|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-383 |
9.81e-50 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 171.98 E-value: 9.81e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLC 92
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG-RRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIGPPLLVALAEALGWRHA 172
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFN--AGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 173 FIVSLLPGLLIAWLiwrhvrpdppraqrpapraeeakgkrlallksrNILLCTLISCVFVTWFIVLISFTPTFLVNARGF 252
Cdd:COG2271 167 FLILGLPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 253 SPATMGRLMSCLGVAWVVWGFAVPAISDRIGRR--PTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMA 330
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599291 331 TIPAETVSRGVIATALGLIMGLGeLVGGFLAPTVAGFAADRFGLSIVMWMSCG 383
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFG-FLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-382 |
1.93e-46 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 163.16 E-value: 1.93e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 15 LCVLFLTFGFVFFDRLALSFLFPFMEQE--LQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLC 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIG-RKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAG--LLGAVIGPPLLVALAEALGWR 170
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALgaLLAALVASLLIPLLSGDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 171 HAFIVSLLPGLLIAWLIwrhvrpdppraqrpapraeeakgkrlallksRNILLCTLISCVFVTWFIVLISFTPTFLVNAR 250
Cdd:cd17316 160 ILFLIGALPALLALLLR-------------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 251 GFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLF-- 328
Cdd:cd17316 209 GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWga 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15599291 329 MATIPAETVSRGVIATALGLIMGLGELVGGFLAPTVAGFAADRFGLSIVMWMSC 382
Cdd:cd17316 289 LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILA 342
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-373 |
2.88e-42 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 152.34 E-value: 2.88e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALS 96
Cdd:cd17319 7 LLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARK-VLAVSMLLWSLFTALT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 97 GLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVS 176
Cdd:cd17319 86 GFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAP--LGAAIGPPLSGWLLLLFGWRWAFIIE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 LLPGLLIAWLIWRHVrpdppraqrpapraeeakgkrlallksRNILLCTLI--SCVFVTWFivLISFTPTFLVNARGFSP 254
Cdd:cd17319 164 GLLGLLLAVLWWFYL---------------------------RQVWGLALGyfGINYALYG--LLTWLPTYLKQARGFSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 255 ATMGRLMSCLGVAWVVWGFAVPAISDRI---GRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMAT 331
Cdd:cd17319 215 KQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWS 294
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15599291 332 IPAETVSRGVIATALGLIMGLGELvGGFLAPTVAGFAADRFG 373
Cdd:cd17319 295 LPADLLPGEAAATAGGLINSGGNL-GGFVAPLLIGYLVDATG 335
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-357 |
5.61e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 148.58 E-value: 5.61e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 5 NNSASYENVLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIV 84
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG-RRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 85 AVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIGPPLLVALA 164
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLG--AGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 165 EALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEeakgkrLALLKSRNILLCTLISCVFVTWFIVLISFTPT 244
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 245 FLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGC 324
Cdd:COG2814 233 YLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|...
gi 15599291 325 FTLFMATIPAETVSRGVIATALGLIMGLGELVG 357
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-373 |
1.03e-38 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 143.48 E-value: 1.03e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAvILFSLC 92
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL-LLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGsaAGLLGAVIGPPLLVALAEALGWRHA 172
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAG--GGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 173 FIVSLLPGLLIAWLIWRHVRPDPPRAQRPAPraeEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGF 252
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAK---ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 253 SPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGL--GCFTLFMA 330
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAlgGGNGAVFA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15599291 331 TIPaETVSRGVIATALGLImGLGELVGGFLAPTVAGFAADRFG 373
Cdd:COG2223 319 LVP-DIFPTKNAGAVYGLV-GAAGGLGGFLGPLLFGALLDATG 359
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-381 |
2.76e-35 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 133.86 E-value: 2.76e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 18 LFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSG 97
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-RKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 98 LVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSL 177
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIF--SSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 178 LPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATM 257
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 258 GRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETV 337
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15599291 338 SRGVIATALGLIMGLGELvGGFLAPTVAGFAADRFGLSIVMWMS 381
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFATPFLAA 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-378 |
6.87e-33 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 127.42 E-value: 6.87e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 19 FLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIvAVILFSLCSALSGL 98
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVI-TILLFAVFTLLCGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 99 VGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQ-GSAAGLLGAVIGPPLLVALA-EALGWRHAFIVS 176
Cdd:cd17371 84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQsGWAVGWLLATLLAALLFPLLpPEIAWRVLFLLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 LLPGLLIaWLIWRHVrPDPPRAQRP-APRAEEAKGKRLALLKSRNILLCTLISCVFVT------WFIvlISFTPTFLVNA 249
Cdd:cd17371 164 ALPALLV-LFIRRFV-KEPPQWQAArAARRHFADRPSLRELFSPPLLRTTLLASLLATgalggyYGI--TTWLPSYLTGE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 250 RGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTglgcFTLF- 328
Cdd:cd17371 240 RGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLG----FFASg 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15599291 329 ----MATIPAETVSRGVIATALGLIMGLGELVGGfLAPTVAGFAADRFGLSIVM 378
Cdd:cd17371 316 pfsgMGAYLTELFPTAVRATAQGFCYNVGRIIGA-LFPFLVGFLATSGSLGTAI 368
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
31-373 |
8.15e-32 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 124.60 E-value: 8.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 31 ALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIvAVILFSLCSALSGLVGGFLSLLLFRG 110
Cdd:COG2807 36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLL-ALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 111 IMGLAEGPILPLSQSLmVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRH 190
Cdd:COG2807 115 LIGAGIAVGNVLLPGL-IKRWFPDRVGLMTGLY--TAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 191 VRPDPPRAQRPAPRAeeakgKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVnARGFSPATMGRLMSCLGVAWVV 270
Cdd:COG2807 192 LRRRPAAAAAAPAAA-----SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 271 WGFAVPAISDRIG-RRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGLI 349
Cdd:COG2807 266 GSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMA 345
|
330 340
....*....|....*....|....
gi 15599291 350 MGLGELvGGFLAPTVAGFAADRFG 373
Cdd:COG2807 346 QSVGYL-LAALGPLLVGALHDATG 368
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-381 |
2.27e-31 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 123.05 E-value: 2.27e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 32 LSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGI 111
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKP-RRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 112 MGLAEGPILPLSqSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHV 191
Cdd:cd17478 94 AGIGSAAFHPEG-ARLASQAAGGRRGLAMSIF--SVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 192 RPDPPRAqrpaPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIV-LISFTPTFLVnARGFSPATMGRLMSCLGVAWVV 270
Cdd:cd17478 171 PLKKPEA----KKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSsLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 271 WGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATipAETVSRGVIATALGLIM 350
Cdd:cd17478 246 GTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVL--AQELLPGNVGLASGLMM 323
|
330 340 350
....*....|....*....|....*....|.
gi 15599291 351 GLGELVGGFLAPtVAGFAADRFGLSIVMWMS 381
Cdd:cd17478 324 GLSFGLGGIGAP-VLGALADAFGLESVLLIL 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-362 |
8.13e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 120.99 E-value: 8.13e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALS 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG-RRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 97 GLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVS 176
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV--SAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 LLPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFlVNARGFSPAT 256
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 257 MGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPA-- 334
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAlv 316
|
330 340
....*....|....*....|....*....
gi 15599291 335 -ETVSRGVIATALGLIMGLGELvGGFLAP 362
Cdd:pfam07690 317 sDLAPKEERGTASGLYNTAGSL-GGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
17-307 |
8.67e-28 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 113.03 E-value: 8.67e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALS 96
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIE-RRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 97 GLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVS 176
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLT--LGLVLGRPLGGLLGQLLGWRAAFLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 LLPGLLIAWLIWRHVrpdpPRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPAT 256
Cdd:cd17324 160 AVLALLAALLLWRLL----PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSA 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15599291 257 MGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPN 307
Cdd:cd17324 236 IIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPS 286
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-383 |
4.23e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 111.36 E-value: 4.23e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 18 LFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSG 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 98 LVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQ--GSAAGLLGAVIGPPLlvALAEALGWRHAFIV 175
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQafGSVGGILGPLLGGIL--ASSLGFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 176 SLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLA--LLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFS 253
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLkrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 254 PATMGRLMSCLGVAWVVWGFAVPAISDR-IGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATI 332
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15599291 333 PAETVSRGVIATALGLIMGLGELVGGFLAPTVAGFAADRFGLSIVMWMSCG 383
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAV 368
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-384 |
7.68e-25 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 105.01 E-value: 7.68e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 18 LFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILfSLCSALSG 97
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLM-GAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 98 LVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIGPPLLVALAEALGWRHAFIVSL 177
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQ--TGVPLGGALAAALLPPLALHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 178 LPGLLIAWLIWRHVRpDPPRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATM 257
Cdd:cd17475 158 LVSILAAVLFWLFYR-EPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 258 GRLMSCLGVAWVVWGFAVPAISDRI--GRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFT-----LFMA 330
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAigwngLYLT 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15599291 331 TIpAETVSRGVIATALGLIMGLGeLVGGFLAPTVAGFAADRFGLSIVMWMSCGG 384
Cdd:cd17475 317 LV-AESAGPEQAGTALGLANTIN-FIGIAIGPPLFGLLVDATHSYAPAWLALAL 368
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-380 |
2.04e-24 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 103.78 E-value: 2.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFfdrLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLC 92
Cdd:COG0738 11 IAIYLLFFLWGFAT---ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFG-YKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGpILPLSQSLMVEASSPHRRGLNMGLLQG--SAAGLLGAVIGPpLLVALAEALGWR 170
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLG-LLDVAANPYVAALGPETAASRLNLLHAffSLGALLGPLLGG-LLILLGLSLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 171 HAFIVSLLPGLLIAWLIWRHVRPDPpraQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNAR 250
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSKLPEI---EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 251 GFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLT-YTGLGCFTLFM 329
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVgLGLSLMFPTIF 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15599291 330 ATIPAETVSRGVIATALGLIMGlgeLVGGFLAPTVAGFAADRFGLSIVMWM 380
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMG---IVGGAIGPPLIGFLADAFGLRAAFLV 369
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-373 |
5.25e-23 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 99.76 E-value: 5.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 19 FLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIvAVILFSLCSALSGL 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPI-GLILCAIVNLFFGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 99 VGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLL 178
Cdd:TIGR00881 80 STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWN-CSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 179 PGLLIAWLIWRHVRPDP------PRAQRPAPRAEEAKGKRLALLKSRNILLCTL--------ISCVFVTWFIVLISFT-- 242
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPqscglpPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVllnkvlwyISLGYVFVYVVRTGILdw 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 243 -PTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRI---GRRPTLVAFSLLAACCplALLYAPNATSLGLLLLLT 318
Cdd:TIGR00881 239 sPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVS--LLVYWLNPAANPLMDLIC 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599291 319 YTGLGCFT----LFMATIPAETVSRGVIATALGLImGLGELVGGFLAPTVAGFAADRFG 373
Cdd:TIGR00881 317 LFALGFLVygpqMLIGVIASELAPKKAAGTAAGFV-GFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-384 |
1.01e-22 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 98.88 E-value: 1.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRkPLLIVAVILFSLC 92
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPR-RVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSL-LLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRH 171
Cdd:cd17355 82 LVLLALATSLWQLyLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGIL--TAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 172 AFIVSLLPGLLI---AWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKSRN--ILLCTLISCVFVTWFIVLisFTPTFL 246
Cdd:cd17355 160 ALLVLALLALLVlvpVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASfwLLALAFFLCGFAVVGLIV--HLVPYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 247 VNaRGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGcft 326
Cdd:cd17355 238 AD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGW--- 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599291 327 LFMATIPAETVSRGVIATALGLIMGL---GELVGGFLAPTVAGFAADRFGLSIVMWMSCGG 384
Cdd:cd17355 314 GATVPLTAALAARYFGARSYGTLFGLvfaPHQLGSALGPWLGGLLYDRTGSYTAAWALAVA 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
15-373 |
1.98e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 98.46 E-value: 1.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 15 LCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSA 94
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 95 LSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQ--GSAAGLLGAVIGPplLVALAeALGWRHA 172
