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Conserved domains on  [gi|15598828|ref|NP_252322|]
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hypothetical protein PA3632 [Pseudomonas aeruginosa PAO1]

Protein Classification

SirA-like protein( domain architecture ID 10013705)

SirA-like protein similar to SirA, TusA, and the uncharacterized protein YedF; SirA belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence, TusA interacts with cysteine desulfurase IscS and acts as the first member in a sulfur relay

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11018 PRK11018
putative sulfurtransferase YedF;
1-78 2.72e-46

putative sulfurtransferase YedF;


:

Pssm-ID: 236822  Cd Length: 78  Bit Score: 142.11  E-value: 2.72e-46
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598828   1 MSQTDKPTLSLDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIEV 78
Cdd:PRK11018  1 MMKNIVPDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLIQK 78
 
Name Accession Description Interval E-value
PRK11018 PRK11018
putative sulfurtransferase YedF;
1-78 2.72e-46

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 142.11  E-value: 2.72e-46
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598828   1 MSQTDKPTLSLDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIEV 78
Cdd:PRK11018  1 MMKNIVPDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLIQK 78
YedF cd03422
YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and ...
 10-78 4.61e-40

YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239514  Cd Length: 69  Bit Score: 126.39  E-value: 4.61e-40
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598828 10 SLDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIEV 78
Cdd:cd03422  1 RLDLRGEPCPYPAIATLEALPSLKPGEILEVISDCPQSINNIPIDARNHGYKVLAIEQSGPTIRYLIQK 69
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 11-77 3.69e-19

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 73.31  E-value: 3.69e-19
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598828 11 LDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIE 77
Cdd:COG0425  1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEEEGGVYRILIR 67
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 11-73 7.14e-18

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 69.91  E-value: 7.14e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598828   11 LDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFR 73
Cdd:pfam01206  2 LDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEEEDGEYR 64
 
Name Accession Description Interval E-value
PRK11018 PRK11018
putative sulfurtransferase YedF;
1-78 2.72e-46

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 142.11  E-value: 2.72e-46
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598828   1 MSQTDKPTLSLDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIEV 78
Cdd:PRK11018  1 MMKNIVPDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLIQK 78
YedF cd03422
YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and ...
 10-78 4.61e-40

YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239514  Cd Length: 69  Bit Score: 126.39  E-value: 4.61e-40
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598828 10 SLDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIEV 78
Cdd:cd03422  1 RLDLRGEPCPYPAIATLEALPSLKPGEILEVISDCPQSINNIPIDARNHGYKVLAIEQSGPTIRYLIQK 69
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 11-77 1.88e-21

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 79.14  E-value: 1.88e-21
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598828 11 LDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIE 77
Cdd:cd00291  2 LDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEVEEEGGVYRILIR 68
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 11-77 3.69e-19

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 73.31  E-value: 3.69e-19
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598828 11 LDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLIE 77
Cdd:COG0425  1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELLSVEEEGGVYRILIR 67
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 11-73 7.14e-18

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 69.91  E-value: 7.14e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598828   11 LDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFR 73
Cdd:pfam01206  2 LDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEVEEEDGEYR 64
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 11-76 2.88e-05

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 38.11  E-value: 2.88e-05
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598828 11 LDLRGEHCPYNAIATLETLATMQPGERLEVVTDCSQSVHGIPEDTQRQGYKCLAVEQHGALFRFLI 76
Cdd:cd03423  2 LDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELLAQETEDEPYRYLI 67
PRK06209 PRK06209
glutamate-1-semialdehyde 2,1-aminomutase; Provisional
 19-74 7.10e-03

glutamate-1-semialdehyde 2,1-aminomutase; Provisional


Pssm-ID: 180471 [Multi-domain]  Cd Length: 431  Bit Score: 33.48  E-value: 7.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15598828   19 PYNAIATLETLATMQPGERLEVVTDCSQSVHgiPEDTQRQGYKCLAVEqHGALFRF 74
Cdd:PRK06209 170 RYNDIASLEALFEDHPGRIACVILEPATADE--PQDGFLHEVRRLCHE-NGALFIL 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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