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Conserved domains on  [gi|15600108|ref|NP_253602|]
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chemotaxis transducer [Pseudomonas aeruginosa PAO1]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
9-541 1.87e-77

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 253.40  E-value: 1.87e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108   9 IRLLVLALLPLTMLVTVIAMALANASRLDASFQDLFNNRMKPISQLKIVADAVAVSVVDALHKYRAGVFDEERLQQELSG 88
Cdd:COG0840   2 LILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  89 ALSRIEKSWADYSADHRTAAEKEIIESLVPTLERVKRMTLAYGEQARAGSLRNVEAGTFNREMYGAFDPLGTALSTLIDL 168
Cdd:COG0840  82 LALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 169 QLSEGAKLNEQMEKRYDSMRTTFLLIGAAALVLIVAAAWFISLSIMRPLSDLRGVIRRVQDSsNLTLRADARGRDEVSDT 248
Cdd:COG0840 162 ALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEG-DLTVRIDVDSKDEIGQL 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 249 ARAFNMMLESQQALLRHLAETARKLTITSDEMSAISNQVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAES 328
Cdd:COG0840 241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEE 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 329 ANSEAHTGTGLVHANLDAIQGLSVMVGEAGAVIDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAV 408
Cdd:COG0840 321 ASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAV 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 409 VADEVRSLATNTHKATETIREMIEALQAGASSAVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATE 488
Cdd:COG0840 401 VADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASE 480

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|...
gi 15600108 489 EQTATASEVSQNIDSLNASIGEVAEGAVKTSTSSVELAKLANGLEQQIQRFTV 541
Cdd:COG0840 481 EQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
9-541 1.87e-77

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 253.40  E-value: 1.87e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108   9 IRLLVLALLPLTMLVTVIAMALANASRLDASFQDLFNNRMKPISQLKIVADAVAVSVVDALHKYRAGVFDEERLQQELSG 88
Cdd:COG0840   2 LILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  89 ALSRIEKSWADYSADHRTAAEKEIIESLVPTLERVKRMTLAYGEQARAGSLRNVEAGTFNREMYGAFDPLGTALSTLIDL 168
Cdd:COG0840  82 LALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 169 QLSEGAKLNEQMEKRYDSMRTTFLLIGAAALVLIVAAAWFISLSIMRPLSDLRGVIRRVQDSsNLTLRADARGRDEVSDT 248
Cdd:COG0840 162 ALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEG-DLTVRIDVDSKDEIGQL 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 249 ARAFNMMLESQQALLRHLAETARKLTITSDEMSAISNQVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAES 328
Cdd:COG0840 241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEE 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 329 ANSEAHTGTGLVHANLDAIQGLSVMVGEAGAVIDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAV 408
Cdd:COG0840 321 ASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAV 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 409 VADEVRSLATNTHKATETIREMIEALQAGASSAVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATE 488
Cdd:COG0840 401 VADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASE 480

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|...
gi 15600108 489 EQTATASEVSQNIDSLNASIGEVAEGAVKTSTSSVELAKLANGLEQQIQRFTV 541
Cdd:COG0840 481 EQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 281-540 4.66e-56

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 188.65  E-value: 4.66e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    281 SAISNQVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAESANSEAHTGTGLVHANLDAIQGLSVMVGEAGAV 360
Cdd:smart00283   3 SEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    361 IDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEALQAGASS 440
Cdd:smart00283  83 VEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    441 AVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATEEQTATASEVSQNIDSLNASIGEVAEGAVKTST 520
Cdd:smart00283 163 AVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISA 242

                          250       260
                   ....*....|....*....|
gi 15600108    521 SSVELAKLANGLEQQIQRFT 540
Cdd:smart00283 243 AAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 306-505 9.83e-45

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 156.63  E-value: 9.83e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 306 HQMSMAVQDVARNAQAAAASAESANSEAHTGTGLVHANLDAIQGLSVMVGEAGAVIDTLRNKTDEISTVLEVIQNIAQQT 385
Cdd:cd11386   1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 386 NLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEALQAGASSAVSVMQQSREQAQVSVQRAHEAGKA 465
Cdd:cd11386  81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15600108 466 LGLIAQAVEGIAQSNAQISTATEEQTATASEVSQNIDSLN 505
Cdd:cd11386 161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 354-506 1.02e-33

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 126.01  E-value: 1.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108   354 VGEAGAVIDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEA 433
Cdd:pfam00015  18 VANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALIIE 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15600108   434 LQAGASSAVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATEEQTATASEVSQNIDSLNA 506
Cdd:pfam00015  98 IQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQ 170
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 207-540 1.43e-21