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYfaIPLGSGLGYVVGG--LVAQA-TGGWRWA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 173 FIVSLLPGLLIAWLIWRhVRPDPPRAQRPAPRAEEAKGKRL-----ALLKSRNILLCTL--ISCVFVTWfiVLISFTPTF 245
Cdd:cd17328 157 FRVTGVLGVLLAILLLL-FVREPPRGAAEGGVMAKSTATSFladlkALAKNPSFILSTLgfTAVSFVTG--ALAFWAPTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 246 LVNARGFSPATMGRLMSCLGVAWVVWGFA----VPAISDRIGR-----RPTLVAFSLLAA--CCPLALLYAPNATSLGLL 314
Cdd:cd17328 234 FLRAFGVGDLSSADVGLIFGAITCIAGVLgvllGGILADRLRRktpraDPLVCAVGLLAAapFLFLALVLALSNLLLAWV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 315 LLLTYTGLGCFTL-FMATIPAETVSRGVIATALGLIMGLGELVGGFLAPTVAGFAADRFG 373
Cdd:cd17328 314 LLFLGEFLLSLNWaPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLR 373
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
27-308 |
1.81e-21 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 95.34 E-value: 1.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 27 FDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALSGLVGGFLSLL 106
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRR-LFLTALALFTLGSLLCGLAPNLASLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 107 LFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWL 186
Cdd:cd17503 89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLV--GLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 187 iwrhvrpdppraqrpapraeeAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGV 266
Cdd:cd17503 167 ---------------------APLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGL 225
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 15599291 267 AWVVWGFAVPAISDRIGRRPTLVA-FSLLAACCPLALLYAPNA 308
Cdd:cd17503 226 ASAILSPLVGRLLDKFGPRLLLLAgLLLLALGTLLLAFLTPDT 268
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-367 |
4.12e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 94.35 E-value: 4.12e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 9 SYENVLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVlALAWAVSGALVGAW-SDRRGqRKPLLIVAVI 87
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSA-GLIGMAFGALFFGPlADRIG-RRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 88 LFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQ------GSAAGLLGAVIGPpllv 161
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFcgypigAAVGGFLAGWLIP---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 162 alaeALGWRHAFIVSLLPGLLIAWLIWRH-------------------VRPDPPRAQRPAP--------RAEEAKGKRLA 214
Cdd:TIGR00895 167 ----VFGWRSLFYVGGIAPLLLLLLLMRFlpesidflvskrpetvrriVNAIAPQMQAEAQsalpeqksTQGTKRSVFKA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 215 LLKSR----NILLCTLISCVFVTWFIvLISFTPTFLVNArGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVA 290
Cdd:TIGR00895 243 LFQGKtariTVLLWLLYFMLLVGVYF-LTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599291 291 FSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGLIMGLGELvGGFLAPTVAGF 367
Cdd:TIGR00895 321 LLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRL-GAIIGPILAGY 396
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
13-307 |
5.67e-20 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 90.34 E-value: 5.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFvfFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLC 92
Cdd:cd17365 1 LALCFLIIVLDG--FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFG-RKRVLLVSVALFGLF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHA 172
Cdd:cd17365 78 TLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLM--FCGYPLGAALGGFLAAALIPAFGWRSV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 173 FIVSLLPGLLIawliwrhvrpdppraqrpapraeeakgkrLALLKSRNILLCTLISCVFVTWFivLISFTPTfLVNARGF 252
Cdd:cd17365 156 FLLGGVPPLIL-----------------------------LPLLRGTLLLWVTFFMGLLLVYL--LNSWLPK-LMVEAGY 203
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 15599291 253 SPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPN 307
Cdd:cd17365 204 SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPA 258
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
25-383 |
3.80e-19 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 88.02 E-value: 3.80e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 25 VFFDRLALSFLFPFMEQ------ELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGL 98
Cdd:cd17330 5 VFLDALGFGIVFPVLPFyvrefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYG-RKPVLLLSLAGSAVSYVLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 99 VGGFLSLLLFRGIMGLAEGPIlPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLL 178
Cdd:cd17330 84 SRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGII--SAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 179 PGLLIAWLIWRHVRPdppraqrpapraeeakgkrlallksrnILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMG 258
Cdd:cd17330 161 LALLNLVLVLFFLPP---------------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 259 RLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALL-YAPNATSLGLLLLLTYTGLGCFTLFMATIPAETV 337
Cdd:cd17330 214 LLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLpFASSVPLLVLAAAILAFGTGIVFPALSALLSKSV 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15599291 338 SRGVIATALGLIMGLGELvGGFLAPTVAGFAADRFGLSIVMWMSCG 383
Cdd:cd17330 294 PSKEQGKAQGIIQSLQSL-ARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-296 |
1.39e-18 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 85.63 E-value: 1.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCS 93
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYG-RKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 94 ALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIGPPLLVALAEALGWRHAF 173
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWG--AAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 174 IVSLLPGLLIAWLIWRhvrpdppraqRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFS 253
Cdd:COG0477 172 LINAPLGLLALVLRLR----------LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 15599291 254 PATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAA 296
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-373 |
2.26e-18 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 86.49 E-value: 2.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 19 FLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSD----RRGQRKPLLIVAVILFSLCSA 94
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 95 L----------SGLVGGFLSLLLFRGIMGLAEGPIlplsQSLMVE-ASSPHRRGLNMGLLQ--GSAAGLLGAVIGPPLLV 161
Cdd:COG2211 97 LlftapdlsptGKLIYALVTYLLLGLAYTLVNIPY----SALGAElTPDYEERTRLSSWRFafAGLGGLLASVLPPPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 162 ALAE--ALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKgkrlALLKSRN-ILLCTLISCVFVTWFIVL 238
Cdd:COG2211 173 AFGGdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLK----ALLKNRPfLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 239 iSFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPN-------ATSL 311
Cdd:COG2211 249 -ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnlwlllVLAA 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599291 312 GLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGL-IMGLGELVGGFLAPTVAGFAADRFG 373
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFgIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-296 |
2.32e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 86.09 E-value: 2.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 51 GMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEA 130
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFG-RKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 131 SSPHRRGLNMGLlQGSAAGLLGAVIgpPLLVALAEALGWRHAFIVSLLpGLLIAWLIWRHVrPDPPRAQRPAPRAEEAKG 210
Cdd:cd17473 117 FEGEERAKMLGL-QSAAMSLGGVVF--LLLGGALAEIGWRAPFLVYLL-ALPVLILVLLFL-PEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 211 KrlALLKSRNILLCTLISCVFVTWFIVLIsFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVA 290
Cdd:cd17473 192 A--ALPWKRVLPIYFLAFLAMLLFYVIPI-QLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268
|
....*.
gi 15599291 291 FSLLAA 296
Cdd:cd17473 269 GFALMA 274
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-383 |
3.16e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 85.34 E-value: 3.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDRLALSFLfPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALS 96
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVL-PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFG-RKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 97 GLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVS 176
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYY--GLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 LLPGLLIAWLIWrhvrpdpPRAQRPAPRAEEAKGKRLALLKSRN--ILLCTLISCVFVTWFIVLISFTPTFlVNARGFSP 254
Cdd:cd17489 157 AVLALLALLLVF-------LVKDPPPVAAEEAEAGTRAFRRLVEkkVLPPALILFLASIAYGAISTFLPLY-AAERGISN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 255 AtmGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGlgcFTLFMATIPA 334
Cdd:cd17489 229 A--GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG---FGLLFPALQA 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15599291 335 ETVSRGV---IATALGlIMGLGELVGGFLAPTVAGFAADRFGLSIVMWMSCG 383
Cdd:cd17489 304 LAVDLVPphrRGAANG-TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAV 354
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-368 |
1.82e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.38 E-value: 1.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 18 LFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSG 97
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFG-RKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 98 LVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSL 177
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW--GAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 178 LPGLLIAWLiwrhvrpdppraqrpapraeeakgkrlallkSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATM 257
Cdd:cd17321 158 PIGLVALLL-------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 258 GRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETV 337
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286
|
330 340 350
....*....|....*....|....*....|....*..
gi 15599291 338 S------RGVIATALGLIMGLGELVGGFLAPTVAGFA 368
Cdd:cd17321 287 SsvpkekAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
35-383 |
2.36e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 83.00 E-value: 2.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 35 LFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGL 114
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKK-VLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 115 AEGPILPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIGpPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVRPD 194
Cdd:cd17474 100 GAAGLGPLALTLIGDLFEGGERAKAMGLYE--AALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 195 PPRAQRPaprAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFA 274
Cdd:cd17474 177 KEKAKSS---SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 275 V-PAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGL-GCFTLFMATIP--AETVSRGVIATALGLIM 350
Cdd:cd17474 254 VgRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTelAPEEERGTASSLYNFVR 333
|
330 340 350
....*....|....*....|....*....|...
gi 15599291 351 GLGELVGgflaPTVAGFAADRFGLSIVMWMSCG 383
Cdd:cd17474 334 FLGQAVG----PLLFGLLLEIFGLSAPFLVGAA 362
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
13-384 |
8.07e-17 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 81.90 E-value: 8.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFvFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPL---LIVAVILF 89
Cdd:cd17345 4 VFLGIFIGYAGY-YLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLaigLILSAIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 90 SLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGS---AAGLLGAVIGppLLVALAEA 166
Cdd:cd17345 83 ILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIShnvGGGLVGPLAG--LGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 167 LGWRHAFIVSLLPGLLIAWLIWRHVRPDPP----------RAQRPAPRAEEAKGKRLA--------LLKSRNILLCTLIS 228
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPEseglppieeyKGDYPEEADGEEEEQELSaweifvkyVLKNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 229 cVFVtwFIV---LISFTPTFLVNARGFSPATMGRLMSCLGVAWV----VWGFavpaISDRI--GRR-PTLVAFSLLAACC 298
Cdd:cd17345 241 -VFV--YLVrygILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIpgtlLAGW----LSDKLfkGRRaPTGIIFMILVIVA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 299 PLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGLIMGLGELVGGFLAPTVAGFAADRFGLS--- 375
Cdd:cd17345 314 LIVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNggf 393
|
....*....
gi 15599291 376 IVMWMSCGG 384
Cdd:cd17345 394 IVLLASCIL 402
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
37-302 |
2.34e-16 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 80.39 E-value: 2.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 37 PFMEQELQLSNSHLGMLSSVLALAWAVsGALVGAW-SDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLA 115
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLP-GALLGGRlADRIG-RKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 116 EGPILPLSQSLMVEASSPHRRGLNMGLLQgsaAGL-LGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVrPD 194
Cdd:PRK11551 117 LGGALPNLIALTSEAVGPRLRGTAVSLMY---CGVpFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWL-PE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 195 PPRAQRPAPRAEEAKGKRLALL-KSRNILLCTLISCVFVTWFIV--LISFTPTFLVnARGFSPATMGRLMSCLGVAWVVW 271
Cdd:PRK11551 193 SRAFAQAAGAGKQRAPVLRALFgEGRATATLLLWISYFFTLIVLyfLLNWLPSLLV-GQGLSRSQAGLVQIAFNIGGALG 271
|
250 260 270
....*....|....*....|....*....|...
gi 15599291 272 GFAVPAISDRIGRRPT--LVAFSLLAACCPLAL 302
Cdd:PRK11551 272 SLLIGALMDRLRPRRVvlLIYAGILASLAALAA 304
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
63-365 |
2.70e-16 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 80.11 E-value: 2.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 63 VSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGF--------LSLLLFRGIMGLAEGPILPLSQSLMVEASSPH 134
Cdd:cd17368 55 IGAIVLGAYADRIG-RKPAMTLTLAIMALGTLLIALAPTYatigiaapLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 135 RRGLNMG------LLQGSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLiWRHVRPDPPRAQRPAPRAEEA 208
Cdd:cd17368 134 RRGFYTSwqsasqQVAIVAGALVGYLLSLTLTAEALAEWGWRIPFFIGLLIIPLGLWL-RRSLEETEAFLERKARPTRRE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 209 KGKRLALLKsRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTL 288
Cdd:cd17368 213 LFALLANNR-RIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 289 VAFSLLAACCP----LALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGLIMGLGELVGGFLAPTV 364
Cdd:cd17368 292 LVITLAALVTLypvfAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFI 371
|
.
gi 15599291 365 A 365
Cdd:cd17368 372 V 372
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
27-365 |
3.97e-16 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 79.65 E-value: 3.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 27 FDRLALSFLFPFMEQELQLSNSHLGMLSSVLA------LAWAVSGALVGAWSDRRGQRKPLLiVAVILFSLCSALSGL-- 98
Cdd:cd17367 13 YDWYVYAAFALYFAPQFFPSGDPTVALLSTAAvfavgfLMRPIGGWLFGRLADRIGRRAALT-LSVSLMAAGSLVIAVtp 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 99 ------VGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAG--LLGAVIGPPLLVALAE----A 166
Cdd:cd17367 92 tyatigIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGgqLLALGVLLVLQHTLGEdqmaA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 167 LGWRHAFIVSLLPGLLIAWLiwRHVRPDPPRAQRPAPRAEEAKGKRLALLKS-RNILLCTLISCVFVTWFIVLISFTPTF 245
Cdd:cd17367 172 WGWRIPFLLGGVLAVVVLWL--RRGLEETESFEAIAESNEASAGTLRELRRHpRELLLVVGLTAGGTLAFYTWTTYLQKF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 246 LVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYA----PNATSLGLLLLLTYTG 321
Cdd:cd17367 250 LVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAldhtDSPYTAFALVLVGLVF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15599291 322 LGCFTLFMATIPAETVSRGVIATALGLIMGLGELVGGFLAPTVA 365
Cdd:cd17367 330 LSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVA 373
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
37-367 |
1.81e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 77.23 E-value: 1.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 37 PFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVIlFSLCSALSGLVGGFLSLLLFRGIMGLAe 116
Cdd:cd17504 20 PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAI-YTAGSLLAAFAPNLPVLIAGRALQGIG- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 117 GPILPLSQSLMVEASSPHRRGLNMGLLQGSAAGllGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIwrhvrpdpp 196
Cdd:cd17504 98 GAVFPLAFALVREEFPPERVPVAQGILSATFGI--GAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV--------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 197 raqrpapraeeaKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNAR----GFSPATMGRLMSCLGVAWVVWG 272
Cdd:cd17504 167 ------------PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 273 FAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTY-TGLGCFTLFMATIPAETVSRGVIATALGLIMG 351
Cdd:cd17504 235 PLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIgIGLGLAFASLPNIVVESVPPDRTGIATGMNTV 314
|
330
....*....|....*.
