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Conserved domains on  [gi|15600501|ref|NP_253995|]
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leucine-responsive regulatory protein [Pseudomonas aeruginosa PAO1]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11169 super family cl32651
leucine-responsive transcriptional regulator Lrp;
9-155 2.45e-69

leucine-responsive transcriptional regulator Lrp;


The actual alignment was detected with superfamily member PRK11169:

Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 206.92  E-value: 2.45e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501    9 RELDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEISLDYKSGDT 88
Cdd:PRK11169  10 KDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDV 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15600501   89 FEEFRRAVLKLPHVLECHLVSGHFDYLVKARISEMASYRKLLGDILLKLPHVRESKSYIVMEEVKES 155
Cdd:PRK11169  90 FEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQT 156
 
Name Accession Description Interval E-value
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
9-155 2.45e-69

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 206.92  E-value: 2.45e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501    9 RELDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEISLDYKSGDT 88
Cdd:PRK11169  10 KDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDV 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15600501   89 FEEFRRAVLKLPHVLECHLVSGHFDYLVKARISEMASYRKLLGDILLKLPHVRESKSYIVMEEVKES 155
Cdd:PRK11169  90 FEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQT 156
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-149 1.77e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 163.41  E-value: 1.77e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501   9 RELDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEISLDyksGDT 88
Cdd:COG1522   1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP---PHR 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15600501  89 FEEFRRAVLKLPHVLECHLVSGHFDYLVKARISEMASYRKLLGDILLKLPHVRESKSYIVM 149
Cdd:COG1522  78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 11-119 4.86e-41

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 133.41  E-value: 4.86e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501     11 LDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEISLDykSGDTFE 90
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLE--NPDKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 15600501     91 EFRRAVLKLPHVLECHLVSGHFDYLVKAR 119
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 77-151 3.68e-19

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 76.41  E-value: 3.68e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15600501    77 VEISLDykSGDTFEEFRRAVLKLPHVLECHLVSGHFDYLVKARISEMASYRKLLGDILLKLPHVRESKSYIVMEE 151
Cdd:pfam01037   1 VEVKLE--PGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-57 4.17e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.67  E-value: 4.17e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15600501  12 DKIDRNILRILQEEGRiSFTELGERVGLSTTPCTERVRRLEREGLI 57
Cdd:cd00090   6 DPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLV 50
 
Name Accession Description Interval E-value
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
9-155 2.45e-69

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 206.92  E-value: 2.45e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501    9 RELDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEISLDYKSGDT 88
Cdd:PRK11169  10 KDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDV 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15600501   89 FEEFRRAVLKLPHVLECHLVSGHFDYLVKARISEMASYRKLLGDILLKLPHVRESKSYIVMEEVKES 155
Cdd:PRK11169  90 FEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQT 156
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-149 1.77e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 163.41  E-value: 1.77e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501   9 RELDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEISLDyksGDT 88
Cdd:COG1522   1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP---PHR 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15600501  89 FEEFRRAVLKLPHVLECHLVSGHFDYLVKARISEMASYRKLLGDILLKLPHVRESKSYIVM 149
Cdd:COG1522  78 LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 11-119 4.86e-41

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 133.41  E-value: 4.86e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501     11 LDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEISLDykSGDTFE 90
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLE--NPDKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 15600501     91 EFRRAVLKLPHVLECHLVSGHFDYLVKAR 119
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 77-151 3.68e-19

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 76.41  E-value: 3.68e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15600501    77 VEISLDykSGDTFEEFRRAVLKLPHVLECHLVSGHFDYLVKARISEMASYRKLLGDILLKLPHVRESKSYIVMEE 151
Cdd:pfam01037   1 VEVKLE--PGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
12-52 5.25e-17

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 70.09  E-value: 5.25e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15600501    12 DKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLE 52
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
13-57 1.14e-15

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 66.69  E-value: 1.14e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15600501    13 KIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLI 57
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-117 6.06e-11

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 57.41  E-value: 6.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600501    1 MRTQHQskreLDKIDRNILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIMGYHARLNPQHLKASLLVFVEIS 80
Cdd:PRK11179   1 MMENYQ----IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGII 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 15600501   81 LdyKSGDTFEEFRRAVLKLPHVLECHLVSGHFDYLVK 117
Cdd:PRK11179  77 L--KSAKDYPSALAKLESLDEVVEAYYTTGHYSIFIK 111
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-57 4.17e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.67  E-value: 4.17e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15600501  12 DKIDRNILRILQEEGRiSFTELGERVGLSTTPCTERVRRLEREGLI 57
Cdd:cd00090   6 DPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLV 50
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 18-58 1.17e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 38.30  E-value: 1.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15600501    18 ILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLIM 58
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE 48
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
18-57 1.80e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.73  E-value: 1.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15600501     18 ILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLI 57
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV 54
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
18-57 6.26e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 38.03  E-value: 6.26e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15600501  18 ILRILQEEGRISFTELGERVGLSTTPCTERVRRLEREGLI 57
Cdd:COG1846  43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 10-57 6.67e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 36.82  E-value: 6.67e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15600501  10 ELDKIDRNILRILQE-EGRISFTELGERVGLSTTPCTERVRRLEREGLI 57
Cdd:COG2512  12 ELLEDERRVLELLREnGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLI 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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