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 98.15  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  207 WF-ISLSIMRPLSDLRGVIRRVQdSSNLTLRADARGRDEVSDTARAFNMMLESQQALLRHLAETARKLTITSDEMSAISN 285
Cdd:PRK15048 209 WYgIRRMLLTPLAKIIAHIREIA-GGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNT 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  286 QVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAESANSEAHTGTGLVHAnldaiqglsvmvgeagaVIDTLR 365
Cdd:PRK15048 288 DLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDG-----------------VVKTMH 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  366 NKTD---EISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEALQAGASSAv 442
Cdd:PRK15048 351 EIADsskKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTG- 429

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  443 SVMQQSreqaqvsvqraheAGKALGLIAQAVEGIAQSNAQISTATEEQtatasevSQNIDSLNASIGEVAEGAVKTSTSS 522
Cdd:PRK15048 430 SVLVES-------------AGETMNNIVNAVTRVTDIMGEIASASDEQ-------SRGIDQVALAVSEMDRVTQQNASLV 489

                        330
                 ....*....|....*...
gi 15600108  523 VELAKLANGLEQQIQRFT 540
Cdd:PRK15048 490 QESAAAAAALEEQASRLT 507
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
9-541 1.87e-77

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 253.40  E-value: 1.87e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108   9 IRLLVLALLPLTMLVTVIAMALANASRLDASFQDLFNNRMKPISQLKIVADAVAVSVVDALHKYRAGVFDEERLQQELSG 88
Cdd:COG0840   2 LILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  89 ALSRIEKSWADYSADHRTAAEKEIIESLVPTLERVKRMTLAYGEQARAGSLRNVEAGTFNREMYGAFDPLGTALSTLIDL 168
Cdd:COG0840  82 LALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 169 QLSEGAKLNEQMEKRYDSMRTTFLLIGAAALVLIVAAAWFISLSIMRPLSDLRGVIRRVQDSsNLTLRADARGRDEVSDT 248
Cdd:COG0840 162 ALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEG-DLTVRIDVDSKDEIGQL 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 249 ARAFNMMLESQQALLRHLAETARKLTITSDEMSAISNQVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAES 328
Cdd:COG0840 241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEE 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 329 ANSEAHTGTGLVHANLDAIQGLSVMVGEAGAVIDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAV 408
Cdd:COG0840 321 ASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAV 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 409 VADEVRSLATNTHKATETIREMIEALQAGASSAVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATE 488
Cdd:COG0840 401 VADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASE 480

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|...
gi 15600108 489 EQTATASEVSQNIDSLNASIGEVAEGAVKTSTSSVELAKLANGLEQQIQRFTV 541
Cdd:COG0840 481 EQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 281-540 4.66e-56

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 188.65  E-value: 4.66e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    281 SAISNQVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAESANSEAHTGTGLVHANLDAIQGLSVMVGEAGAV 360
Cdd:smart00283   3 SEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    361 IDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEALQAGASS 440
Cdd:smart00283  83 VEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    441 AVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATEEQTATASEVSQNIDSLNASIGEVAEGAVKTST 520
Cdd:smart00283 163 AVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISA 242

                          250       260
                   ....*....|....*....|
gi 15600108    521 SSVELAKLANGLEQQIQRFT 540
Cdd:smart00283 243 AAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 306-505 9.83e-45

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 156.63  E-value: 9.83e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 306 HQMSMAVQDVARNAQAAAASAESANSEAHTGTGLVHANLDAIQGLSVMVGEAGAVIDTLRNKTDEISTVLEVIQNIAQQT 385
Cdd:cd11386   1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 386 NLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEALQAGASSAVSVMQQSREQAQVSVQRAHEAGKA 465
Cdd:cd11386  81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15600108 466 LGLIAQAVEGIAQSNAQISTATEEQTATASEVSQNIDSLN 505
Cdd:cd11386 161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 354-506 1.02e-33

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 126.01  E-value: 1.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108   354 VGEAGAVIDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEA 433
Cdd:pfam00015  18 VANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALIIE 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15600108   434 LQAGASSAVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATEEQTATASEVSQNIDSLNA 506
Cdd:pfam00015  98 IQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQ 170
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 207-540 1.43e-21