gi 15599291 352 LgELVGGFLAPTVAGF 367
Cdd:cd17504 315 L-RTIGSAIGPAIAGA 329
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
22-289 |
5.44e-15 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 76.12 E-value: 5.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 22 FGFVF--FDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLV 99
Cdd:PRK12307 25 LGYVFdgFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFG-RKPLMMWSIVAYSVGTGLSGLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 100 GGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHrrglnmglLQGSAAGLL------GAVIGPPLLVALAEALGWRHAF 173
Cdd:PRK12307 104 SGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKH--------LKSKASAFLvsgfgiGNIIAAYFMPSFAEAYGWRAAF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 174 IVSLLPGLLIAWliwrhVRPDPPRAQRPAPRAEEAKGKR---------LALLKSRNILLCTLISCVFVTWFIV------L 238
Cdd:PRK12307 176 FVGLLPVLLVIY-----IRARAPESKEWEEAKLSGKGKHsqsawsvfsLSMKGLFNRAQFPLTLCVFIVLFSIfganwpI 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 15599291 239 ISFTPTFLVNaRGFSPATMGRLMSCLGVAWV----VWGFavpaISDRIGRRPTLV 289
Cdd:PRK12307 251 FGLLPTYLAG-EGFDTGVVSNLMTAAAFGTVlgniVWGL----CADRIGLKKTFS 300
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
17-380 |
1.14e-14 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 75.00 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALS 96
Cdd:cd17312 7 GVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRR-FMSAGLLLSALANIFM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 97 GLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVS 176
Cdd:cd17312 86 GFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHN--FGGILAPILAASLASYYGWRAAFLVP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 LLPGLLIAWLIWRHVRPDPPRAqrpapraeeakgkrlallksrnILLCTLISCVFVTWFIVLiSFTPTFLVNARGFSPAT 256
Cdd:cd17312 164 GIVGLVVAIILFFFLRDSPPYV----------------------WVLSLAYAFVYIVRYACL-DWGPLYLYEVKGYSLID 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 257 MGRLMSCLGVAWVVWGFAVPAISDRI--GRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCF---TLFMAT 331
Cdd:cd17312 221 AGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGgpiNLIGGA 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15599291 332 IPAETVSRGVIATALGLIMGLGElVGGFLAPTVAGFAADRFGLSIVMWM 380
Cdd:cd17312 301 AAQDIGRKEAAGTATGFVGLFGY-LGASLAGLPLGYIIDHYGWSTVFYF 348
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-193 |
1.36e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 74.52 E-value: 1.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLTFGFVFFdrLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQR-KPLLIVAVILFSLC 92
Cdd:COG2271 184 LLALAYFLVYFALY--GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHA 172
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV--NTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|.
gi 15599291 173 FIVSLLPGLLIAWLIWRHVRP 193
Cdd:COG2271 340 FLLLAALALLAALLALLLLRE 360
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
59-304 |
1.58e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 74.14 E-value: 1.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 59 LAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGL 138
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFG-RKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 139 NMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIwrhvrpdppraqrpapraeeakgkrlallks 218
Cdd:cd17502 120 YQGYI--GAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL------------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 219 RNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACC 298
Cdd:cd17502 167 RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSV 246
|
....*.
gi 15599291 299 PLALLY 304
Cdd:cd17502 247 GAGLLT 252
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-189 |
2.47e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 73.76 E-value: 2.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDRLALSFLFPF-MEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSAL 95
Cdd:cd17474 202 TFLVSAFLYFFLYFAFLTYLPFlLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 96 SGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLlqGSAAGLLGAVIGPPLLVALAEALGWRHAFIV 175
Cdd:cd17474 282 LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL--YNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV 359
|
170
....*....|....
gi 15599291 176 SLLPGLLIAWLIWR 189
Cdd:cd17474 360 GAAIALAAAVLLAL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
69-382 |
3.73e-14 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 73.35 E-value: 3.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 69 GAWSDRRGQRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgsAA 148
Cdd:cd17370 55 GYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHR--AL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 149 GLLGAVIGPPLLVAL--AEALGWRHAFIVSLLPGLLIAWLIWRhVRPDPPRAQRPApraEEAKGKRLALLKSRNILLctl 226
Cdd:cd17370 133 DTLGAVLGPLLAALLlyLLGGNYRTIFLLAAIPALLALLILLF-VVKEYPRPPKLR---KKSKKTSLKKLPKAFWLY--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 227 iscVFVTWFIVLISFTPTFLV---NARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALL 303
Cdd:cd17370 206 ---LLAVALFALGNFSFAFLIlraQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFA 282
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599291 304 YAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGlIMGLGELVGGFLAPTVAGFAADRFGLSIVMWMSC 382
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG-LFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSA 360
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
65-365 |
5.15e-14 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 73.33 E-value: 5.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 65 GALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGF--------LSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRR 136
Cdd:cd17369 61 GVVFGHFGDRIG-RKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 137 GLNMGLLQ-GSAAGLLGA--VIGPPLLVALAEAL---GWRHAFIVSLLpgLLIAWLIWRHVRPDPP--RAQRPAPRAEEA 208
Cdd:cd17369 140 GFYGSFPQlGAPVGLLLAtgVFLLLSALLSDEAFlswGWRIPFLLSAV--LVAVGLYIRLRLEETPvfRRAKEAGQVVRA 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 209 KGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMgrlMSCLGVAWVVWGFAVP---AISDRIGRR 285
Cdd:cd17369 218 PLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTV---LLAVLIASVVAAITIPlfgWLSDRVGRR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 286 PTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFM----ATIPAETVSRGVIATALGLIMGLGELVGGFLA 361
Cdd:cd17369 295 PVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMygpqAAFLAELFPTRVRYTGASLGYQLGAILGGGFA 374
|
....
gi 15599291 362 PTVA 365
Cdd:cd17369 375 PLIA 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-384 |
1.04e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 72.26 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 42 ELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIV----AVILFSLCSALSGLVGGFLSLLLFRGIMGLAEG 117
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 118 PILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPR 197
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQ--LARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 198 AQRPAPRAEEAKGKRLALLKSRNILL-CTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVP 276
Cdd:cd06173 186 PGESSSLLLRDLREGLRYLRRSPLLRlLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 277 AISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVS---RGVIATALGLIMGLG 353
Cdd:cd06173 266 RLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPdelRGRVFSVYNALNSGA 345
|
330 340 350
....*....|....*....|....*....|.
gi 15599291 354 ELVGGFLaptvAGFAADRFGLSIVMWMSCGG 384
Cdd:cd06173 346 MPLGALL----AGLLADALGLSAVFLLAGAL 372
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-373 |
1.47e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.44 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 51 GMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILfSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEA 130
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAIT-AVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 131 SSPHRRGLNMGLLqgSAAGLLGAVIGpPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRhvrpdppRAQRPAPRAEEAKG 210
Cdd:cd17477 113 ATNENRGRVLGLY--STVLGLGFALG-PLLLALVGTAGALPFLIAAVLLLLALVPLLLT-------RRAAPEIEEAESIS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 211 KRLALLKSRNILLCTLISCVFVTwfiVLISFTPTFLVNArGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVA 290
Cdd:cd17477 183 LRRLLRIAPLALLGAFVAGFLEG---AFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 291 FSLLAACCPLALLYAPNATSLGLLLLLTY--TGLGCFTLFMATIPAETVSRGVIATALGLIMGLGelVGGFLAPTVAGFA 368
Cdd:cd17477 259 CALLGALAALLLPLVPGLPLALLVLLFLWggAAGPLYTLALALAGDRLPGDELVAANAALLLLYG--LGSVIGPLLAGAL 336
|
....*
gi 15599291 369 ADRFG 373
Cdd:cd17477 337 MDAFG 341
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
13-289 |
3.00e-13 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 70.83 E-value: 3.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRrgqrkpllIVAVILFSLC 92
Cdd:cd17343 3 TIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQ--------ISARWLFSSG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLV----GGFLSLLLFRGIM---GLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAE 165
Cdd:cd17343 75 LVLSGLTtvafSGSSSVWVFSILWflnGLAQGLGWPPCAKILRKWFSPSQFGTWWSVL--STSMNLAGSLGPILATLLAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 166 ALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKSRNILLCTL-------ISCVFVTWFIVL 238
Cdd:cd17343 153 SYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRGESTLKELLlspflwlLSLGYLVVFGVK 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15599291 239 ISFT---PTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLV 289
Cdd:cd17343 233 TAVTdwgQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSS 286
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
59-201 |
5.33e-13 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 70.49 E-value: 5.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 59 LAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGL 138
Cdd:TIGR00711 48 LANAISIPLTGWLAKRFGTRR-LFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGR 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599291 139 NMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPRAQRP 201
Cdd:TIGR00711 127 AMAIW--GLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAASEN 187
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
27-306 |
9.93e-12 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 65.79 E-value: 9.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 27 FDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVsGALVGAWSDRRGQRKPLLIVAVILFSLCSALSGLVGGFLSLL 106
Cdd:cd06180 13 IGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLV-GALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 107 LFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWL 186
Cdd:cd06180 92 ALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLF-AGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 187 IWRhVRPDPPRAQRPAPRAEEAKGKRLALLksrnilLCTLISCVFVTWFIVLISFTPTFlVNARGFSPATMGRLMSCLGV 266
Cdd:cd06180 171 SFL-LLRRGPSAPTEASAAESAPGLNRPLW------RLALAYGLFGFGYIITATFLPLI-ARETGAGSLLAGLLWSLFGL 242
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 15599291 267 AWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAP 306
Cdd:cd06180 243 AAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSP 282
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
31-373 |
1.29e-11 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 65.68 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 31 ALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILF--SLCSALSGLVGGFLSLLLf 108
Cdd:cd17339 17 SVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAagILLRSLGGIALLFLGTAL- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 109 rGIMGLAEGPILPLSqslMVEASSPHRRGLNMGL----LQGSAAglLGAVIGPPLlvALAEALGWRHAFIVSLLPGL--L 182
Cdd:cd17339 96 -AGAGIAVGNVLLPS---LIKRDFPRRVGLMTGLyttsMNLGAA--LASGLSVPL--AQALGGGWRGALAIWALPALlaL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 183 IAWL--IWRHVRPDPPRAQRPAPRaeeakgkrlaLLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNaRGFSPATMGRL 260
Cdd:cd17339 168 LIWLpqLRRRKRAAAAAAPLTKIS----------VWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILID-AGLSAATAGWL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 261 MSCLGVAWVVWGFAVPAISDRI-GRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSR 339
Cdd:cd17339 237 LSLFQLVGIPASLLVPILATRLkNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALTLISLRSSDP 316
|
330 340 350
....*....|....*....|....*....|....
gi 15599291 340 GVIATALGLIMGLGELVGGFlAPTVAGFAADRFG 373
Cdd:cd17339 317 AEAAALSGMAQSVGYLLAAL-GPLLFGVLHDLTG 349
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
36-305 |
2.46e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 64.90 E-value: 2.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 36 FPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLiVAVILFSLCSALSGLVGGFLSLLLFRGIMGLA 115
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLL-AGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 116 EGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRhVRPDP 195
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLL--MMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL-FLPET 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 196 PRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAV 275
Cdd:cd17320 178 LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLN 257
|
250 260 270
....*....|....*....|....*....|.
