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Conserved domains on  [gi|15597243|ref|NP_250737|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 13722860)

AraC family transcriptional regulator contains a helix-turn-helix DNA-binding motif and controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Gene Ontology:  GO:0003700|GO:0006355|GO:0043565

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 59-211 1.37e-66

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


:

Pssm-ID: 461994  Cd Length: 152  Bit Score: 205.81  E-value: 1.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243    59 AVEPLALIRADGPTLPARGMHKPALCIIAQGRKEVQLAEERYIYDPLHYLVVSVTLPLAGQVIDASPDAPYLCVRLDIDP 138
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTEASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597243   139 AEITQLISDAGPMEVASRRGdRGLYVDRIDASLLDAVLRLIHLLDSPRDIPMLAPLILREIFYRLLRSGQGQR 211
Cdd:pfam06719  81 ALLAELLLEAPPPGPPPRAG-RGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQGAR 152
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 205-329 4.72e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.85  E-value: 4.72e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243 205 RSGQGQRlheIAIADSQAH---RITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEAR 281
Cdd:COG4977 192 PGGQAQF---SPLLVPLGHrdpRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERAR 268

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15597243 282 RLIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPPLRDLARARNTA 329
Cdd:COG4977 269 RLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 59-211 1.37e-66

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 205.81  E-value: 1.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243    59 AVEPLALIRADGPTLPARGMHKPALCIIAQGRKEVQLAEERYIYDPLHYLVVSVTLPLAGQVIDASPDAPYLCVRLDIDP 138
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTEASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597243   139 AEITQLISDAGPMEVASRRGdRGLYVDRIDASLLDAVLRLIHLLDSPRDIPMLAPLILREIFYRLLRSGQGQR 211
Cdd:pfam06719  81 ALLAELLLEAPPPGPPPRAG-RGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQGAR 152
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 205-329 4.72e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.85  E-value: 4.72e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243 205 RSGQGQRlheIAIADSQAH---RITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEAR 281
Cdd:COG4977 192 PGGQAQF---SPLLVPLGHrdpRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERAR 268

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15597243 282 RLIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPPLRDLARARNTA 329
Cdd:COG4977 269 RLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
239-318 3.14e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 91.46  E-value: 3.14e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243    239 PLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80
HTH_18 pfam12833
Helix-turn-helix domain;
245-324 3.78e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.33  E-value: 3.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243   245 LAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARR-LIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPPLRDLA 323
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRlLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 15597243   324 R 324
Cdd:pfam12833  81 R 81
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
203-318 2.52e-15

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 75.01  E-value: 2.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  203 LLRSGQGQRLHEIAIADsqaHRITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARR 282
Cdd:PRK10572 166 LLRCMEAIPESLHPPMD---PRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKL 242

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15597243  283 LIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:PRK10572 243 LLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASP 278
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 59-211 1.37e-66

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 205.81  E-value: 1.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243    59 AVEPLALIRADGPTLPARGMHKPALCIIAQGRKEVQLAEERYIYDPLHYLVVSVTLPLAGQVIDASPDAPYLCVRLDIDP 138
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTEASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597243   139 AEITQLISDAGPMEVASRRGdRGLYVDRIDASLLDAVLRLIHLLDSPRDIPMLAPLILREIFYRLLRSGQGQR 211
Cdd:pfam06719  81 ALLAELLLEAPPPGPPPRAG-RGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLTGPQGAR 152
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 205-329 4.72e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.85  E-value: 4.72e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243 205 RSGQGQRlheIAIADSQAH---RITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEAR 281
Cdd:COG4977 192 PGGQAQF---SPLLVPLGHrdpRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERAR 268

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15597243 282 RLIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPPLRDLARARNTA 329
Cdd:COG4977 269 RLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
239-318 3.14e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 91.46  E-value: 3.14e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243    239 PLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
152-327 1.13e-21

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 92.54  E-value: 1.13e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243 152 EVASRRGDRGLYVDRIDASLLDAVLRLIHLLDSPRDIPMLAPLILREIFYRLLRSGQGQRLHEIAIADSQAHRITRAIDW 231
Cdd:COG2207  85 LLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLL 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243 232 INQNygkpLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRVGYESPSQFSREYS 311
Cdd:COG2207 165 LLLL----LTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFK 240

                       170
                ....*....|....*.
gi 15597243 312 RLFGAPPLRDLARARN 327
Cdd:COG2207 241 KRFGVTPSEYRKRLRA 256
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 221-326 2.41e-20

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 90.11  E-value: 2.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243 221 QAHRITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIfSEGLEVAAAGYRVGY 300
Cdd:COG2169  82 RADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGF 160