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 98.15  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  207 WF-ISLSIMRPLSDLRGVIRRVQdSSNLTLRADARGRDEVSDTARAFNMMLESQQALLRHLAETARKLTITSDEMSAISN 285
Cdd:PRK15048 209 WYgIRRMLLTPLAKIIAHIREIA-GGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNT 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  286 QVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAESANSEAHTGTGLVHAnldaiqglsvmvgeagaVIDTLR 365
Cdd:PRK15048 288 DLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDG-----------------VVKTMH 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  366 NKTD---EISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEALQAGASSAv 442
Cdd:PRK15048 351 EIADsskKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTG- 429

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  443 SVMQQSreqaqvsvqraheAGKALGLIAQAVEGIAQSNAQISTATEEQtatasevSQNIDSLNASIGEVAEGAVKTSTSS 522
Cdd:PRK15048 430 SVLVES-------------AGETMNNIVNAVTRVTDIMGEIASASDEQ-------SRGIDQVALAVSEMDRVTQQNASLV 489

                        330
                 ....*....|....*...
gi 15600108  523 VELAKLANGLEQQIQRFT 540
Cdd:PRK15048 490 QESAAAAAALEEQASRLT 507
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
207-540 1.46e-21

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 98.10  E-value: 1.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  207 WF-ISLSIMRPLSDLRGVIRRVQdSSNLTLRADARGRDEVSDTARAFNMMlesQQALLRHLAET---ARKLTITSDEMSA 282
Cdd:PRK15041 211 WFgIKASLVAPMNRLIDSIRHIA-GGDLVKPIEVDGSNEMGQLAESLRHM---QGELMRTVGDVrngANAIYSGASEIAT 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  283 ISNQVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQAAAASAESANSEAHTGTGLVHAnldaiqglsvmvgeagaVID 362
Cdd:PRK15041 287 GNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASHLALSASETAQRGGKVVDN-----------------VVQ 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  363 TLRN---KTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEVRSLATNTHKATETIREMIEalqagas 439
Cdd:PRK15041 350 TMRDistSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIE------- 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  440 savsvmqQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSNAQISTATEEQtatasevSQNIDSLNASIGEVAEGAVKTS 519
Cdd:PRK15041 423 -------DSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQ-------SRGIDQVGLAVAEMDRVTQQNA 488

                        330       340
                 ....*....|....*....|.
gi 15600108  520 TSSVELAKLANGLEQQIQRFT 540
Cdd:PRK15041 489 ALVEESAAAAAALEEQASRLT 509
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
174-541 9.09e-18

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 86.28  E-value: 9.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  174 AKLNEQMEKRYDSMRTTFLLIGAAALVLIVAAAWFISLSIMRPLSDLRGVIRRVQDSsNLTLRADARGRDEVSDTARAFN 253
Cdd:PRK09793 175 EAASAQSQRNYQISALVFISMIIVAAIYISSALWWTRKMIVQPLAIIGSHFDSIAAG-NLARPIAVYGRNEITAIFASLK 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  254 MMLESQQALLRHLAETARKLTITSDEMSAISNQVSHVATSQGDQTDMVATAVHQMSMAVqdvarnaqaaaasaESANSEA 333
Cdd:PRK09793 254 TMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATV--------------GQNADNA 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  334 HTGTGLVHANLDAIQGLSVMVGEAGAVIDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAGEAGRGFAVVADEV 413
Cdd:PRK09793 320 RQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEV 399

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  414 RSLATNTHKATETIREMIEalqagasSAVSVMQQSREQAQVSVQRAHEagkalglIAQAVEGIAQSNAQISTATEEQTAT 493
Cdd:PRK09793 400 RNLASRSAQAAKEIKGLIE-------ESVNRVQQGSKLVNNAAATMTD-------IVSSVTRVNDIMGEIASASEEQRRG 465

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 15600108  494 ASEVSQNIDSLNASIGEVAEGAVKTSTSSVELAKLANGLEQQIQRFTV 541
Cdd:PRK09793 466 IEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
4HB_MCP_1 pfam12729
Four helix bundle sensory module for signal transduction; This family is a four helix bundle ...
 21-184 2.89e-05