gi 15599291 276 PAISDRIGRRPTL-VAFSLLAACCPLALLYA 305
Cdd:cd17320 258 GRLVRRFGPRRLLrLGLLLLLAAALVLLLAA 288
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
41-298 |
4.21e-11 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 64.22 E-value: 4.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 41 QELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILF--SLCSALSGLVGGFLSLLLFRGIMGLAEGP 118
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVigAVLQGAAKGKWSVYQLIVGRVLVGIGVGG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 119 ILPLSQSLMVEASSPHRRGLNMGLLQ-GSAAG-LLGAVIGppLLVAL-AEALGWRHAFIVSLLPGLLIawLIWRHVRPDP 195
Cdd:pfam00083 119 ASVLAPMYISEIAPKKLRGALGSLYQlAITFGiLLAYIFG--LGLNKtSNSDGWRIPLGLQLVPALLL--IIGLLFLPES 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 196 PRAQRPAPRAEEAK---------------------------------GKRLALLKSRNILLCTLISCVFVTWF--IVLIS 240
Cdd:pfam00083 195 PRWLVEKGRLEEARevlaklrgvpdvdreldeikdsleagqeaekasWKELFSTKTRRQRLLIGVMLQIFQQLtgINAIF 274
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 241 FTPTFLVNARGFSPAtmgrLMSCLGVAWVVWGFAVPAI--SDRIGRRPTLVAFSLLAACC 298
Cdd:pfam00083 275 YYSTTIFENLGLSDS----FLVTIIVGVVNFVFTFIAIflVDRFGRRPLLLLGAAGMAIC 330
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
13-193 |
4.71e-10 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 60.65 E-value: 4.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCvlFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLC 92
Cdd:cd17380 1 VILL--FLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKK-VLLLAVALWSLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLV--GGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWR 170
Cdd:cd17380 78 TLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIV--TAGSYLGTLLGGLIGPLLLEYYGWP 155
|
170 180
....*....|....*....|...
gi 15599291 171 HAFIVSLLPGLLIAWLIWRHVRP 193
Cdd:cd17380 156 SVFYFFGLLGLLWALVWLIYLPP 178
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-296 |
4.77e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 4.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 26 FFDRLALSFLFPFM----EQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGG 101
Cdd:cd17329 9 FLNRLGFFMVWPFMaiylHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG-RKPVMLAGLLLRALGFALLGFAHS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 102 FLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGpPLLVALAEALGWRHAFIV-SLLPG 180
Cdd:cd17329 88 PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL--YWAINLGVAIG-PLLGGLLLLYSFRLLFLAaAVLFL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 181 LLIAWLIWRhvrpdPPRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIV--LISFTPTFLVNARGFSPATMG 258
Cdd:cd17329 165 LAALVLLFL-----LPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYfqLESTLPVYVVEILGLGESLLG 239
|
250 260 270
....*....|....*....|....*....|....*...
gi 15599291 259 RLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAA 296
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA 277
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
30-304 |
5.26e-10 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 60.64 E-value: 5.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 30 LALSFLFPFME----QELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSALSGLVGGFLSL 105
Cdd:cd17471 10 LAGAFVLPYLSlfltEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWVL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 106 LL----FRGIMGLAEGPILPLSQSLmVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVSLLPGL 181
Cdd:cd17471 90 LLvgvvLLSLGAAAFPQLFALAREY-ADRSSGRDATLFNSVLRAAFS--LAWVIGPPLAFLLLDVLGFTGLFLLAALLYL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 182 LIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRlallkSRNILLCTLI-SCVFVTWFIVLISFtPTFLVNARGFSPATMGRL 260
Cdd:cd17471 167 VVALLVLFLLPSVKPPAQKATPASSLVKAPV-----NRRLLLLFAAfTLLFAANSMYIIAM-PLYVTNELGGSESWVGLL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 15599291 261 MSCLGVAWVVWGFAVPAISDRIGRRpTLVAFSLLAACCPLALLY 304
Cdd:cd17471 241 FGLAAALEIPIMLLAGLLAKRFGKR-RLLLAGFLAGVLFYLGLA 283
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
17-374 |
1.50e-09 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 59.15 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDrlALSF-----LFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSL 91
Cdd:cd17331 1 VLLIVHLNIVLY--ATCYwlqqpVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRA-ALVLSFLSSAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 92 CSALSGLVGGFLSLLLFRgIMGLAEGpILPLSQSLMVEASSPHRRGLNMGLLqGSAAGlLGAVIGPPLLVALAEALGWRH 171
Cdd:cd17331 78 SYLLLAFASSVPMLFLSR-LPSVFMH-AMQAAQMVVTDLTDPGERAAALGRL-GLSYG-IGMVVGSFLGGLLTKKFGEQA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 172 AFIVSLLPGLLIAWLIWRHVrPDPPRAQRPAPRAEEAKGK-------RLALLKSRNILLCTLISCVFVTWFIVLISFTPT 244
Cdd:cd17331 154 AALVAAVGSLLSIVLVILLI-PSNTKSKREKEAKESASPPsvfnlkeILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 245 FLVNARGFSPATMGRLMSCLGVA-WVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLG 323
Cdd:cd17331 233 VAMDFFGLTPEENGYLMSYAGVLgMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGS 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15599291 324 CFTLFMATIPAETVSRGVIATALGLIMGLGELVGGfLAPTVAGFAADRFGL 374
Cdd:cd17331 313 VLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRT-VSPTIGGALLQAYGF 362
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
19-370 |
1.65e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 59.19 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 19 FLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSALSGL 98
Cdd:cd17341 5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 99 VGGFLSLLLFRGIMGLAeGPILPLSQSLMVEASSPHRRGLNMGLLQGsaAGLLGAVIGPPLLVALAEAL-------GWRH 171
Cdd:cd17341 85 VSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAG--AGNMGVAVSQLLAPLIAGAIvfdggfvGWRN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 172 AFIVSLLPGLLIAWLIWRHVRPDPpraQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTwFIVLISFTPTFLVNARG 251
Cdd:cd17341 162 AFFVPGILLAIAAVLVLLFGDDLP---TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGS-FVGFSNVLPTYFKTRFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 252 FSPATMGRLMSCLGVAWVVWGFAVPAISDRIG-RRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFT---- 326
Cdd:cd17341 238 LPLVTAGILAALFPLAGALARPAGGWLSDRFGgRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAgagn 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15599291 327 -LFMATIPAetVSRGVIATALGLIMGLGELvGGFLAPTVAGFAAD 370
Cdd:cd17341 318 gSVFRMVPF--IFRRELGAVTGLVGAIGGL-GGFFLPLLFGSSAL 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
55-379 |
2.05e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 58.78 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 55 SVLALAWAVSGALVGAWSDRRGQRKPLLIVAvILFSLCSALSGLVGGFLSLLLFRGIM---GLAEGPILPLSqslMVEAS 131
Cdd:cd17353 45 TLTIVFLAISAPFAGRLVDRGGPRKAILIGG-ILFGLGFILSAFAISLPLLFLGYGVLggiGAGIGYITPVS---TAVKW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 132 SPHRRGLNMGLlqgSAAGL-LGAVIGPPLLVALAEALGWRHAF----IVSLLPGLLIAWLIwRHVRPDPPRAQRPAPRAE 206
Cdd:cd17353 121 FPDKRGLATGI---VIAGFgLGSLIFSPLIAYLINTVGVPTTFlilgIIFLIIIVIGAFLI-RDPPKGWVPPGVDPLANN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 207 EAKGKRLA----LLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVA----WVVWGFavpaI 278
Cdd:cd17353 197 AENSPRDYtpreMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFngggRPFWGW----L 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 279 SDRIGRRPTLVAFSLLAACCPLALLYAPNAtsLGLLLLLTYTGLGCFTLFMATIPAeTVSRGVIATALGLIMGL---GEL 355
Cdd:cd17353 273 SDKIGRKNTLSIAFLIQGVAMFLLPFIGSV--AVLFVLGVALIGFCYGGGFALFPA-LTADFFGTKNAGTNYGLlytAKG 349
|
330 340
....*....|....*....|....
gi 15599291 356 VGGFLAPTVAGFAADRFGLSIVMW 379
Cdd:cd17353 350 VGGLIGPIIAAYVLYTGGYNAAFI 373
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
51-189 |
2.42e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 55.35 E-value: 2.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 51 GMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEA 130
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFG-RKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599291 131 SSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWR 189
Cdd:TIGR00880 80 YPPEERGVALGLM--SAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAF 136
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
15-380 |
6.29e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 57.33 E-value: 6.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 15 LCVLFLTFGFVFFdrlALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSA 94
Cdd:cd17333 1 LYISFFSNGLTDA---LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLG-RRRTLILGLLLISLALA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 95 LSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASsPHRRGLNMGLLQGSAAglLGAVIGPPLL-VALAEALGWRHAF 173
Cdd:cd17333 77 LIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFG--LGALIGPLIAtSLLTSELSWSWAY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 174 IVSLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFS 253
Cdd:cd17333 154 LIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 254 PATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNatslgllLLLTYTGLGCFTLFMA--- 330
Cdd:cd17333 234 DGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPT-------LVVGLVATALLGLFMAalf 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599291 331 -TIPAETVSRGVIAT--ALGLIMGLGElVGGFLAPTVAGFAADRFGLSIVMWM 380
Cdd:cd17333 307 pTILSLGISNLPYAKgkGTSVLLAAGS-IGGAIIPFIMGFIAEAVGIQTAMLL 358
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
36-283 |
1.35e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 56.24 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 36 FPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIvAVILFSLCSALSGLVGGFLSLLLFRGIMGLA 115
Cdd:TIGR00710 28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLL-GLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 116 EGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRhvRPDP 195
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSIL--MPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFF--ILPE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 196 PRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAV 275
Cdd:TIGR00710 183 TLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLN 262
|
....*...
gi 15599291 276 PAISDRIG 283
Cdd:TIGR00710 263 GRFIKKWG 270
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-193 |
1.71e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.02 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLtFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLC 92
Cdd:COG0738 212 LLLGGLAI-FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFrGIMGLAEGPILPLSQSLMVEaSSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHA 172
Cdd:COG0738 291 LLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALD-GLGKRTAAAVSAV--LIMGIVGGAIGPPLIGFLADAFGLRAA 366
|
170 180
....*....|....*....|.
gi 15599291 173 FIVSLLPGLLIAWLIWRHVRP 193
Cdd:COG0738 367 FLVPLVCYLLILLLALALKRK 387
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
24-370 |
1.86e-08 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 55.70 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 24 FVFFDRLALSFLFPFME---QELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVG 100
Cdd:cd17390 4 VGFLDLFGVSMILPLLSthiRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVG-RRPVLLICLLLTALGYVLLGFST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 101 GFLSLLLFRGIMGLAEGPILpLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGwrHAFIVSLLPG 180
Cdd:cd17390 83 SLALLFLSRIPLGIFKHTQS-LCKAYLSDLVSEQERSRVLGRF--NAASSLGFILGPVVGGHLAETDG--GFYYVALLCS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 181 LLI---AWLIWrhvrpdppraqrpapraeeakgkrLALLKSRNILLCTliscvFVTWFIVLISFTPTFLVNARGF--SPA 255
Cdd:cd17390 158 AIFilnAGLVW------------------------FLLSKLWDLLLVR-----FLMGFSVLLFRSNFSLYLEERFdlSPK 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 256 TMGRLMSCLGVAWVVWGFAVPAISDRIGRRPT--LVAFSLLAACCPLALLYAPNatslglllllTYTGLGCFTLFMATIP 333
Cdd:cd17390 209 TIGYLISYSGVLGALSGFLVGRILKLYKNNEYllLLHSFILLALSLLGLALAPS----------IWLLVLCLTPLSISSA 278
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15599291 334 A------ETVSRGVIATALGLIMGLGELV---GGFLAPTVAGFAAD 370
Cdd:cd17390 279 VlrtcstSLLLSRGKSKERGTLLGVGQSVtslARILAPLLSGLLQE 324
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
68-380 |
2.16e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 55.69 E-value: 2.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 68 VGAWSDRRGQRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSqSLMVEASSPHRRGLNMGLLqgSA 147
Cdd:cd17490 51 LGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFT-VLYASYFPPDEAAKAMGLI--NL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 148 AGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEeakgkRLALLKSRNILLCTLI 227
Cdd:cd17490 128 VNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKE-----LLSVLKDKKLLFFSLL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 228 S-CVFVTWFIVLISFTPTFLvNARGFSPATMGRLMSC-LGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYA 305
Cdd:cd17490 203 AiLQQMITFSTTFGFTPLIA-KQLGASSFQLGLLSIIyLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFA 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599291 306 PNATSLGLLLLLT-YTGLGCFTLFMaTIPAETVSRGVIATALGL---IMGLGELVGgflaPTVAGFAADRFGLSIVMWM 380
Cdd:cd17490 282 PNLTLLYLLQALNgFGTGILFPLLM-SLSIEGVPAEQRSTAMGFfqaIYALGMFLG----PVLVGIISEAFGLQTGFFV 355
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
27-186 |
2.18e-08 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 55.86 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 27 FDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLL 106
Cdd:PRK03893 34 FDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYG-RRLAMVISIVLFSVGTLACGFAPGYWTLF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 107 LFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMG-LLQGSAaglLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAW 185
Cdd:PRK03893 113 IARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGfLISGFS---IGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALW 189
|
.