                        90       100
                ....*....|....*....|....*...
gi 15597243 301 ESPSQFSREYSRLFGAPP--LRDLARAR 326
Cdd:COG2169 161 GSLSRFYEAFKKLLGMTPsaYRRGGAGA 188
HTH_18 pfam12833
Helix-turn-helix domain;
245-324 3.78e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.33  E-value: 3.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243   245 LAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARR-LIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPPLRDLA 323
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRlLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 15597243   324 R 324
Cdd:pfam12833  81 R 81
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
203-318 2.52e-15

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 75.01  E-value: 2.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  203 LLRSGQGQRLHEIAIADsqaHRITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARR 282
Cdd:PRK10572 166 LLRCMEAIPESLHPPMD---PRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKL 242

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15597243  283 LIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:PRK10572 243 LLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASP 278
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
166-326 1.88e-12

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 66.62  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  166 RIDASLLDAVLRLIHLLDSPRDIPMLAPLILREI-FYRLLRSGQGQRLHEIAiaDSQAHRITRAIDWINQNYGKPLRIEQ 244
Cdd:PRK13503 115 RVNQSVLQQVRQLVAQMEQQEESNDLEAIASREIlFMQLLVLLRKSSLQENG--ENSDARLNQLLAWLEDHFAEEVNWEA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  245 LAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPPlRDLAR 324
Cdd:PRK13503 193 LADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSP-RDIRQ 271


                 ..
gi 15597243  325 AR 326
Cdd:PRK13503 272 GR 273
ftrA PRK09393
transcriptional activator FtrA; Provisional
 207-318 5.52e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 62.67  E-value: 5.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  207 GQGQRLHEiAIADSQAHRITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFS 286
Cdd:PRK09393 203 GQAQFVPR-PVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLES 281

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15597243  287 EGLEVAAAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:PRK09393 282 SALSIDQIAERAGFGSEESLRHHFRRRAATSP 313
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
218-318 2.56e-08

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 54.80  E-value: 2.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  218 ADSQAHR---ITRAIDWINQNygKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRlqeARRL--IFSEGLEVA 292
Cdd:PRK15435  77 ANPQQHRldkITHACRLLEQE--TPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWR---ARRLreALAKGESVT 151

                         90       100
                 ....*....|....*....|....*.
gi 15597243  293 AAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:PRK15435 152 TSILNAGFPDSSSYYRKADETLGMTA 177
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 232-273 2.81e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 46.38  E-value: 2.81e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15597243   232 INQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQK 273
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
215-318 2.23e-06

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 48.76  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  215 IAIADSQAHR-----ITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARR-LI--FS 286
Cdd:PRK10130 227 MVTAESISHQsyrrlLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRReLIspWS 306

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15597243  287 EGLEVAAAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:PRK10130 307 QSTTVKDAAMQWGFWHLGQFATDYQQLFAEKP 338
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
225-318 3.63e-06

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 45.30  E-value: 3.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  225 ITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRVGYESPS 304
Cdd:PRK10219   7 IQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQ 86

                         90
                 ....*....|....
gi 15597243  305 QFSREYSRLFGAPP 318
Cdd:PRK10219  87 TFSRVFRRQFDRTP 100
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
219-318 4.66e-06

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 45.48  E-value: 4.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  219 DSQAHRITRAIDWINQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRV 298
Cdd:PRK11511   5 NTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERY 84

                         90       100
                 ....*....|....*....|
gi 15597243  299 GYESPSQFSREYSRLFGAPP 318
Cdd:PRK11511  85 GFESQQTLTRTFKNYFDVPP 104
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
232-318 3.41e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 41.81  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  232 INQNYGKPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRVGYESPSQFSREYS 311
Cdd:PRK13501 185 LQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFT 264


                 ....*..
gi 15597243  312 RLFGAPP 318
Cdd:PRK13501 265 REAGMTP 271
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
238-318 3.99e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 41.58  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  238 KPLRIEQLAQVVNLSPSTLHHRFKAVTAMSPLQYQKQLRLQEARRLIFSEGLEVAAAGYRVGYESPSQFSREYSRLFGAP 317
Cdd:PRK13502 191 CPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMT 270


                 .
gi 15597243  318 P 318
Cdd:PRK13502 271 P 271
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 166-318 1.65e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 39.63  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  166 RIDASLldAVLRLIHLL--DSPRDIPMLAPL--ILREIFYRLLRSGQGQRLHEIAIADSQAHRITRAIDwinQNYGKP-L 240
Cdd:PRK09685 141 RLSASL--PMVQLSHRLlqQSMNGPALSETEseALLEALIALLRPALHQRESVQPRRERQFQKVVALID---QSIQEEiL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597243  241 RIEQLAQVVNLSPSTLHHRFkAVTAMSPLQYQKQLRLQEARRLI--FSEGLEVAAAGYRVGYESPSQFSREYSRLFGAPP 318
Cdd:PRK09685 216 RPEWIAGELGISVRSLYRLF-AEQGLVVAQYIRNRRLDRCADDLrpAADDEKITSIAYKWGFSDSSHFSTAFKQRFGVSP 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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