Four helix bundle sensory module for signal transduction; This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterized in E coli chemoreceptors. This domain recognizes citrate and TCA cycle intermediates, cis-aconitate, boric acid, Phenanthrene, pyrene and benzopyrene (Matilla et el., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 432749 [Multi-domain]  Cd Length: 181  Bit Score: 44.93  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    21 MLVTVIAMALANASRLDASFQDLFNNRMKPISQLkivadavaVSVVDALHKYRAGVFD---------EERLQQELSGALS 91
Cdd:pfam12729  18 LLIIVGVVGLYSLKQINDNLDTMYEDRLLPIKWL--------GDIRANLLELRANLLElilttdpaeRDELLKDIEELRA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108    92 RIEKSWADYSADHRTAAEKEIIESL---VPTLERVKRMTLAYgeqARAGslRNVEAGT-FNREMYGAFDPLGTALSTLID 167
Cdd:pfam12729  90 EIDKLLEKYEKTILTDEEKKLFAEFkenLNAYRAVRNKVLEL---AKAG--NKDEAYQlYKTEGRPAREAMIEALEELVD 164

                         170
                  ....*....|....*..
gi 15600108   168 LQLSEGAKLNEQMEKRY 184
Cdd:pfam12729 165 YNLKVAKEAYKDNKASY 181
HAMP pfam00672
HAMP domain;
208-258 5.38e-05

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 40.69  E-value: 5.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15600108   208 FISLSIMRPLSDLRGVIRRVQDSsNLTLRADARGRDEVSDTARAFNMMLES 258
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASG-DLDVRLPVSGRDEIGELARAFNQMAER 50
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
212-264 8.91e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 40.31  E-value: 8.91e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 15600108    212 SIMRPLSDLRGVIRRVQDSsNLTLRADARGRDEVSDTARAFNMMLESQQALLR 264
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADG-DLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 214-258 1.06e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 39.74  E-value: 1.06e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15600108 214 MRPLSDLRGVIRRVQDSsNLTLRADARGRDEVSDTARAFNMMLES 258
Cdd:cd06225   1 TRPLRRLTEAARRIAEG-DLDVRVPVRSKDEIGELARAFNQMAER 44
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 190-282 4.35e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 42.64  E-value: 4.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 190 TFLLIGAAALVLIVAAAWFISLSIMRPLSDLRGVIRRVQDsSNLTLRADARGRDEVSDTARAFNMMLESQQALLRHLAET 269
Cdd:COG5000  10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAA-GDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEER 88

                        90
                ....*....|...
gi 15600108 270 ARKLTITSDEMSA 282
Cdd:COG5000  89 RRYLETILENLPA 101
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
178-273 4.88e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 42.70  E-value: 4.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 178 EQMEKRYDSMRTTFLLIGAAALVLIVAAAWFISLSIMRPLSDLRGVIRRVqdSSNLTLRADARGRDEVSDTARAFNMMLE 257
Cdd:COG2972 146 SELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKV--EKGDLVRLEVSGNDEIGILARSFNEMVE 223

                        90
                ....*....|....*.
gi 15600108 258 SQQALLRHLAETARKL 273
Cdd:COG2972 224 RIKELIEEVYELELEK 239
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
1-541 8.26e-04

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 42.02  E-value: 8.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108   1 MLTGVTVRIRLLVLALLPLTMLVTVIAMALANASRLDASFQDLFNNRMKPISQLKIVADAVAVSVVDALHKYRAGVFDEE 80
Cdd:COG2770  24 ALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108  81 RLQQELSGALSRIEKSWADYSADHRTAAEKEIIESLVPTLERVKRMTLAYGEQARAGSLRNVEAGTFNREMYGAFDPLGT 160
Cdd:COG2770 104 LLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAI 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 161 ALSTLIDLQLSEGAKLNEQMEKRYDSMRTTFLLIGAAALVLIVAAAWFISLSIMRPLSDLRGVIRRVQDSsNLTLRADAR 240
Cdd:COG2770 184 AALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAG-DLDVRIPVS 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 241 GRDEVSDTARAFNMMLESQQALLRHLAETARKLTITSDEMSAISNQVSHVATSQGDQTDMVATAVHQMSMAVQDVARNAQ 320
Cdd:COG2770 263 RKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLL 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 321 AAAASAESANSEAHTGTGLVHANLDAIQGLSVMVGEAGAVIDTLRNKTDEISTVLEVIQNIAQQTNLLALNAAIEAARAG 400
Cdd:COG2770 343 LLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALL 422

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600108 401 EAGRGFAVVADEVRSLATNTHKATETIREMIEALQAGASSAVSVMQQSREQAQVSVQRAHEAGKALGLIAQAVEGIAQSN 480
Cdd:COG2770 423 ALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAA 502

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15600108 481 AQISTATEEQTATASEVSQNIDSLNASIGEVAEGAVKTSTSSVELAKLANGLEQQIQRFTV 541
Cdd:COG2770 503 EELAEELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEA 563
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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