gi 15599291 186 L 186
Cdd:PRK03893 190 L 190
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
23-288 |
4.15e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 4.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 23 GFVF-FDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAwAVSGALVGAW-SDRRGQRKPLLIVAvILFSLCSALSGLVG 100
Cdd:cd17359 10 GLLFgYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLG-AAIGALFAGRlADRFGRRKTLLISA-VLFFISALGSAFSP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 101 GFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQ------GSAAGLLGAVIGPPLLVALAEALGWRHAFI 174
Cdd:cd17359 88 NFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQlmivfgQLLAYIVNYLIANAGGADWLGAEGWRWMLG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 175 VSLLPGLLIAWLIWRhvRPDPPRAqrpapraeeakgkrlaLLKSRNILLCTLISCVFVTWFI---VLISFTPTFLVNArG 251
Cdd:cd17359 168 LEAIPAILFLLGMLF--IPESPRW----------------LVSKGKPILIIGIGLAIFQQFVginVIFYYGPEIFQNA-G 228
|
250 260 270
....*....|....*....|....*....|....*...
gi 15599291 252 FSpATMGRLMSCL-GVAWVVWGFAVPAISDRIGRRPTL 288
Cdd:cd17359 229 FS-ENAALLQTIGiGVVNVIFTIIAILLVDKVGRKPLL 265
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
23-373 |
5.05e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 54.51 E-value: 5.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 23 GFVFFDRLALSFLFPFME---QELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLC-SALSGL 98
Cdd:cd17335 4 LFYFFFFAALGSLLPFLSvylKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFfLSLFFV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 99 VGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASspHRRGLNMGL--LQGSAAGLLGAVIGPPLLVALAEALGWRHAFIVS 176
Cdd:cd17335 84 AQIFWLLLLLVILGAFFSAPVVPLVDSITLQYL--GEERERYGKqrLWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 LLpGLLIAWLIWRHVRPDPPRaqrpaPRAEEAKGKRLALLKSRNILLctlisCVFVTWFIVLI-SFTPTFLV---NARGF 252
Cdd:cd17335 162 AV-LMLLALLLALKFPFRPKH-----PEPNENTGGLLALLRNPRVLA-----FLLVAFLMGFGhGLIYSFLFwhlQDLGG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 253 SPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLvafSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATI 332
Cdd:cd17335 231 SKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLL---YLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15599291 333 P---AETVSRGVIATALGLIMGLGELVGGFLAPTVAGFAADRFG 373
Cdd:cd17335 308 VsyaSAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFG 351
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-189 |
8.03e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 8.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 12 NVLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSL 91
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR-LLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 92 CSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRH 171
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVY--NALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*...
gi 15599291 172 AFIVSLLPGLLIAWLIWR 189
Cdd:cd06173 365 VFLLAGALLLLAALLLLL 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-188 |
1.35e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.20 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFdrLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLC 92
Cdd:cd06174 206 WLLLLAIFLVNLAYY--SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLL-VALAEALGWRH 171
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLL--NTFGFLGGAIGPLLAgFLLAATFGLTG 361
|
170
....*....|....*..
gi 15599291 172 AFIVSLLPGLLIAWLIW 188
Cdd:cd06174 362 AFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
14-193 |
1.57e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.95 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLTFGFVFFdrlALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFsLCS 93
Cdd:COG2807 219 LLTLFFGLQSLLYY---AVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLG-LAG 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 94 ALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVE-ASSPHRRGLNMGLLQGsaAGLLGAVIGPPLLVALAEALG-WRH 171
Cdd:COG2807 295 LLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLrARTPAEAAALSGMAQS--VGYLLAALGPLLVGALHDATGsWTA 372
|
170 180
....*....|....*....|..
gi 15599291 172 AFIVSLLPGLLIAWLIWRHVRP 193
Cdd:COG2807 373 ALLLLAALAVLMLVAGLLAGRP 394
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
71-373 |
1.99e-07 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 52.61 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 71 WSDRRGQRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEgpILPLSQ-----SLMVEASSPHRRGL-NMglLQ 144
Cdd:cd17485 58 GLPRLGRRRSWLLPTQLGLALLLLALAFLPPTTNLLAFLGLLFLLN--LFSATQdiatdGLAVELLTPEERGLgNA--AQ 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 145 gSAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKSRNILLC 224
Cdd:cd17485 134 -VVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 225 TLISCVFVTWFIVLISFTPTFLVNaRGFSPATMGRLMSCLGVAWVVWG-FAVPAISDRIGRRPTLVAFSLLAACCplALL 303
Cdd:cd17485 213 LLFLLLYKLGEQGALAMLPPFLVD-RGFSLSQIGLLSGVGGSLVSIAGsLLGGYLLKRRGRRRLLLLGGLLRLLL--LGL 289
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599291 304 YAPNATSLGLLLLLTYTGLGCFTLF---MATIPAETV----SRGVIATALGLIMGLGELVGGFLAPTVAGFAADRFG 373
Cdd:cd17485 290 YTLLALGGSGLNWVLLLASLALLHLvggMITTALFTLmmdcSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLG 366
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
32-169 |
2.02e-07 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 53.06 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 32 LSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIvAVILFSLCSALSGLVGGFLSLLLFRGI 111
Cdd:TIGR01299 186 VGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLI-CLSVNGFFAFFSSFVQGYGFFLFCRLL 264
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599291 112 MGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGW 169
Cdd:TIGR01299 265 SGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWL--CMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-188 |
2.05e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 52.65 E-value: 2.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 51 GMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEA 130
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHR-ILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKI 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599291 131 SSPHRRGLNMGLLQGsaAGLLGAVIGPPLLVALAEALGWRHAFIVSllPGLLIAWLIW 188
Cdd:cd17391 322 TPKEVAGRIFGYNQS--FQYLGNVAGPLLGSAIAAHFGYRAVFVVT--ALLVLLNAIW 375
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
55-285 |
2.48e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 52.19 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 55 SVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPH 134
Cdd:cd17323 41 SLFVLGFGLGPLIWAPLSELYG-RRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 135 RRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAFIVsLLPGLLIAWLiwrhvrpdppraqrpapraeeakgkrLA 214
Cdd:cd17323 120 ERGKAMGVY--SLGPLLGPALGPIIGGFITQSLGWRWIFWF-LAIISGFCLI--------------------------LI 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599291 215 LLKSRNILLCTLISC-VFVTWFIVLISFTPTFlVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRR 285
Cdd:cd17323 171 FLFLPIVLLLGLYVGlVYAILYLFLTAFPYVF-GEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRR 241
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
17-383 |
3.70e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 51.78 E-value: 3.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFfdrlALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRkPLLIVAVILFSLCSALS 96
Cdd:cd17352 11 VNFFTDGILN----SFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCR-PVAIAGGLLAALGLLLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 97 GLVGGFLSLLLFRGIM-GLAEGPILPLSqSLMVEASSPHRRGLNMGLlqGSAAGLLGAVIGPPLLVALAEALGWRHAFIV 175
Cdd:cd17352 86 SFATSLWQLYLTYGVLgGLGLGLIYSPA-IVIVGQYFEKKRGLATGI--AVAGSGVGTFVFPPLLRYLLDNYGWRGALLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 176 ---SLLPGLLIAWLiwrhvrpdppraqrpapraeeakgkrLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNaRGF 252
Cdd:cd17352 163 lggLCLNLCVCGLL--------------------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKS-LGI 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 253 SPATMGRLMSCLGVAWVVWGFAVPAISDRIG-RRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTY-TGLGCFTLFMA 330
Cdd:cd17352 216 DESDAAFLLSIIGISDIVGRILLGLLADKPRiGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFgFCSGSYSSLTP 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599291 331 TIPAETVSRGVIATALGLIMgLGELVGGFLAPTVAGFAADRFGLSIVMWMSCG 383
Cdd:cd17352 296 VILADLVGLEKLSNAYGLVL-LFQGLAALVGPPIAGLLRDYTGDYDAAFYFCG 347
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
24-379 |
4.20e-07 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 51.73 E-value: 4.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 24 FVFFDRLALSFLFPFMeQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVI--LFSLCSALSGLVGG 101
Cdd:cd17337 9 FMIGDGVEQGFLSPYL-VDLGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIwlVFEVLFLAFGLPSH 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 102 -FLSLLLFRGIMGLAegpiLPL-SQSLMV---EASSPHRRGLNMGLLQGSAAGLLGaVIGPPLLVALAEALGWRHAFIVS 176
Cdd:cd17337 88 nYPLMLLTYGLRGFG----YPLfAYSFLVwitYRTPAERLGSAVGWFWFAFTGGLP-VLGSYLASFTIPVIGEIGTLWLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 177 L---LPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFS 253
Cdd:cd17337 163 LvfvALGGLIALFLVRDRTGEQPLANPSEEPLKELLSGITILFRNPKIAIGGIVRIINTLSQFGFPVFMPLYFTDTGGFS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 254 PATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFS-LLAACCPLALLYAPNAtslglLLLLTYTGLGCFTLFMATI 332
Cdd:cd17337 243 TSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGgVGCAISTLLFYYVPQL-----FGHNYWAALIAAILFGIGL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15599291 333 pAETVSRGVIATAL-----GLIMGLGELVGG---FLAPTVAGFAADRFGLSIVMW 379
Cdd:cd17337 318 -AGFVPLSALMPSLapehkGAAMSILNLGAGlsnFVGPAIVTLFLGSFGAGGVVW 371
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
26-187 |
6.00e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.11 E-value: 6.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 26 FFDRLALSFLFPFM----EQELQLSNSHLGMLS----SVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSG 97
Cdd:cd17391 6 FFTGIGFSLIAPFLplyiEQLGVTSGGLVELWSglafSSTFLVSAIFSPIWGRLADRYG-RKPMLLRASLGMAIVIGLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 98 LVGGFLSLLLFRGIMGLAEGPIlPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAF-IVS 176
Cdd:cd17391 85 FVTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTL--STGVVAGTLIGPLLGGFLADLFGIRNVFfITG 161
|
170
....*....|.
gi 15599291 177 LLpgLLIAWLI 187
Cdd:cd17391 162 GL--LFLAFLL 170
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
32-189 |
9.68e-07 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 50.61 E-value: 9.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 32 LSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFsLCSALSGLVGGFLSLLLFRGI 111
Cdd:cd17372 18 LSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTF-YAGFLSAFAPNYMWLIILRCL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 112 MGLAEGPIlPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIA----WLI 187
Cdd:cd17372 97 VGLGLGGG-PQLASWYLEFLPAKSRGTWMVLFS--VFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLvfyrWTP 173
|
..
gi 15599291 188 WR 189
Cdd:cd17372 174 KT 175
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
44-205 |
1.01e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 50.43 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 44 QLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAViLFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLS 123
Cdd:cd17362 35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAAL-LYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 124 QSLMVEASSPHRRGLNMGLLQGSAAG--LLGAVIGPPLLVALaeaLGWRHAFIVSLLPGLLIAWLIWRhvRPDPPRAQRP 201
Cdd:cd17362 114 PVYIAETSPSHIRGLLVSLKELFIVLgiLLGYVSGYAFADVV---GGWRYMYGLAAPPALLLGIGMWF--LPPSPRWQGN 188
|
....
gi 15599291 202 APRA 205
Cdd:cd17362 189 YRKP 192
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-186 |
2.09e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.53 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 15 LCVLFLTFGFVFfdrlalSFLfPFMEQELQLSNSHLGMLSSVLALAWAVSGALVG-AWSDRRGQRKPLLIVAVILfSLCS 93
Cdd:cd17490 204 ILQQMITFSTTF------GFT-PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLL-GAYC 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 94 ALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAF 173
Cdd:cd17490 276 FLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYA--LGMFLGPVLVGIISEAFGLQTGF 353
|
170
....*....|...
gi 15599291 174 IVSLLPGLLIAWL 186
Cdd:cd17490 354 FVIGVIALLAAIL 366
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-188 |
2.43e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.14 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCS 93
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG-RKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 94 ALSGLV--GGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLlqGSAAGLLGAVIGPPLLVALAEALGWRH 171
Cdd:cd17316 258 LPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGL--SYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*..
gi 15599291 172 AFIVSLLPGLLIAWLIW 188
Cdd:cd17316 336 VPALILALLAIVALIVA 352
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
14-196 |
2.71e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 48.94 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCS 93
Cdd:cd17488 4 ILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRY-FMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 94 ALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgSAAGLLGAVIgpPLLVALAEAL-GWRHA 172
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWN-TSHNIGGALI--PILTGFAALTyGWRAG 159
|
170 180
....*....|....*....|....*...
