score: 51.25  E-value: 5.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   7 NNGIEMPLLGFGV---FQMTDAAECERAVI-DAINTGYRLIDTAASYQnePQVGNA-------LKQSGIA-RNELFVTTK 74
Cdd:cd19151   7 RSGLKLPAISLGLwhnFGDVDRYENSRAMLrRAFDLGITHFDLANNYG--PPPGSAeenfgriLKEDLKPyRDELIISTK 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  75 ----LWlqDTSYE--GAK----AQFERSLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRL 142
Cdd:cd19151  85 agytMW--PGPYGdwGSKkyliASLDQSLKRMGLDYVDIFYHHRPDPEtpLEETMGALDQIVRQGKALYVGISNYPPEEA 162


                ....*
gi 15829589 143 ADLIA 147
Cdd:cd19151 163 REAAA 167
PRK10376 PRK10376
putative oxidoreductase; Provisional
 12-143 6.61e-07

putative oxidoreductase; Provisional


Pssm-ID: 236676 [Multi-domain]  Cd Length: 290  Bit Score: 48.04  E-value: 6.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   12 MPLLGFGVF---QMTDAAeceRAVI-DAINTGYRLIDTAASYQnePQVGNALKQSGIA--RNELFVTTKL---------W 76
Cdd:PRK10376  25 MQLAGPGVFgppKDRDAA---IAVLrEAVALGVNHIDTSDFYG--PHVTNQLIREALHpyPDDLTIVTKVgarrgedgsW 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15829589   77 LQDTSYEGAKAQFERSLNRLQ---LDYVDLYLIhqpyGDVHG--------AWRAMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:PRK10376 100 LPAFSPAELRRAVHDNLRNLGldvLDVVNLRLM----GDGHGpaegsieePLTVLAELQRQGLVRHIGLSNVTPTQVA 173
AKR_AKR9A3_9B1-4 cd19147
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ...
 39-136 6.29e-06

Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381373 [Multi-domain]  Cd Length: 319  Bit Score: 45.59  E-value: 6.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  39 GYRLIDTAASYQNEPQ---VGNALKQSGIaRNELFVTTKLWLQDTSYE---GAKAQF------------ERSLNRLQLDY 100
Cdd:cd19147  47 GGNFIDTANNYQDEQSetwIGEWMKSRKN-RDQIVIATKFTTDYKAYEvgkGKAVNYcgnhkrslhvsvRDSLRKLQTDW 125

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15829589 101 VDLYLIH--QPYGDVHGAWRAMEELQQAGKIRAIGVSN 136
Cdd:cd19147 126 IDILYVHwwDYTTSIEEVMDSLHILVQQGKVLYLGVSD 163
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
 31-136 9.07e-05

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 42.03  E-value: 9.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589  31 AVIDAI-NTGYRLIDTAASYQNEPQ---VGNALKQSGIaRNELFVTTKLWL---------QDTSYEGAKAQ-----FERS 92
Cdd:cd19146  39 KLLDAFyEQGGNFIDTANNYQGEESerwVGEWMASRGN-RDEMVLATKYTTgyrrggpikIKSNYQGNHAKslrlsVEAS 117

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15829589  93 LNRLQLDYVDLYLIHqpYGD----VHGAWRAMEELQQAGKIRAIGVSN 136
Cdd:cd19146 118 LKKLQTSYIDILYVH--WWDyttsIPELMQSLNHLVAAGKVLYLGVSD 163
AKR_AKR14A1 cd19150
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ...
 9-147 2.28e-04

Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.


Pssm-ID: 381376 [Multi-domain]  Cd Length: 309  Bit Score: 40.90  E-value: 2.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829589   9 GIEMPLLGFGV---FQMTDAAECERAVI-DAINTGYRLIDTAASY-----QNEPQVGNALKQSGIA-RNELFVTTK---- 74
Cdd:cd19150   9 GLKLPALSLGLwhnFGDDTPLETQRAILrTAFDLGITHFDLANNYgpppgSAEENFGRILREDFAGyRDELIISTKagyd 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15829589  75 LWLQDTSYEGAK----AQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIA 147
Cdd:cd19150  89 MWPGPYGEWGSRkyllASLDQSLKRMGLDYVDIFYSHRfdPDTPLEETMGALDHAVRSGKALYVGISSYSPERTREAAA 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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