gi 15599291 173 F----IVSLLPGLliaWLIWRhVRPDPP 196
Cdd:cd17488 160 MyvpgIIAILMGI---VLCWR-LRDRPP 183
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
19-306 |
3.42e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 48.84 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 19 FLTFGFVFFDRLALSFLFPFM-EQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSALSG 97
Cdd:TIGR00886 7 WFGFFLSFLVWFAFSPLAVFLiKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 98 LVGGFLSLLLFRGIMGLAEGPILPlSQSLMVEASSPHRRGLNMGLLQ--GSAAGLLGAVIGPPLLVALAEALG------W 169
Cdd:TIGR00886 87 AVQSYSVLLLIRLFIGIAGGSFAS-CMPWISFFFPKKIQGTALGLAAgwGNMGGGVAQFVMPPIIGSLIFGGGqpahlaW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 170 RHAF-----IVSLLPGLLIAWLIWRHVRpdppraQRPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTwFIVLISFTPT 244
Cdd:TIGR00886 166 GWAFvivpaGILLLPALLIFFVGADTPP------GKPATGKLSFKEALKVFGNRHTWILALLYSVTFGS-FLGVSSIFAM 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599291 245 FLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIG-RRPTLVAFSLLAACCPLALLYAP 306
Cdd:TIGR00886 239 LFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGgARKLLMNFLGVAMGAFLVVLGLV 301
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
42-308 |
3.81e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 48.72 E-value: 3.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 42 ELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAViLFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILP 121
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAV-LYVIGALLSALAPNVWVLIVGRFLLGLGVGLASV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 122 LSQSLMVEASSPHRRGLNMGLLQ--GSAAGLLGAVIGppLLVALAEALGWRHAFIVSLLPGLLIAWLIwrhvrpdppraq 199
Cdd:cd17315 107 LVPLYISEIAPAKIRGALGTLNQlmITFGILLAYLLG--LALSLSPPGWWRLMFALAAVPALLQLLLM------------ 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 200 rpapraeeakgkrLALLKSRNILLCTLISCVF-VTWFIVLISFTPTFLVNARGFSPATMGRLmsCLGVAWVVWGFAVPAI 278
Cdd:cd17315 173 -------------FFLPESRALLVGVGLQLLQqLTGINAVMYYAPTIFKSAGGGTASILASI--IVGVVNLLATLVAIRL 237
|
250 260 270
....*....|....*....|....*....|..
gi 15599291 279 SDRIGRRPTL-VAFSLLAACC-PLALLYAPNA 308
Cdd:cd17315 238 VDKVGRRPLLlIGFAGMAASLlLLAIAFLLPA 269
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
46-308 |
4.01e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 48.61 E-value: 4.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 46 SNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSALSGLVGG----FLSLLLFRGIMGLAEGpiLP 121
Cdd:COG2270 50 ATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVAPgglwLGLLLFVLANIGFEGS--LV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 122 LSQSLMVEASSPHRRGLNMGLlqGSAAGLLGAVIG---PPLLVALAEALGW-------RHAFIVSLLPGLLIAWLIWRHV 191
Cdd:COG2270 128 FYNAFLPDIATPEEIGRVSGL--GWALGYLGGVLLlliNLALFLKPEAFGLpdageavRISFLLTALWWLLFALPLFLFL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 192 rPDPPRAQRPAPRAEEAKGKR-----LALLKSRNILLCTLISCVFvtwFI----VLISFTPTFLVNARGFSPATMGRLMS 262
Cdd:COG2270 206 -PERPRPGPAPPRGAVRAGFRelrrtLRELRRYRDLLRFLLAYFF---YRdgvqTVIAFAGIYAAGVLGFSTTELIVFGL 281
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 15599291 263 CLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNA 308
Cdd:COG2270 282 LVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTA 327
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
53-295 |
4.90e-06 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 48.43 E-value: 4.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 53 LSSVLALAWAVSGALV-GAWSDRRGqRKPLLIVAVILFSLCSALSGLV------GGFLSLLLFRGIMGLAEGPILPLSQS 125
Cdd:cd17364 43 LVNAAALVGTIIGQLFfGFLGDRFG-RKRVYGVELIIMIIGTILSALSpgstplGVMGWLIFFRFLLGIGIGGDYPLSAT 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 126 LMVEASSPHRRGLNMG---LLQGsaaglLGAVIGPplLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVRPDPPraqrpa 202
Cdd:cd17364 122 IMSEYANKKRRGALIAavfAMQG-----FGILAGA--IVTLILSAIFEHPLPAGTYHHADLVWRIVLGLGAIPA------ 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 203 praeeakgkrLALLKSRNILLCTLiscvfVTWFIVLISFTPTFLVNARGFSPATMGRLMSC--------LGVAWVVWGFA 274
Cdd:cd17364 189 ----------LSVLYFRKHLLGTA-----GTWFLLDIAFYGQNLFQSTIISAIGFSKTMNAyqelfniaVGQLIIALAGT 253
|
250 260
....*....|....*....|....*...
gi 15599291 275 VP------AISDRIGRRPTLVA-FSLLA 295
Cdd:cd17364 254 VPgywftvFLIDRIGRKKIQMMgFFGMT 281
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
32-169 |
6.60e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 48.10 E-value: 6.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 32 LSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIvAVILFSLCSALSGLVGGFLSLLLFRGI 111
Cdd:cd17439 18 VGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLI-SLSVNSVFAFFSSFVQGYGTFLFCRLL 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599291 112 MGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGW 169
Cdd:cd17439 97 SGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWL--CMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
32-137 |
6.95e-06 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 48.25 E-value: 6.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 32 LSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGI 111
Cdd:cd17363 18 VGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLG-RKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLL 96
|
90 100
....*....|....*....|....*.
gi 15599291 112 MGLAEGPILPLSQSLMVEASSPHRRG 137
Cdd:cd17363 97 SGIGIGGSIPIVFSYFAEFLAREKRG 122
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
28-208 |
1.17e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 47.22 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 28 DRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALSGLVGGFLSLLL 107
Cdd:cd17438 14 EVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKR-CLIISLAINASFAFLSSFVQGYGAFLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 108 FRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALG-------------WRHAFI 174
Cdd:cd17438 93 CRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWL--CMFWMIGGLYASAMAWSIIPHYGwgfsmgtnyhfhsWRVFVI 170
|
170 180 190
....*....|....*....|....*....|....
gi 15599291 175 VSLLPglLIAWLIWRHVRPDPPRAQRPAPRAEEA 208
Cdd:cd17438 171 ICALP--CIASIIALKFMPESPRFLLEMGKHDEA 202
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
37-380 |
1.47e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.87 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 37 PFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRkPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAE 116
Cdd:cd17393 23 PAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSR-RVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 117 GPILPL--SQSLMVEASSPhRRGLNMGLLQGSAAGLLGAVIGPPLLVALAEAlgWRHAFIVSLLpGLLIAWLIWRHVRPD 194
Cdd:cd17393 102 GALDVAmnAQGVAVERAYG-RPIMSSLHAMWSLGGLAGALLGAAAIGAGVSP--GVHLLAAAVL-LLLAALVAIRALLPG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 195 PPRAqrPAPRAEEAKGKRLALLKSRNILLCTLISCVFVTWFIVLiSFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFA 274
Cdd:cd17393 178 TGEA--AEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAA-DWSALYLRDVLGASAALAALGYAVFSLAMTVGRLF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 275 VPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGC-FTLFMATIPAETVSRGVIATALGLIMGLG 353
Cdd:cd17393 255 GDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVvVPLAFSAAGALPGLAAGIAVARVATLGYL 334
|
330 340
....*....|....*....|....*..
gi 15599291 354 elvGGFLAPTVAGFAADRFGLSIVMWM 380
Cdd:cd17393 335 ---GFLVGPPLIGFLADATGLRTAFLV 358
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-188 |
1.52e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.78 E-value: 1.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 31 ALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLI--VAVILFSLCSALSGLVGGFLSLLLF 108
Cdd:cd17478 213 SLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIAslLLAAPFLLLFLLTPGIWSYILLVLA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 109 RGIMGLAEGPILPLSQSLMveassPHRRGLNMGLLQGSAAGLlgAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIW 188
Cdd:cd17478 293 GFLLFASFPVTVVLAQELL-----PGNVGLASGLMMGLSFGL--GGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
32-186 |
1.83e-05 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 46.34 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 32 LSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGI 111
Cdd:cd17441 18 LSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYG-RKTGLKISVLWTLYYGILSAFAPIYSWILVLRGL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599291 112 MGLAEGPIlPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWL 186
Cdd:cd17441 97 VGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWA--LGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVL 168
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
65-295 |
1.99e-05 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 46.47 E-value: 1.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 65 GALV-GAWSDRRGQRKPLlIVAVILFSLCSALSGLVGGFLSL--------LLFRGIMGLAEGPILPLSQSLMVEASSPHR 135
Cdd:PRK15075 72 GAIVlGAYIDRVGRRKGL-IVTLSIMASGTLLIAFVPGYATIglaapllvLLGRLLQGFSAGVELGGVSVYLAEIATPGR 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 136 RGLNMGLLQGS------AAGLLGAVIGPPLLVALAEALGWRHAFIVsllpGLLIA---WLIWRHVRPDPPRAQRPA-PRA 205
Cdd:PRK15075 151 KGFYTSWQSASqqvavvFAALLGYLLNQWLSPAQMAEWGWRIPFLI----GCLIVpfiFLIRRSLEETEEFLARKHrPSM 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 206 EEAKgkRLALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRR 285
Cdd:PRK15075 227 REIF--RSLAANWRIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRR 304
|
250
....*....|
gi 15599291 286 PTLVAFSLLA 295
Cdd:PRK15075 305 PVLIAFTVLA 314
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
50-307 |
2.06e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 46.55 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 50 LGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVI--LFSLCSALSGlvgGFLSLLLFRGIMGLAEGPILPLSQSLM 127
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVtaVSGVLTAFSP---NYTVFLVFRLLVGMGIGGIWVQAVVLN 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 128 VEassphrrglNMGLLQGSAAGLLGAV---IGPPLLVALAEAL-GWRHAFIVSLLPGLLIAWLIWrhVRPDPPRAQRPAP 203
Cdd:TIGR00898 206 TE---------FLPKKQRAIVGTLIQVffsLGLVLLPLVAYFIpDWRWLQLAVSLPTFLFFLLSW--FVPESPRWLISQG 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 204 RAEEAKG--KRLALLKSRNILLCTLISCV----------------FVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLG 265
Cdd:TIGR00898 275 RIEEALKilQRIAKINGKKLPAEVLSLSLekdlssskkqysfldlFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLG 354
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15599291 266 VAwVVWGFAVPAIS------------DRIGRRPTLVAFSLLAACCPLALLYAPN 307
Cdd:TIGR00898 355 GN-IYLDLFISGLVelpaklitllliDRLGRRYTMAASLLLAGVALLLLLFVPV 407
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
17-360 |
2.88e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 45.87 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFD---RLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCS 93
Cdd:cd17314 4 VLYVSFLLSAMStgfILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 94 ALSGLVGGFLSLLLFRGIMGLAEGpILPLSQSLMVEASSPHRRGLNMGLLqgSAAGLLGAVIGPPLLVALAEALGWRHAF 173
Cdd:cd17314 84 YLSYVFNSFPLSYACFVFIGAGTG-ILYGSAVLVTTQYFPDTKGLALGLP--TTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 174 IVSLLPGLLIAWLIWRHVRPDPPRAQRPAPRAEEAKGKRLALLKS-RNILLCTLISCVFVTWFIVLI---SFTPTFLVNA 249
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDkVFWILFIAIFLVLIGGFLFIAnmaSLVRSLQLDA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 250 RGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFM 329
Cdd:cd17314 241 PSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYP 320
|
330 340 350
....*....|....*....|....*....|....
gi 15599291 330 ATIPaETVSRGVIATALGLIM---GLGELVGGFL 360
Cdd:cd17314 321 ATVS-TVFGTESFATLYGILLfapAIGSILGPML 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
217-414 |
3.88e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 3.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 217 KSRNILLCTLISCVFVTWF-IVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLA 295
Cdd:COG2814 6 RRRWLALLALALGAFLSGLgIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 296 ACCPLALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGLIMgLGELVGGFLAPTVAGFAADRFGLS 375
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLG-AGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15599291 376 IVMWMSCG-GALLAAFLSLFLRETAPAVLARQRSAPTSVL 414
Cdd:COG2814 165 WVFLVNAVlALLALLLLLRLLPESRPAARARLRGSLRELL 204
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
17-187 |
4.78e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.29 E-value: 4.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGF-VFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSAL 95
Cdd:cd17353 217 LLWLMFFLnATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 96 SGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIGPPLLVALAEALGWRHAFIV 175
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLY--TAKGVGGLIGPIIAAYVLYTGGYNAAFII 374
|
170
....*....|....*
gi 15599291 176 ---SLLPGLLIAWLI 187
Cdd:cd17353 375 aaaLSLVALALALLL 389
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
39-188 |
5.00e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.88 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 39 MEQELQLSNSHLGMLSSVLALAWAVSGALVGAW-SDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEG 117
Cdd:cd17317 15 TEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYlADRFG-RRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSA 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599291 118 PILPLSQSLMVEASSPHRRGLnMGLLQGsaaglLGAVIGPPLLVALAEALG-WRHAFIVSLLPGLLIAWLIW 188
Cdd:cd17317 94 GIFTVGFVLGMEIVGPKYRSF-VGILFG-----LFWALGYMLLALLAYLIRdWRWLQLAISLPGLLFLLLLW 159
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
51-192 |
7.23e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 44.91 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 51 GMLSSVLALAWAVSGALVGAWSDRRGQRKpLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEA 130
Cdd:PRK09874 261 GMIASVPGVAALLSAPRLGKLGDRIGPEK-ILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYN 339
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599291 131 SSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWRHVR 192
Cdd:PRK09874 340 SSNQIAGRIFSYNQSFRD--IGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLR 399
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
13-262 |
8.16e-05 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 44.52 E-value: 8.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFDRLALSFLFpfmEQELQLSNSHLGMLSSVLALAWAVSgALVGAWSD------RRgqRKPLLIVAV 86
Cdd:cd17484 1 SVIAVVYFSQGVAGLSWLAVSYYY---KDDLHLGPASVQALTSIASLPWAIK-PLYGLLSDsvpifgYR--RKPYLILAG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 87 ILFSLCS---ALSGLVGGFLSLLLFrGIMGLAEGPILPLSQSLMVEAS---SPHRRGLNMGLLQGSAA--GLLGAVIGPP 158
Cdd:cd17484 75 ALGALSWlalALVSNSSLALALLLL-LLASLGVAFSDVVIDALVVEASrgaPQSLAGDLQSLCWGSSAigGIVGSYFSGY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 159 LLvalaEALGWRHAFIV-SLLPGLLIAWLIWRHVRPDPPraQRPAPRAEEAKGKRLALLKSRNILLCTLiscvFVTWFIV 237
Cdd:cd17484 154 LL----ELLGPRTVFAVtSFFPLLLLIVAFFVKEERVPP--HRTKENFDEQLKALWETVKQPSIWLPAL----FIFLYQA 223
|
250 260
....*....|....*....|....*...
gi 15599291 238 LISFTPT---FLVNARGFSPATMGRLMS 262
Cdd:cd17484 224 TPSSGSAmfyFMTNELGFSPEFLGRLRV 251
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
13-182 |
8.57e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 8.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFDRLALSFlfpfmeQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLC 92
Cdd:cd17370 205 YLLAVALFALGNFSFAFLILRA------QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIG-RKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHA 172
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVG--IGWLLASLIAGYLWDLISPSAA 355
|
170
....*....|
gi 15599291 173 FIVSLLPGLL 182
Cdd:cd17370 356 FLFSAVLALI 365
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
36-295 |
1.06e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 44.27 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 36 FPFMEQELQLSNSHLGMlsSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLS--------LLL 107
Cdd:cd17366 30 FPGGDPTAQLLATFATF--AVAFLVRPLGGLVFGPLGDKYG-RQKVLAITIILMAASTFCIGLLPTYATigvwapilLLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 108 FRGIMGLAEGPILPLSQSLMVEASSPHRRG-LNMGLLQGSAAG-LLGAVIGPPLLVALAEA----LGWRHAFIVSLLPGL 181
Cdd:cd17366 107 ARMVQGFSTGGEYGGAATFVAEYAPDRKRGfLGSWLEFGTLAGfILGAGLVTLLTLLLTEAqmldWGWRIPFLIAAPLGL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 182 LiawliwrhvrpdppraqrpapraeeakgkrlALLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLM 261
Cdd:cd17366 187 V-------------------------------GLYLRRPLLICIGLVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVI 235
|
250 260 270
....*....|....*....|....*....|....
gi 15599291 262 SCLGVAWVVWGFAVPAISDRIGRRPtLVAFSLLA 295
Cdd:cd17366 236 IIIMVTMLVLQPFLGRLSDRVGRKP-VYAAGLAG 268
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
74-189 |
1.38e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 43.73 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 74 RRGQRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGA 153
Cdd:PRK03545 69 SNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTA--LAM 146
|
90 100 110
....*....|....*....|....*....|....*.
gi 15599291 154 VIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWR 189
Cdd:PRK03545 147 VLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIK 182
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
43-303 |
1.58e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.79 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 43 LQLSNSHLGMLSSVLALAWAVsGALVGAWS-----DRRGQRKPLLIVAVILF--SLCSALSGLVGGFLSLLLFRGIMGLA 115
Cdd:cd17357 40 LNLSDSELDLLWSLIVSIFFI-GGAIGSFIsaflaNRFGRKNGLLISNALLVvsSLLMFLSKSAKSPELLIFGRFLVGIA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 116 EGPILPLSQSLMVEASSPHRRGLnMGLLQG---SAAGLLGAVIGPPLLvaLAEALGWRHAFIVSLLPGLL-IAWLIWRhv 191
Cdd:cd17357 119 CGLSTGFVPMYLQEISPSELRGA-LGSLTQigvTLGILLGQVFGLPSV--LGTETLWPYLLFFPGIPALLqLAALPFF-- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 192 rPDPPR----------------------AQRPAPRAEEAK-----------GKRLALLKSRNILLCTLISCV--FVTWF- 235
Cdd:cd17357 194 -PESPKflliskgdeeeaekslkflrgiEDDVDQELEEIKkeseqmgdqkqVSLMQLLRDPSLRLPLLLVLVvsASQQFs 272
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599291 236 -IVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFsllAACCPLALL 303
Cdd:cd17357 273 gINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLIS---LSVCAVALL 338
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
55-365 |
1.98e-04 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 43.55 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 55 SVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILfSLCSALSGLVGGFLS--------LLLFRGIMGLAEGPILPlSQSL 126
Cdd:PRK10642 64 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM-SISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYT-GASI 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 127 MVEASSPHRRGLNMG--LLQGSAAG-LLGAVIGPPLLVALAEA----LGWRHAFIVSLLPGLLIAWLiwRHVRPDPPRAQ 199
Cdd:PRK10642 142 FVAEYSPDRKRGFMGswLDFGSIAGfVLGAGVVVLISTIVGEAnfldWGWRIPFFIALPLGIIGLYL--RHALEETPAFQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 200 RPAPRAEE------AKG-----KRLALLKSRNILLCT-LISCVFVTWFIvLISFTPTFLVNARGFSPATMGRLMSCLGVA 267
Cdd:PRK10642 220 QHVDKLEQgdreglQDGpkvsfKEIATKHWRSLLTCIgLVIATNVTYYM-LLTYMPSYLSHNLHYSEDHGVLIIIAIMIG 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 268 WVvwgFAVPAI---SDRIGRRPTLVA--FSLLAACCPLALLYAPNATSLGLLLLLTYTGLG-CFTLFMA-TIPAETVSRg 340
Cdd:PRK10642 299 ML---FVQPVMgllSDRFGRRPFVILgsVALFVLAIPAFILINSNVIGLIFAGLLMLAVILnCFTGVMAsTLPAMFPTH- 374
|
330 340
....*....|....*....|....*
gi 15599291 341 VIATALGLIMGLGELVGGfLAPTVA 365
Cdd:PRK10642 375 IRYSALAAAFNISVLVAG-LTPTLA 398
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
13-383 |
2.28e-04 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 43.19 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRkPLLIVAVILFSLC 92
Cdd:TIGR00892 19 VVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCR-PVVIAGGLLASLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRG-IMGLaeGPILPLSQSL-MVEASSPHRRGLNMGLlqGSAAGLLGAVIGPPLLVALAEALGWR 170
Cdd:TIGR00892 98 MILASFSSNVIELYLTAGfITGL--GLAFNFQPSLtMLGKYFYRRRPLANGL--AMAGSPVFLSTLAPLNQYLFESFGWR 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 171 HAFIV--SLLPGLLIAWLIWRHV----RPDPPRAQRPAPRAEEAK-GKRLALLKSRNILL----------CTLISCVFVt 233
Cdd:TIGR00892 174 GSFLIlgGLLLHCCVCGALMRPVgpsqRVSKSKSKEGLPPDGSTKkLSKKSTAEKINRFLdfslfthrgfLVYLSGNVI- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 234 wfIVLISFTP-TFLVN---ARGFSPATMGRLMSCLGVAWVVWGFAVPAISDR---IGRRPTLVAFSLLAA-----CCPLA 301
Cdd:TIGR00892 253 --MFLGFFAPiIFLVPyakDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLkwiRPHVQYLFSFALLFNglthlLCALA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 302 LLY-APNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRgviatALGLIMgLGELVGGFLAPTVAGFAADRFGLSIVMWM 380
Cdd:TIGR00892 331 GDYtGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSS-----AVGLVT-IVECCAVLIGPPLAGRLVDATKNYKYIFY 404
|
...
gi 15599291 381 SCG 383
Cdd:TIGR00892 405 ASG 407
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
63-364 |
3.12e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 42.66 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 63 VSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGL 142
Cdd:cd17374 50 VGALIFGHLSDRFG-RKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 143 LQGSAAgllgavIGPPLLVALAEAL-GWRHAFIVSLLPGLLIAWLIWrhvrpdppraqrpapraeeakgkrlallksrni 221
Cdd:cd17374 129 TSCFFS------IGQMLLAGLAYAIrDWRLLQLVVSVPFFLFFLYSW--------------------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 222 LLCTLISCVFVTWFIVLISFTpTFLVNARGFSpATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLA 301
Cdd:cd17374 170 WLPKRTLILSFVWFANSFSYY-GLSLDLQHLG-LNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILA 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599291 302 LLYAPnATSLGLLLLLTYTGLGCFTLFMATI---PAETVSRGVIATALGLImGLGELVGGFLAPTV 364
Cdd:cd17374 248 NIFVP-QEMQTLRTVLAVLGKGSSAAAFTISyvyTAELFPTVLRQTGMGLN-SMFARIGGILAPLI 311
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
27-306 |
3.36e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 42.36 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 27 FDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVsGALVGAWSDRRGQ--RKPLLIVAVILFSLCSALSGLVGGFLS 104
Cdd:pfam06779 7 IGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLA-GALLASFAWRHGAsrLRPALLAGLLATVLLLLAMAATSSFWA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 105 LLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLL-QGSAAG-LLGAVIGPPLLVALAEALGWRHAFIVSLLPGLL 182
Cdd:pfam06779 86 VLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLfAGVGIGiALSGLLVPLGLQLGLGGSSLWYGAGVLSAVLTL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 183 IAWLIWRHVRPDPPRAQRPAPRAEEAkgkrlallkSRNILLCTLISCVFVTWFIVLISFTPTFlVNARGFSPATMGRLMS 262
Cdd:pfam06779 166 AVFPLLPRRAPRHASAPAPAAKPLQR---------SLPLWILTLAYGLAGFGYIITATFLPAM-ARDGFGGPAAAALFWS 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 15599291 263 CLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALLYAP 306
Cdd:pfam06779 236 LFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSP 279
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
35-184 |
4.24e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 35 LFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGL 114
Cdd:cd17477 210 LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 115 AEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIA 184
Cdd:cd17477 290 AAGPLYTLALALAGDRLPGDELVAANAALLLLYG--LGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFL 357
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
37-302 |
4.64e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 42.32 E-value: 4.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 37 PFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAE 116
Cdd:PRK10473 27 PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSG-RKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 117 GPILPLSQSLMVEASSPHRRGLNMGLLQGSAA--GLLGAVIGPPLLVALAealgWRHAFIVSLLPGLLI---AWLIWRHV 191
Cdd:PRK10473 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNGITCiiPVLAPVLGHLIMLKFP----WQSLFYTMAAMGILVlllSLFILKET 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 192 RPDPPRAQRPAPRAEEAKgkrlalLKSRNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGVAWVVW 271
Cdd:PRK10473 182 RPARAPAASSKPRENSES------LLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGEYAIIMALTAGVSMTV 255
|
250 260 270
....*....|....*....|....*....|....
gi 15599291 272 GFAVPAISDRIGRRpTLVAFS---LLAACCPLAL 302
Cdd:PRK10473 256 SFSTPFALGIFKPR-TLMLTSqvlFLAAGITLAL 288
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
14-189 |
6.86e-04 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 41.62 E-value: 6.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLTFGFVFFDRLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLI------VAVI 87
Cdd:PRK11663 24 ILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIgliatgIINI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 88 LFSLCSALsglvggfLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQgSAAGLLGAVIgpPLLV-ALAEA 166
Cdd:PRK11663 104 LFGFSSSL-------WAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWN-TAHNVGGALI--PLVVgAIALH 173
|
170 180
....*....|....*....|....
gi 15599291 167 LGWRHAFIVSLLPGLLIA-WLIWR 189
Cdd:PRK11663 174 YGWRYGMMIAGIIAIVVGlFLCWR 197
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
51-157 |
9.71e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 41.11 E-value: 9.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 51 GMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILpLSQSLMVEA 130
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYG-RKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADV 144
|
90 100
....*....|....*....|....*..
gi 15599291 131 SSPHRRGLNMGLLqgSAAGLLGAVIGP 157
Cdd:cd17389 145 TSPKKRSKGMALI--GVAFSLGFIIGP 169
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
13-156 |
1.26e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 40.69 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 13 VLLCVLFLTFGFVF--FDRLALSFlfpfmEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRgqRKPLLI-VAVILF 89
Cdd:cd17336 6 VLLCLLGLLQGAVVsyFVSTITTI-----EKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRG--HRPRWIgIGSILM 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599291 90 SLCSALSGLVGGFLSLLLFRGIMGlaeGPILPLSQSLMVEASSPHRRGLNMGLLQgsAAGLLGAVIG 156
Cdd:cd17336 79 GLGCFLLALPHFLFVGQFLLGIGS---SPLYTLGITYIDDNVSKKNSPLYIGILY--AMRVLGPALG 140
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
38-290 |
1.32e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 40.85 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 38 FMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVIlFSLCSALSGLVGGFLSLLLFRGIMGLAEG 117
Cdd:cd17437 22 FIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALI-FFVGALLMGVAPNYPVLMVGRFVAGIGVG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 118 PILPLSQSLMVEASSPHRRG---------LNMGLLQGSAAGLLgavigpplLVALAEALGWRHAFIVSLLPGLLIAWLIW 188
Cdd:cd17437 101 FALMIAPVYTAEVAPASSRGfltsfpeifINIGILLGYVSNYA--------FSGLPLHVGWRLMLGVGAVPSLFLAIGVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 189 RhvRPDPPRAQRPAPRaeeakgkrlallksrnillcTLISCVFVTWFIVLISFTPTFLVNARGFSPATM----GRLMSCL 264
Cdd:cd17437 173 A--MPESPRWTPAVRR--------------------MLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIkskdKLLLATV 230
|
250 260
....*....|....*....|....*...
gi 15599291 265 GVAWVVWGFAVPAIS--DRIGRRPTLVA 290
Cdd:cd17437 231 AVGVTKTLFILVATFllDKVGRRPLLLT 258
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
12-187 |
1.81e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.28 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 12 NVLLCVLFLTFGFVFFdrlalSFLFP-FMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFS 90
Cdd:cd17331 211 FLLLVKLLSGLPIGMF-----QSMFSlVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 91 LCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLlqGSAAGLLGAVIGPPLLVALAEALGWR 170
Cdd:cd17331 286 IGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGL--SHALFSLVRTVSPTIGGALLQAYGFP 363
|
170
....*....|....*...
gi 15599291 171 H-AFIVSLLPGLLIAWLI 187
Cdd:cd17331 364 SfGLLGAAINGLLTVYLL 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
224-416 |
2.23e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 224 CTLISCVFVTWFIVLISFTPTFLVNArGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPLALL 303
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 304 YAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGLIMGlGELVGGFLAPTVAGFAADRFGLSIVMWMSCG 383
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSS-AIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170 180 190
....*....|....*....|....*....|...
gi 15599291 384 GALLAAFLSLFLRETAPAVLARQRSAPTSVLQG 416
Cdd:cd17325 159 LALLALVLALLLLPEPRPPPNKRAVSAARLRSG 191
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
46-173 |
2.37e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 46 SNSHLGMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQS 125
Cdd:cd17476 31 SPNQLSWLAASYSLTVGTFILIFGRLGDIYG-HKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMA 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15599291 126 LMVEASSPHRRgLNMGLLQGSAAGLLGAVIGPPLLVALAEALGWRHAF 173
Cdd:cd17476 110 LLGRTYPPGPR-KNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
32-143 |
2.95e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 39.90 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 32 LSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIvAVILFSLCSALSGLVGGFLSLLLFRGI 111
Cdd:cd17440 18 VGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLI-CMSVNGFFAFLSSFVQGYGLFLFCRLL 96
|
90 100 110
....*....|....*....|....*....|..
gi 15599291 112 MGLAEGPILPLSQSLMVEASSPHRRGLNMGLL 143
Cdd:cd17440 97 SGFGIGGAVPTVFSYFAEVLAREKRGEHLSWL 128
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-383 |
3.28e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 221 ILLCTLISCVFVTWFIVLIsftPTFLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPL 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAL---PLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 301 ALLYAPNATSLGLLLLLTYTGLGCFTLFMATIPAETVSRGVIATALGlIMGLGELVGGFLAPTVAGFAADRFGLSIVMWM 380
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALG-LVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
...
gi 15599291 381 SCG 383
Cdd:pfam07690 157 LAI 159
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
14-188 |
3.28e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 39.52 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLtfgFVFFDRLALSFLFPFMeQELQLSNSHLGMLSSVLALAWAVSGALVGAW-SDRRGQRKPLLIVAVILFSLC 92
Cdd:cd17485 212 LLLFLLL---YKLGEQGALAMLPPFL-VDRGFSLSQIGLLSGVGGSLVSIAGSLLGGYlLKRRGRRRLLLLGGLLRLLLL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 93 SALSGLVGGFLSLLLFRGI-----MGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGsaAGLLGAVIGPPLLVALAEAL 167
Cdd:cd17485 288 GLYTLLALGGSGLNWVLLLaslalLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLAT--VEVLGKLLFGSLAGFLADHL 365
|
170 180
....*....|....*....|.
gi 15599291 168 GWRHAFIVSLLPGLLIAWLIW 188
Cdd:cd17485 366 GYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
14-186 |
3.68e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 14 LLCVLFLTFGFVFFdrLALSFLFPFMEQELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCS 93
Cdd:cd17330 178 RLLLVYFLIALAFA--GLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 94 ALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAF 173
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQS--LARIIGPLLAGPLYSFLGPGVPF 333
|
170
....*....|....*.
gi 15599291 174 IVS---LLPGLLIAWL 186
Cdd:cd17330 334 LLAaglLLIALFLLSL 349
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
82-308 |
4.29e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.15 E-value: 4.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 82 LIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLAEGPILPLSQSLMveasSPHRRGLNMGLLQG--SAAGLLGAVIGPPL 159
Cdd:cd17327 74 LSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYL----GMWYKREEQAKRIAffYAAAGLGSIFGGLL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 160 LVALAEAL------GWRHAFI----VSLLPGLLIAWLIwrhvrPDPP----------------RAQRPAPRAEEAKGK-- 211
Cdd:cd17327 150 AYGVFKILgvgglaGWRWLFIieglITIIIGLVIFFWL-----PDNPskawflteeekelaveRLRANQTGKGDQKFKwk 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 212 --RLALLKSRNILLCTLISCVFVTWFIvLISFTPTFLVNARGFSPAT--MGRLMSCLGVAWVvwgFAVPAISDRIGRR-P 286
Cdd:cd17327 225 qiKEAFKDPRTWLLFLFFFCSQITNNG-ISNFLPLILKSLGFYSLQTnlLSVPIGALGAVSL---LIAALLSDRFKKRgL 300
|
250 260
....*....|....*....|..
gi 15599291 287 TLVAFSLLAACCPLALLYAPNA 308
Cdd:cd17327 301 FAIFACVLALVGSIILLAAPNP 322
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
30-189 |
6.80e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 38.36 E-value: 6.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 30 LALSFLFPfMEQELQLSNSHLGMLSSVLALAwAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSALSGLVGGFLSLLLFR 109
Cdd:PRK10213 38 LPVSLLTP-MAQDLGISEGVAGQSVTVTAFV-AMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 110 GIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALAEALGWRHAFIVSLLPGLLIAWLIWR 189
Cdd:PRK10213 116 ACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVS--IALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIK 193
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
51-209 |
7.32e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 38.49 E-value: 7.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 51 GMLSSVLALAWAVSGALVGAWSDRRGqRKPLLIVAVILfSLCSALSGLVGG-FLSLLLFRGIMGLAEGPilPLSQSLMVE 129
Cdd:pfam06609 81 GLFSTLWTMGQAVSILMMGRLTDRFG-RRPFVIATHII-GLVGAIVGCTANkFNTLLAAMTLLGVAAGP--AGASPLFIG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 130 ASSPHRRGLnMGLLQGSAAGLLGAVIGPPLLVALAEALGWRHAF----IVSLLPGLLIawLIWRHvrpdPP-----RAQR 200
Cdd:pfam06609 157 ELMSNKTKF-LGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFyiyiIMSAIAVLLI--IIWYH----PPsfaqlHGKK 229
|
....*....
gi 15599291 201 PAPRAEEAK 209
Cdd:pfam06609 230 ARKRDELAK 238
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
24-164 |
7.66e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 38.34 E-value: 7.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 24 FVFFDRLALSFLF----PFMEQ-ELQLSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFSLCSALSGL 98
Cdd:cd17326 7 TMFLSSLQFSIVLtsiwPYLQKiDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGNILYAL 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599291 99 VGGFLS-----LLLFRGIMGLAEGPILPLsQSLMVEASSPHRRGLNMGLLQGSAAglLGAVIGPPLLVALA 164
Cdd:cd17326 87 AEYFPSnrkyvMLVARFLIGVGAGNVAVL-RAYVAAASTLKDRTRAMAVISAAQA--LGFIVGPALQAAFT 154
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
69-384 |
8.43e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 37.97 E-value: 8.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 69 GAWSDRRGqRKPLLIVAVILFSLCSALSGLVGGFLSLLLFRGIMGLaeGPILPLSQSLMVEASSPHRRGLNMGLLQGS-- 146
Cdd:cd17472 53 GLLSDRIG-RKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASig 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 147 AAGLLGAVIGPpllvALAEALGWRHAFIVSLLPGlLIAWLIWRHVRPDPPRAQRpapRAEEAKGKRLALLKSRNILLCTL 226
Cdd:cd17472 130 IAFAISMVLGP----LLAAHLGVSGLFLITAILS-LVSLLILLFFVPDPPKIVQ---ISEKEKKKLKKLLKNKRLLRLDF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 227 IscVFVTWFIVLISFT--PTFLVNArGFSPATMGRL-MSCLGVAWVVWGFAVpaISDRIGRRPTLVAFSLLAACCPLALL 303
Cdd:cd17472 202 S--IFILHFVLMAFFYilPLLLTQL-GGGKGQLWKVyLPAILIGFILMVPFV--IYAEKKGKMKQVFVSSILLIAVGFLL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 304 YAPNATSLGLLLLLTYTGLGCFTLFMATIPAeTVSRGVIATALGLIMG-----------LGELVGGFLAPTVAGFAADRF 372
Cdd:cd17472 277 LLFAATSLWLLIIGLIIFFIGFNLLEALLPS-LVSKIAPKEYRGTAMGiyntsqflgsfLGGALGGLLWGLLGYSSVFLT 355
|
330
....*....|...
gi 15599291 373 GLSI-VMWMSCGG 384
Cdd:cd17472 356 ILILaLLWLLVSF 368
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
17-159 |
8.85e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 37.94 E-value: 8.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 17 VLFLTFGFVFFDRLALSFLFPFMEQELQlSNSHLGMLSSVLALAWAVSGALVGAWSDRRGQRKPLLIVAVILFslCSALS 96
Cdd:cd17384 1 VLVIVYVALLLDNMLLTVVVPIIPDYLN-ENVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMF--ISTLL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599291 97 -GLVGGFLSLLLFRGIMGLAEGPILPLSQSLMVEA-SSPHRRGLNMGLLQGSAAglLGAVIGPPL 159
Cdd:cd17384 78 fAFGESYGVLFLARALQGVGSACSSVAGMGMLASLyPDDKERGKAMGIALGGLA--LGVLVGPPF 140
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
221-307 |
9.40e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 37.92 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 221 ILLCTLISCVFVTWFIVLISFtptfLVNARGFSPATMGRLMSCLGVAWVVWGFAVPAISDRIGRRPTLVAFSLLAACCPL 300
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSL----RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
....*..
gi 15599291 301 ALLYAPN 307
Cdd:cd17477 77 LLALTDS 83
|
|
| oat |
TIGR00805 |
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ... |
102-266 |
9.96e-03 |
|
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.
Pssm-ID: 273279 [Multi-domain] Cd Length: 632 Bit Score: 38.17 E-value: 9.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 102 FLSLLLFRGIMGLAEGPILPLSQSLMVEASSPHRRGLNMGLLQ-----GSAAGLLGAVIGPPLLVAL----AEALG---- 168
Cdd:TIGR00805 171 WLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILEsgsvfGPAFGFLLGSFCLQIYVDTgsvnTEDLIitpt 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599291 169 -------WRHAFIVS------------LLPGLLIAWLIWRHVRPDppRAQRPAPRAEEAKGKR-----------LALLKS 218
Cdd:TIGR00805 251 dprwigaWWIGFLVCgfvalltsiplfFFPKTLPKEGKRVNVDVH--EAEKLEKSRGEDRKKNsgitkdfpkfiKRLLCN 328
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 15599291 219 RNILLCTLISCVFVTWFIVLISFTPTFLVNARGFSPATMGRLMSCLGV 266
Cdd:TIGR00805 329 KIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNV 376
|
|
| |
